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La Santa Muerte is a folk saint depicted as a female Grim Reaper in Mexico and the Southwestern United States. The Grim Reaper, as an iconic representation of death, was derived from the Angel of Death found in pseudepigrapha and apocalyptic writings of Jewish and early Christian writers. The Angel

La Santa Muerte is a folk saint depicted as a female Grim Reaper in Mexico and the Southwestern United States. The Grim Reaper, as an iconic representation of death, was derived from the Angel of Death found in pseudepigrapha and apocalyptic writings of Jewish and early Christian writers. The Angel of Death arose from images and practices in pre-Christian Europe and throughout the Mediterranean region. Images taken from Revelation were used to console the survivors of the Black Death in Western Europe and produced a material culture that taught the Christian notion of dying well. The combination of the scythe (used in the eschatological harvest), the black cowl (worn by medieval priests and monks officiating at funerals), and the skeleton (as the physical body of the deceased) are a series of apocalyptic Christian referents that form a metonymical composite referred to as the Grim Reaper.

In medieval Iberian Dances of Death, the Grim Reaper was depicted as female, an unyielding social leveler, and an important participant in the Last Judgment. Personalized Death became associated with healing, renewal, magic, and binding, as apocalyptic Christianity blended with the Christian cult of the saints and the Virgin Mary during the Reconquista and the colonization of Mesoamerica. Utilizing secondary historical sources, metonymy, and iconology this Master of Arts thesis posits that the La Santa Muerte image resulted from a long historical interaction of Greek, Roman, Jewish, Visogothic, Islamic, and Christian death imagery leading up to the colonization of Mesoamerica.
ContributorsBreault, Eric (Author) / Astor-Aguilera, Miguel A (Thesis advisor) / Gereboff, Joel (Committee member) / Maupin, Jonathan (Committee member) / Arizona State University (Publisher)
Created2014
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Description
The influenza virus, also known as "the flu", is an infectious disease that has constantly affected the health of humanity. There is currently no known cure for Influenza. The Center for Innovations in Medicine at the Biodesign Institute located on campus at Arizona State University has been developing synbodies as

The influenza virus, also known as "the flu", is an infectious disease that has constantly affected the health of humanity. There is currently no known cure for Influenza. The Center for Innovations in Medicine at the Biodesign Institute located on campus at Arizona State University has been developing synbodies as a possible Influenza therapeutic. Specifically, at CIM, we have attempted to design these initial synbodies to target the entire Influenza virus and preliminary data leads us to believe that these synbodies target Nucleoprotein (NP). Given that the synbody targets NP, the penetration of cells via synbody should also occur. Then by Western Blot analysis we evaluated for the diminution of NP level in treated cells versus untreated cells. The focus of my honors thesis is to explore how synthetic antibodies can potentially inhibit replication of the Influenza (H1N1) A/Puerto Rico/8/34 strain so that a therapeutic can be developed. A high affinity synbody for Influenza can be utilized to test for inhibition of Influenza as shown by preliminary data. The 5-5-3819 synthetic antibody's internalization in live cells was visualized with Madin-Darby Kidney Cells under a Confocal Microscope. Then by Western Blot analysis we evaluated for the diminution of NP level in treated cells versus untreated cells. Expression of NP over 8 hours time was analyzed via Western Blot Analysis, which showed NP accumulation was retarded in synbody treated cells. The data obtained from my honors thesis and preliminary data provided suggest that the synthetic antibody penetrates live cells and targets NP. The results of my thesis presents valuable information that can be utilized by other researchers so that future experiments can be performed, eventually leading to the creation of a more effective therapeutic for influenza.
ContributorsHayden, Joel James (Author) / Diehnelt, Chris (Thesis director) / Johnston, Stephen (Committee member) / Legutki, Bart (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / Department of Chemistry and Biochemistry (Contributor)
Created2014-05
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Description
Advancements in both the medical field and public health have substantially minimized the detrimental impact of infectious diseases. Health education and disease prevention remains a vital tool to maintain and propagate this success. In order to determine the relationship between knowledge of disease and reported preventative behavior 180 participants amongst

Advancements in both the medical field and public health have substantially minimized the detrimental impact of infectious diseases. Health education and disease prevention remains a vital tool to maintain and propagate this success. In order to determine the relationship between knowledge of disease and reported preventative behavior 180 participants amongst the ASU student population were surveyed about their knowledge and prevention behavior for 10 infectious diseases. Of the 180 participants only 138 were completed surveys and used for analysis. No correlation was found between knowledge or perceived risk and preventative measures within the total sample of 138 respondents, however there was a correlation found within Lyme disease and Giardia exposure to information and prevention. Additionally, a cultural consensus analysis was used to compare the data of 17 US-born and 17 foreign-born participants to analyze patterns of variation and agreement on disease education based on national origins. Cultural consensus analysis showed a strong model of agreement among all participants as well as within the US-born and foreign-born student groups. There was a model of agreement within the questions pertaining to transmission and symptoms. There was not however a model of agreement within treatment questions. The findings suggest that accurate knowledge on infectious diseases may be less impactful on preventative behavior than social expectations.
ContributorsVernon, Samantha (Author) / Maupin, Jonathan (Thesis director) / Jehn, Megan (Committee member) / Barrett, The Honors College (Contributor) / School of Human Evolution and Social Change (Contributor)
Created2018-05