Polymer drug delivery system offers a key to a glaring issue in modern administration routes of drugs and biologics. Poly(lactic-co-glycolic acid) (PLGA) can be used to encapsulate drugs and biologics and deliver them into the patient, which allows high local concentration (compared to current treatment methods), protection of the cargo from the bodily environment, and reduction in systemic side effects. This experiment used a single emulsion technique to encapsulate L-tyrosine in PLGA microparticles and UV spectrophotometry to analyze the drug release over a period of one week. The release assay found that for the tested samples, the released amount is distinct initially, but is about the same after 4 days, and they generally follow the same normalized percent released pattern. The experiment could continue with testing more samples, test the same samples for a longer duration, and look into higher w/w concentrations such as 20% or 50%.

The goal of this research project is to create a Mathcad template file capable of statistically modelling the effects of mean and standard deviation on a microparticle batch characterized by the log normal distribution model. Such a file can be applied during manufacturing to explore tolerances and increase cost and time effectiveness. Theoretical data for the time to 60% drug release and the slope and intercept of the log-log plot were collected and subjected to statistical analysis in JMP. Since the scope of this project focuses on microparticle surface degradation drug release with no drug diffusion, the characteristic variables relating to the slope (n = diffusional release exponent) and the intercept (k = kinetic constant) do not directly apply to the distribution model within the scope of the research. However, these variables are useful for analysis when the Mathcad template is applied to other types of drug release models.

The history of Arizona is filled with ambitious pioneers, courageous Natives, and loyal<br/>soldiers, but there is a seeming disconnect between those who came before us and many of those<br/>who currently inhabit this space. Many historic locations that are vital to discovering the past in<br/>Arizona are both hard to find and lacking in information pertaining to what happened there.<br/>However, despite the apparent lack of history and knowledge pertaining to these locations, they<br/>are vitally present in the public memory of the region, and we wish to shed some much-needed<br/>light on a few of these locations and the historical takeaways that can be gleaned from their<br/>study. This thesis argues the significance of three concepts: place-making, public memory, and<br/>stories. Place-making is the reinvention of history in the theater of mind which creates a<br/>plausible reality of the past through what is known in the present. Public memory is a way to<br/>explain how events in a location affect the public consciousness regarding that site and further<br/>events that stem from it. Lastly, stories about a place and event help to explain its overall impact<br/>and what can be learned from the occurrences there. Throughout this thesis we will be discussing<br/>seven sites across Arizona, the events that occurred there, and how these three aspects of study<br/>can be used to experience history in a personal way that gives us a special perspective on the<br/>land around us. The importance of personalizing history lies in finding our own identity as<br/>inhabitants of this land we call home and knowing the stories gives us greater attachment to the<br/>larger narrative of humanity as it has existed in this space.

The privatization of prisons within Arizona has been a hot button issue and needs to be further analyzed to determine their benefits and expenses. To begin this investigation into the effectiveness of private prisons within Arizona and possible steps that need to be taken for its rehabilitation certain definitions and prior research need to be understood. Following this explanation, areas such as costs analysis across different types of prisons, liability rates across differing types of prison guards, and the differing psychology of different types of prisons can be examined to gain an overall assessment of the current performance of privatized prisons within Arizona. After this in-depth analysis of the current private prison system within Arizona, the flaws of the system will become abundantly clear and the solutions that should be implemented to alleviate these problems will be discussed.