Matching Items (4)
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- All Subjects: Glucose Sensors
- Creators: LaBelle, Jeffrey
- Creators: Janis, William Edward
- Creators: Liu, Deming
- Resource Type: Text
Description
Bioscience High School, a small magnet high school located in Downtown Phoenix and a STEAM (Science, Technology, Engineering, Arts, Math) focused school, has been pushing to establish a computer science curriculum for all of their students from freshman to senior year. The school's Mision (Mission and Vision) is to: "..provide a rigorous, collaborative, and relevant academic program emphasizing an innovative, problem-based curriculum that develops literacy in the sciences, mathematics, and the arts, thus cultivating critical thinkers, creative problem-solvers, and compassionate citizens, who are able to thrive in our increasingly complex and technological communities." Computational thinking is an important part in developing a future problem solver Bioscience High School is looking to produce. Bioscience High School is unique in the fact that every student has a computer available for him or her to use. Therefore, it makes complete sense for the school to add computer science to their curriculum because one of the school's goals is to be able to utilize their resources to their full potential. However, the school's attempt at computer science integration falls short due to the lack of expertise amongst the math and science teachers. The lack of training and support has postponed the development of the program and they are desperately in need of someone with expertise in the field to help reboot the program. As a result, I've decided to create a course that is focused on teaching students the concepts of computational thinking and its application through Scratch and Arduino programming.
ContributorsLiu, Deming (Author) / Meuth, Ryan (Thesis director) / Nakamura, Mutsumi (Committee member) / Computer Science and Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Electromyography (EMG) and Electroencephalography (EEG) are techniques used to detect electrical activity produced by the human body. EMG detects electrical activity in the skeletal muscles, while EEG detects electrical activity from the scalp. The purpose of this study is to capture different types of EMG and EEG signals and to determine if the signals can be distinguished between each other and processed into output signals to trigger events in prosthetics. Results from the study suggest that the PSD estimates can be used to compare signals that have significant differences such as the wrist, scalp, and fingers, but it cannot fully distinguish between signals that are closely related, such as two different fingers. The signals that were identified were able to be translated into the physical output simulated on the Arduino circuit.
ContributorsJanis, William Edward (Author) / LaBelle, Jeffrey (Thesis director) / Santello, Marco (Committee member) / Barrett, The Honors College (Contributor) / Computer Science and Engineering Program (Contributor)
Created2013-12
Description
Research concerning increased sensitivity and accurate glucose sensors have been on the forefront of diabetes mellitus. In this study, Electroactive Poly-Amidoamine Polymer (EPOP) was studied to determine if it can be used as a biocompatible electrode, with known redox mediators to determine if it can transfer its own electrons or amplify signal, and if signal is amplified when using an Ag/AgCl working electrode. From the results, it was determined that EPOP is neither a redox mediator, since it cannot transfer its own electrons, nor an electron mediator, since it does not amplify measured current at a specific voltage. Rather, it behaves as an electron sink capacitor with inconsistent behavior when Ag/AgCl is used as the working electrode with the redox mediator alone or with the redox mediator using in combination with glucose oxidase (GOx) and glucose. This was validated using AC-Impedance which gave a -3.3999 slope for isolated 0.05 g/mL EPOP in solution and R2 value of 0.992 displaying it had more capacitor-like behavior compared to resistor-like behavior. For this reason, EPOP was infused into a carbon screen-printed electrode by adding it dissolved and undissolved at two levels into carbon ink. The effectiveness of this electrode was tested using a potentiostatic CV. For the 0.1 g/mL EPOP dissolved in carbon ink, the reduction voltage peak (0.18 V) was found to be slightly higher than a GDE (0.14 V); however, the measured current was found to be 1.57 times the amplitude of a GDE. When 0.05 g/mL EPOP in PBS dissolved in graphite ink was used to detect glucose as the working electrode, there was increased signal amplification, and therefore, increased sensitivity to glucose when using EPOP infused electrodes. This offers promising results for disposable glucose sensors.
ContributorsKapadia, Meera Vipul (Author) / LaBelle, Jeffrey (Thesis director) / Islam, Rafiqul (Committee member) / Honikel, Mackenzie (Committee member) / Chemical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
A point of care glucose sensor using electrochemical impedance spectroscopy (EIS) with a glutaraldehyde-linked enzyme shows promise as an effective biosensor platform. This report details the characterization of various factors on optimal binding frequency (OBF) and sensor performance to better prepare the sensor for future experimentation. Utilizing a screen printed carbon electrode, the necessary amount of glucose oxidase was determined to be 10 mg/mL. Binding time trials ranging from 1-3 minutes demonstrated that 1.5 minutes was the optimal binding time. This timeframe produced the strongest impedance response at each glucose concentration. Using this enzyme concentration and binding time, the native OBF of the biosensor was found to be 1.18 Hz using vector analysis. Temperature testing showed little change in OBF in sensors exposed to 4 \u00B0C through 43.3 \u00B0C. Only exposure to 60 \u00B0C resulted in rapid OBF change which was likely due to glucose oxidase becoming denatured. Humidity tests showed little change in OBF and sensor performance between sensors prepared at the humidities of 7.5%, 10.625% and 16.5% humidity. Alternatively, solutions containing common interference molecules such as uric acid, acetaminophen, and ascorbic acid resulted in a highly shifted OBF and drastically reduced signal.
ContributorsMatloff, Daniel (Co-author) / Khanwalker, Mukund (Co-author) / Johns, Jared (Co-author) / LaBelle, Jeffrey (Thesis director) / Pizziconi, Vincent (Committee member) / Lin, Chi (Committee member) / Dean, W.P. Carey School of Business (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12