This study examines the economic impact of the opioid crisis in the United States. Primarily testing the years 2007-2018, I gathered data from the Census Bureau, Centers for Disease Control, and Kaiser Family Foundation in order to examine the relative impact of a one dollar increase in GDP per Capita on the death rates caused by opioids. By implementing a fixed-effects panel data design, I regressed deaths on GDP per Capita while holding the following constant: population, U.S. retail opioid prescriptions per 100 people, annual average unemployment rate, percent of the population that is Caucasian, and percent of the population that is male. I found that GDP per Capita and opioid related deaths are negatively correlated, meaning that with every additional person dying from opioids, GDP per capita decreases. The finding of this research is important because opioid overdose is harmful to society, as U.S. life expectancy is consistently dropping as opioid death rates rise. Increasing awareness on this topic can help prevent misuse and the overall reduction in opioid related deaths.