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- All Subjects: Africa
- Creators: Caplan, Michael
- Creators: Annor-Wiafe, Stephen
Description
Sickle cell disease is a genetic disorder that can cause substantial helath problems. It is the result of a mutation in the DNA coding for hemoglobin. As a result of changes in two important amino acids, a person suffering from sickle cell disease will have erythrocytes that do not maintain the typical biconcave shape and instead for a crescent shape. Individuals with sickle cell disease may have many health problems tied to their irregular hemoglobin. The unusual shape of the erythrocytes leads to a much shorter cell life, which means that even though bone marrow remains active long past childhood to try to keep up with the loss of erythrocytes, the body is still unable to accommodate the rapid death of erythrocytes. The malformed erythrocytes can also cause vascular occlusion, blocking blood vessels and slowing blood flow. While sickle cell disease has the potential to spread worldwide, it is particularly common in Africa. This may be because people with the sickle cell trait have a high resistance to malaria, making them more likely to survive that ubiquitous disease and pass on their traits to their offspring. However, the mortality rate in young children with sickle cell disease is very high, in part because the spleen, already stressed by filtering out dead erythrocytes, has difficulties filtering out bacteria. One of the keys to stopping the spread of the disease is neonatal screening, but this requires specialized equipment that is fairly uncommon in rural areas, as can be seen in Kenya. Therefore, it would be highly beneficial to develop a more cost-effective and widely available method for testing for sickle cell disease.
ContributorsWold, John (Author) / Caplan, Michael (Thesis director) / LaBelle, Jeffrey (Committee member) / Snyder, Jan (Committee member) / Barrett, The Honors College (Contributor)
Created2012-05
Description
Sickle Cell Disease (SCD) is a prevalent genetic disease in Africa, and specifically in Kenya. The lack of available relevant disease education and screening mean that most don't understand the importance of getting testing and many children die before they can get prophylactic care. This project was designed to address the lack of knowledge with supplemental educational materials to be partnered with an engineering capstone project that provides a low cost diagnostic test.
ContributorsShawver, Jamie Christine (Author) / Caplan, Michael (Thesis director) / Snyder, Jan (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor) / Harrington Bioengineering Program (Contributor)
Created2014-05
Description
This research focused on how low-income communities in Ghana could convert Waste Vegetable Oil (WVO) into biodiesel to supplement their energy demands. The 2016 World Energy Outlook estimates that about 8 million Ghanaians do not have access to electricity while 82% of the population use biomass as cooking fuel. However, WVO is available in almost every home and is also largely produced by hotels and schools. There are over 2,700 registered hotels and more than 28,000 educational institutions from Basic to the Tertiary level. Currently, most WVOs are often discarded in open gutters or left to go rancid and later disposed of. Therefore, WVOs serve as cheap materials available in large quantities with a high potential for conversion into biodiesel and commercializing to support the economic needs of low-income communities. In 2013, a group of researchers at Kwame Nkrumah University of Science and Technology (KNUST) in Ghana estimated that the country could be producing between 82,361 and 85,904 tons of biodiesel from WVOs generated by hotels alone in 2015. Further analysis was also carried out to examine the Ghana National Biofuel Policy that was introduced in 2005 with support from the Ghana Energy Commission. Based on the information identified in the research, a set of recommendations were made to help the central government in promoting the biodiesel industry in Ghana, with a focus on low-income or farming communities. Lastly, a self-sustaining biodiesel production model with high potential for commercialization, was proposed to enable low-income communities to produce their own biodiesel from WVOs to meet their energy demands.
ContributorsAnnor-Wiafe, Stephen (Author) / Henderson, Mark (Thesis director) / Rogers, Bradley (Committee member) / Engineering Programs (Contributor) / Department of Management and Entrepreneurship (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
Ather Arop is bilingual. He is also fluent in Spanish and speaks some French. “Lost Boys Found” is an ongoing, interdisciplinary project that is collecting, recording and archiving the oral histories of the Lost Boys/Girls of Sudan. The collection is a work-in-progress, seeking to record the oral history of as many Lost Boys/Girls as are willing, and will be used in a future book.
ContributorsArop, Ather (Interviewee) / Amparano, Julie (Director) / Garcia, James (Interviewer) / MacNeill, MacNeill (Editor)
Created2017-10-14