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- All Subjects: Democracy
- Creators: School of Politics and Global Studies
One of the largest problems facing modern medicine is drug resistance. Many classes of drugs can be rendered ineffective if their target is able to acquire beneficial mutations. While this is an excellent showcase of the power of evolution, it necessitates the development of increasingly stronger drugs to combat resistant pathogens. Not only is this strategy costly and time consuming, it is also unsustainable. To contend with this problem, many multi-drug treatment strategies are being explored. Previous studies have shown that resistance to some drug combinations is not possible, for example, resistance to a common antifungal drug, fluconazole, seems impossible in the presence of radicicol. We believe that in order to understand the viability of multi-drug strategies in combating drug resistance, we must understand the full spectrum of resistance mutations that an organism can develop, not just the most common ones. It is possible that rare mutations exist that are resistant to both drugs. Knowing the frequency of such mutations is important for making predictions about how problematic they will be when multi-drug strategies are used to treat human disease. This experiment aims to expand on previous research on the evolution of drug resistance in S. cerevisiae by using molecular barcodes to track ~100,000 evolving lineages simultaneously. The barcoded cells were evolved with serial transfers for seven weeks (200 generations) in three concentrations of the antifungal Fluconazole, three concentrations of the Hsp90 inhibitor Radicicol, and in four combinations of Fluconazole and Radicicol. Sequencing data was used to track barcode frequencies over the course of the evolution, allowing us to observe resistant lineages as they rise and quantify differences in resistance evolution across the different conditions. We were able to successfully observe over 100,000 replicates simultaneously, revealing many adaptive lineages in all conditions. Our results also show clear differences across drug concentrations and combinations, with the highest drug concentrations exhibiting distinct behaviors.
The right to cast a meaningful vote, equal in value to other votes, is a fundamental tenet US elections. Despite the 1964 Supreme Court decision formally establishing the one person, one vote principle as a legal requirement of elections, our democracy consistently falls short of it. With mechanisms including the winner-take-all format in the Electoral College, disproportioned geographic allocation of senators, extreme partisan gerrymandering in the House of Representatives, and first-past-the-post elections, many voters experience severe vote dilution. <br/><br/>In order to legitimize our democratic structures, American elections should be reformed so every person’s vote has equal weight, ensuring that the election outcomes reflect the will of the people. Altering the current election structure to include more proportional structures including rank choice voting and population-based representation, will result in a democracy more compatible with the one person, one vote principle.
Czechoslovakia failed to implement democracy and nationalism in an equal and fair manner to the Czechs and Slovaks. As Masaryk mirrored Czechoslovakia off of the United States and his close friend President Wilson, the founding Czechoslovakian documents created an unequal version of the basic democratic principles. The domestic geopolitical culture of nationalism and nationalism abroad influenced ethnic identification between the new borders for the Czechs and Slovaks. Without the shared social language of Czechoslovakian nationalism the Czechs and Slovaks did not unite politically, ethnically, or at all. This allowed for the Czechs to take over and create their idealist democracy, otherwise known as an ethnocracy.
As the world watched the United States Capitol Building come under siege by thousands of insurrectionists on January 6th, 2021, it was clear that a nation once regarded by conservatives as a “City Upon a Hill” was now in the process of a radical reawakening and party transformation. The American far-right’s radical transformation of the Republican Party and the relentless false belief of “The Big Lie”, that the 2020 election was stolen and fraudulent, delegitimizes America’s political institutions while undermining the nation’s electoral process. This has created a modern rebirth of racism, hatred, and political violence that is seen in American politics and society. Because of this, the far-right has weaponized American institutions to push both racist, discriminatory ideas and laws throughout the country. This study aims to answer the question of "how is The Big Lie dismantling American democracy and reshaping GOP?".