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Description
Electrical neural activity detection and tracking have many applications in medical research and brain computer interface technologies. In this thesis, we focus on the development of advanced signal processing algorithms to track neural activity and on the mapping of these algorithms onto hardware to enable real-time tracking. At the heart

Electrical neural activity detection and tracking have many applications in medical research and brain computer interface technologies. In this thesis, we focus on the development of advanced signal processing algorithms to track neural activity and on the mapping of these algorithms onto hardware to enable real-time tracking. At the heart of these algorithms is particle filtering (PF), a sequential Monte Carlo technique used to estimate the unknown parameters of dynamic systems. First, we analyze the bottlenecks in existing PF algorithms, and we propose a new parallel PF (PPF) algorithm based on the independent Metropolis-Hastings (IMH) algorithm. We show that the proposed PPF-IMH algorithm improves the root mean-squared error (RMSE) estimation performance, and we demonstrate that a parallel implementation of the algorithm results in significant reduction in inter-processor communication. We apply our implementation on a Xilinx Virtex-5 field programmable gate array (FPGA) platform to demonstrate that, for a one-dimensional problem, the PPF-IMH architecture with four processing elements and 1,000 particles can process input samples at 170 kHz by using less than 5% FPGA resources. We also apply the proposed PPF-IMH to waveform-agile sensing to achieve real-time tracking of dynamic targets with high RMSE tracking performance. We next integrate the PPF-IMH algorithm to track the dynamic parameters in neural sensing when the number of neural dipole sources is known. We analyze the computational complexity of a PF based method and propose the use of multiple particle filtering (MPF) to reduce the complexity. We demonstrate the improved performance of MPF using numerical simulations with both synthetic and real data. We also propose an FPGA implementation of the MPF algorithm and show that the implementation supports real-time tracking. For the more realistic scenario of automatically estimating an unknown number of time-varying neural dipole sources, we propose a new approach based on the probability hypothesis density filtering (PHDF) algorithm. The PHDF is implemented using particle filtering (PF-PHDF), and it is applied in a closed-loop to first estimate the number of dipole sources and then their corresponding amplitude, location and orientation parameters. We demonstrate the improved tracking performance of the proposed PF-PHDF algorithm and map it onto a Xilinx Virtex-5 FPGA platform to show its real-time implementation potential. Finally, we propose the use of sensor scheduling and compressive sensing techniques to reduce the number of active sensors, and thus overall power consumption, of electroencephalography (EEG) systems. We propose an efficient sensor scheduling algorithm which adaptively configures EEG sensors at each measurement time interval to reduce the number of sensors needed for accurate tracking. We combine the sensor scheduling method with PF-PHDF and implement the system on an FPGA platform to achieve real-time tracking. We also investigate the sparsity of EEG signals and integrate compressive sensing with PF to estimate neural activity. Simulation results show that both sensor scheduling and compressive sensing based methods achieve comparable tracking performance with significantly reduced number of sensors.
ContributorsMiao, Lifeng (Author) / Chakrabarti, Chaitali (Thesis advisor) / Papandreou-Suppappola, Antonia (Thesis advisor) / Zhang, Junshan (Committee member) / Bliss, Daniel (Committee member) / Kovvali, Narayan (Committee member) / Arizona State University (Publisher)
Created2013
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Description
Adaptive processing and classification of electrocardiogram (ECG) signals are important in eliminating the strenuous process of manually annotating ECG recordings for clinical use. Such algorithms require robust models whose parameters can adequately describe the ECG signals. Although different dynamic statistical models describing ECG signals currently exist, they depend considerably on

Adaptive processing and classification of electrocardiogram (ECG) signals are important in eliminating the strenuous process of manually annotating ECG recordings for clinical use. Such algorithms require robust models whose parameters can adequately describe the ECG signals. Although different dynamic statistical models describing ECG signals currently exist, they depend considerably on a priori information and user-specified model parameters. Also, ECG beat morphologies, which vary greatly across patients and disease states, cannot be uniquely characterized by a single model. In this work, sequential Bayesian based methods are used to appropriately model and adaptively select the corresponding model parameters of ECG signals. An adaptive framework based on a sequential Bayesian tracking method is proposed to adaptively select the cardiac parameters that minimize the estimation error, thus precluding the need for pre-processing. Simulations using real ECG data from the online Physionet database demonstrate the improvement in performance of the proposed algorithm in accurately estimating critical heart disease parameters. In addition, two new approaches to ECG modeling are presented using the interacting multiple model and the sequential Markov chain Monte Carlo technique with adaptive model selection. Both these methods can adaptively choose between different models for various ECG beat morphologies without requiring prior ECG information, as demonstrated by using real ECG signals. A supervised Bayesian maximum-likelihood (ML) based classifier uses the estimated model parameters to classify different types of cardiac arrhythmias. However, the non-availability of sufficient amounts of representative training data and the large inter-patient variability pose a challenge to the existing supervised learning algorithms, resulting in a poor classification performance. In addition, recently developed unsupervised learning methods require a priori knowledge on the number of diseases to cluster the ECG data, which often evolves over time. In order to address these issues, an adaptive learning ECG classification method that uses Dirichlet process Gaussian mixture models is proposed. This approach does not place any restriction on the number of disease classes, nor does it require any training data. This algorithm is adapted to be patient-specific by labeling or identifying the generated mixtures using the Bayesian ML method, assuming the availability of labeled training data.
ContributorsEdla, Shwetha Reddy (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Chakrabarti, Chaitali (Committee member) / Kovvali, Narayan (Committee member) / Tepedelenlioğlu, Cihan (Committee member) / Arizona State University (Publisher)
Created2012
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Description
Tracking a time-varying number of targets is a challenging

dynamic state estimation problem whose complexity is intensified

under low signal-to-noise ratio (SNR) or high clutter conditions.

This is important, for example, when tracking

multiple, closely spaced targets moving in the same direction such as a

convoy of low observable vehicles moving

Tracking a time-varying number of targets is a challenging

dynamic state estimation problem whose complexity is intensified

under low signal-to-noise ratio (SNR) or high clutter conditions.

This is important, for example, when tracking

multiple, closely spaced targets moving in the same direction such as a

convoy of low observable vehicles moving through a forest or multiple

targets moving in a crisscross pattern. The SNR in

these applications is usually low as the reflected signals from

the targets are weak or the noise level is very high.

An effective approach for detecting and tracking a single target

under low SNR conditions is the track-before-detect filter (TBDF)

that uses unthresholded measurements. However, the TBDF has only been used to

track a small fixed number of targets at low SNR.

This work proposes a new multiple target TBDF approach to track a

dynamically varying number of targets under the recursive Bayesian framework.

For a given maximum number of

targets, the state estimates are obtained by estimating the joint

multiple target posterior probability density function under all possible

target

existence combinations. The estimation of the corresponding target existence

combination probabilities and the target existence probabilities are also

derived. A feasible sequential Monte Carlo (SMC) based implementation

algorithm is proposed. The approximation accuracy of the SMC

method with a reduced number of particles is improved by an efficient

proposal density function that partitions the multiple target space into a

single target space.

The proposed multiple target TBDF method is extended to track targets in sea

clutter using highly time-varying radar measurements. A generalized

likelihood function for closely spaced multiple targets in compound Gaussian

sea clutter is derived together with the maximum likelihood estimate of

the model parameters using an iterative fixed point algorithm.

The TBDF performance is improved by proposing a computationally feasible

method to estimate the space-time covariance matrix of rapidly-varying sea

clutter. The method applies the Kronecker product approximation to the

covariance matrix and uses particle filtering to solve the resulting dynamic

state space model formulation.
ContributorsEbenezer, Samuel P (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Chakrabarti, Chaitali (Committee member) / Bliss, Daniel (Committee member) / Kovvali, Narayan (Committee member) / Arizona State University (Publisher)
Created2015
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Description
This work considers the problem of multiple detection and tracking in two complex time-varying environments, urban terrain and underwater. Tracking multiple radar targets in urban environments is rst investigated by exploiting multipath signal returns, wideband underwater acoustic (UWA) communications channels are estimated using adaptive learning methods, and multiple UWA communications

This work considers the problem of multiple detection and tracking in two complex time-varying environments, urban terrain and underwater. Tracking multiple radar targets in urban environments is rst investigated by exploiting multipath signal returns, wideband underwater acoustic (UWA) communications channels are estimated using adaptive learning methods, and multiple UWA communications users are detected by designing the transmit signal to match the environment. For the urban environment, a multi-target tracking algorithm is proposed that integrates multipath-to-measurement association and the probability hypothesis density method implemented using particle filtering. The algorithm is designed to track an unknown time-varying number of targets by extracting information from multiple measurements due to multipath returns in the urban terrain. The path likelihood probability is calculated by considering associations between measurements and multipath returns, and an adaptive clustering algorithm is used to estimate the number of target and their corresponding parameters. The performance of the proposed algorithm is demonstrated for different multiple target scenarios and evaluated using the optimal subpattern assignment metric. The underwater environment provides a very challenging communication channel due to its highly time-varying nature, resulting in large distortions due to multipath and Doppler-scaling, and frequency-dependent path loss. A model-based wideband UWA channel estimation algorithm is first proposed to estimate the channel support and the wideband spreading function coefficients. A nonlinear frequency modulated signaling scheme is proposed that is matched to the wideband characteristics of the underwater environment. Constraints on the signal parameters are derived to optimally reduce multiple access interference and the UWA channel effects. The signaling scheme is compared to a code division multiple access (CDMA) scheme to demonstrate its improved bit error rate performance. The overall multi-user communication system performance is finally analyzed by first estimating the UWA channel and then designing the signaling scheme for multiple communications users.
ContributorsZhou, Meng (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Tepedelenlioğlu, Cihan (Committee member) / Kovvali, Narayan (Committee member) / Berisha, Visar (Committee member) / Arizona State University (Publisher)
Created2014
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Description
Peptide microarrays have been used in molecular biology to profile immune responses and develop diagnostic tools. When the microarrays are printed with random peptide sequences, they can be used to identify antigen antibody binding patterns or immunosignatures. In this thesis, an advanced signal processing method is proposed to estimate

Peptide microarrays have been used in molecular biology to profile immune responses and develop diagnostic tools. When the microarrays are printed with random peptide sequences, they can be used to identify antigen antibody binding patterns or immunosignatures. In this thesis, an advanced signal processing method is proposed to estimate epitope antigen subsequences as well as identify mimotope antigen subsequences that mimic the structure of epitopes from random-sequence peptide microarrays. The method first maps peptide sequences to linear expansions of highly-localized one-dimensional (1-D) time-varying signals and uses a time-frequency processing technique to detect recurring patterns in subsequences. This technique is matched to the aforementioned mapping scheme, and it allows for an inherent analysis on how substitutions in the subsequences can affect antibody binding strength. The performance of the proposed method is demonstrated by estimating epitopes and identifying potential mimotopes for eight monoclonal antibody samples.

The proposed mapping is generalized to express information on a protein's sequence location, structure and function onto a highly localized three-dimensional (3-D) Gaussian waveform. In particular, as analysis of protein homology has shown that incorporating different kinds of information into an alignment process can yield more robust alignment results, a pairwise protein structure alignment method is proposed based on a joint similarity measure of multiple mapped protein attributes. The 3-D mapping allocates protein properties into distinct regions in the time-frequency plane in order to simplify the alignment process by including all relevant information into a single, highly customizable waveform. Simulations demonstrate the improved performance of the joint alignment approach to infer relationships between proteins, and they provide information on mutations that cause changes to both the sequence and structure of a protein.

In addition to the biology-based signal processing methods, a statistical method is considered that uses a physics-based model to improve processing performance. In particular, an externally developed physics-based model for sea clutter is examined when detecting a low radar cross-section target in heavy sea clutter. This novel model includes a process that generates random dynamic sea clutter based on the governing physics of water gravity and capillary waves and a finite-difference time-domain electromagnetics simulation process based on Maxwell's equations propagating the radar signal. A subspace clutter suppression detector is applied to remove dominant clutter eigenmodes, and its improved performance over matched filtering is demonstrated using simulations.
ContributorsO'Donnell, Brian (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Bliss, Daniel (Committee member) / Johnston, Stephen A. (Committee member) / Kovvali, Narayan (Committee member) / Tepedelenlioğlu, Cihan (Committee member) / Arizona State University (Publisher)
Created2014
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Description
The detection and characterization of transients in signals is important in many wide-ranging applications from computer vision to audio processing. Edge detection on images is typically realized using small, local, discrete convolution kernels, but this is not possible when samples are measured directly in the frequency domain. The concentration factor

The detection and characterization of transients in signals is important in many wide-ranging applications from computer vision to audio processing. Edge detection on images is typically realized using small, local, discrete convolution kernels, but this is not possible when samples are measured directly in the frequency domain. The concentration factor edge detection method was therefore developed to realize an edge detector directly from spectral data. This thesis explores the possibilities of detecting edges from the phase of the spectral data, that is, without the magnitude of the sampled spectral data. Prior work has demonstrated that the spectral phase contains particularly important information about underlying features in a signal. Furthermore, the concentration factor method yields some insight into the detection of edges in spectral phase data. An iterative design approach was taken to realize an edge detector using only the spectral phase data, also allowing for the design of an edge detector when phase data are intermittent or corrupted. Problem formulations showing the power of the design approach are given throughout. A post-processing scheme relying on the difference of multiple edge approximations yields a strong edge detector which is shown to be resilient under noisy, intermittent phase data. Lastly, a thresholding technique is applied to give an explicit enhanced edge detector ready to be used. Examples throughout are demonstrate both on signals and images.
ContributorsReynolds, Alexander Bryce (Author) / Gelb, Anne (Thesis director) / Cochran, Douglas (Committee member) / Viswanathan, Adityavikram (Committee member) / School of Mathematical and Statistical Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Description
Tracking targets in the presence of clutter is inevitable, and presents many challenges. Additionally, rapid, drastic changes in clutter density between different environments or scenarios can make it even more difficult for tracking algorithms to adapt. A novel approach to target tracking in such dynamic clutter environments is proposed using

Tracking targets in the presence of clutter is inevitable, and presents many challenges. Additionally, rapid, drastic changes in clutter density between different environments or scenarios can make it even more difficult for tracking algorithms to adapt. A novel approach to target tracking in such dynamic clutter environments is proposed using a particle filter (PF) integrated with Interacting Multiple Models (IMMs) to compensate and adapt to the transition between different clutter densities. This model was implemented for the case of a monostatic sensor tracking a single target moving with constant velocity along a two-dimensional trajectory, which crossed between regions of drastically different clutter densities. Multiple combinations of clutter density transitions were considered, using up to three different clutter densities. It was shown that the integrated IMM PF algorithm outperforms traditional approaches such as the PF in terms of tracking results and performance. The minimal additional computational expense of including the IMM more than warrants the benefits of having it supplement and amplify the advantages of the PF.
ContributorsDutson, Karl (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Kovvali, Narayan (Committee member) / Bliss, Daniel W (Committee member) / Arizona State University (Publisher)
Created2015
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Description
As the demand for spectrum sharing between radar and communications systems is steadily increasing, the coexistence between the two systems is a growing and very challenging problem. Radar tracking in the presence of strong communications interference can result in low probability of detection even when sequential Monte Carlo

tracking methods

As the demand for spectrum sharing between radar and communications systems is steadily increasing, the coexistence between the two systems is a growing and very challenging problem. Radar tracking in the presence of strong communications interference can result in low probability of detection even when sequential Monte Carlo

tracking methods such as the particle filter (PF) are used that better match the target kinematic model. In particular, the tracking performance can fluctuate as the power level of the communications interference can vary dynamically and unpredictably.

This work proposes to integrate the interacting multiple model (IMM) selection approach with the PF tracker to allow for dynamic variations in the power spectral density of the communications interference. The model switching allows for a necessary transition between different communications interference power spectral density (CI-PSD) values in order to reduce prediction errors. Simulations demonstrate the high performance of the integrated approach with as many as six dynamic CI-PSD value changes during the target track. For low signal-to-interference-plus-noise ratios, the derivation for estimating the high power levels of the communications interference is provided; the estimated power levels would be dynamically used in the IMM when integrated with a track-before-detect filter that is better matched to low SINR tracking applications.
ContributorsZhou, Jian (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Kovvali, Narayan (Committee member) / Berisha, Visar (Committee member) / Arizona State University (Publisher)
Created2015
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Description
In recent years, there has been an increased interest in sharing available bandwidth to avoid spectrum congestion. With an ever-increasing number wireless users, it is critical to develop signal processing based spectrum sharing algorithms to achieve cooperative use of the allocated spectrum among multiple systems in order to reduce

In recent years, there has been an increased interest in sharing available bandwidth to avoid spectrum congestion. With an ever-increasing number wireless users, it is critical to develop signal processing based spectrum sharing algorithms to achieve cooperative use of the allocated spectrum among multiple systems in order to reduce interference between systems. This work studies the radar and communications systems coexistence problem using two main approaches. The first approach develops methodologies to increase radar target tracking performance under low signal-to-interference-plus-noise ratio (SINR) conditions due to the coexistence of strong communications interference. The second approach jointly optimizes the performance of both systems by co-designing a common transmit waveform.

When concentrating on improving radar tracking performance, a pulsed radar that is tracking a single target coexisting with high powered communications interference is considered. Although the Cramer-Rao lower bound (CRLB) on the covariance of an unbiased estimator of deterministic parameters provides a bound on the estimation mean squared error (MSE), there exists an SINR threshold at which estimator covariance rapidly deviates from the CRLB. After demonstrating that different radar waveforms experience different estimation SINR thresholds using the Barankin bound (BB), a new radar waveform design method is proposed based on predicting the waveform-dependent BB SINR threshold under low SINR operating conditions.

A novel method of predicting the SINR threshold value for maximum likelihood estimation (MLE) is proposed. A relationship is shown to exist between the formulation of the BB kernel and the probability of selecting sidelobes for the MLE. This relationship is demonstrated as an accurate means of threshold prediction for the radar target parameter estimation of frequency, time-delay and angle-of-arrival.



For the co-design radar and communications system problem, the use of a common transmit waveform for a pulse-Doppler radar and a multiuser communications system is proposed. The signaling scheme for each system is selected from a class of waveforms with nonlinear phase function by optimizing the waveform parameters to minimize interference between the two systems and interference among communications users. Using multi-objective optimization, a trade-off in system performance is demonstrated when selecting waveforms that minimize both system interference and tracking MSE.
ContributorsKota, John S (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Berisha, Visar (Committee member) / Bliss, Daniel (Committee member) / Kovvali, Narayan (Committee member) / Arizona State University (Publisher)
Created2016
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Description
This work examines two main areas in model-based time-varying signal processing with emphasis in speech processing applications. The first area concentrates on improving speech intelligibility and on increasing the proposed methodologies application for clinical practice in speech-language pathology. The second area concentrates on signal expansions matched to physical-based models but

This work examines two main areas in model-based time-varying signal processing with emphasis in speech processing applications. The first area concentrates on improving speech intelligibility and on increasing the proposed methodologies application for clinical practice in speech-language pathology. The second area concentrates on signal expansions matched to physical-based models but without requiring independent basis functions; the significance of this work is demonstrated with speech vowels.

A fully automated Vowel Space Area (VSA) computation method is proposed that can be applied to any type of speech. It is shown that the VSA provides an efficient and reliable measure and is correlated to speech intelligibility. A clinical tool that incorporates the automated VSA was proposed for evaluation and treatment to be used by speech language pathologists. Two exploratory studies are performed using two databases by analyzing mean formant trajectories in healthy speech for a wide range of speakers, dialects, and coarticulation contexts. It is shown that phonemes crowded in formant space can often have distinct trajectories, possibly due to accurate perception.

A theory for analyzing time-varying signals models with amplitude modulation and frequency modulation is developed. Examples are provided that demonstrate other possible signal model decompositions with independent basis functions and corresponding physical interpretations. The Hilbert transform (HT) and the use of the analytic form of a signal are motivated, and a proof is provided to show that a signal can still preserve desirable mathematical properties without the use of the HT. A visualization of the Hilbert spectrum is proposed to aid in the interpretation. A signal demodulation is proposed and used to develop a modified Empirical Mode Decomposition (EMD) algorithm.
ContributorsSandoval, Steven, 1984- (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Liss, Julie M (Committee member) / Turaga, Pavan (Committee member) / Kovvali, Narayan (Committee member) / Arizona State University (Publisher)
Created2016