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- Creators: Barrett, The Honors College
- Creators: Green, Matthew D.
- Creators: Close, Emily Charlotte
- Member of: Barrett, The Honors College Thesis/Creative Project Collection
- Resource Type: Text
The objective of the experimentation was to explore the effect of crosslinker chain length on the morphology of nanofiber mats. Specifically, poly(vinyl alcohol (PVA) was electrospun into nanofiber mats and poly(ethylene) glycol bis(carboxylic acid) (PEG diacid) was used as the crosslinking agent. As-spun fibers had average fiber diameter of 70 ± 30 nm with an average pore size of 0.10 ± 0.16 μm^2. The fiber diameter for the mats crosslinked with the shorter PEG diacid (Mn = 250) increased to 110 ± 40 nm with an average pore size of 0.11 ± 0.04 μm^2. The mats crosslinked with the longer PEG diacid (Mn = 600) had fiber diameters of 180 ± 10 nm with an average pore size 0.01 ± 0.02 μm^2.
A growing body of research suggests a link between adverse childhood experiences and negative health outcomes. However, less is known about where racial discrimination ranks compared to other adverse childhood experiences, such as maltreatment. To address this issue, I conducted two systematic reviews of meta-analyses to compare the magnitudes of the links between racial discrimination and depressive symptoms and childhood maltreatment and depressive symptoms. My aim was to establish if racial discrimination should be considered an adverse childhood experience. My results demonstrated that the link between racial discrimination and depressive symptoms (r = 0.27) is comparable to the links between 4 different manifestations of maltreatment and depressive symptoms (physical abuse: r = 0.257, emotional abuse: r = 0.301, neglect: r = 0.381, sexual abuse: r = 0.408). I discuss the implications of these findings and propose future research directions.
Methods: After searching through PubMed and PsycINFO and screening each article to see if the studies matched our inclusion and exclusion criteria, 7 studies qualified for this meta-analysis. Across all studies, 274 children with NSCL/P were compared to 267 of their typically developing peers. The mean age for children with NSCL/P was 118.8 months (SD = 49.19) and 119.8 months (SD = 49.81) for typically developing children. Effect sizes and demographic information (i.e. study location, sample size, assessments used, etc.) were pulled from each study.
Results: The average effect size for this systematic review is -0.41, demonstrating that children with NSCL/P performed 0.41 standard deviations less than their typically developing peers on measures of word decoding. This was calculated using the RVE-model. Both the older and younger age range showed deficits in their word decoding abilities compared to their typically developing peers. Hearing status, language abilities, and speech abilities were reported minimally with many inconsistencies between studies.
Conclusions: These findings suggest that children with NSCL/P perform poorer on word decoding tasks than their noncleft peers. These differences are found in both the younger and older populations of our sample. More evidence and fewer inconsistencies in the research are needed to determine whether hearing, language, and speech abilities have an effect on the word decoding skills of children with NSCL/P.
Currently, there are a number of studies confirming the link between exposure to certain chemicals, notably pesticides (Costello et. al. 2009, Wang et. al 2014), heavy metals such as arsenic (Chen et. al. 2017), ambient air pollution (Chen et. al. 2016), and chemicals specific to certain industrial fields (Nielsen et. al. 2021). However, few papers have attempted to perform a widespread analysis of the factors associated with Parkinson’s disease to identify whether the risk of developing the disease is dependent on different factors regionally. The goal of my thesis project is to complete a meta-analysis of toxins- where exposure may occur in both residential and occupational settings- that are associated with Parkinson’s to determine such regional differences and to identify any gaps in current literature, which may direct the course of future research in the field. As seen in this paper, it appears that occupational exposure to toxins appears to have the greatest impact on the risk of developing Parkinson’s disease, particularly pesticides and industrial toxins. However, there are numerous gaps with regards to data collection, regions studied, and quantification of toxin concentrations. However, this data may be useful in identifying at-risk populations if more extensive incremental and biopsy data regarding these toxins is provided.
Psychological therapy is the process of understanding, treating, and maintaining a healthy psyche. Psychological therapy comes in many shapes and sizes. Different methods of therapy include but are not limited to cognitive behavioral therapy, psychodynamic therapy, psychoanalytic therapy, group therapy, and humanistic therapy. Most of these major therapeutic options fall under the umbrella of “talk therapy”. Although talk therapy is effective, practicing talk therapy exclusively limits not only the capabilities of therapy, but also potential clientele who would benefit from alternatives to talk therapy. Because each psyche is as unique and individual as fingerprints, each person seeking therapy should be able to create a personalized therapy program. Generating unique combinations of various therapy methods that are catered specifically to the client is a way to achieve this lofty goal. This research intends to better understand whether this proposal of combining various therapeutic techniques and methods in order to achieve individualized therapy programs will increase the effectiveness of the therapy being administered. In this meta analysis, the focus will be on animal therapy and poetry therapy used in conjunction theoretically as an example of potential applications for various combinations in conjunctive therapy. Conjunctive therapy is the main idea being piloted in this thesis and is a new form of therapy that involved the usage of two therapeutic techniques together while maintaining and equal prevalence and importance between them.