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The main objective of this research is to develop an integrated method to study emergent behavior and consequences of evolution and adaptation in engineered complex adaptive systems (ECASs). A multi-layer conceptual framework and modeling approach including behavioral and structural aspects is provided to describe the structure of a class of

The main objective of this research is to develop an integrated method to study emergent behavior and consequences of evolution and adaptation in engineered complex adaptive systems (ECASs). A multi-layer conceptual framework and modeling approach including behavioral and structural aspects is provided to describe the structure of a class of engineered complex systems and predict their future adaptive patterns. The approach allows the examination of complexity in the structure and the behavior of components as a result of their connections and in relation to their environment. This research describes and uses the major differences of natural complex adaptive systems (CASs) with artificial/engineered CASs to build a framework and platform for ECAS. While this framework focuses on the critical factors of an engineered system, it also enables one to synthetically employ engineering and mathematical models to analyze and measure complexity in such systems. In this way concepts of complex systems science are adapted to management science and system of systems engineering. In particular an integrated consumer-based optimization and agent-based modeling (ABM) platform is presented that enables managers to predict and partially control patterns of behaviors in ECASs. Demonstrated on the U.S. electricity markets, ABM is integrated with normative and subjective decision behavior recommended by the U.S. Department of Energy (DOE) and Federal Energy Regulatory Commission (FERC). The approach integrates social networks, social science, complexity theory, and diffusion theory. Furthermore, it has unique and significant contribution in exploring and representing concrete managerial insights for ECASs and offering new optimized actions and modeling paradigms in agent-based simulation.
ContributorsHaghnevis, Moeed (Author) / Askin, Ronald G. (Thesis advisor) / Armbruster, Dieter (Thesis advisor) / Mirchandani, Pitu (Committee member) / Wu, Tong (Committee member) / Hedman, Kory (Committee member) / Arizona State University (Publisher)
Created2013
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Description
A Pairwise Comparison Matrix (PCM) is used to compute for relative priorities of criteria or alternatives and are integral components of widely applied decision making tools: the Analytic Hierarchy Process (AHP) and its generalized form, the Analytic Network Process (ANP). However, a PCM suffers from several issues limiting its application

A Pairwise Comparison Matrix (PCM) is used to compute for relative priorities of criteria or alternatives and are integral components of widely applied decision making tools: the Analytic Hierarchy Process (AHP) and its generalized form, the Analytic Network Process (ANP). However, a PCM suffers from several issues limiting its application to large-scale decision problems, specifically: (1) to the curse of dimensionality, that is, a large number of pairwise comparisons need to be elicited from a decision maker (DM), (2) inconsistent and (3) imprecise preferences maybe obtained due to the limited cognitive power of DMs. This dissertation proposes a PCM Framework for Large-Scale Decisions to address these limitations in three phases as follows. The first phase proposes a binary integer program (BIP) to intelligently decompose a PCM into several mutually exclusive subsets using interdependence scores. As a result, the number of pairwise comparisons is reduced and the consistency of the PCM is improved. Since the subsets are disjoint, the most independent pivot element is identified to connect all subsets. This is done to derive the global weights of the elements from the original PCM. The proposed BIP is applied to both AHP and ANP methodologies. However, it is noted that the optimal number of subsets is provided subjectively by the DM and hence is subject to biases and judgement errors. The second phase proposes a trade-off PCM decomposition methodology to decompose a PCM into a number of optimally identified subsets. A BIP is proposed to balance the: (1) time savings by reducing pairwise comparisons, the level of PCM inconsistency, and (2) the accuracy of the weights. The proposed methodology is applied to the AHP to demonstrate its advantages and is compared to established methodologies. In the third phase, a beta distribution is proposed to generalize a wide variety of imprecise pairwise comparison distributions via a method of moments methodology. A Non-Linear Programming model is then developed that calculates PCM element weights which maximizes the preferences of the DM as well as minimizes the inconsistency simultaneously. Comparison experiments are conducted using datasets collected from literature to validate the proposed methodology.
ContributorsJalao, Eugene Rex Lazaro (Author) / Shunk, Dan L. (Thesis advisor) / Wu, Teresa (Thesis advisor) / Askin, Ronald G. (Committee member) / Goul, Kenneth M (Committee member) / Arizona State University (Publisher)
Created2013
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Description
In a healthcare setting, the Sterile Processing Department (SPD) provides ancillary services to the Operating Room (OR), Emergency Room, Labor & Delivery, and off-site clinics. SPD's function is to reprocess reusable surgical instruments and return them to their home departments. The management of surgical instruments and medical devices can impact

In a healthcare setting, the Sterile Processing Department (SPD) provides ancillary services to the Operating Room (OR), Emergency Room, Labor & Delivery, and off-site clinics. SPD's function is to reprocess reusable surgical instruments and return them to their home departments. The management of surgical instruments and medical devices can impact patient safety and hospital revenue. Any time instrumentation or devices are not available or are not fit for use, patient safety and revenue can be negatively impacted. One step of the instrument reprocessing cycle is sterilization. Steam sterilization is the sterilization method used for the majority of surgical instruments and is preferred to immediate use steam sterilization (IUSS) because terminally sterilized items can be stored until needed. IUSS Items must be used promptly and cannot be stored for later use. IUSS is intended for emergency situations and not as regular course of action. Unfortunately, IUSS is used to compensate for inadequate inventory levels, scheduling conflicts, and miscommunications. If IUSS is viewed as an adverse event, then monitoring IUSS incidences can help healthcare organizations meet patient safety goals and financial goals along with aiding in process improvement efforts. This work recommends statistical process control methods to IUSS incidents and illustrates the use of control charts for IUSS occurrences through a case study and analysis of the control charts for data from a health care provider. Furthermore, this work considers the application of data mining methods to IUSS occurrences and presents a representative example of data mining to the IUSS occurrences. This extends the application of statistical process control and data mining in healthcare applications.
ContributorsWeart, Gail (Author) / Runger, George C. (Thesis advisor) / Li, Jing (Committee member) / Shunk, Dan (Committee member) / Arizona State University (Publisher)
Created2014
Description
To guide the timetabling and vehicle assignment of urban bus systems, a group of optimization models were developed for scenarios from simple to complex. The model took the interaction of prospective passengers and bus companies into consideration to achieve the maximum financial benefit as

To guide the timetabling and vehicle assignment of urban bus systems, a group of optimization models were developed for scenarios from simple to complex. The model took the interaction of prospective passengers and bus companies into consideration to achieve the maximum financial benefit as well as social satisfaction. The model was verified by a series of case studies and simulation from which some interesting conclusions were drawn.
ContributorsHuang, Shiyang (Author) / Askin, Ronald G. (Thesis advisor) / Mirchandani, Pitu (Committee member) / McCarville, Daniel R. (Committee member) / Arizona State University (Publisher)
Created2014
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Description
This research develops heuristics for scheduling electric power production amid uncertainty. Reliability is becoming more difficult to manage due to growing uncertainty from renewable resources. This challenge is compounded by the risk of resource outages, which can occur any time and without warning. Stochastic optimization is a promising tool but

This research develops heuristics for scheduling electric power production amid uncertainty. Reliability is becoming more difficult to manage due to growing uncertainty from renewable resources. This challenge is compounded by the risk of resource outages, which can occur any time and without warning. Stochastic optimization is a promising tool but remains computationally intractable for large systems. The models used in industry instead schedule for the forecast and withhold generation reserve for scenario response, but they are blind to how this reserve may be constrained by network congestion. This dissertation investigates more effective heuristics to improve economics and reliability in power systems where congestion is a concern.

Two general approaches are developed. Both approximate the effects of recourse decisions without actually solving a stochastic model. The first approach procures more reserve whenever approximate recourse policies stress the transmission network. The second approach procures reserve at prime locations by generalizing the existing practice of reserve disqualification. The latter approach is applied for feasibility and is later extended to limit scenario costs. Testing demonstrates expected cost improvements around 0.5%-1.0% for the IEEE 73-bus test case, which can translate to millions of dollars per year even for modest systems. The heuristics developed in this dissertation perform somewhere between established deterministic and stochastic models: providing an economic benefit over current practices without substantially increasing computational times.
ContributorsLyon, Joshua Daniel (Author) / Zhang, Muhong (Thesis advisor) / Hedman, Kory W (Thesis advisor) / Askin, Ronald G. (Committee member) / Mirchandani, Pitu (Committee member) / Arizona State University (Publisher)
Created2015
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Description
A good production schedule in a semiconductor back-end facility is critical for the on time delivery of customer orders. Compared to the front-end process that is dominated by re-entrant product flows, the back-end process is linear and therefore more suitable for scheduling. However, the production scheduling of the back-end process

A good production schedule in a semiconductor back-end facility is critical for the on time delivery of customer orders. Compared to the front-end process that is dominated by re-entrant product flows, the back-end process is linear and therefore more suitable for scheduling. However, the production scheduling of the back-end process is still very difficult due to the wide product mix, large number of parallel machines, product family related setups, machine-product qualification, and weekly demand consisting of thousands of lots. In this research, a novel mixed-integer-linear-programming (MILP) model is proposed for the batch production scheduling of a semiconductor back-end facility. In the MILP formulation, the manufacturing process is modeled as a flexible flow line with bottleneck stages, unrelated parallel machines, product family related sequence-independent setups, and product-machine qualification considerations. However, this MILP formulation is difficult to solve for real size problem instances. In a semiconductor back-end facility, production scheduling usually needs to be done every day while considering updated demand forecast for a medium term planning horizon. Due to the limitation on the solvable size of the MILP model, a deterministic scheduling system (DSS), consisting of an optimizer and a scheduler, is proposed to provide sub-optimal solutions in a short time for real size problem instances. The optimizer generates a tentative production plan. Then the scheduler sequences each lot on each individual machine according to the tentative production plan and scheduling rules. Customized factory rules and additional resource constraints are included in the DSS, such as preventive maintenance schedule, setup crew availability, and carrier limitations. Small problem instances are randomly generated to compare the performances of the MILP model and the deterministic scheduling system. Then experimental design is applied to understand the behavior of the DSS and identify the best configuration of the DSS under different demand scenarios. Product-machine qualification decisions have long-term and significant impact on production scheduling. A robust product-machine qualification matrix is critical for meeting demand when demand quantity or mix varies. In the second part of this research, a stochastic mixed integer programming model is proposed to balance the tradeoff between current machine qualification costs and future backorder costs with uncertain demand. The L-shaped method and acceleration techniques are proposed to solve the stochastic model. Computational results are provided to compare the performance of different solution methods.
ContributorsFu, Mengying (Author) / Askin, Ronald G. (Thesis advisor) / Zhang, Muhong (Thesis advisor) / Fowler, John W (Committee member) / Pan, Rong (Committee member) / Sen, Arunabha (Committee member) / Arizona State University (Publisher)
Created2011
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Description
The ever-changing economic landscape has forced many companies to re-examine their supply chains. Global resourcing and outsourcing of processes has been a strategy many organizations have adopted to reduce cost and to increase their global footprint. This has, however, resulted in increased process complexity and reduced customer satisfaction. In order

The ever-changing economic landscape has forced many companies to re-examine their supply chains. Global resourcing and outsourcing of processes has been a strategy many organizations have adopted to reduce cost and to increase their global footprint. This has, however, resulted in increased process complexity and reduced customer satisfaction. In order to meet and exceed customer expectations, many companies are forced to improve quality and on-time delivery, and have looked towards Lean Six Sigma as an approach to enable process improvement. The Lean Six Sigma literature is rich in deployment strategies; however, there is a general lack of a mathematical approach to deploy Lean Six Sigma in a global enterprise. This includes both project identification and prioritization. The research presented here is two-fold. Firstly, a process characterization framework is presented to evaluate processes based on eight characteristics. An unsupervised learning technique, using clustering algorithms, is then utilized to group processes that are Lean Six Sigma conducive. The approach helps Lean Six Sigma deployment champions to identify key areas within the business to focus a Lean Six Sigma deployment. A case study is presented and 33% of the processes were found to be Lean Six Sigma conducive. Secondly, having identified parts of the business that are lean Six Sigma conducive, the next steps are to formulate and prioritize a portfolio of projects. Very often the deployment champion is faced with the decision of selecting a portfolio of Lean Six Sigma projects that meet multiple objectives which could include: maximizing productivity, customer satisfaction or return on investment, while meeting certain budgetary constraints. A multi-period 0-1 knapsack problem is presented that maximizes the expected net savings of the Lean Six Sigma portfolio over the life cycle of the deployment. Finally, a case study is presented that demonstrates the application of the model in a large multinational company. Traditionally, Lean Six Sigma found its roots in manufacturing. The research presented in this dissertation also emphasizes the applicability of the methodology to the non-manufacturing space. Additionally, a comparison is conducted between manufacturing and non-manufacturing processes to highlight the challenges in deploying the methodology in both spaces.
ContributorsDuarte, Brett Marc (Author) / Fowler, John W (Thesis advisor) / Montgomery, Douglas C. (Thesis advisor) / Shunk, Dan (Committee member) / Borror, Connie (Committee member) / Konopka, John (Committee member) / Arizona State University (Publisher)
Created2011
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Description
In the entire supply chain, demand planning is one of the crucial aspects of the production planning process. If the demand is not estimated accurately, then it causes revenue loss. Past research has shown forecasting can be used to help the demand planning process for production. However, accurate forecasting from

In the entire supply chain, demand planning is one of the crucial aspects of the production planning process. If the demand is not estimated accurately, then it causes revenue loss. Past research has shown forecasting can be used to help the demand planning process for production. However, accurate forecasting from historical data is difficult in today's complex volatile market. Also it is not the only factor that influences the demand planning. Factors, namely, Consumer's shifting interest and buying power also influence the future demand. Hence, this research study focuses on Just-In-Time (JIT) philosophy using a pull control strategy implemented with a Kanban control system to control the inventory flow. Two different product structures, serial product structure and assembly product structure, are considered for this research. Three different methods: the Toyota Production System model, a histogram model and a cost minimization model, have been used to find the number of kanbans that was used in a computer simulated Just-In-Time Kanban System. The simulation model was built to execute the designed scenarios for both the serial and assembly product structure. A test was performed to check the significance effects of various factors on system performance. Results of all three methods were collected and compared to indicate which method provides the most effective way to determine number of kanbans at various conditions. It was inferred that histogram model and cost minimization models are more accurate in calculating the required kanbans for various manufacturing conditions. Method-1 fails to adjust the kanbans when the backordered cost increases or when product structure changes. Among the product structures, serial product structures proved to be effective when Method-2 or Method-3 is used to calculate the kanban numbers for the system. The experimental result data also indicated that the lower container capacity collects more backorders in the system, which increases the inventory cost, than the high container capacity for both serial and assembly product structures.
ContributorsSahu, Pranati (Author) / Askin, Ronald G. (Thesis advisor) / Shunk, Dan L. (Thesis advisor) / Fowler, John (Committee member) / Arizona State University (Publisher)
Created2012
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Description
Buildings (approximately half commercial and half residential) consume over 70% of the electricity among all the consumption units in the United States. Buildings are also responsible for approximately 40% of CO2 emissions, which is more than any other industry sectors. As a result, the initiative smart building which aims to

Buildings (approximately half commercial and half residential) consume over 70% of the electricity among all the consumption units in the United States. Buildings are also responsible for approximately 40% of CO2 emissions, which is more than any other industry sectors. As a result, the initiative smart building which aims to not only manage electrical consumption in an efficient way but also reduce the damaging effect of greenhouse gases on the environment has been launched. Another important technology being promoted by government agencies is the smart grid which manages energy usage across a wide range of buildings in an effort to reduce cost and increase reliability and transparency. As a great amount of efforts have been devoted to these two initiatives by either exploring the smart grid designs or developing technologies for smart buildings, the research studying how the smart buildings and smart grid coordinate thus more efficiently use the energy is currently lacking. In this dissertation, a "system-of-system" approach is employed to develop an integrated building model which consists a number of buildings (building cluster) interacting with smart grid. The buildings can function as both energy consumption unit as well as energy generation/storage unit. Memetic Algorithm (MA) and Particle Swarm Optimization (PSO) based decision framework are developed for building operation decisions. In addition, Particle Filter (PF) is explored as a mean for fusing online sensor and meter data so adaptive decision could be made in responding to dynamic environment. The dissertation is divided into three inter-connected research components. First, an integrated building energy model including building consumption, storage, generation sub-systems for the building cluster is developed. Then a bi-level Memetic Algorithm (MA) based decentralized decision framework is developed to identify the Pareto optimal operation strategies for the building cluster. The Pareto solutions not only enable multiple dimensional tradeoff analysis, but also provide valuable insight for determining pricing mechanisms and power grid capacity. Secondly, a multi-objective PSO based decision framework is developed to reduce the computational effort of the MA based decision framework without scarifying accuracy. With the improved performance, the decision time scale could be refined to make it capable for hourly operation decisions. Finally, by integrating the multi-objective PSO based decision framework with PF, an adaptive framework is developed for adaptive operation decisions for smart building cluster. The adaptive framework not only enables me to develop a high fidelity decision model but also enables the building cluster to respond to the dynamics and uncertainties inherent in the system.
ContributorsHu, Mengqi (Author) / Wu, Teresa (Thesis advisor) / Weir, Jeffery (Thesis advisor) / Wen, Jin (Committee member) / Fowler, John (Committee member) / Shunk, Dan (Committee member) / Arizona State University (Publisher)
Created2012
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Description
This dissertation presents methods for the evaluation of ocular surface protection during natural blink function. The evaluation of ocular surface protection is especially important in the diagnosis of dry eye and the evaluation of dry eye severity in clinical trials. Dry eye is a highly prevalent disease affecting vast numbers

This dissertation presents methods for the evaluation of ocular surface protection during natural blink function. The evaluation of ocular surface protection is especially important in the diagnosis of dry eye and the evaluation of dry eye severity in clinical trials. Dry eye is a highly prevalent disease affecting vast numbers (between 11% and 22%) of an aging population. There is only one approved therapy with limited efficacy, which results in a huge unmet need. The reason so few drugs have reached approval is a lack of a recognized therapeutic pathway with reproducible endpoints. While the interplay between blink function and ocular surface protection has long been recognized, all currently used evaluation techniques have addressed blink function in isolation from tear film stability, the gold standard of which is Tear Film Break-Up Time (TFBUT). In the first part of this research a manual technique of calculating ocular surface protection during natural blink function through the use of video analysis is developed and evaluated for it's ability to differentiate between dry eye and normal subjects, the results are compared with that of TFBUT. In the second part of this research the technique is improved in precision and automated through the use of video analysis algorithms. This software, called the OPI 2.0 System, is evaluated for accuracy and precision, and comparisons are made between the OPI 2.0 System and other currently recognized dry eye diagnostic techniques (e.g. TFBUT). In the third part of this research the OPI 2.0 System is deployed for use in the evaluation of subjects before, immediately after and 30 minutes after exposure to a controlled adverse environment (CAE), once again the results are compared and contrasted against commonly used dry eye endpoints. The results demonstrate that the evaluation of ocular surface protection using the OPI 2.0 System offers superior accuracy to the current standard, TFBUT.
ContributorsAbelson, Richard (Author) / Montgomery, Douglas C. (Thesis advisor) / Borror, Connie (Committee member) / Shunk, Dan (Committee member) / Pan, Rong (Committee member) / Arizona State University (Publisher)
Created2012