Matching Items (4)
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- All Subjects: cluster analysis
- Creators: Bliss, Daniel
Description
Immunosignaturing is a medical test for assessing the health status of a patient by applying microarrays of random sequence peptides to determine the patient's immune fingerprint by associating antibodies from a biological sample to immune responses. The immunosignature measurements can potentially provide pre-symptomatic diagnosis for infectious diseases or detection of biological threats. Currently, traditional bioinformatics tools, such as data mining classification algorithms, are used to process the large amount of peptide microarray data. However, these methods generally require training data and do not adapt to changing immune conditions or additional patient information. This work proposes advanced processing techniques to improve the classification and identification of single and multiple underlying immune response states embedded in immunosignatures, making it possible to detect both known and previously unknown diseases or biothreat agents. Novel adaptive learning methodologies for un- supervised and semi-supervised clustering integrated with immunosignature feature extraction approaches are proposed. The techniques are based on extracting novel stochastic features from microarray binding intensities and use Dirichlet process Gaussian mixture models to adaptively cluster the immunosignatures in the feature space. This learning-while-clustering approach allows continuous discovery of antibody activity by adaptively detecting new disease states, with limited a priori disease or patient information. A beta process factor analysis model to determine underlying patient immune responses is also proposed to further improve the adaptive clustering performance by formatting new relationships between patients and antibody activity. In order to extend the clustering methods for diagnosing multiple states in a patient, the adaptive hierarchical Dirichlet process is integrated with modified beta process factor analysis latent feature modeling to identify relationships between patients and infectious agents. The use of Bayesian nonparametric adaptive learning techniques allows for further clustering if additional patient data is received. Significant improvements in feature identification and immune response clustering are demonstrated using samples from patients with different diseases.
ContributorsMalin, Anna (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Bliss, Daniel (Committee member) / Chakrabarti, Chaitali (Committee member) / Kovvali, Narayan (Committee member) / Lacroix, Zoé (Committee member) / Arizona State University (Publisher)
Created2013
Description
As the number of devices with wireless capabilities and the proximity of these devices to each other increases, better ways to handle the interference they cause need to be explored. Also important is for these devices to keep up with the demand for data rates while not compromising on industry established expectations of power consumption and mobility. Current methods of distributing the spectrum among all participants are expected to not cope with the demand in a very near future. In this thesis, the effect of employing sophisticated multiple-input, multiple-output (MIMO) systems in this regard is explored. The efficacy of systems which can make intelligent decisions on the transmission mode usage and power allocation to these modes becomes relevant in the current scenario, where the need for performance far exceeds the cost expendable on hardware. The effect of adding multiple antennas at either ends will be examined, the capacity of such systems and of networks comprised of many such participants will be evaluated. Methods of simulating said networks, and ways to achieve better performance by making intelligent transmission decisions will be proposed. Finally, a way of access control closer to the physical layer (a 'statistical MAC') and a possible metric to be used for such a MAC is suggested.
ContributorsThontadarya, Niranjan (Author) / Bliss, Daniel W (Thesis advisor) / Berisha, Visar (Committee member) / Ying, Lei (Committee member) / Arizona State University (Publisher)
Created2014
Description
Multiple-input multiple-output systems have gained focus in the last decade due to the benefits they provide in enhancing the quality of communications. On the other hand, full-duplex communication has attracted remarkable attention due to its ability to improve the spectral efficiency compared to the existing half-duplex systems. Using full-duplex communications on MIMO co-operative networks can provide us solutions that can completely outperform existing systems with simultaneous transmission and reception at high data rates.
This thesis considers a full-duplex MIMO relay which amplifies and forwards the received signals, between a source and a destination that do not a have line of sight. Full-duplex mode raises the problem of self-interference. Though all the links in the system undergo frequency flat fading, the end-to-end effective channel is frequency selective. This is due to the imperfect cancellation of the self-interference at the relay and this residual self-interference acts as intersymbol interference at the destination which is treated by equalization. This also leads to complications in form of recursive equations to determine the input-output relationship of the system. This also leads to complications in the form of recursive equations to determine the input-output relationship of the system.
To overcome this, a signal flow graph approach using Mason's gain formula is proposed, where the effective channel is analyzed with keen notice to every loop and path the signal traverses. This gives a clear understanding and awareness about the orders of the polynomials involved in the transfer function, from which desired conclusions can be drawn. But the complexity of Mason's gain formula increases with the number of antennas at relay which can be overcome by the proposed linear algebraic method. Input-output relationship derived using simple concepts of linear algebra can be generalized to any number of antennas and the computation complexity is comparatively very low.
For a full-duplex amplify-and-forward MIMO relay system, assuming equalization at the destination, new mechanisms have been implemented at the relay that can compensate the effect of residual self-interference namely equal-gain transmission and antenna selection. Though equal-gain transmission does not perform better than the maximal ratio transmission, a trade-off can be made between performance and implementation complexity. Using the proposed antenna selection strategy, one pair of transmit-receive antennas at the relay is selected based on four selection criteria discussed. Outage probability analysis is performed for all the strategies presented and detailed comparison has been established. Considering minimum mean-squared error decision feedback equalizer at the destination, a bound on the outage probability has been obtained for the antenna selection case and is used for comparisons. A cross-over point is observed while comparing the outage probabilities of equal-gain transmission and antenna selection techniques, as the signal-to-noise ratio increases and from that point antenna selection outperforms equal-gain transmission and this is explained by the fact of reduced residual self-interference in antenna selection method.
This thesis considers a full-duplex MIMO relay which amplifies and forwards the received signals, between a source and a destination that do not a have line of sight. Full-duplex mode raises the problem of self-interference. Though all the links in the system undergo frequency flat fading, the end-to-end effective channel is frequency selective. This is due to the imperfect cancellation of the self-interference at the relay and this residual self-interference acts as intersymbol interference at the destination which is treated by equalization. This also leads to complications in form of recursive equations to determine the input-output relationship of the system. This also leads to complications in the form of recursive equations to determine the input-output relationship of the system.
To overcome this, a signal flow graph approach using Mason's gain formula is proposed, where the effective channel is analyzed with keen notice to every loop and path the signal traverses. This gives a clear understanding and awareness about the orders of the polynomials involved in the transfer function, from which desired conclusions can be drawn. But the complexity of Mason's gain formula increases with the number of antennas at relay which can be overcome by the proposed linear algebraic method. Input-output relationship derived using simple concepts of linear algebra can be generalized to any number of antennas and the computation complexity is comparatively very low.
For a full-duplex amplify-and-forward MIMO relay system, assuming equalization at the destination, new mechanisms have been implemented at the relay that can compensate the effect of residual self-interference namely equal-gain transmission and antenna selection. Though equal-gain transmission does not perform better than the maximal ratio transmission, a trade-off can be made between performance and implementation complexity. Using the proposed antenna selection strategy, one pair of transmit-receive antennas at the relay is selected based on four selection criteria discussed. Outage probability analysis is performed for all the strategies presented and detailed comparison has been established. Considering minimum mean-squared error decision feedback equalizer at the destination, a bound on the outage probability has been obtained for the antenna selection case and is used for comparisons. A cross-over point is observed while comparing the outage probabilities of equal-gain transmission and antenna selection techniques, as the signal-to-noise ratio increases and from that point antenna selection outperforms equal-gain transmission and this is explained by the fact of reduced residual self-interference in antenna selection method.
ContributorsJonnalagadda, Geeta Sankar Kalyan (Author) / Tepedelenlioğlu, Cihan (Thesis advisor) / Bliss, Daniel (Committee member) / Kosut, Oliver (Committee member) / Arizona State University (Publisher)
Created2018
Description
The radar performance of detecting a target and estimating its parameters can deteriorate rapidly in the presence of high clutter. This is because radar measurements due to clutter returns can be falsely detected as if originating from the actual target. Various data association methods and multiple hypothesis filtering approaches have been considered to solve this problem. Such methods, however, can be computationally intensive for real time radar processing. This work proposes a new approach that is based on the unsupervised clustering of target and clutter detections before target tracking using particle filtering. In particular, Gaussian mixture modeling is first used to separate detections into two Gaussian distinct mixtures. Using eigenvector analysis, the eccentricity of the covariance matrices of the Gaussian mixtures are computed and compared to threshold values that are obtained a priori. The thresholding allows only target detections to be used for target tracking. Simulations demonstrate the performance of the new algorithm and compare it with using k-means for clustering instead of Gaussian mixture modeling.
ContributorsFreeman, Matthew Gregory (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Bliss, Daniel (Thesis advisor) / Chakrabarti, Chaitali (Committee member) / Arizona State University (Publisher)
Created2016