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A variety of studies have shown that the tendency toward nicotine dependence has a genetic component. The work described in this thesis addresses three separate questions: i) are there unidentified SNPs in the nicotinic receptors or other genes that contribute to the risk for nicotine dependence; ii) is there evidence of ongoing selection at nicotinic receptor loci; and, iii) since nicotine dependence is unlikely to be the phenotype undergoing selection, is a positive effect on memory or cognition the selected phenotype. I first undertook a genome –wide association scan of imputed data using samples from the Collaborative Study of the Genetics of Nicotine Dependence (COGEND). A novel association was found between nicotine dependence and SNPs at 13q31. The genes at this newly associated locus on chromosome 13 encode a group of micro-RNAs and a member of the glypican gene family. These are among the first findings to implicate a non-candidate gene in risk for nicotine dependence. I applied several complimentary methods to sequence data from the 1000 Genomes Project to test for evidence of selection at the nicotinic receptor loci. I found strong evidence for selection for alleles in the nicotinic receptor cluster on chromosome 8 that confer risk of nicotine dependence. I then used the dataset from the Collaborative Studies on the Genetics of Alcoholism (COGA) and looked for an association between neuropsychological phenotypes and SNPs conferring risk of nicotine dependence. One SNP passed multiple test correction for association with WAIS digit symbol score. This SNP is not itself associated with nicotine dependence but is in reasonable (r 2 = 0.75) LD with SNPs that are associated with nicotine dependence. These data suggest at best, a weak correlation between nicotine dependence and any of the tested cognitive phenotypes. Given the reproducible finding of an inverse relationship between SNPs associated with risk for nicotine dependence and cocaine dependence, I hypothesize that the apparently detrimental phenotype of nicotine dependence may confer decreased risk for cocaine dependence. As cocaine use impairs the positive rewards associated with social interactions, reducing the risk of cocaine addiction may be beneficial to both the individual and the group.
ContributorsSadler, Brooke (Author) / Hurtado, Ana Magdalena (Thesis advisor) / Goate, Alison (Thesis advisor) / Hill, Kim (Committee member) / Nagoshi, Craig (Committee member) / Arizona State University (Publisher)
Created2014
Description
In the United States, there is a national agenda to increase the number of qualified science, technology, engineering, and maths (STEM) professionals and a movement to promote science literacy among the general public. This project explores the association between formal human evolutionary biology education (HEB) and high school science class enrollment, academic achievement, interest in a STEM degree program, motivation to pursue a STEM career, and socioscientific decision–making for a sample of students enrolled full–time at Arizona State University. Given a lack of a priori knowledge of these relationships, the Grounded Theory Method was used and was the foundation for a mixed–methods analysis involving qualitative and quantitative data from one–on–one interviews, focus groups, questionnaires, and an online survey. Theory development and hypothesis generation were based on data from 44 students. The survey instrument, developed to test the hypotheses, was completed by 486 undergraduates, age 18–22, who graduated from U.S. public high schools. The results showed that higher exposure to HEB was correlated with greater high school science class enrollment, particularly for advanced biological science classes, and that, for some students, HEB exposure may have influenced their enrollment, because the students found the content interesting and relevant. The results also suggested that students with higher K–12 HEB exposure felt more prepared for undergraduate science coursework. There was a positive correlation between HEB exposure and interest in a STEM degree and an indirect relationship between higher HEB exposure and motivation to pursue a STEM career. Regarding a number of socioscientific issues, including but not limited to climate change, homosexuality, and stem cell research, students' behaviors and decision–making more closely reflected a scientific viewpoint—or less–closely aligned to a religion–based perspective—when students had greater HEB exposure, but this was sometimes contingent on students' lifetime exposure to religious doctrine and acceptance of general evolution or human evolution. This study has implications for K–12 and higher education and justifies a paradigm shift in evolution education research, such that more emphasis is placed on students' interests, perceived preparation for continued learning, professional goals and potential contributions to society rather than just their knowledge and acceptance.
ContributorsSchrein, Caitlin M (Author) / Toon, Richard (Thesis advisor) / Johanson, Donald (Thesis advisor) / Hackett, Edward (Committee member) / Molina-Walters, Debra (Committee member) / Arizona State University (Publisher)
Created2014
Description
At present, the ideological bias in the human enhancement debate holds that opponents to human enhancement are primarily techno-conservatives who, lacking any reasonable, systematic account of why we ought to be so opposed, simply resort to a sort of fear-mongering and anti-meliorism. This dissertation means to counteract said bias by offering just such an account. Offered herein is a heuristic explanation of how, given a thorough understanding of enhancement both as a technology and as an attitude, we can predict a likely future of rampant commodification and dehumanization of man, and a veritable assault on human flourishing.
ContributorsMilleson, Valerye Michelle (Author) / McGregor, Joan (Thesis advisor) / Robert, Jason (Committee member) / French, Peter (Committee member) / Arizona State University (Publisher)
Created2012
Description
Criticisms of technocratic and managerial sustainability responses to global environmental change have led scholars to argue for transformative shifts in ideology, policy, and practice favoring alternative, plural transformation pathways to sustainability. This raises key debates around how we build transformative capacity and who will lead the way. To further this critical dialogue, this dissertation explores the potential for sustainability experiential learning (SEL) to serve as a capacity building mechanism for global ecological citizenship in support of transformation pathways to sustainable wellbeing. In the process it considers how the next generation of those primed for sustainability leadership identify with and negotiate diversity—of perceptions, values, agency, and lived experiences—in what constitutes sustainable wellbeing and the approaches needed to get there.
Inspired by the STEPS (Social, Technological and Environmental Pathways to Sustainability) Centre’s transformation pathways approach, this research proposes a Transformative Capacity Building model grounded in a Transformation Pathways to Sustainable Wellbeing framework that integrates and builds upon tenets of the original pathways approach with transformative learning, Value-Believe-Norm, and global ecological citizenship (eco-citizenship) theories and concepts. The proposed model and framework were applied to an in-depth ethnographic case study of sustainability experiential learning communities formed within the four Summer 2015 Global Sustainability Studies (GSS) programs at Arizona State University. Using mixed methods, including semi-structured interviews, participant observation, and Photovoice, this study examines the values, perceptions, and perceived agency of participants post-program in relation to the knowledge-making and mobilization processes that unfolded during their international GSS programs. Of particular interest are participants’ cognitive, moral, and affective engagement as SEL community members.
Through multi-level thematic analyses, key values, perceptions, agency and engagement themes are identified and influencing relationships highlighted across the different SEL communities and programs. Implications of these factors and their relationships for capacity building for eco-citizenship and future program development are considered. The dissertation concludes by translating study findings into actionable pathways for future research AND practice, including the proposal of program development and implementation recommendations that could enable future sustainability experiential learning programs to better contribute to transformative capacity building for eco-citizenship.
Inspired by the STEPS (Social, Technological and Environmental Pathways to Sustainability) Centre’s transformation pathways approach, this research proposes a Transformative Capacity Building model grounded in a Transformation Pathways to Sustainable Wellbeing framework that integrates and builds upon tenets of the original pathways approach with transformative learning, Value-Believe-Norm, and global ecological citizenship (eco-citizenship) theories and concepts. The proposed model and framework were applied to an in-depth ethnographic case study of sustainability experiential learning communities formed within the four Summer 2015 Global Sustainability Studies (GSS) programs at Arizona State University. Using mixed methods, including semi-structured interviews, participant observation, and Photovoice, this study examines the values, perceptions, and perceived agency of participants post-program in relation to the knowledge-making and mobilization processes that unfolded during their international GSS programs. Of particular interest are participants’ cognitive, moral, and affective engagement as SEL community members.
Through multi-level thematic analyses, key values, perceptions, agency and engagement themes are identified and influencing relationships highlighted across the different SEL communities and programs. Implications of these factors and their relationships for capacity building for eco-citizenship and future program development are considered. The dissertation concludes by translating study findings into actionable pathways for future research AND practice, including the proposal of program development and implementation recommendations that could enable future sustainability experiential learning programs to better contribute to transformative capacity building for eco-citizenship.
ContributorsGwiszcz, Julianna Marie (Author) / Eder, James (Thesis advisor) / Haglund, LaDawn (Committee member) / Wutich, Amber (Committee member) / Arizona State University (Publisher)
Created2018
Description
Over the past three decades, medical anthropology research, published within both public health and anthropological journals, demonstrates both the prevalence of traditional folk medicine in Latino populations in the United States and the potential difficulty of negotiating these beliefs and practices with clinical, western biomedicine. I bring attention to what might be a narrative of divergent values that occurs in Latino communities in the United States. A well-documented source (Pachter, 1994) of this clash is the culturally pervasive use of folk medicine in Latino layperson populations seeking biomedical care in the Unites States (U.S.). Numerous studies (Padilla, 2001; Koss 1972) suggest that a significant portion of Latinos in the continental United States call upon folk knowledge to diagnose, reinterpret, and treat illness. The Puerto Rican population seems to be no exception, though few studies are specific to native-born Puerto Ricans living in Puerto Rico, where the issue of access to quality public health care becomes increasingly problematic. In this honors undergraduate thesis project, I conduct a review of the literature that bridges anthropology and public health research and proceed to describe a study I conducted on Culebra Island, Puerto Rico in May of 2015. The study aims to determine whether patient satisfaction can be linked to being treated by a physician hailing from a similar cultural background, or if an irredeemable disparity between patient and provider present a roadblock to health outcomes. I found that the Puerto Rican physicians are receptive to folk illness (symptoms) and consider folk therapy as part of the treatment regimen. The physicians make patients feel understood, which might improve treatment adherence and thus health outcomes. Still, respondents demonstrated that there is high patient trust in the biomedical model by emphasizing the use of conventional medications in tandem with the folk therapy. Nevertheless, the health care provider's disposition in regards to folk knowledge and modalities are important but does not present a roadblock to optimal care and health outcomes as much as access, available services or clinic resources.
ContributorsVanasse-Torres, Elena Georgina (Author) / Maupin, Jonathan (Thesis director) / Maienschein, Jane (Thesis director) / MartÃÂnez, AirÃÂn (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Physician-assisted suicide occurs when a physician facilitates a patient's death by prescribing a lethal medication that they understand will be used for the purpose of ending the patient's life. It is a highly contentious subject and, with the recent addition of California to the list of states that allow physician-assisted suicide, is an increasingly relevant subject. Physician-assisted suicide is rarely framed as a healthcare experience, despite being a choice in the process of end-of-life care. The research seeks to bring together the debates about physician-assisted suicide with conversations about health care experiences. The experiences and perspectives of young people are particularly valuable to evaluate now, as their voices will soon be the leaders in the debate over physician-assisted suicide. Within this research, there is an underlying theme of independence of individuals that is present through both the literature review and the body of data collected and analyzed. The study found that there was no significant relationship between the quality of a person's healthcare and their perspectives about physician-assisted suicide.
ContributorsMoeur, Katherine Elizabeth (Author) / Brian, Jennifer (Thesis director) / Graff, Sarah (Committee member) / Stevenson, Christine (Committee member) / School of Life Sciences (Contributor) / School of Human Evolution and Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
How are perceptions of morality and disgust regarding meat consumption related to each other? Which factor is more salient in determining one's willingness to eat the meat of a specific animal? How do these answers vary across religious groups? This study investigates the ways that concepts like morality and disgust are related to food preferences and hopes to shed light on the mechanisms that enforce culturally sanctioned food taboos. The study compares 4 groups of people in the U.S.: Christians (n = 39), Hindus (n = 29), Jews (n = 23), and non-religious people (n = 63). A total of 154 participants were given surveys in which they rated their feelings about eating various animals. Data from Christian and non-religious groups exhibited similar patterns such as a high likelihood of eating a given animal when starving, while results from Jews and Hindus were consistent with their religion's respective food taboos. Despite these differences, morality and disgust are strongly correlated with one another in almost all instances. Moreover, morality and disgust are almost equally important considerations when determining willingness to eat when starving.
ContributorsParekh, Shaili Rajul (Author) / Hruschka, Daniel (Thesis director) / Jacobs, Mark (Committee member) / Barrett, The Honors College (Contributor) / School of Nutrition and Health Promotion (Contributor) / School of Human Evolution and Social Change (Contributor) / Hugh Downs School of Human Communication (Contributor)
Created2014-12
Description
Some scholars have suggested that individuals are inclined to believe that they have souls because they are also inclined to believe that they have a core, immutable self. The present study will explore this question in several parts. First, what is the extent to which individuals report having a core self? Next, how do beliefs about a core self relate to belief or non-belief in an eternal soul? The final question looks at location as an extension of the core self and soul relationship. Where is the self perceived to reside within a dualistic framework, the body or the soul? This study assessed the stated beliefs of 200 respondents using Amazon Mechanical Turk as a recruiting platform. Greater belief in a core self was moderately associated with greater belief in an eternal soul (r= 0.30, p<.01), and with belief in the self as a reflection of the soul (r=0.31, p<.01) and as a reflection of the brain (r=0.21, p<.01). This suggests that belief in a core self does hold association with belief in an eternal soul. However, its perceived location seems to show little preference as residing withing the soul versus the body.
ContributorsLy, Destiny (Author) / Hruschka, Daniel (Thesis director) / Parker, John (Contributor) / Barrett, The Honors College (Contributor)
Created2014-12
Description
In this study, we propose and then assess the efficacy of a new approach to static suspension to correct for facial paralysis. Our method involves placing barbed sutures through the superficial muscular aponeurotic system (SMAS) and anchoring them in the temporal fascia parallel to the underlying facial muscles. We first analyzed the ability of this procedure to improve facial symmetry by comparing the degree of asymmetry between the paralyzed and unaffected sides of a patient's face (N=10) prior to and following surgery. Then, to determine if symmetry is improved as a result of placing the sutures parallel to the direction of facial muscle forces, we measured the vectors of levator labii superioris and zygomaticus major in cadaver hemifaces (N=3) and compared them to the angles of the vectors of correction from the patient sample to angles of muscle vectors in three facial hemispheres from cadaver controls. Results indicate that: (1) facial symmetry was significantly improved in these patients and (2) this improvement. We conclude that, compared to existing protocols, our novel surgical method is a better means of static suspension for reconstruction following onset of facial paralysis as it is simple to perform, easy to replicate, able to be post-operatively adjusted in-office, has a good long-term prognosis, and, as we have demonstrated, effectively corrects the appearance of asymmetry by working with the underlying facial anatomy.
ContributorsLeach, Garrison Alecsander (Co-author) / Joganic, Jessica (Co-author) / Hooft, Nicole (Co-author) / Joganic, Edward (Co-author, Committee member) / Foy, Joseph (Thesis director) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Paleodietary analysis through the interpretation of stable isotopic analyses can be used to determine the approximate diet consumed at archaeological sites. The following question was investigated through the course of this research: What are the differences between the Middle Horizon capital of Tiwanaku and the associated colony of Chen Chen; and what do these differences, including those associated with paleodiet, suggest about interactions between the two sites? The main hypothesis suggested a similar dietary analysis between the two sites with two possible explanations. First, it is possible that similarities between the sites were due to the exchange and consumption of goods at both locations, perhaps through trade. Secondly, it is possible that the similarities were due to the acquisition of similar goods through local sourcing or limited trade. To assess this, an analysis was conducted based on δ13Cdiet (VPDB) values in the comparison of the city center Tiwanaku and the agricultural site of Chen Chen. Archaeological bone samples were processed from a diverse group of individuals at Chen Chen and combined with published values by Tomczak (2001), then compared against δ13C from Tiwanaku, published by Berryman (2010). After conversion to δ13Cdiet (VPDB) as described by Kellner and Schoeninger (2007), it was determined that there was no statistically significant difference between the δ13Cdiet (VPDB) values from either site, suggesting a similar ratio of goods consumed. These values were then compared to baseline values from the region to determine an approximate ratio of C3 to C4 flora or dependent fauna consumed. These data most likely support the second explanation of the main hypothesis, that both sites had access to similar goods through local sourcing or limited trade as an explanation for their similarity. However, because a similar ratio of foods consumed was determined in this analysis, it is still possible that trade occurred in both directions between Tiwanaku and Chen Chen. Additional isotopic analyses would be required to support the first claim, which can be addressed in future research projects.
ContributorsDouglas, Brynn Babette (Author) / Knudson, Kelly (Thesis director) / Spielmann, Katherine (Committee member) / Barrett, The Honors College (Contributor) / School of Human Evolution and Social Change (Contributor) / School of Life Sciences (Contributor)
Created2015-05