Matching Items (5)
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- All Subjects: Anthropology
- Creators: Hill, Kim
- Creators: Wutich, Amber
- Member of: Theses and Dissertations
- Resource Type: Text
Description
A variety of studies have shown that the tendency toward nicotine dependence has a genetic component. The work described in this thesis addresses three separate questions: i) are there unidentified SNPs in the nicotinic receptors or other genes that contribute to the risk for nicotine dependence; ii) is there evidence of ongoing selection at nicotinic receptor loci; and, iii) since nicotine dependence is unlikely to be the phenotype undergoing selection, is a positive effect on memory or cognition the selected phenotype. I first undertook a genome –wide association scan of imputed data using samples from the Collaborative Study of the Genetics of Nicotine Dependence (COGEND). A novel association was found between nicotine dependence and SNPs at 13q31. The genes at this newly associated locus on chromosome 13 encode a group of micro-RNAs and a member of the glypican gene family. These are among the first findings to implicate a non-candidate gene in risk for nicotine dependence. I applied several complimentary methods to sequence data from the 1000 Genomes Project to test for evidence of selection at the nicotinic receptor loci. I found strong evidence for selection for alleles in the nicotinic receptor cluster on chromosome 8 that confer risk of nicotine dependence. I then used the dataset from the Collaborative Studies on the Genetics of Alcoholism (COGA) and looked for an association between neuropsychological phenotypes and SNPs conferring risk of nicotine dependence. One SNP passed multiple test correction for association with WAIS digit symbol score. This SNP is not itself associated with nicotine dependence but is in reasonable (r 2 = 0.75) LD with SNPs that are associated with nicotine dependence. These data suggest at best, a weak correlation between nicotine dependence and any of the tested cognitive phenotypes. Given the reproducible finding of an inverse relationship between SNPs associated with risk for nicotine dependence and cocaine dependence, I hypothesize that the apparently detrimental phenotype of nicotine dependence may confer decreased risk for cocaine dependence. As cocaine use impairs the positive rewards associated with social interactions, reducing the risk of cocaine addiction may be beneficial to both the individual and the group.
ContributorsSadler, Brooke (Author) / Hurtado, Ana Magdalena (Thesis advisor) / Goate, Alison (Thesis advisor) / Hill, Kim (Committee member) / Nagoshi, Craig (Committee member) / Arizona State University (Publisher)
Created2014
Description
Criticisms of technocratic and managerial sustainability responses to global environmental change have led scholars to argue for transformative shifts in ideology, policy, and practice favoring alternative, plural transformation pathways to sustainability. This raises key debates around how we build transformative capacity and who will lead the way. To further this critical dialogue, this dissertation explores the potential for sustainability experiential learning (SEL) to serve as a capacity building mechanism for global ecological citizenship in support of transformation pathways to sustainable wellbeing. In the process it considers how the next generation of those primed for sustainability leadership identify with and negotiate diversity—of perceptions, values, agency, and lived experiences—in what constitutes sustainable wellbeing and the approaches needed to get there.
Inspired by the STEPS (Social, Technological and Environmental Pathways to Sustainability) Centre’s transformation pathways approach, this research proposes a Transformative Capacity Building model grounded in a Transformation Pathways to Sustainable Wellbeing framework that integrates and builds upon tenets of the original pathways approach with transformative learning, Value-Believe-Norm, and global ecological citizenship (eco-citizenship) theories and concepts. The proposed model and framework were applied to an in-depth ethnographic case study of sustainability experiential learning communities formed within the four Summer 2015 Global Sustainability Studies (GSS) programs at Arizona State University. Using mixed methods, including semi-structured interviews, participant observation, and Photovoice, this study examines the values, perceptions, and perceived agency of participants post-program in relation to the knowledge-making and mobilization processes that unfolded during their international GSS programs. Of particular interest are participants’ cognitive, moral, and affective engagement as SEL community members.
Through multi-level thematic analyses, key values, perceptions, agency and engagement themes are identified and influencing relationships highlighted across the different SEL communities and programs. Implications of these factors and their relationships for capacity building for eco-citizenship and future program development are considered. The dissertation concludes by translating study findings into actionable pathways for future research AND practice, including the proposal of program development and implementation recommendations that could enable future sustainability experiential learning programs to better contribute to transformative capacity building for eco-citizenship.
Inspired by the STEPS (Social, Technological and Environmental Pathways to Sustainability) Centre’s transformation pathways approach, this research proposes a Transformative Capacity Building model grounded in a Transformation Pathways to Sustainable Wellbeing framework that integrates and builds upon tenets of the original pathways approach with transformative learning, Value-Believe-Norm, and global ecological citizenship (eco-citizenship) theories and concepts. The proposed model and framework were applied to an in-depth ethnographic case study of sustainability experiential learning communities formed within the four Summer 2015 Global Sustainability Studies (GSS) programs at Arizona State University. Using mixed methods, including semi-structured interviews, participant observation, and Photovoice, this study examines the values, perceptions, and perceived agency of participants post-program in relation to the knowledge-making and mobilization processes that unfolded during their international GSS programs. Of particular interest are participants’ cognitive, moral, and affective engagement as SEL community members.
Through multi-level thematic analyses, key values, perceptions, agency and engagement themes are identified and influencing relationships highlighted across the different SEL communities and programs. Implications of these factors and their relationships for capacity building for eco-citizenship and future program development are considered. The dissertation concludes by translating study findings into actionable pathways for future research AND practice, including the proposal of program development and implementation recommendations that could enable future sustainability experiential learning programs to better contribute to transformative capacity building for eco-citizenship.
ContributorsGwiszcz, Julianna Marie (Author) / Eder, James (Thesis advisor) / Haglund, LaDawn (Committee member) / Wutich, Amber (Committee member) / Arizona State University (Publisher)
Created2018
Description
Early humans adapted to eating cooked food with increased energy density and absorption of macronutrients. However, in modern times many suffer from diseases like obesity and type 2 diabetes which can result from too much energy being absorbed from food. This study measures glucose responses to a high glycemic meal with a side dish of raw or cooked vegetables. There was a slight trend for raw vegetables to have decreased postprandial blood glucose responses when compared to cooked vegetables.
ContributorsWilkins, Christine Marie (Author) / Johnston, Carol (Thesis director) / Jacobs, Mark (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor)
Created2014-05
Description
The Culture, Health, and Environment Lab (CHEL) at Arizona State University uses anthropological methods and field-based studies to research how cultural knowledge may be used to help understand and respond to contemporary environmental and health issues—primarily the global challenges of water insecurity and obesity. In their efforts to research water insecurity and it implications, CHEL has been working on studying water insecurity through the Global Ethnohydrology Study (GES). The Global Ethnohydrology study examines local knowledge and perceptions of water issues, using transdisciplinary methods in a multi-year and cross-country program. In the 2015-2016 study, the GES examined water, hygiene norms, and hygiene stigma. It sought to investigate how hygiene norms are impacted by the level of water security, examining if water-poor communities have laxer laxer or more accommodating hygiene norms. This paper will explore the development of the codebook for this study, following the process in which the qualitative data from the GES 2015 was organized through a series of codes so that it may later be analyzed.
ContributorsPfeiffer, Ainsley Josephine (Author) / Wutich, Amber (Thesis director) / Schuster, Roseanne (Committee member) / School of Human Evolution and Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
For most of human history hunting has been the primary economic activity of men. Hunted animals are valued for their food energy and nutrients, however, hunting is associated with a high risk of failure. Additionally, large animals cannot be consumed entirely by the nuclear family, so much of the harvest may be shared to others. This has led some researchers to ask why men hunt large and difficult game. The “costly signaling” and “show-off” hypotheses propose that large prey are hunted because the difficulty of finding and killing them is a reliable costly signal of the phenotypic quality of the hunter.
These hypotheses were tested using original interview data from Aché (hunter gatherer; n=52, age range 50-76, 46% female) and Tsimané (horticulturalist; n=40, age range 15-77, 45% female) informants. Ranking tasks and paired comparison tasks were used to determine the association between the costs of killing an animal and its value as a signal of hunter phenotypic quality for attracting mates and allies. Additional tasks compared individual large animals to groups of smaller animals to determine whether assessments of hunters’ phenotypes and preferred status were more impacted by the signal value of the species or by the weight and number of animals killed.
Aché informants perceived hunters who killed larger or harder to kill animals as having greater provisioning ability, strength, fighting ability, and disease susceptibility, and preferred them as mates and allies. Tsimané informants held a similar preference for hunters who killed large game, but not for hunters targeting hard to kill species. When total biomass harvested was controlled, both populations considered harvesting more animals in a given time period to be a better signal of preferred phenotypes than killing a single large and impressive species. Male and female informants both preferred hunters who consistently brought back small game over hunters who sometimes killed large animals and sometimes killed nothing. No evidence was found that hunters should forgo overall food return rates in order to signal phenotypic qualities by specializing on large game. Nutrient provisioning rather than costly phenotypic signaling was the strategy preferred by potential mates and allies.
These hypotheses were tested using original interview data from Aché (hunter gatherer; n=52, age range 50-76, 46% female) and Tsimané (horticulturalist; n=40, age range 15-77, 45% female) informants. Ranking tasks and paired comparison tasks were used to determine the association between the costs of killing an animal and its value as a signal of hunter phenotypic quality for attracting mates and allies. Additional tasks compared individual large animals to groups of smaller animals to determine whether assessments of hunters’ phenotypes and preferred status were more impacted by the signal value of the species or by the weight and number of animals killed.
Aché informants perceived hunters who killed larger or harder to kill animals as having greater provisioning ability, strength, fighting ability, and disease susceptibility, and preferred them as mates and allies. Tsimané informants held a similar preference for hunters who killed large game, but not for hunters targeting hard to kill species. When total biomass harvested was controlled, both populations considered harvesting more animals in a given time period to be a better signal of preferred phenotypes than killing a single large and impressive species. Male and female informants both preferred hunters who consistently brought back small game over hunters who sometimes killed large animals and sometimes killed nothing. No evidence was found that hunters should forgo overall food return rates in order to signal phenotypic qualities by specializing on large game. Nutrient provisioning rather than costly phenotypic signaling was the strategy preferred by potential mates and allies.
ContributorsBishop, Andrew Phillip Carson (Author) / Hill, Kim (Thesis advisor) / Boyd, Robert (Committee member) / Trumble, Benjamin (Committee member) / Arizona State University (Publisher)
Created2019