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The influenza virus, also known as "the flu", is an infectious disease that has constantly affected the health of humanity. There is currently no known cure for Influenza. The Center for Innovations in Medicine at the Biodesign Institute located on campus at Arizona State University has been developing synbodies as

The influenza virus, also known as "the flu", is an infectious disease that has constantly affected the health of humanity. There is currently no known cure for Influenza. The Center for Innovations in Medicine at the Biodesign Institute located on campus at Arizona State University has been developing synbodies as a possible Influenza therapeutic. Specifically, at CIM, we have attempted to design these initial synbodies to target the entire Influenza virus and preliminary data leads us to believe that these synbodies target Nucleoprotein (NP). Given that the synbody targets NP, the penetration of cells via synbody should also occur. Then by Western Blot analysis we evaluated for the diminution of NP level in treated cells versus untreated cells. The focus of my honors thesis is to explore how synthetic antibodies can potentially inhibit replication of the Influenza (H1N1) A/Puerto Rico/8/34 strain so that a therapeutic can be developed. A high affinity synbody for Influenza can be utilized to test for inhibition of Influenza as shown by preliminary data. The 5-5-3819 synthetic antibody's internalization in live cells was visualized with Madin-Darby Kidney Cells under a Confocal Microscope. Then by Western Blot analysis we evaluated for the diminution of NP level in treated cells versus untreated cells. Expression of NP over 8 hours time was analyzed via Western Blot Analysis, which showed NP accumulation was retarded in synbody treated cells. The data obtained from my honors thesis and preliminary data provided suggest that the synthetic antibody penetrates live cells and targets NP. The results of my thesis presents valuable information that can be utilized by other researchers so that future experiments can be performed, eventually leading to the creation of a more effective therapeutic for influenza.
ContributorsHayden, Joel James (Author) / Diehnelt, Chris (Thesis director) / Johnston, Stephen (Committee member) / Legutki, Bart (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / Department of Chemistry and Biochemistry (Contributor)
Created2014-05
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The purpose of this thesis was to develop a tool to provide information and data for design teams to use throughout the mobile application design process. Ideally, this would enable teams to see patterns in iterative design, and ultimately use data-driven analysis to make their own decisions. The initial problem

The purpose of this thesis was to develop a tool to provide information and data for design teams to use throughout the mobile application design process. Ideally, this would enable teams to see patterns in iterative design, and ultimately use data-driven analysis to make their own decisions. The initial problem was a lack of available information offered by mobile application design teams—the initial goal being to work closely with design teams to learn their decision-making methodology. However, every team that was reached out to responded with rejection, presenting a new problem: a lack of access to quality information regarding the decision-making process for mobile applications. This problem was addressed by the development of an ethical hacking script that retrieves reviews in bulk from the Google Play Store using Python. The project was a success—by feeding an application’s unique Play Store ID, the script retrieves a user-specified amount of reviews (up to millions) for that mobile application and the 4 “recommended” applications from the Play Store. Ultimately, this thesis proved that protected reviews on the Play Store can be ethically retrieved and used for data-driven decision making and identifying patterns in an application’s iterative design. This script provides an automated tool for teams to “put a finger on the pulse” of their target applications.
ContributorsDyer, Mitchell Patrick (Author) / Lin, Elva (Thesis director) / Giles, Charles (Committee member) / Department of Information Systems (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
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Description

Creation of a database and Python API to clean, organize, and streamline data collection from an updated Qualtrics survey used to capture applicant information for the Fleischer Scholars Program run by the W. P. Carey UG Admissions Office.

ContributorsMoreno, Luciano (Co-author) / Gordan, Nicholas (Co-author) / Sopha, Matt (Thesis director) / Moser, Kathleen (Committee member) / Stark, Karen (Committee member) / Department of Information Systems (Contributor, Contributor) / Department of Supply Chain Management (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

Creation of a database and Python API to clean, organize, and streamline data collection from an updated Qualtrics survey used to capture applicant information for the Fleischer Scholars Program run by the W. P. Carey UG Admissions Office.

ContributorsGordon, Nicolas A (Co-author) / Moreno, Luciano (Co-author) / Sopha, Matthew (Thesis director) / Moser, Kathleen (Committee member) / Department of Supply Chain Management (Contributor) / Department of Information Systems (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

Sports analytics is a growing field that attempts to showcase interesting aspects of a sport with the use of modern technology and machine learning techniques. This thesis will demonstrate how the NBA has progressed in the past decade by comparing the performance have five teams (SAS, OKC, PHO, MIN, and

Sports analytics is a growing field that attempts to showcase interesting aspects of a sport with the use of modern technology and machine learning techniques. This thesis will demonstrate how the NBA has progressed in the past decade by comparing the performance have five teams (SAS, OKC, PHO, MIN, and SAC). It will also provide key insight on what an NBA team should focus on to build an optimized NBA team composition, which will better their performance in the league, which will improve their chances of making into the playoffs. These teams were chosen after conducting extensive analysis on all NBA teams. These five teams were chosen because of the variability in performance (two successful and three less successful teams). Two successful teams, SAS and OKC, and three less successful teams, PHO, MIN, and SAC, were chosen to exemplify the different approaches of teams in the NBA and to distinguish what an NBA team should consider build an optimized team composition to better their performance in the league stage.

ContributorsJegadesan, Sai (Author) / Shin, Donghyuk (Thesis director) / Benjamin, Victor (Committee member) / Department of Information Systems (Contributor) / WPC Graduate Programs (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

The field of biomedical research relies on the knowledge of binding interactions between various proteins of interest to create novel molecular targets for therapeutic purposes. While many of these interactions remain a mystery, knowledge of these properties and interactions could have significant medical applications in terms of understanding cell signaling

The field of biomedical research relies on the knowledge of binding interactions between various proteins of interest to create novel molecular targets for therapeutic purposes. While many of these interactions remain a mystery, knowledge of these properties and interactions could have significant medical applications in terms of understanding cell signaling and immunological defenses. Furthermore, there is evidence that machine learning and peptide microarrays can be used to make reliable predictions of where proteins could interact with each other without the definitive knowledge of the interactions. In this case, a neural network was used to predict the unknown binding interactions of TNFR2 onto LT-ɑ and TRAF2, and PD-L1 onto CD80, based off of the binding data from a sampling of protein-peptide interactions on a microarray. The accuracy and reliability of these predictions would rely on future research to confirm the interactions of these proteins, but the knowledge from these methods and predictions could have a future impact with regards to rational and structure-based drug design.

ContributorsPoweleit, Andrew Michael (Author) / Woodbury, Neal (Thesis director) / Diehnelt, Chris (Committee member) / Chiu, Po-Lin (Committee member) / School of Molecular Sciences (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

This paper describes a project involving the optimization of the analysis process of FreeSurfer and ANTS Registration for neuroscience analytics of patients at risk of cognitive decline using Nipype. The paper details the process of discovering more about Nipype, learning to use a supercomputer, and implementing the open-source python code

This paper describes a project involving the optimization of the analysis process of FreeSurfer and ANTS Registration for neuroscience analytics of patients at risk of cognitive decline using Nipype. The paper details the process of discovering more about Nipype, learning to use a supercomputer, and implementing the open-source python code to fit the needs of the research lab. Nipype is a python-based initiative to unify the various software packages used within the neuroscience community for data analysis. This paper also serves as documentation of the steps taken to complete the project so that future students are able to continue the optimization process to result in one cohesive workflow in which data is able to flow through a unified pipeline of analysis in the future.

ContributorsCave, Elizabet (Author) / Ofori, Edward (Thesis director) / Sopha, Matthew (Committee member) / Barrett, The Honors College (Contributor) / Department of Information Systems (Contributor)
Created2023-05
Description

Financial decisions, which are major life decisions, can often be overly complicated. Day-to-day financial calculations and investment decisions can be time-consuming and prone to human error. Thus, keeping in mind the complicated nature of finance and the heavy dependence on these formulas for decision-making, the need for a comprehensive financial

Financial decisions, which are major life decisions, can often be overly complicated. Day-to-day financial calculations and investment decisions can be time-consuming and prone to human error. Thus, keeping in mind the complicated nature of finance and the heavy dependence on these formulas for decision-making, the need for a comprehensive financial calculator rises. The financial calculator is a set of comprehensive logical formulas that takes user input and provides recommendations along with numerical values. The program uses Python scripting language and is focused on the core logic. The program also uses a variety of finance topics and related concepts.

ContributorsJee, Ambika (Author) / Hoffman, David (Thesis director) / McDaniel, Cara (Committee member) / Barrett, The Honors College (Contributor) / School of Criminology and Criminal Justice (Contributor) / Department of Information Systems (Contributor)
Created2023-05
Description
Financial decisions, which are major life decisions, can often be overly complicated. Day-to-day financial calculations and investment decisions can be time-consuming and prone to human error. Thus, keeping in mind the complicated nature of finance and the heavy dependence on these formulas for decision-making, the need for a comprehensive financial

Financial decisions, which are major life decisions, can often be overly complicated. Day-to-day financial calculations and investment decisions can be time-consuming and prone to human error. Thus, keeping in mind the complicated nature of finance and the heavy dependence on these formulas for decision-making, the need for a comprehensive financial calculator rises. The financial calculator is a set of comprehensive logical formulas that takes user input and provides recommendations along with numerical values. The program uses Python scripting language and is focused on the core logic. The program also uses a variety of finance topics and related concepts.
ContributorsJee, Ambika (Author) / Hoffman, David (Thesis director) / McDaniel, Cara (Committee member) / Barrett, The Honors College (Contributor) / School of Criminology and Criminal Justice (Contributor) / Department of Information Systems (Contributor)
Created2023-05
Description
Financial decisions, which are major life decisions, can often be overly complicated. Day-to-day financial calculations and investment decisions can be time-consuming and prone to human error. Thus, keeping in mind the complicated nature of finance and the heavy dependence on these formulas for decision-making, the need for a comprehensive financial

Financial decisions, which are major life decisions, can often be overly complicated. Day-to-day financial calculations and investment decisions can be time-consuming and prone to human error. Thus, keeping in mind the complicated nature of finance and the heavy dependence on these formulas for decision-making, the need for a comprehensive financial calculator rises. The financial calculator is a set of comprehensive logical formulas that takes user input and provides recommendations along with numerical values. The program uses Python scripting language and is focused on the core logic. The program also uses a variety of finance topics and related concepts.
ContributorsJee, Ambika (Author) / Hoffman, David (Thesis director) / McDaniel, Cara (Committee member) / Barrett, The Honors College (Contributor) / School of Criminology and Criminal Justice (Contributor) / Department of Information Systems (Contributor)
Created2023-05