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Description
Neuron models that behave like their biological counterparts are essential for computational neuroscience.Reduced neuron models, which abstract away biological mechanisms in the interest of speed and interpretability, have received much attention due to their utility in large scale simulations of the brain, but little care has been taken to ensure that these models exhibit behaviors that closely resemble real neurons.
In order to improve the verisimilitude of these reduced neuron models, I developed an optimizer that uses genetic algorithms to align model behaviors with those observed in experiments.
I verified that this optimizer was able to recover model parameters given only observed physiological data; however, I also found that reduced models nonetheless had limited ability to reproduce all observed behaviors, and that this varied by cell type and desired behavior.
These challenges can partly be surmounted by carefully designing the set of physiological features that guide the optimization. In summary, we found evidence that reduced neuron model optimization had the potential to produce reduced neuron models for only a limited range of neuron types.
In order to improve the verisimilitude of these reduced neuron models, I developed an optimizer that uses genetic algorithms to align model behaviors with those observed in experiments.
I verified that this optimizer was able to recover model parameters given only observed physiological data; however, I also found that reduced models nonetheless had limited ability to reproduce all observed behaviors, and that this varied by cell type and desired behavior.
These challenges can partly be surmounted by carefully designing the set of physiological features that guide the optimization. In summary, we found evidence that reduced neuron model optimization had the potential to produce reduced neuron models for only a limited range of neuron types.
ContributorsJarvis, Russell Jarrod (Author) / Crook, Sharon M (Thesis advisor) / Gerkin, Richard C (Thesis advisor) / Zhou, Yi (Committee member) / Abbas, James J (Committee member) / Arizona State University (Publisher)
Created2020
Description
The Tutoring Center Management System is a web-based application for ASU’s University Academic Success Programs (UASP) department, particularly the Math Tutoring Center. It is aimed at providing a user-friendly interface to track queue requests from students visiting the tutoring centers and convert that information into actionable data with the potential to live-track and assess the performance of each tutoring center and each tutor. Numerous UASP processes are streamlined to create an efficient and integrated workflow, such as tutor scheduling, tutor search, shift coverage requests, and analytics. The intended users of the application feature ASU students and the UASP staff, including tutors and supervisors.
ContributorsJain, Prakshal (Co-author) / Gulati, Sachit (Co-author) / Nakamura, Mutsumi (Thesis director) / Selgrad, Justin (Committee member) / Department of Information Systems (Contributor) / Computer Science and Engineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2019-12