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Mammary gland development in humans during puberty involves the enlargement of breast tissue, but this is not true in non-human primates. To identify potential causes of this difference, I examined variation in substitution rates across genes related to mammary development. Genes undergoing purifying selection show slower-than-average substitution rates, while genes undergoing positive selection show faster rates. These may be related to the difference between humans and other primates. Three genes were found to be accelerated were FOXF1, IGFBP5, and ATP2B2, but only the latter one was found in humans and it seems unlikely that it would be related to the differences between mammary gland development at puberty between humans and non-human primates.
ContributorsArroyo, Diana (Author) / Cartwright, Reed (Thesis director) / Wilson Sayres, Melissa (Committee member) / Schwartz, Rachel (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Mammals with a habitually orthograde trunk posture possess a more anterior foramen magnum than mammals with non-orthograde trunk postures. Russo & Kirk (2013) also found that bipedal orthograde mammals possess a more anteriorly placed foramen magnum than those that are just habitually orthograde. This finding has allowed us to use foramen magnum position as a predictor of trunk posture in early hominins. This prompts more research of how the other landmarks on the cranial base move in relation to this shift in foramen magnum positioning. I collected landmark data on images of 125 mammalian basicrania spanning 41 species that differed in trunk posture. Using Procrustes and Principal Components Analysis (PCA), I attempted to evaluate the effects of trunk posture on basicranial morphology, primarily focusing on the placement of the carotid and jugular foramina. The results supported Russo and Kirk's finding of a more anterior foramen magnum placement in orthograde mammals; in addition, the results displayed correlations between foramen magnum position and carotid foramen position among primates and diprotodonts.
ContributorsPena, Angela (Author) / Kimbel, William (Thesis director) / Schwartz, Gary T. (Committee member) / Barrett, The Honors College (Contributor) / School of Human Evolution and Social Change (Contributor)
Created2015-05
Description
Cancer rates in our nearest relatives are largely unknown. Comparison of human cancer rates with other primates should help us to understand the nature of our susceptibilities to cancer. Data from deceased primates was gathered from 3 institutions, the Duke Lemur Center, San Diego Zoo, and Jungle Friends primate sanctuary. This data contained over 400 unique individuals across 45 species with information on cancer incidence and mortality. Cancer incidence ranged from 0-71% and cancer mortality ranged from 0-67%. We used weighted phylogenetic regressions to test for an association between life history variables (specifically body mass and lifespan) and cancer incidence as well as mortality. Cancer incidence did not correlate with both body mass and lifespan (p>.05) however, cancer mortality did (p<.05). However, it is uncertain if the variables can be used as reliable predictors of cancer, because the data come from different organizations. This analysis presents cancer incidence rates and cancer mortality rates in species where it was previously unknown, and in some primate species, is surprisingly high. Microcebus murinus(grey mouse lemur) appear to be particularly vulnerable to cancer, mostly lymphomas. Further studies will be required to determine the causes of these vulnerabilities.
ContributorsWalker, William Charles (Author) / Maley, Carlo (Thesis director) / Boddy, Amy (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
There is little research on volunteer tourism to primate sanctuaries. The purpose of this study was to help fill this knowledge gap and gain insights into how animal sanctuaries with volunteers in Costa Rica can be improved operationally to strengthen their conservation efforts. My research questions were: 1. How does volunteer tourism with primates in Costa Rica affect volunteers? 2. How does this volunteer tourism affect Costa Rica’s environment? The methodology used was an exploratory qualitative design that included a literature review of previous research and case studies and a visit with interviews at a primate sanctuary in Costa Rica. The findings did not generate sufficient data to answer the first research question. I did find that altruism was a key factor in recruiting effective volunteers. The study also found that conservation in Costa Rica relies on volunteer tourism to fill a human resource gap. This research will allow sanctuaries in Costa Rica to respond better to protect biodiversity.
ContributorsCavalier, Rebecca (Author) / Chhetri, Nalini (Thesis director) / Castillo, Elizabeth (Committee member) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Recombination is the process of exchange between maternal and paternal chromosomal segments which gives rise to new allele combinations in the offspring. The rate of recombination refers to the chances that such crossing over events will take place. Recombination is an especially important process for driving genetic diversity and therefore evolution. However, the specifics of the factors affecting the recombination frequency and how the rate itself can evolve have not been the focus of many studies in the past. The purpose of this study was to utilize sequenced genomes of parent-offspring trios of Rhesus Macaque to create a high quality dataset from which a direct, sex-specific, estimate of recombination rate can be calculated for the species.
ContributorsJohal, Ravneet (Author) / Pfeifer, Susanne (Thesis director) / Johri, Parul (Committee member) / Versoza, Cyril (Committee member) / La Rosa, Bruno (Committee member)
Created2022-05