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- All Subjects: Glioblastoma Multiforme
- Creators: College of Liberal Arts and Sciences
- Creators: Scheiner, Georganne
- Member of: Barrett, The Honors College Thesis/Creative Project Collection
- Resource Type: Text
- Status: Published
Description
The intent of this thesis was to explore current literature to further understand the work environments of medical fields and the obstacles that are unique to women pursuing medical careers. It is acknowledged that a significant glass ceiling exists for women in medical fields, specifically areas such as academia and surgery. Thus, the research is focused on determining explanations for a lack of women in said medical specialties, as well as understanding the source of the obstacles women face in medicine. This study was designed to obtain a general background from a literature review and then, to compare and supplement the findings with in-depth interviews of females in a variety of medical careers. From the literature review and the interviews, it was confirmed that the largest area of inequality women in medical fields faced was struggling to balance work and personal life, specifically motherhood. Furthermore, the knowledge gained from the literature review and interviews provided a framework for suggesting possible solutions to help women successfully balance a professional medical career and a personal life.
ContributorsHaugen, Kelsey Blair (Author) / Fonow, Mary Margaret (Thesis director) / Scheiner, Georganne (Committee member) / McGibbney, Michelle (Committee member) / Barrett, The Honors College (Contributor) / T. Denny Sanford School of Social and Family Dynamics (Contributor)
Created2013-05
Description
Parenting magazines within the U.S. have long been a source of comfort and information for parents. As evidenced by subscription numbers in the millions, parents’ desire for ‘expert’ advice on all aspects of child rearing make them prime consumers for the magazine industry. One study found that when parents seek advice, parenting magazines were second only to friends as a resource, and were consulted more often than professional resources such as doctors or health organizations (Koepke & Williams, 1989). Ultimately, the images and concepts parents retain from their exposure to parenting magazines are conveyed (explicitly or implicitly) to their children. At its very core, gender scripts serve as an institutionalized form of social control, or as Bem believes, “a basic organizing principle for every human culture” (1981). Further, researchers have elaborated, “gender inequalities and sex stereotypes hurt the majority of individuals by limiting their range of experiences, and thus their growth” (Spees & Zimmerman, 2002). This provides an absolute disservice to individuals and to our communities two fold, as gendered messages in parenting magazines can shape (or indeed limit) the experiences and perceptions of both parents and their children. The intention of this study is to examine the ways in which editorial content in Parents magazine has the potential to influence parents’ perception of gender in relation to their children and child rearing practices. It also seeks to explore how these gender messages have changed over the last ten years, as well as what these messages may be communicating to parents about their children. I aim to frame this discussion within a condensed review of literature that supports the importance and influence of parenting magazines in recent history. I will also consider how early on children display an understanding of gender and a few of the many ways gender typing may affect them in childhood and beyond. In this thesis, I approach this issue through the theory of socialization, in which I argue the magazine’s gender messages are communicated to parents, who then convey these messages to their children during childhood. However, this study acknowledges the importance of observing an issue from multiple standpoints and I believe that further research on this topic should be done from both a socialization and a social construction viewpoint. I will then critically analyze, through a feminist theoretical framework, gender implications found among the images and some of the accompanying text in Parents magazine in 2002 and 2012. Through this thesis, I argue that Parents magazine, through its editorial content, provides some unique spaces in which gender equality can be furthered, while it has also become more stereotyped and restricted within other areas in the last ten years.
ContributorsSheldon, Jessica (Author) / Scheiner, Georganne (Thesis director) / McGibbney, Michelle (Committee member) / Katsulis, Yasmina (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12
Description
Glioblastoma multiforme (GBMs) is the most prevalent brain tumor type and causes approximately 40% of all non-metastic primary tumors in adult patients [1]. GBMs are malignant, grade-4 brain tumors, the most aggressive classication as established by the World Health Organization and are marked by their low survival rate; the median survival time is only twelve months from initial diagnosis: Patients who live more than three years are considered long-term survivors [2]. GBMs are highly invasive and their diffusive growth pattern makes it impossible to remove the tumors by surgery alone [3]. The purpose of this paper is to use individual patient data to parameterize a model of GBMs that allows for data on tumor growth and development to be captured on a clinically relevant time scale. Such an endeavor is the rst step to a clinically applicable predictions of GBMs. Previous research has yielded models that adequately represent the development of GBMs, but they have not attempted to follow specic patient cases through the entire tumor process. Using the model utilized by Kostelich et al. [4], I will attempt to redress this deciency. In doing so, I will improve upon a family of models that can be used to approximate the time of development and/or structure evolution in GBMs. The eventual goal is to incorporate Magnetic Resonance Imaging (MRI) data into a parameterized model of GBMs in such a way that it can be used clinically to predict tumor growth and behavior. Furthermore, I hope to come to a denitive conclusion as to the accuracy of the Koteslich et al. model throughout the development of GBMs tumors.
ContributorsManning, Miles (Author) / Kostelich, Eric (Thesis director) / Kuang, Yang (Committee member) / Preul, Mark (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12
Description
Glioblastoma multiforme is associated with a very low survival rate and is recognized as the most vicious form of intracranial cancer. The Akt gene pathway has three different isoforms, each of which has a different role in the tumors of GBM. Preliminary data suggests that Akt3 may work to decrease tumorigenicity. A produced image that visualizes the subcellular localization of Akt3 led the author to believe that Akt3 may reduce tumorigenicity by decreasing genomic instability caused by the cancer. To explore this, flow cytometry was performed on GBM cell lines with Akt3v1 over-expression, Akt3v2 over-expression, and a control glioma cell line.
ContributorsGhorayeb, Antoine (Author) / Neisewander, Janet (Thesis director) / Diehnelt, Chris (Committee member) / Moussallem, Suzan (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12