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Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost the immune system. Bex has been shown to be effective

Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost the immune system. Bex has been shown to be effective in the treatment of multiple types of cancer, including lung cancer. However, the disadvantages of using Bex include increased instances of hypothyroidism and excessive concentrations of blood triglycerides. If an analog of Bex can be developed which retains high affinity RXR binding similar to the 9-cis retinoic acid while exhibiting less interference for heterodimerization pathways, it would be of great clinical significance in improving the quality of life for patients with CTCL. This thesis will detail the biological profiling of additional novel (Generation Two) analogs, which are currently in submission for publication, as well as that of Generation Three analogs. The results from these studies reveal that specific alterations in the core structure of the Bex "parent" compound structure can have dramatic effects in modifying the biological activity of RXR agonists.
ContributorsYang, Joanna (Author) / Jurutka, Peter (Thesis director) / Wagner, Carl (Committee member) / Hibler, Elizabeth (Committee member) / Barrett, The Honors College (Contributor)
Created2012-05
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Description
Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor

Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor and in return control cell differentiation and proliferation. Bexarotene targets RXR homodimerization to drive transcription of tumor suppressing genes; however, adverse reactions occur simultaneously when bound to other nuclear receptors. In this study, we used novel bexarotene analogs throughout 5 iterations synthesized in the laboratory of Dr. Wagner to test for their potency and ability to bind RXR. The aim of our study is to quantitatively measure RXR homodimerization driven by bexarotene analogs using a yeast two-hybrid system. Our results suggests there to be several compounds with higher protein activity than bexarotene, particularly in generations 3.0 and 5.0. This higher affinity for RXR homodimers may help scientists identify a compound that will minimize adverse effects and toxicity of bexarotene and serve as a better cancer treatment alternative.
ContributorsSeto, David Hua (Author) / Marshall, Pamela (Thesis director) / Wagner, Carl (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2015-05
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Description
Millennials turn out to vote at significantly lower rates than the rest of the population, sparking commentary on their apathy and lack of contributions to American society. This thesis attempts to paint an accurate description of why these trends have persisted in the past, and finds that there are many

Millennials turn out to vote at significantly lower rates than the rest of the population, sparking commentary on their apathy and lack of contributions to American society. This thesis attempts to paint an accurate description of why these trends have persisted in the past, and finds that there are many complex reasons that serve as explanations. Many of these reasons can be explained by an analysis of Millennials' characteristics and political attitudes, which research has found includes a prioritization of achievement and Independent political ideologies. Additionally, by differentiating between civic engagement and political engagement, data and research find that Millennials choose forms of civic participation over political participation as an active choice and alternative avenue for electoral participation. Ultimately, Millennials are disillusioned with the politically polarized landscape and are unable to navigate the saturated information environment to make confident voting decisions. The rest of the thesis explores organizations, campaigns, and potential reforms that attempt to turn out Millennials. A thorough evaluation of campaigns' and nonpartisan organizations' efforts reveal the best practices for reaching Millennials, which include prioritizing substantive policy discussions, implementing grassroots and bottom-up organizational strategies, and avoiding flashiness and pandering. Another clear area for potential reform is civic education, which is currently not prioritized in the public education system. Some education reforms that would be particularly effective at reversing these negative trends include allowing for political debate within the classroom, teaching civics through more vibrant and hands-on curriculum and directly highlighting and perpetuating the importance of voting in the classroom. This thesis evaluates these and many other potential policy reforms that will encourage Millennials' political engagement as they further enter into adulthood.
Created2017-05
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Description
Young voters are the future of the country, yet are disengaged and disinterested in politics, leading to low turnout rates. This paper focuses on the Millennial generation, which consists of adults ages 18 to 33, and at times, narrowly focuses on the subset of college students. Since individuals should learn

Young voters are the future of the country, yet are disengaged and disinterested in politics, leading to low turnout rates. This paper focuses on the Millennial generation, which consists of adults ages 18 to 33, and at times, narrowly focuses on the subset of college students. Since individuals should learn about the presidential candidates and the election before casting a vote, I analyze the similarities and differences between receiving election content through television news, a traditional source, compared to social media. Next, I examine the importance of political expression and political discussion, along with how millennials engaging in such activity on social media allows for a deeper level of engagement in elections than what was possible before the birth of social media. Thus, as opposed to focusing on the reasons milllennials shy away from politics, the purpose of the first three chapters is to highlight the potential benefits for using social media during presidential elections. Lastly, I analyze millennials' voting behaviors, particularly the generation's preference for liberal social values. Since we are currently in the 2016 U.S. presidential election season, the purpose of this chapter is to highlight current research regarding millennials' voting patterns, which should then be compared to the future 2016 general election studies. By analyzing consistent and divergent trends, researchers can further add to the discussion of millennials' political behavior. Although I dedicate a brief part to the 2016 presidential election in Chapters 2 through 4 to discuss how trends are similar or different from current research, the overall purpose of this paper is to inform readers about how millennials learn, engage, and participate in presidential elections.
ContributorsLarson, Dakota Alexis Ok-Ran (Author) / Ackroyd, William (Thesis director) / Cisler, Sherry (Committee member) / Department of Management (Contributor) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Description

This project offers an argument that isolates several major forces that it contends pose a critical threat to the endurance of modern American democracy. It evaluates modern and classic political philosophy to identify the prerequisites for a stable democracy, identifying and defining voter education and participation as necessary contributors to

This project offers an argument that isolates several major forces that it contends pose a critical threat to the endurance of modern American democracy. It evaluates modern and classic political philosophy to identify the prerequisites for a stable democracy, identifying and defining voter education and participation as necessary contributors to civic engagement. It provides a socio-legal framework for evaluating four phenomena that have shifted in their impact on politics over the past 20 years: the roles of money and media in politics, as well as disenfranchisement by gerrymandering and by felon voting restrictions. It demonstrates how each has a new and worsening impact on voter education and/or participation, thus threatening the continued existence of modern American democracy.

ContributorsBurnquist, Andrew (Co-author) / Morote, Nicole (Co-author) / Mason, Maria (Co-author) / Affolter, Jacob (Thesis director) / Hoekstra, Valeria (Committee member) / School of Politics and Global Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

This project offers an argument that isolates several major forces that it contends pose a critical threat to the endurance of modern American democracy. It evaluates modern and classic political philosophy to identify the prerequisites for a stable democracy, identifying and defining voter education and participation as necessary contributors to

This project offers an argument that isolates several major forces that it contends pose a critical threat to the endurance of modern American democracy. It evaluates modern and classic political philosophy to identify the prerequisites for a stable democracy, identifying and defining voter education and participation as necessary contributors to civic engagement. It provides a socio-legal framework for evaluating four phenomena that have shifted in their impact on politics over the past 20 years: the roles of money and media in politics, as well as disenfranchisement by gerrymandering and by felon voting restrictions. It demonstrates how each has a new and worsening impact on voter education and/or participation, thus threatening the continued existence of modern American democracy.

ContributorsMason, Maria (Co-author) / Morote, Nicole (Co-author) / Burnquist, Andrew (Co-author) / Affolter, Jacob (Thesis director) / Hoekstra, Valerie (Committee member) / School of Politics and Global Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

This paper focusses on voter disenfranchisement among people who have been previously incarcerated in Arizona. It seeks to answer the question how does removing a felon’s right to vote affect their ties to community?

ContributorsPrida, Savannah (Author) / Comstock, Audrey (Thesis director) / Gruber, Diane (Committee member) / Chapman, Darren (Committee member) / Barrett, The Honors College (Contributor) / School of Social and Behavioral Sciences (Contributor) / Watts College of Public Service & Community Solut (Contributor) / College of Integrative Sciences and Arts (Contributor)
Created2022-05
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Description

Gen Z is very active on social media where there is a large amount of misinformation on human trafficking. This bears the question, does correct knowledge of human trafficking have a correlation with how Gen Z votes? This study looks into the correlation between Generation Z’s (Gen Z) voting patterns

Gen Z is very active on social media where there is a large amount of misinformation on human trafficking. This bears the question, does correct knowledge of human trafficking have a correlation with how Gen Z votes? This study looks into the correlation between Generation Z’s (Gen Z) voting patterns and their knowledge of human trafficking. The underlying thought is how media and social media play a role in what information Gen Z is taking to the voting booths. The results will show if both Republicans and Democrats or just one are affected by inadequate knowledge of human trafficking and if therefore, they are voting a specific way. A result emerged by surveying 30 people across the United States with ages ranging from 18-24, on where trafficking happens and to whom it happens to, alongside asking the participants different political questions to determine their voting patterns. The survey questions were written and analyzed quantitatively to use the data numerically as the results.

ContributorsMac Donald, Bridget (Author) / DeCarolis, Claudine (Thesis director) / Barnhart, Patricia (Committee member) / Barrett, The Honors College (Contributor) / School of Social and Behavioral Sciences (Contributor) / School of Criminology and Criminal Justice (Contributor)
Created2022-05