In response to the Bosnian and Rwandan genocides of the 1990’s, the United Nations created the Responsibility to Protect (R2P) doctrine as part of its 2005 World Summit Outcome document. The goal of R2P is to promote the idea that the international community should act to protect populations from mass atrocity crimes (genocide, crimes against humanity, war crimes, and ethnic cleansing) in the case a State fails to meet their responsibility. This report seeks to examine the Responsibility to Protect principle and see how its concepts are perceived and implemented in the private sector, given the sector’s significant influence in the world today. Using R2P as a frame of reference, I explored the concept that private sector organizations, through their actions and operations, have a responsibility to not profit from or enable systems that perpetuate mass atrocity crimes against populations. This was done through an analysis of private sector firms, regulatory frameworks, industry norms, organization initiatives, and perspectives of actors engaging with the subject matter, in addition to a modern case study regarding the experience of Uighurs and Turkic Muslims in Xinjiang, China. The scope of this project was focused on select American companies that are multinational publicly traded companies with a market capitalization of over $200 billion. This report is meant to serve as a guide for into the concepts of R2P in the private sector and provides access to resources for further exploration.