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- Status: Published
Description
Since its discovery in 1524, many people have characterized the vermiform appendix. Charles Darwin considered the human appendix to be a vestige and a useless structure. Others at the time opposed this hypothesis. However, Darwin's hypothesis became prevalent one until recently when there became a renewed interest in the appendix because of advancements in microscopes, knowledge of the immune system, and phylogenetics. In this review, I will argue that the vermiform appendix, although still not completely understood, has important functions. First, I will give the anatomy of the appendix. I will discuss the comparative anatomy between different animals and also primates. I will address the effects of appendicitis and appendectomy. I will give background on vestigial structures and will discuss if the appendix is a vestige. Following, I will review the evolution of the appendix. Finally, I will argue that the function of the appendix is as an immune organ, including discussion of gut-associated lymphoid tissue (GALT), development of lymphoid follicles in GALT and their comparison within different organs, Immunoglobulin A (IgA) function in the gut, biofilms as evidence that the appendix is a safe-house for beneficial bacteria, re-inoculation of the bowel, and protection against recurring infection. I will conclude with future studies that should be conducted to further our understanding of the vermiform appendix.
ContributorsPrestwich, Shelby Elizabeth (Author) / Cartwright, Reed (Thesis director) / Lynch, John (Committee member) / Furstenau, Tara (Committee member) / School of Geographical Sciences and Urban Planning (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Spatial-Temporal Analysis of Barrett Freshmen 2007-2012: Source Area Analysis and Poisson Regression
Description
In order to help enhance admissions and recruiting efforts, this longitudinal study analyzed the geographic distribution of matriculated Barrett freshmen from 2007-2012 and sought to explore hot and cold spot locations of Barrett enrollment numbers using geographic information science (GIS) methods. One strategy involved   weighted mean center and standard distance analyses for each year of data for non-resident (out-of-state) freshmen home zip codes. Another strategy, a Poisson regression model, revealed recruitment "hot and cold spots" across the U.S. to project the expected counts of Barrett freshmen by zip code. This projected count served as a comparison for the actual admissions data, where zip codes with over and under predictions represented cold and hot spots, respectively. The mean center analysis revealed a westward shift from 2007 to 2012 with similar distance dispersions. The Poisson model projected zero-student zip codes with 99.2% accuracy and non-zero zip codes with 73.8% accuracy. Norwalk, CA (90650) and New York, NY (10021) represented the top out-of-state cold spot zip codes, while the model indicated that Chandler, AZ (85249) and Queen Creek, AZ (85242) had the most in-state potential for recruitment. The model indicated that more students have come from Albuquerque, NM (87122) and Aurora, CO (80015) than anticipated, while Phoenix, AZ (85048) and Tempe, AZ (85284) represent in-state locations with higher correlations between the variables included, especially regarding distance decay, and the than expected numbers of freshmen. The regression also indicated the existence of strong likelihood of attracting Barrett students.
ContributorsKostanick, Megan Elizabeth (Author) / Rey, Sergio (Thesis director) / Dorn, Ron (Committee member) / Koschinsky, Julia (Committee member) / Barrett, The Honors College (Contributor) / School of Geographical Sciences and Urban Planning (Contributor) / School of Politics and Global Studies (Contributor)
Created2013-05
Description
I was a curious child who grew up to be a curious adult. Ever since I learned how to read, I have had a passion for science and learning new things. I chose to watch the Discovery channel over any other network on TV, and I was drawn to the non-fiction section of the Phoenix Public Library. My parents encouraged my curiosity and helped me learn in any way they could. My mom took me to Juniper Library every weekend while my dad sat through countless episodes of Mythbusters, How It’s Made, and Shark Week specials. Eventually, there came a time when they could no longer answer the endless questions I would throw their way. My mom likes to remind me of one question in particular that I would ask that she was unable to form any kind of answer to. This question ended up shaping my scientific interests and became the basis for my chosen college major. The question was “why are people people?”
ContributorsMaiorella, Madeline Jo (Author) / Meissinger, Ellen (Thesis director) / Lawrence, Julie (Committee member) / School of Life Sciences (Contributor) / School of Geographical Sciences and Urban Planning (Contributor) / School of Human Evolution & Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05