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Fluoroquinolone antibiotics have been known to cause severe, multisystem adverse side effects, termed fluoroquinolone toxicity (FQT). This toxicity syndrome can present with adverse effects that vary from individual to individual, including effects on the musculoskeletal and nervous systems, among others. The mechanism behind FQT in mammals is not known, although various possibilities have been investigated. Among the hypothesized FQT mechanisms, those that could potentially explain multisystem toxicity include off-target mammalian topoisomerase interactions, increased production of reactive oxygen species, oxidative stress, and oxidative damage, as well as metal chelating properties of FQs. This review presents relevant information on fluoroquinolone antibiotics and FQT and explores the mechanisms that have been proposed. A fluoroquinolone-induced increase in reactive oxygen species and subsequent oxidative stress and damage presents the strongest evidence to explain this multisystem toxicity syndrome. Understanding the mechanism of FQT in mammals is important to aid in the prevention and treatment of this condition.
Keeping this in mind, non-invasive methods to geo-physically work on it needs attention. There is a lot of potential in this field of work to even help with environmental crisis as this helps in places where water theft is big and is conducted through leaks in the distribution system. Methods like Acoustic sensing and ground penetrating radars have shown good results, and the work done in this thesis helps us realise the limitations and extents to which they can be used in the phoenix are.
The concrete pipes used by SRP are would not be able to generate enough acoustic signals to be affectively picked up by a hydrophone at the opening, so the GPR would be helpful in finding the initial location of the leak, as the water around the leak would make the sand wet and hence show a clear difference on the GPR. After that the frequency spectrum can be checked around that point which would show difference from another where we know a leak is not present.