Matching Items (2)
Filtering by
- Member of: ASU Electronic Theses and Dissertations
Description
This review aims to provide a comprehensive review of the most recent literature on adaptive therapy, a promising new approach to cancer treatment that leverages evolutionary theory to prolong tumor control1. By capitalizing on the competition between drug-sensitive and drug-resistant cells, adaptive therapy has led to a paradigm shift in oncology. Through mathematical and in silico models, researchers have examined key factors such as dose timing, cost of resistance, and spatial dynamics in tumor response to adaptive therapy. With a partial focus on preclinical experiments involving ovarian and breast cancer, this review will discuss the demonstrated effectiveness of adaptive therapy in improving progression free survival and tumor control. Through the review process, it was determined that dose modulation outperformed drug-vacation strategies, emphasizing the significance of tumor heterogeneity and spatial structure in accurately modeling adaptive therapy mechanisms. The potential of ongoing clinical trials to improve patient outcomes and long-term treatment efficacy is emphasized, while a thorough analysis of study methodologies shapes the future direction of adaptive therapy research.
ContributorsRichker, Harley (Author) / Maley, Carlo C (Thesis advisor) / Compton, Carolyn (Committee member) / Wilson, Melisaa (Committee member) / Arizona State University (Publisher)
Created2023
Description
Water is one of, if not the most valuable natural resource but extremely challenging to manage. According to old research in the field, many Water Distribution Systems (WDSs) around the world lose above 40 percent of clean water pumped into the distribution system because of unfortune leaks before the water gets anywhere from the fresh water resources. By reducing the amount of water leaked, distribution system managers can reduce the amount of money, resources, and energy wasted on finding and repairing the leaks, and then producing and pumping water, increase system reliability and more easily satisfy present and future needs of all consumers. But having access to this information pre-amatively and sufficiently can be complex and time taking. For large companies like SRP who are moving tonnes of water from various water bodies around phoenix area, it is even more crucial to efficiently locate and characterize the leaks. And phoenix being a busy city, it is not easy to go start digging everywhere, whenever a loss in pressure is reported at the destination.
Keeping this in mind, non-invasive methods to geo-physically work on it needs attention. There is a lot of potential in this field of work to even help with environmental crisis as this helps in places where water theft is big and is conducted through leaks in the distribution system. Methods like Acoustic sensing and ground penetrating radars have shown good results, and the work done in this thesis helps us realise the limitations and extents to which they can be used in the phoenix are.
The concrete pipes used by SRP are would not be able to generate enough acoustic signals to be affectively picked up by a hydrophone at the opening, so the GPR would be helpful in finding the initial location of the leak, as the water around the leak would make the sand wet and hence show a clear difference on the GPR. After that the frequency spectrum can be checked around that point which would show difference from another where we know a leak is not present.
Keeping this in mind, non-invasive methods to geo-physically work on it needs attention. There is a lot of potential in this field of work to even help with environmental crisis as this helps in places where water theft is big and is conducted through leaks in the distribution system. Methods like Acoustic sensing and ground penetrating radars have shown good results, and the work done in this thesis helps us realise the limitations and extents to which they can be used in the phoenix are.
The concrete pipes used by SRP are would not be able to generate enough acoustic signals to be affectively picked up by a hydrophone at the opening, so the GPR would be helpful in finding the initial location of the leak, as the water around the leak would make the sand wet and hence show a clear difference on the GPR. After that the frequency spectrum can be checked around that point which would show difference from another where we know a leak is not present.
ContributorsSrivastava, Siddhant (Author) / Lee, Taewoo (Thesis advisor) / Kwan, Beomjin (Committee member) / Kim, Jeonglae (Committee member) / Arizona State University (Publisher)
Created2019