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- All Subjects: Forensic Science
- All Subjects: Vitamin D
- All Subjects: blow flies
- Creators: School of Mathematical and Natural Sciences
- Creators: Weidner, Lauren
- Status: Published
Description
Criminal Justice is a complex subject matter, and not everyone agrees on the way a criminal justice system ought to function. But one feature that is common to virtually all forms of proposed justice systems is that a true justice system treats people ethically. The question, then, is how a justice system can achieve this. This investigation analyzed two ethical theories, Kantianism and Utilitarianism, to determine which one would be better suited for guiding a criminal justice system on how to treat the people involved ethically. This investigation focused on applying the two theories to the U.S. Criminal Justice System in particular.
Kantianism is a duty-based moral theory in which actions have an intrinsic moral worth. This means certain actions are morally right and other are morally wrong, regardless of the intended or realized consequences. The theory relies on the categorical imperative to judge the morality of certain actions. It states that an action is moral if its maxim can be willed universal law and if it avoids treating people as merely a means. In contrast, Utilitarianism is a consequentialist theory which focuses on the consequences of an action in judging moral worth. In Utilitarianism, the morally correct action is the one which will maximize utility; that is to say, the morally right action is the one which will produce the greatest amount of happiness and minimize the amount of pain for the greatest number of people.
After applying these two theories to moral dilemmas facing the U.S. Criminal Justice System, including the appropriate collection of DNA evidence, the use of police deception, and the use of criminal punishments such as solitary confinement or the death penalty, it was clear that Kantianism was the ethical theory best suited for guiding the system in treating people ethically. This is because Kantianism’s focus on the intrinsic moral worth of an action rather than its consequences leaves less room for ambiguity than does Utilitarianism.
Kantianism is a duty-based moral theory in which actions have an intrinsic moral worth. This means certain actions are morally right and other are morally wrong, regardless of the intended or realized consequences. The theory relies on the categorical imperative to judge the morality of certain actions. It states that an action is moral if its maxim can be willed universal law and if it avoids treating people as merely a means. In contrast, Utilitarianism is a consequentialist theory which focuses on the consequences of an action in judging moral worth. In Utilitarianism, the morally correct action is the one which will maximize utility; that is to say, the morally right action is the one which will produce the greatest amount of happiness and minimize the amount of pain for the greatest number of people.
After applying these two theories to moral dilemmas facing the U.S. Criminal Justice System, including the appropriate collection of DNA evidence, the use of police deception, and the use of criminal punishments such as solitary confinement or the death penalty, it was clear that Kantianism was the ethical theory best suited for guiding the system in treating people ethically. This is because Kantianism’s focus on the intrinsic moral worth of an action rather than its consequences leaves less room for ambiguity than does Utilitarianism.
ContributorsMorett, Xavier Laakea (Author) / Manninen, Bertha (Thesis director) / Kimberly, Kobojek (Committee member) / School of Criminology and Criminal Justice (Contributor) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Vitamin D, Klotho, and FOXO3 have all been linked to have anti-aging and anti-cancerous effects as separate pathways. Specifically, mice with knockout Klotho in their genes have displayed signs of premature aging, humans who are vitamin D deficient have been shown to develop cardiovascular disease and cognitive impairments, and those who have displayed overexpression of FOXO3 have shown to have a longer lifespan. Here we took each pathway and attempted to formulate a feedback mechanism loop linking all three separate pathways. We propose that vitamin D levels modulate klotho activity, including the expression of the s-klotho and m-klotho isoforms. Moreover, the anti-oxidation transcription factor FOXO3 is also thought to participate in crosstalk with VDR signaling. Through the connection between 1,25D and Klotho, we probed at their interactions with FOXO3 signaling in kidney and colon cells, and proposed that vitamin D and klotho may reduce oxidative stress and suppress the onset of epithelial cancers through it effects on FOXO3. Results showed a strong support for the cooperation between FOXO3 and 1,25D to stimulate both superoxide dismutase (a FOXO3 response element) and XDR3/ROC (vitamin D response elements). This cooperation was mostly seen in embryonic kidney cells (HEK293) and not in the colon cancer cells (HCT116), which has led to the conclusion that vitamin D and FOXO3 cooperation mainly occurs in kidney tissue and/or in tissue that is not yet been overtaken by cancer. Differences in the Klotho isoforms were seen when measuring FOXO3 and vitamin D activity, but experiments manipulating other components will need to be conducted to further understand the function of Klotho in maintaining reactive oxygenated species levels.
ContributorsSandoval, Ruby (Author) / Jurutka, Peter (Thesis director) / Sandrin, Todd R. (Committee member) / Heck, Michael (Committee member) / School of Social and Behavioral Sciences (Contributor) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Vitamin D, a bioactive lipid and essential nutrient, is obtained by humans through either endogenous synthesis in response to UV light exposure or via nutritional intake. Once activated to its hormonal form, vitamin D binds to and activates the nuclear vitamin D receptor (VDR). Activation of VDR is known to modulate gene transcription in vitamin D target tissues such as kidney, colon, and bone; however, less is known about the ability of VDR to respond to "nutritional modulators". One such potential VDR modulator is resveratrol, a plant-derived polyphenol and potent antioxidant nutrient that also functions as a chemopreventative. Resveratrol is known to activate sirtuin-1, a deacetylase enzyme with potential anti-aging properties. This study explores the potential for resveratrol, an anticancer nutraceutical, to upregulate VDR activity through its effector protein, sirtuin-1. Furthermore, due to its putative interactions with several intracellular signaling pathways, klotho has been proposed as an anti-aging protein and tumor suppressor gene, while the Wnt/β-catenin signaling pathway drives enhanced cellular proliferation leading to numerous types of cancers, especially colorectal neoplasia. Thus, the ability of klotho to cooperate with vitamin D to inhibit oncogenic β-catenin signaling was also analyzed. The experiments and resultant data presented in this thesis explore the potential role of VDR as a physiologically relevant nutritional sensor in human cells. This novel study reveals the importance of nutrient modulation of the VDR system by vitamin D and resveratrol and how this might represent a molecular mechanism that is responsible for the putative anti-cancer actions of vitamin D. Furthermore, this study enhances our understanding of how vitamin D/VDR and resveratrol interact with klotho and how this interaction affects β-catenin signaling to mitigate oncogenic growth and differentiation. This works demonstrates that the vitamin D hormone serves as a likely chemopreventive agent for various types of cancers through control of anti-oxidation and cellular proliferation pathways via its nuclear receptor. Our results also indicate the potential for resveratrol, an anticancer nutraceutical, to upregulate VDR activity through SIRT1. Furthermore, the novel data presented in this work illustrate that klotho, an anti-aging protein, cooperates with vitamin D to synergistically inhibit oncogenic β-catenin signaling. Ultimately, this study enhances our understating of the molecular pathways that underpin nutritional chemoprevention, and how modulation of these pathways via dietary intervention may lead to advances in public health strategies to eventually curb carcinogenesis.
ContributorsKhan, Zainab (Author) / Jurutka, Peter (Thesis director) / Hackney Price, Jennifer (Committee member) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Marine conservation faces the unique challenge of trying to assess and protect species, like sharks, that have long migration tracks and are often targeted by fishing vessels in open and international waters. Over the last two decades, several large predatory shark populations have been greatly depleted despite local and international organizations designed to help regulate and prevent predator removal to avoid disturbing the food web those sharks balance (Myers, Baum, Shepherd, Powers, & Peterson, 2007). Forensic science is a powerful tool that could give shark conservation efforts an edge on identifying shark species currently being targeted by unsustainable fisheries in international waters. Allowing offenders who break international conservation laws to be prosecuted for their crimes. Unfortunately, this unique and powerful tool has not been given the opportunity to be utilized as it should be. An overview of national and international agencies, organizations, and laws disclosed a strong foundation for wildlife conservation. However, current international organizations and laws that govern international waters leave much to be desired in regards to protecting shark species that are threatened due to being popular targets for fishing vessels. This paper examines the level of forensic science involvement in shark conservation efforts through a literature review, revealing a severe lack of real-life application of forensic science to marine conservation cases. Current issues that marine wildlife forensic science encounters while attempting to increase forensic capability. And finally, presenting proposals for the future, and new challenges, which aim to strengthen the relationship between forensic science and marine conservation.
ContributorsParker, Jamie Caitlin (Author) / Kobojek, Kimberly (Thesis director) / Polidoro, Beth (Committee member) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
The diagnosis of irritable bowel syndrome (IBS) is currently based on symptomatic criteria that exclude other conditions affecting the gastrointestinal tract, such as celiac disease, food allergies, and infections. The absence of appropriate diagnostic and therapeutic approaches for IBS places a significant burden on the patient and the health care system due to direct and indirect costs of care. Limitations associated with the application of symptomatic criteria include inappropriate use and/or intrinsic limitations such as the population to which these criteria are applied. The lack of biomarkers specific for IBS, non-specific abdominal symptoms, and considerable variability in the disease course creates additional uncertainty during diagnosis. This project involved screening tissue samples from patients with verified IBS to identify gene expression-based biomarkers associated with IBS. Through validation of microarray gene chip data on the tissue samples using PCR, it was determined that a number of genes within the diseased IBS patient tissue samples were differentially expressed in comparison to the healthy subjects. These findings could potentially lead to the diagnosis of IBS on the basis of a genetic "fingerprint".
ContributorsHockley, Maryam (Author) / Jurutka, Peter (Thesis director) / Sandrin, Todd (Committee member) / Zhang, Lin (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor)
Created2013-12
Description
Due to the nature of animals, even domesticated pets, animal scavenging of human remains is an important taphonomic factor. This area of study has, however, been undercounted in the current literature. The purpose of this study was to begin the first step in creating a taphonomic profile for urban / household animal scavenging as distinguishable from manmade tool marks. Using volunteered animals and regularly available tools, alterations were made on beef ribs in order to characterize the distinguishing profiles between the two groups. It was found that animal scavenging alterations, in the short term (20 minutes used in this study) have a distinctly different appearance than tool mark alterations. Animal scavenging has less visible alterations, consistent bite morphology across different species, and symmetrical cut marks along the midsection of the long bones. Ultimately, this study was a successful first step in furthering taphonomic alteration database research across various biomes and conditions.
ContributorsLittle, Cody Lee (Author) / Kobojek, Kimberly (Thesis director) / Falsetti, Anthony (Committee member) / Ball, Becky (Committee member) / School of Human Evolution and Social Change (Contributor) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
The Impact of Forensic Science on Society examines the relationship between forensic science and society. Before 2009, society believed forensic science to be a important investigative tool. When the National Academy of Sciences released a report in 2009 detailing the issues within forensic science, society's opinion changed. This thesis analyzes factors that influenced the change in the relationship between forensic science and society, specifically focusing on the 2009 report, the CSI effect, the Innocence Project, and the role of the media. It also looks at how we can continue to improve forensic science, as well as how to strengthen the relationship between forensic science and society.
ContributorsDeroin, Shania Waldner (Author) / Kobojek, Kimberly (Thesis director) / Gordon, Karen (Committee member) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
There are unrealistic expectations of the forensic science discipline by the public today. More specifically about the types of evidence that can be recovered from a fired cartridge casing. The common misconception with the evidence that can be recovered from a cartridge casing is that all three types of evidence: DNA, latent prints, and firearms can be recovered from the same cartridge casing. However, just because some analyses are possible does not mean that they are practical. The definition of possibility is that an event can happen. However, the definition of practicality is not only that it can happen, but that the event should occur to optimize the efficiency of a given task. Through literature review of previous studies as well as experimental data, each discipline (DNA, latent prints, and firearms and toolmark analysis) were evaluated. For the experimental trials, three total experiments were carried out. Experiment one focused on the possibility aspect, so in experiment one the best conditions were simulated to receive a positive result. Experiment two focused on creating conditions that would occur at a crime scene, and experiment three refined those variables to serve as middle ground. After evaluation, each discipline was classified as possible and/or practical. These results were then used to determine practical sequential processing for a fired cartridge casing. After both experimentation and review, it was determined that the best possible sequential processing path for a cartridge casing collected at the crime scene to get the quickest information back is as follows: Firearms, DNA, Latent Prints.
ContributorsKephart, Amanda K. (Author) / Armendariz Guajardo, Jose (Thesis director) / Kobojek, Kimberly (Committee member) / Rex, Scott (Committee member) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
The culture surrounding death in America is one of science and silence. When possible, death is hidden away from the public view. When exposure to death is unavoidable, it is sensationalized, made into a spectacle. Our dying are put into hospice care, nursing homes, and other hidden spaces, or else they are plastered over the news and internet. So, we get one of two views of death: the sterile, silent death that happens in the presence of medical professionals or the bloody, tragic deaths that are constantly reported across news outlets and social media or sensationalized on entertainment platforms such as movies and video games. Entire genres of television and movies are created on the foundation of bloody deaths and we are exposed to the concept of death constantly.
Despite the consistent coverage of death on a large scale, the average person is not often exposed to death on a personal level in this day and age. The deaths we see on television or in the movies are not typically connected to people with whom we are attached and so we are not required to work through our emotional response and experience. We are afforded the space to be a casual observer in most of the deaths that we see—we do not need the emotional and mental tools to cope with death on a personal level. While this distance from death may be true of the American whole, it is not entirely generalizable. Professionals in select fields are required to deal with death on a much more regular basis than the average person, including, but not limited to, healthcare and forensic professionals. In these professions, death is a fundamental aspect of the job—either as an expected risk or a necessary precursor. These professionals deal intimately with death, its causes, and its effects on a regular basis because of their chose line of work and, in doing so, are regularly exposed to death and other trauma which has the potential to affect them on both a professional and personal level. In doing so, these professionals are required to, as scientists, analyze and record these experiences with death through the lens of objectivity. These professionals are expected to maintain a professional distance while also being required to give an empathetic response to other’s trauma. The potential effect of this secondary trauma on these professionals is only sharpened by the culture of machismo in these science-based fields that prevents many professionals from expressing emotions regarding their job and getting the social support they need from others within their community.
Despite the consistent coverage of death on a large scale, the average person is not often exposed to death on a personal level in this day and age. The deaths we see on television or in the movies are not typically connected to people with whom we are attached and so we are not required to work through our emotional response and experience. We are afforded the space to be a casual observer in most of the deaths that we see—we do not need the emotional and mental tools to cope with death on a personal level. While this distance from death may be true of the American whole, it is not entirely generalizable. Professionals in select fields are required to deal with death on a much more regular basis than the average person, including, but not limited to, healthcare and forensic professionals. In these professions, death is a fundamental aspect of the job—either as an expected risk or a necessary precursor. These professionals deal intimately with death, its causes, and its effects on a regular basis because of their chose line of work and, in doing so, are regularly exposed to death and other trauma which has the potential to affect them on both a professional and personal level. In doing so, these professionals are required to, as scientists, analyze and record these experiences with death through the lens of objectivity. These professionals are expected to maintain a professional distance while also being required to give an empathetic response to other’s trauma. The potential effect of this secondary trauma on these professionals is only sharpened by the culture of machismo in these science-based fields that prevents many professionals from expressing emotions regarding their job and getting the social support they need from others within their community.
ContributorsSandoval, Alicia Rose (Author) / Kobojek, Kimberly (Thesis director) / Watrous, Lisa (Committee member) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
Description
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder that afflicts more than 20% of the population in the United States. Symptoms include mild to severe abdominal discomfort accompanied by a change in stool character and form ranging from constipation to diarrhea. Additionally, IBS is associated with secondary effects including depression, anxiety, poor quality of life, insomnia and sexual dysfunction. Despite the known association of secondary effects, patients are often tested for potential illnesses that share similar pathological symptoms. This process can be costly and protracted and yet not deliver a completely accurate diagnosis. The aim of this research is to identify gene expression-based biological signatures and unique biomarkers for the detection of IBS. Through the use of quantitative polymerase chain reaction (qPCR), comparison of pooled samples of non-IBS patient-derived RNA were used to identify differentially expressed genes in patients with IBS. Data obtained from preliminary DNA microarray analysis demonstrated a degree of success in differentiating between IBS and asymptomatic patients. Additional comprehensive DNA microarray analyses have led to the identification of a series of 858 differentially expressed genes, including genes associated with serotonin metabolism, which may characterize the IBS pathological state. The microarray results were screened using a combination of gene ontological analysis and qPCR. Real-time PCR revealed repressed levels of tryptophan hydroxylase (TPH1), an enzyme involved in the rate- limiting step in serotonin biosynthesis, in IBS patients relative to controls. Lower concentrations of serum 25(OH)D were also observed among the IBS cohort relative to asymptomatic patients, especially among IBS-D subtype. Vitamin D was shown to modulate differentially expressed genes in IBS patients, suggesting that IBS pathophysiology may involve vitamin D insufficiency and/or an irregularity in serotonin metabolism. Additional qPCR analysis of 32 differentially expressed genes in IBS patients identified 7 putative genetic biomarkers proposed for a potential IBS diagnostic panel. Based on the quality of these results, we may be able to develop, test, and market a diagnostic kit for IBS.
ContributorsGrozic, Aleksandra (Author) / Jurutka, Peter (Thesis director) / Sandrin, Todd (Committee member) / Foxx-Orenstein, Amy (Committee member) / School of Mathematical and Natural Sciences (Contributor) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12