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Description
In the last 15 years, there has been a significant increase in the number of motor neural prostheses used for restoring limb function lost due to neurological disorders or accidents. The aim of this technology is to enable patients to control a motor prosthesis using their residual neural pathways (central or peripheral). Recent studies in non-human primates and humans have shown the possibility of controlling a prosthesis for accomplishing varied tasks such as self-feeding, typing, reaching, grasping, and performing fine dexterous movements. A neural decoding system comprises mainly of three components: (i) sensors to record neural signals, (ii) an algorithm to map neural recordings to upper limb kinematics and (iii) a prosthetic arm actuated by control signals generated by the algorithm. Machine learning algorithms that map input neural activity to the output kinematics (like finger trajectory) form the core of the neural decoding system. The choice of the algorithm is thus, mainly imposed by the neural signal of interest and the output parameter being decoded. The various parts of a neural decoding system are neural data, feature extraction, feature selection, and machine learning algorithm. There have been significant advances in the field of neural prosthetic applications. But there are challenges for translating a neural prosthesis from a laboratory setting to a clinical environment. To achieve a fully functional prosthetic device with maximum user compliance and acceptance, these factors need to be addressed and taken into consideration. Three challenges in developing robust neural decoding systems were addressed by exploring neural variability in the peripheral nervous system for dexterous finger movements, feature selection methods based on clinically relevant metrics and a novel method for decoding dexterous finger movements based on ensemble methods.
ContributorsPadmanaban, Subash (Author) / Greger, Bradley (Thesis advisor) / Santello, Marco (Committee member) / Helms Tillery, Stephen (Committee member) / Papandreou-Suppappola, Antonia (Committee member) / Crook, Sharon (Committee member) / Arizona State University (Publisher)
Created2017
Description
Retinotopic map, the map between visual inputs on the retina and neuronal activation in brain visual areas, is one of the central topics in visual neuroscience. For human observers, the map is typically obtained by analyzing functional magnetic resonance imaging (fMRI) signals of cortical responses to slowly moving visual stimuli on the retina. Biological evidences show the retinotopic mapping is topology-preserving/topological (i.e. keep the neighboring relationship after human brain process) within each visual region.
Unfortunately, due to limited spatial resolution and the signal-noise ratio of fMRI, state of art retinotopic map is not topological.
The topic was to model the topology-preserving condition mathematically, fix non-topological retinotopic map with numerical methods, and improve the quality of retinotopic maps.
The impose of topological condition, benefits several applications.
With the topological retinotopic maps, one may have a better insight on human retinotopic maps, including better cortical magnification factor quantification, more precise description of retinotopic maps, and potentially better exam ways of in Ophthalmology clinic.
ContributorsTu, Yanshuai (Author) / Wang, Yalin (Thesis advisor) / Lu, Zhong-Lin (Committee member) / Crook, Sharon (Committee member) / Yang, Yezhou (Committee member) / Zhang, Yu (Committee member) / Arizona State University (Publisher)
Created2022
Description
The concept of multi-scale, heterogeneous modeling is well-known to be central in the complexities of natural and built systems. Therefore, whole models that have parts with different spatiotemporal scales are preferred to those specified using a monolithic modeling approach and tightly integrated. To build simulation frameworks that are expressive and flexible, model composability is crucial where a whole model's structure and behavior traits must be concisely specified according to those of its parts and their interactions. To undertake the spatiotemporal model composability, a breast cancer cells chemotaxis exemplar is used. In breast cancer biology, the receptors CXCR4+ and CXCR7+ and the secreting CXCL12+ cells are implicated in spreading normal and malignant cells. As discrete entities, these can be modeled using Agent-Based Modeling (ABM). The receptors and ligand bindings with chemokine diffusion regulate the cells' movement gradient. These continuous processes can be modeled as Ordinary Differential Equations (ODE) and Partial Differential Equations (PDE). A customized, text-based BrSimulator exists to model and simulate this kind of breast cancer phenomenon. To build a multi-scale, spatiotemporal simulation framework supporting model composability, this research proposes using composable cellular automata (CCA) modeling. Toward this goal, the Cellular Automata DEVS (CA-DEVS) model is used, and the novel Composable Cellular Automata DEVS (CCA-DEVS) modeling is proposed. The DEVS-Suite simulator is extended to support CA and CCA Parallel DEVS models. This simulator introduces new capabilities for controlled and modular run-time animation and superdense time trajectory visualization. Furthermore, this research proposes using the Knowledge Interchange Broker (KIB) approach to model and simulate the interactions between separate geo-referenced CCA models developed using the DEVS and Modelica modeling languages. To demonstrate the proposed model composability approach and its use in the extended DEVS-Suite simulator, the breast cancer cells chemotaxis and others have been studied. The BrSimulator is used as a proxy for evaluating the proposed model composability approach using an integrated DEVS-Suite and OpenModelica simulator. Simulation experiments are developed that show the composition of spatiotemporal ABM, ODE, and PDE models reproduce the behaviors of the same model developed in the BrSimulator.
ContributorsZhang, Chao (Author) / Sarjoughian, Hessam S (Thesis advisor) / Crook, Sharon (Committee member) / Collofello, James (Committee member) / Pavlic, Theodore (Committee member) / Arizona State University (Publisher)
Created2021