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- All Subjects: Computer Science
- Genre: Doctoral Dissertation
- Creators: Arizona State University
Description
In the last decade, the immense growth of computational power, enhanced data storage capabilities, and the increasing popularity of online learning systems has led to adaptive learning systems becoming more widely available. Parallel to infrastructure enhancements, more researchers have started to study the adaptive task selection systems, concluding that suggesting tasks appropriate to students' needs may increase students' learning gains.
This work built an adaptive task selection system for undergraduate organic chemistry students using a deep learning algorithm. The proposed model is based on a recursive neural network (RNN) architecture built with Long-Short Term Memory (LSTM) cells that recommends organic chemistry practice questions to students depending on their previous question selections.
For this study, educational data were collected from the Organic Chemistry Practice Environment (OPE) that is used in the Organic Chemistry course at Arizona State University. The OPE has more than three thousand questions. Each question is linked to one or more knowledge components (KCs) to enable recommendations that precisely address the knowledge that students need. Subject matter experts made the connection between questions and related KCs.
A linear model derived from students' exam results was used to identify skilled students. The neural network based recommendation system was trained using those skilled students' problem solving attempt sequences so that the trained system recommends questions that will likely improve learning gains the most. The model was evaluated by measuring the predicted questions' accuracy against learners' actual task selections. The proposed model not only accurately predicted the learners' actual task selection but also the correctness of their answers.
This work built an adaptive task selection system for undergraduate organic chemistry students using a deep learning algorithm. The proposed model is based on a recursive neural network (RNN) architecture built with Long-Short Term Memory (LSTM) cells that recommends organic chemistry practice questions to students depending on their previous question selections.
For this study, educational data were collected from the Organic Chemistry Practice Environment (OPE) that is used in the Organic Chemistry course at Arizona State University. The OPE has more than three thousand questions. Each question is linked to one or more knowledge components (KCs) to enable recommendations that precisely address the knowledge that students need. Subject matter experts made the connection between questions and related KCs.
A linear model derived from students' exam results was used to identify skilled students. The neural network based recommendation system was trained using those skilled students' problem solving attempt sequences so that the trained system recommends questions that will likely improve learning gains the most. The model was evaluated by measuring the predicted questions' accuracy against learners' actual task selections. The proposed model not only accurately predicted the learners' actual task selection but also the correctness of their answers.
ContributorsKOSELER EMRE, Refika (Author) / VanLehn, Kurt A (Thesis advisor) / Davulcu, Hasan (Committee member) / Hsiao, Sharon (Committee member) / Hansford, Dianne (Committee member) / Arizona State University (Publisher)
Created2020
Description
Despite an abundance of defenses that work to protect Internet users from online threats, malicious actors continue deploying relentless large-scale phishing attacks that target these users. Effectively mitigating phishing attacks remains a challenge for the security community due to attackers' ability to evolve and adapt to defenses, the cross-organizational nature of the infrastructure abused for phishing, and discrepancies between theoretical and realistic anti-phishing systems. Although technical countermeasures cannot always compensate for the human weakness exploited by social engineers, maintaining a clear and up-to-date understanding of the motivation behind---and execution of---modern phishing attacks is essential to optimizing such countermeasures.
In this dissertation, I analyze the state of the anti-phishing ecosystem and show that phishers use evasion techniques, including cloaking, to bypass anti-phishing mitigations in hopes of maximizing the return-on-investment of their attacks. I develop three novel, scalable data-collection and analysis frameworks to pinpoint the ecosystem vulnerabilities that sophisticated phishing websites exploit. The frameworks, which operate on real-world data and are designed for continuous deployment by anti-phishing organizations, empirically measure the robustness of industry-standard anti-phishing blacklists (PhishFarm and PhishTime) and proactively detect and map phishing attacks prior to launch (Golden Hour). Using these frameworks, I conduct a longitudinal study of blacklist performance and the first large-scale end-to-end analysis of phishing attacks (from spamming through monetization). As a result, I thoroughly characterize modern phishing websites and identify desirable characteristics for enhanced anti-phishing systems, such as more reliable methods for the ecosystem to collectively detect phishing websites and meaningfully share the corresponding intelligence. In addition, findings from these studies led to actionable security recommendations that were implemented by key organizations within the ecosystem to help improve the security of Internet users worldwide.
In this dissertation, I analyze the state of the anti-phishing ecosystem and show that phishers use evasion techniques, including cloaking, to bypass anti-phishing mitigations in hopes of maximizing the return-on-investment of their attacks. I develop three novel, scalable data-collection and analysis frameworks to pinpoint the ecosystem vulnerabilities that sophisticated phishing websites exploit. The frameworks, which operate on real-world data and are designed for continuous deployment by anti-phishing organizations, empirically measure the robustness of industry-standard anti-phishing blacklists (PhishFarm and PhishTime) and proactively detect and map phishing attacks prior to launch (Golden Hour). Using these frameworks, I conduct a longitudinal study of blacklist performance and the first large-scale end-to-end analysis of phishing attacks (from spamming through monetization). As a result, I thoroughly characterize modern phishing websites and identify desirable characteristics for enhanced anti-phishing systems, such as more reliable methods for the ecosystem to collectively detect phishing websites and meaningfully share the corresponding intelligence. In addition, findings from these studies led to actionable security recommendations that were implemented by key organizations within the ecosystem to help improve the security of Internet users worldwide.
ContributorsOest, Adam (Author) / Ahn, Gail-Joon (Thesis advisor) / Doupe, Adam (Thesis advisor) / Shoshitaishvili, Yan (Committee member) / Johnson, RC (Committee member) / Arizona State University (Publisher)
Created2020
Description
Social links form the backbone of human interactions, both in an offline and online world. Such interactions harbor network diffusion or in simpler words, information spreading in a population of connected individuals. With recent increase in user engagement in social media platforms thus giving rise to networks of large scale, it has become imperative to understand the diffusion mechanisms by considering evolving instances of these network structures. Additionally, I claim that human connections fluctuate over time and attempt to study empirically grounded models of diffusion that embody these variations through evolving network structures. Patterns of interactions that are now stimulated by these fluctuating connections can be harnessed
towards predicting real world events. This dissertation attempts at analyzing
and then modeling such patterns of social network interactions. I propose how such
models could be used in advantage over traditional models of diffusion in various
predictions and simulations of real world events.
The specific three questions rooted in understanding social network interactions that have been addressed in this dissertation are: (1) can interactions captured through evolving diffusion networks indicate and predict the phase changes in a diffusion process? (2) can patterns and models of interactions in hacker forums be used in cyber-attack predictions in the real world? and (3) do varying patterns of social influence impact behavior adoption with different success ratios and could they be used to simulate rumor diffusion?
For the first question, I empirically analyze information cascades of Twitter and Flixster data and conclude that in evolving network structures characterizing diffusion, local network neighborhood surrounding a user is particularly a better indicator of the approaching phases. For the second question, I attempt to build an integrated approach utilizing unconventional signals from the "darkweb" forum discussions for predicting attacks on a target organization. The study finds that filtering out credible users and measuring network features surrounding them can be good indicators of an impending attack. For the third question, I develop an experimental framework in a controlled environment to understand how individuals respond to peer behavior in situations of sequential decision making and develop data-driven agent based models towards simulating rumor diffusion.
towards predicting real world events. This dissertation attempts at analyzing
and then modeling such patterns of social network interactions. I propose how such
models could be used in advantage over traditional models of diffusion in various
predictions and simulations of real world events.
The specific three questions rooted in understanding social network interactions that have been addressed in this dissertation are: (1) can interactions captured through evolving diffusion networks indicate and predict the phase changes in a diffusion process? (2) can patterns and models of interactions in hacker forums be used in cyber-attack predictions in the real world? and (3) do varying patterns of social influence impact behavior adoption with different success ratios and could they be used to simulate rumor diffusion?
For the first question, I empirically analyze information cascades of Twitter and Flixster data and conclude that in evolving network structures characterizing diffusion, local network neighborhood surrounding a user is particularly a better indicator of the approaching phases. For the second question, I attempt to build an integrated approach utilizing unconventional signals from the "darkweb" forum discussions for predicting attacks on a target organization. The study finds that filtering out credible users and measuring network features surrounding them can be good indicators of an impending attack. For the third question, I develop an experimental framework in a controlled environment to understand how individuals respond to peer behavior in situations of sequential decision making and develop data-driven agent based models towards simulating rumor diffusion.
ContributorsSarkar, Soumajyoti (Author) / Shakarian, Paulo (Thesis advisor) / Liu, Huan (Committee member) / Lakkaraju, Kiran (Committee member) / Sen, Arunabha (Committee member) / Arizona State University (Publisher)
Created2020
Description
Learning programming involves a variety of complex cognitive activities, from abstract knowledge construction to structural operations, which include program design,modifying, debugging, and documenting tasks. In this work, the objective was to explore and investigate the barriers and obstacles that programming novice learners encountered and how the learners overcome them. Several lab and classroom studies were designed and conducted, the results showed that novice students had different behavior patterns compared to experienced learners, which indicates obstacles encountered. The studies also proved that proper assistance could help novices find helpful materials to read. However, novices still suffered from the lack of background knowledge and the limited cognitive load while learning, which resulted in challenges in understanding programming related materials, especially code examples. Therefore, I further proposed to use the natural language generator (NLG) to generate code explanations for educational purposes. The natural language generator is designed based on Long Short Term Memory (LSTM), a deep-learning translation model. To establish the model, a data set was collected from Amazon Mechanical Turks (AMT) recording explanations from human experts for programming code lines.
To evaluate the model, a pilot study was conducted and proved that the readability of the machine generated (MG) explanation was compatible with human explanations, while its accuracy is still not ideal, especially for complicated code lines. Furthermore, a code-example based learning platform was developed to utilize the explanation generating model in programming teaching. To examine the effect of code example explanations on different learners, two lab-class experiments were conducted separately ii in a programming novices’ class and an advanced students’ class. The experiment result indicated that when learning programming concepts, the MG code explanations significantly improved the learning Predictability for novices compared to control group, and the explanations also extended the novices’ learning time by generating more material to read, which potentially lead to a better learning gain. Besides, a completed correlation model was constructed according to the experiment result to illustrate the connections between different factors and the learning effect.
To evaluate the model, a pilot study was conducted and proved that the readability of the machine generated (MG) explanation was compatible with human explanations, while its accuracy is still not ideal, especially for complicated code lines. Furthermore, a code-example based learning platform was developed to utilize the explanation generating model in programming teaching. To examine the effect of code example explanations on different learners, two lab-class experiments were conducted separately ii in a programming novices’ class and an advanced students’ class. The experiment result indicated that when learning programming concepts, the MG code explanations significantly improved the learning Predictability for novices compared to control group, and the explanations also extended the novices’ learning time by generating more material to read, which potentially lead to a better learning gain. Besides, a completed correlation model was constructed according to the experiment result to illustrate the connections between different factors and the learning effect.
ContributorsLu, Yihan (Author) / Hsiao, I-Han (Thesis advisor) / VanLehn, Kurt (Committee member) / Tong, Hanghang (Committee member) / Yang, Yezhou (Committee member) / Price, Thomas (Committee member) / Arizona State University (Publisher)
Created2020
Description
Recently, a well-designed and well-trained neural network can yield state-of-the-art results across many domains, including data mining, computer vision, and medical image analysis. But progress has been limited for tasks where labels are difficult or impossible to obtain. This reliance on exhaustive labeling is a critical limitation in the rapid deployment of neural networks. Besides, the current research scales poorly to a large number of unseen concepts and is passively spoon-fed with data and supervision.
To overcome the above data scarcity and generalization issues, in my dissertation, I first propose two unsupervised conventional machine learning algorithms, hyperbolic stochastic coding, and multi-resemble multi-target low-rank coding, to solve the incomplete data and missing label problem. I further introduce a deep multi-domain adaptation network to leverage the power of deep learning by transferring the rich knowledge from a large-amount labeled source dataset. I also invent a novel time-sequence dynamically hierarchical network that adaptively simplifies the network to cope with the scarce data.
To learn a large number of unseen concepts, lifelong machine learning enjoys many advantages, including abstracting knowledge from prior learning and using the experience to help future learning, regardless of how much data is currently available. Incorporating this capability and making it versatile, I propose deep multi-task weight consolidation to accumulate knowledge continuously and significantly reduce data requirements in a variety of domains. Inspired by the recent breakthroughs in automatically learning suitable neural network architectures (AutoML), I develop a nonexpansive AutoML framework to train an online model without the abundance of labeled data. This work automatically expands the network to increase model capability when necessary, then compresses the model to maintain the model efficiency.
In my current ongoing work, I propose an alternative method of supervised learning that does not require direct labels. This could utilize various supervision from an image/object as a target value for supervising the target tasks without labels, and it turns out to be surprisingly effective. The proposed method only requires few-shot labeled data to train, and can self-supervised learn the information it needs and generalize to datasets not seen during training.
To overcome the above data scarcity and generalization issues, in my dissertation, I first propose two unsupervised conventional machine learning algorithms, hyperbolic stochastic coding, and multi-resemble multi-target low-rank coding, to solve the incomplete data and missing label problem. I further introduce a deep multi-domain adaptation network to leverage the power of deep learning by transferring the rich knowledge from a large-amount labeled source dataset. I also invent a novel time-sequence dynamically hierarchical network that adaptively simplifies the network to cope with the scarce data.
To learn a large number of unseen concepts, lifelong machine learning enjoys many advantages, including abstracting knowledge from prior learning and using the experience to help future learning, regardless of how much data is currently available. Incorporating this capability and making it versatile, I propose deep multi-task weight consolidation to accumulate knowledge continuously and significantly reduce data requirements in a variety of domains. Inspired by the recent breakthroughs in automatically learning suitable neural network architectures (AutoML), I develop a nonexpansive AutoML framework to train an online model without the abundance of labeled data. This work automatically expands the network to increase model capability when necessary, then compresses the model to maintain the model efficiency.
In my current ongoing work, I propose an alternative method of supervised learning that does not require direct labels. This could utilize various supervision from an image/object as a target value for supervising the target tasks without labels, and it turns out to be surprisingly effective. The proposed method only requires few-shot labeled data to train, and can self-supervised learn the information it needs and generalize to datasets not seen during training.
ContributorsZhang, Jie (Author) / Wang, Yalin (Thesis advisor) / Liu, Huan (Committee member) / Stonnington, Cynthia (Committee member) / Liang, Jianming (Committee member) / Yang, Yezhou (Committee member) / Arizona State University (Publisher)
Created2020
Description
As robots become mechanically more capable, they are going to be more and more integrated into our daily lives. Over time, human’s expectation of what the robot capabilities are is getting higher. Therefore, it can be conjectured that often robots will not act as human commanders intended them to do. That is, the users of the robots may have a different point of view from the one the robots do.
The first part of this dissertation covers methods that resolve some instances of this mismatch when the mission requirements are expressed in Linear Temporal Logic (LTL) for handling coverage, sequencing, conditions and avoidance. That is, the following general questions are addressed:
* What cause of the given mission is unrealizable?
* Is there any other feasible mission that is close to the given one?
In order to answer these questions, the LTL Revision Problem is applied and it is formulated as a graph search problem. It is shown that in general the problem is NP-Complete. Hence, it is proved that the heuristic algorihtm has 2-approximation bound in some cases. This problem, then, is extended to two different versions: one is for the weighted transition system and another is for the specification under quantitative preference. Next, a follow up question is addressed:
* How can an LTL specified mission be scaled up to multiple robots operating in confined environments?
The Cooperative Multi-agent Planning Problem is addressed by borrowing a technique from cooperative pathfinding problems in discrete grid environments. Since centralized planning for multi-robot systems is computationally challenging and easily results in state space explosion, a distributed planning approach is provided through agent coupling and de-coupling.
In addition, in order to make such robot missions work in the real world, robots should take actions in the continuous physical world. Hence, in the second part of this thesis, the resulting motion planning problems is addressed for non-holonomic robots.
That is, it is devoted to autonomous vehicles’ motion planning in challenging environments such as rural, semi-structured roads. This planning problem is solved with an on-the-fly hierarchical approach, using a pre-computed lattice planner. It is also proved that the proposed algorithm guarantees resolution-completeness in such demanding environments. Finally, possible extensions are discussed.
The first part of this dissertation covers methods that resolve some instances of this mismatch when the mission requirements are expressed in Linear Temporal Logic (LTL) for handling coverage, sequencing, conditions and avoidance. That is, the following general questions are addressed:
* What cause of the given mission is unrealizable?
* Is there any other feasible mission that is close to the given one?
In order to answer these questions, the LTL Revision Problem is applied and it is formulated as a graph search problem. It is shown that in general the problem is NP-Complete. Hence, it is proved that the heuristic algorihtm has 2-approximation bound in some cases. This problem, then, is extended to two different versions: one is for the weighted transition system and another is for the specification under quantitative preference. Next, a follow up question is addressed:
* How can an LTL specified mission be scaled up to multiple robots operating in confined environments?
The Cooperative Multi-agent Planning Problem is addressed by borrowing a technique from cooperative pathfinding problems in discrete grid environments. Since centralized planning for multi-robot systems is computationally challenging and easily results in state space explosion, a distributed planning approach is provided through agent coupling and de-coupling.
In addition, in order to make such robot missions work in the real world, robots should take actions in the continuous physical world. Hence, in the second part of this thesis, the resulting motion planning problems is addressed for non-holonomic robots.
That is, it is devoted to autonomous vehicles’ motion planning in challenging environments such as rural, semi-structured roads. This planning problem is solved with an on-the-fly hierarchical approach, using a pre-computed lattice planner. It is also proved that the proposed algorithm guarantees resolution-completeness in such demanding environments. Finally, possible extensions are discussed.
ContributorsKim, Kangjin (Author) / Fainekos, Georgios (Thesis advisor) / Baral, Chitta (Committee member) / Lee, Joohyung (Committee member) / Berman, Spring (Committee member) / Arizona State University (Publisher)
Created2019
Description
Unstructured texts containing biomedical information from sources such as electronic health records, scientific literature, discussion forums, and social media offer an opportunity to extract information for a wide range of applications in biomedical informatics. Building scalable and efficient pipelines for natural language processing and extraction of biomedical information plays an important role in the implementation and adoption of applications in areas such as public health. Advancements in machine learning and deep learning techniques have enabled rapid development of such pipelines. This dissertation presents entity extraction pipelines for two public health applications: virus phylogeography and pharmacovigilance. For virus phylogeography, geographical locations are extracted from biomedical scientific texts for metadata enrichment in the GenBank database containing 2.9 million virus nucleotide sequences. For pharmacovigilance, tools are developed to extract adverse drug reactions from social media posts to open avenues for post-market drug surveillance from non-traditional sources. Across these pipelines, high variance is observed in extraction performance among the entities of interest while using state-of-the-art neural network architectures. To explain the variation, linguistic measures are proposed to serve as indicators for entity extraction performance and to provide deeper insight into the domain complexity and the challenges associated with entity extraction. For both the phylogeography and pharmacovigilance pipelines presented in this work the annotated datasets and applications are open source and freely available to the public to foster further research in public health.
ContributorsMagge, Arjun (Author) / Scotch, Matthew (Thesis advisor) / Gonzalez-Hernandez, Graciela (Thesis advisor) / Greenes, Robert (Committee member) / Arizona State University (Publisher)
Created2019
Description
The use of reactive security mechanisms in enterprise networks can, at times, provide an asymmetric advantage to the attacker. Similarly, the use of a proactive security mechanism like Moving Target Defense (MTD), if performed without analyzing the effects of security countermeasures, can lead to security policy and service level agreement violations. In this thesis, I explore the research questions 1) how to model attacker-defender interactions for multi-stage attacks? 2) how to efficiently deploy proactive (MTD) security countermeasures in a software-defined environment for single and multi-stage attacks? 3) how to verify the effects of security and management policies on the network and take corrective actions?
I propose a Software-defined Situation-aware Cloud Security framework, that, 1) analyzes the attacker-defender interactions using an Software-defined Networking (SDN) based scalable attack graph. This research investigates Advanced Persistent Threat (APT) attacks using a scalable attack graph. The framework utilizes a parallel graph partitioning algorithm to generate an attack graph quickly and efficiently. 2) models single-stage and multi-stage attacks (APTs) using the game-theoretic model and provides SDN-based MTD countermeasures. I propose a Markov Game for modeling multi-stage attacks. 3) introduces a multi-stage policy conflict checking framework at the SDN network's application plane. I present INTPOL, a new intent-driven security policy enforcement solution. INTPOL provides a unified language and INTPOL grammar that abstracts the network administrator from the underlying network controller's lexical rules. INTPOL develops a bounded formal model for network service compliance checking, which significantly reduces the number of countermeasures that needs to be deployed. Once the application-layer policy conflicts are resolved, I utilize an Object-Oriented Policy Conflict checking (OOPC) framework that identifies and resolves rule-order dependencies and conflicts between security policies.
I propose a Software-defined Situation-aware Cloud Security framework, that, 1) analyzes the attacker-defender interactions using an Software-defined Networking (SDN) based scalable attack graph. This research investigates Advanced Persistent Threat (APT) attacks using a scalable attack graph. The framework utilizes a parallel graph partitioning algorithm to generate an attack graph quickly and efficiently. 2) models single-stage and multi-stage attacks (APTs) using the game-theoretic model and provides SDN-based MTD countermeasures. I propose a Markov Game for modeling multi-stage attacks. 3) introduces a multi-stage policy conflict checking framework at the SDN network's application plane. I present INTPOL, a new intent-driven security policy enforcement solution. INTPOL provides a unified language and INTPOL grammar that abstracts the network administrator from the underlying network controller's lexical rules. INTPOL develops a bounded formal model for network service compliance checking, which significantly reduces the number of countermeasures that needs to be deployed. Once the application-layer policy conflicts are resolved, I utilize an Object-Oriented Policy Conflict checking (OOPC) framework that identifies and resolves rule-order dependencies and conflicts between security policies.
ContributorsChowdhary, Ankur (Author) / Huang, Dijiang (Thesis advisor) / Kambhampati, Subbarao (Committee member) / Doupe, Adam (Committee member) / Bao, Youzhi (Committee member) / Arizona State University (Publisher)
Created2020
Description
Next-generation sequencing is a powerful tool for detecting genetic variation. How-ever, it is also error-prone, with error rates that are much larger than mutation rates.
This can make mutation detection difficult; and while increasing sequencing depth
can often help, sequence-specific errors and other non-random biases cannot be de-
tected by increased depth. The problem of accurate genotyping is exacerbated when
there is not a reference genome or other auxiliary information available.
I explore several methods for sensitively detecting mutations in non-model or-
ganisms using an example Eucalyptus melliodora individual. I use the structure of
the tree to find bounds on its somatic mutation rate and evaluate several algorithms
for variant calling. I find that conventional methods are suitable if the genome of a
close relative can be adapted to the study organism. However, with structured data,
a likelihood framework that is aware of this structure is more accurate. I use the
techniques developed here to evaluate a reference-free variant calling algorithm.
I also use this data to evaluate a k-mer based base quality score recalibrator
(KBBQ), a tool I developed to recalibrate base quality scores attached to sequencing
data. Base quality scores can help detect errors in sequencing reads, but are often
inaccurate. The most popular method for correcting this issue requires a known
set of variant sites, which is unavailable in most cases. I simulate data and show
that errors in this set of variant sites can cause calibration errors. I then show that
KBBQ accurately recalibrates base quality scores while requiring no reference or other
information and performs as well as other methods.
Finally, I use the Eucalyptus data to investigate the impact of quality score calibra-
tion on the quality of output variant calls and show that improved base quality score
calibration increases the sensitivity and reduces the false positive rate of a variant
calling algorithm.
This can make mutation detection difficult; and while increasing sequencing depth
can often help, sequence-specific errors and other non-random biases cannot be de-
tected by increased depth. The problem of accurate genotyping is exacerbated when
there is not a reference genome or other auxiliary information available.
I explore several methods for sensitively detecting mutations in non-model or-
ganisms using an example Eucalyptus melliodora individual. I use the structure of
the tree to find bounds on its somatic mutation rate and evaluate several algorithms
for variant calling. I find that conventional methods are suitable if the genome of a
close relative can be adapted to the study organism. However, with structured data,
a likelihood framework that is aware of this structure is more accurate. I use the
techniques developed here to evaluate a reference-free variant calling algorithm.
I also use this data to evaluate a k-mer based base quality score recalibrator
(KBBQ), a tool I developed to recalibrate base quality scores attached to sequencing
data. Base quality scores can help detect errors in sequencing reads, but are often
inaccurate. The most popular method for correcting this issue requires a known
set of variant sites, which is unavailable in most cases. I simulate data and show
that errors in this set of variant sites can cause calibration errors. I then show that
KBBQ accurately recalibrates base quality scores while requiring no reference or other
information and performs as well as other methods.
Finally, I use the Eucalyptus data to investigate the impact of quality score calibra-
tion on the quality of output variant calls and show that improved base quality score
calibration increases the sensitivity and reduces the false positive rate of a variant
calling algorithm.
ContributorsOrr, Adam James (Author) / Cartwright, Reed (Thesis advisor) / Wilson, Melissa (Committee member) / Kusumi, Kenro (Committee member) / Taylor, Jesse (Committee member) / Pfeifer, Susanne (Committee member) / Arizona State University (Publisher)
Created2020
Description
Access to real-time situational information including the relative position and motion of surrounding objects is critical for safe and independent travel. Object or obstacle (OO) detection at a distance is primarily a task of the visual system due to the high resolution information the eyes are able to receive from afar. As a sensory organ in particular, the eyes have an unparalleled ability to adjust to varying degrees of light, color, and distance. Therefore, in the case of a non-visual traveler, someone who is blind or low vision, access to visual information is unattainable if it is positioned beyond the reach of the preferred mobility device or outside the path of travel. Although, the area of assistive technology in terms of electronic travel aids (ETA’s) has received considerable attention over the last two decades; surprisingly, the field has seen little work in the area focused on augmenting rather than replacing current non-visual travel techniques, methods, and tools. Consequently, this work describes the design of an intuitive tactile language and series of wearable tactile interfaces (the Haptic Chair, HaptWrap, and HapBack) to deliver real-time spatiotemporal data. The overall intuitiveness of the haptic mappings conveyed through the tactile interfaces are evaluated using a combination of absolute identification accuracy of a series of patterns and subjective feedback through post-experiment surveys. Two types of spatiotemporal representations are considered: static patterns representing object location at a single time instance, and dynamic patterns, added in the HaptWrap, which represent object movement over a time interval. Results support the viability of multi-dimensional haptics applied to the body to yield an intuitive understanding of dynamic interactions occurring around the navigator during travel. Lastly, it is important to point out that the guiding principle of this work centered on providing the navigator with spatial knowledge otherwise unattainable through current mobility techniques, methods, and tools, thus, providing the \emph{navigator} with the information necessary to make informed navigation decisions independently, at a distance.
ContributorsDuarte, Bryan Joiner (Author) / McDaniel, Troy (Thesis advisor) / Davulcu, Hasan (Committee member) / Li, Baoxin (Committee member) / Venkateswara, Hemanth (Committee member) / Arizona State University (Publisher)
Created2020