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Description
In species with highly heteromorphic sex chromosomes, the degradation of one of the sex chromosomes can result in unequal gene expression between the sexes (e.g., between XX females and XY males) and between the sex chromosomes and the autosomes. Dosage compensation is a process whereby genes on the sex chromosomes

In species with highly heteromorphic sex chromosomes, the degradation of one of the sex chromosomes can result in unequal gene expression between the sexes (e.g., between XX females and XY males) and between the sex chromosomes and the autosomes. Dosage compensation is a process whereby genes on the sex chromosomes achieve equal gene expression which prevents deleterious side effects from having too much or too little expression of genes on sex chromsomes. The green anole is part of a group of species that recently underwent an adaptive radiation. The green anole has XX/XY sex determination, but the content of the X chromosome and its evolution have not been described. Given its status as a model species, better understanding the green anole genome could reveal insights into other species. Genomic analyses are crucial for a comprehensive picture of sex chromosome differentiation and dosage compensation, in addition to understanding speciation.

In order to address this, multiple comparative genomics and bioinformatics analyses were conducted to elucidate patterns of evolution in the green anole and across multiple anole species. Comparative genomics analyses were used to infer additional X-linked loci in the green anole, RNAseq data from male and female samples were anayzed to quantify patterns of sex-biased gene expression across the genome, and the extent of dosage compensation on the anole X chromosome was characterized, providing evidence that the sex chromosomes in the green anole are dosage compensated.

In addition, X-linked genes have a lower ratio of nonsynonymous to synonymous substitution rates than the autosomes when compared to other Anolis species, and pairwise rates of evolution in genes across the anole genome were analyzed. To conduct this analysis a new pipeline was created for filtering alignments and performing batch calculations for whole genome coding sequences. This pipeline has been made publicly available.
ContributorsRupp, Shawn Michael (Author) / Wilson Sayres, Melissa A (Thesis advisor) / Kusumi, Kenro (Committee member) / DeNardo, Dale (Committee member) / Arizona State University (Publisher)
Created2016
DescriptionThis thesis summarizes the process of writing a children's book about achondroplasia directed at children without genetic disorders. The thesis also includes the children's book The Genetics of Little People that was created during the project.
ContributorsWatkins, Payton (Author) / Binsfeld, Allison (Co-author) / Wilson, Melissa (Thesis director) / Hunt-Brendish, Katherine (Committee member) / Barrett, The Honors College (Contributor) / Chemical Engineering Program (Contributor)
Created2022-05
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Description

This thesis summarizes the process of writing a children's book about achondroplasia directed at children without genetic disorders. The thesis also includes the children's book The Genetics of Little People that was created during the project.

ContributorsWatkins, Payton (Author) / Binsfeld, Allison (Co-author) / Wilson, Melissa (Thesis director) / Hunt-Brendish, Katherine (Committee member) / Barrett, The Honors College (Contributor) / Chemical Engineering Program (Contributor)
Created2022-05
164797-Thumbnail Image.png
Description

This thesis summarizes the process of writing a children's book about achondroplasia directed at children without genetic disorders. The thesis also includes the children's book The Genetics of Little People that was created during the project.

ContributorsWatkins, Payton (Author) / Binsfeld, Allison (Co-author) / Wilson, Melissa (Thesis director) / Hunt-Brendish, Katherine (Committee member) / Barrett, The Honors College (Contributor) / Chemical Engineering Program (Contributor)
Created2022-05
Description

This thesis summarizes the process of writing a children's book about achondroplasia directed at children without genetic disorders. The thesis also includes the children's book The Genetics of Little People that was created during the project.

ContributorsBinsfeld, Allison (Author) / Watkins, Payton (Co-author) / Wilson, Melissa (Thesis director) / Hunt Brendish, Katherine (Committee member) / Barrett, The Honors College (Contributor) / School of Molecular Sciences (Contributor) / School of Human Evolution & Social Change (Contributor)
Created2022-05
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ContributorsBinsfeld, Allison (Author) / Watkins, Payton (Co-author) / Wilson, Melissa (Thesis director) / Hunt Brendish, Katherine (Committee member) / Barrett, The Honors College (Contributor) / School of Molecular Sciences (Contributor)
Created2022-05
164708-Thumbnail Image.png
ContributorsBinsfeld, Allison (Author) / Watkins, Payton (Co-author) / Wilson, Melissa (Thesis director) / Hunt Brendish, Katherine (Committee member) / Barrett, The Honors College (Contributor) / School of Molecular Sciences (Contributor)
Created2022-05