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- All Subjects: Statistics
- Creators: Zheng, Yi
- Creators: Wilson, Jeffrey
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Description
Many longitudinal studies, especially in clinical trials, suffer from missing data issues. Most estimation procedures assume that the missing values are ignorable or missing at random (MAR). However, this assumption leads to unrealistic simplification and is implausible for many cases. For example, an investigator is examining the effect of treatment on depression. Subjects are scheduled with doctors on a regular basis and asked questions about recent emotional situations. Patients who are experiencing severe depression are more likely to miss an appointment and leave the data missing for that particular visit. Data that are not missing at random may produce bias in results if the missing mechanism is not taken into account. In other words, the missing mechanism is related to the unobserved responses. Data are said to be non-ignorable missing if the probabilities of missingness depend on quantities that might not be included in the model. Classical pattern-mixture models for non-ignorable missing values are widely used for longitudinal data analysis because they do not require explicit specification of the missing mechanism, with the data stratified according to a variety of missing patterns and a model specified for each stratum. However, this usually results in under-identifiability, because of the need to estimate many stratum-specific parameters even though the eventual interest is usually on the marginal parameters. Pattern mixture models have the drawback that a large sample is usually required. In this thesis, two studies are presented. The first study is motivated by an open problem from pattern mixture models. Simulation studies from this part show that information in the missing data indicators can be well summarized by a simple continuous latent structure, indicating that a large number of missing data patterns may be accounted by a simple latent factor. Simulation findings that are obtained in the first study lead to a novel model, a continuous latent factor model (CLFM). The second study develops CLFM which is utilized for modeling the joint distribution of missing values and longitudinal outcomes. The proposed CLFM model is feasible even for small sample size applications. The detailed estimation theory, including estimating techniques from both frequentist and Bayesian perspectives is presented. Model performance and evaluation are studied through designed simulations and three applications. Simulation and application settings change from correctly-specified missing data mechanism to mis-specified mechanism and include different sample sizes from longitudinal studies. Among three applications, an AIDS study includes non-ignorable missing values; the Peabody Picture Vocabulary Test data have no indication on missing data mechanism and it will be applied to a sensitivity analysis; the Growth of Language and Early Literacy Skills in Preschoolers with Developmental Speech and Language Impairment study, however, has full complete data and will be used to conduct a robust analysis. The CLFM model is shown to provide more precise estimators, specifically on intercept and slope related parameters, compared with Roy's latent class model and the classic linear mixed model. This advantage will be more obvious when a small sample size is the case, where Roy's model experiences challenges on estimation convergence. The proposed CLFM model is also robust when missing data are ignorable as demonstrated through a study on Growth of Language and Early Literacy Skills in Preschoolers.
ContributorsZhang, Jun (Author) / Reiser, Mark R. (Thesis advisor) / Barber, Jarrett (Thesis advisor) / Kao, Ming-Hung (Committee member) / Wilson, Jeffrey (Committee member) / St Louis, Robert D. (Committee member) / Arizona State University (Publisher)
Created2013
Description
It is common in the analysis of data to provide a goodness-of-fit test to assess the performance of a model. In the analysis of contingency tables, goodness-of-fit statistics are frequently employed when modeling social science, educational or psychological data where the interest is often directed at investigating the association among multi-categorical variables. Pearson's chi-squared statistic is well-known in goodness-of-fit testing, but it is sometimes considered to produce an omnibus test as it gives little guidance to the source of poor fit once the null hypothesis is rejected. However, its components can provide powerful directional tests. In this dissertation, orthogonal components are used to develop goodness-of-fit tests for models fit to the counts obtained from the cross-classification of multi-category dependent variables. Ordinal categories are assumed. Orthogonal components defined on marginals are obtained when analyzing multi-dimensional contingency tables through the use of the QR decomposition. A subset of these orthogonal components can be used to construct limited-information tests that allow one to identify the source of lack-of-fit and provide an increase in power compared to Pearson's test. These tests can address the adverse effects presented when data are sparse. The tests rely on the set of first- and second-order marginals jointly, the set of second-order marginals only, and the random forest method, a popular algorithm for modeling large complex data sets. The performance of these tests is compared to the likelihood ratio test as well as to tests based on orthogonal polynomial components. The derived goodness-of-fit tests are evaluated with studies for detecting two- and three-way associations that are not accounted for by a categorical variable factor model with a single latent variable. In addition the tests are used to investigate the case when the model misspecification involves parameter constraints for large and sparse contingency tables. The methodology proposed here is applied to data from the 38th round of the State Survey conducted by the Institute for Public Policy and Michigan State University Social Research (2005) . The results illustrate the use of the proposed techniques in the context of a sparse data set.
ContributorsMilovanovic, Jelena (Author) / Young, Dennis (Thesis advisor) / Reiser, Mark R. (Thesis advisor) / Wilson, Jeffrey (Committee member) / Eubank, Randall (Committee member) / Yang, Yan (Committee member) / Arizona State University (Publisher)
Created2011
Description
Though the likelihood is a useful tool for obtaining estimates of regression parameters, it is not readily available in the fit of hierarchical binary data models. The correlated observations negate the opportunity to have a joint likelihood when fitting hierarchical logistic regression models. Through conditional likelihood, inferences for the regression and covariance parameters as well as the intraclass correlation coefficients are usually obtained. In those cases, I have resorted to use of Laplace approximation and large sample theory approach for point and interval estimates such as Wald-type confidence intervals and profile likelihood confidence intervals. These methods rely on distributional assumptions and large sample theory. However, when dealing with small hierarchical datasets they often result in severe bias or non-convergence. I present a generalized quasi-likelihood approach and a generalized method of moments approach; both do not rely on any distributional assumptions but only moments of response. As an alternative to the typical large sample theory approach, I present bootstrapping hierarchical logistic regression models which provides more accurate interval estimates for small binary hierarchical data. These models substitute computations as an alternative to the traditional Wald-type and profile likelihood confidence intervals. I use a latent variable approach with a new split bootstrap method for estimating intraclass correlation coefficients when analyzing binary data obtained from a three-level hierarchical structure. It is especially useful with small sample size and easily expanded to multilevel. Comparisons are made to existing approaches through both theoretical justification and simulation studies. Further, I demonstrate my findings through an analysis of three numerical examples, one based on cancer in remission data, one related to the China’s antibiotic abuse study, and a third related to teacher effectiveness in schools from a state of southwest US.
ContributorsWang, Bei (Author) / Wilson, Jeffrey R (Thesis advisor) / Kamarianakis, Ioannis (Committee member) / Reiser, Mark R. (Committee member) / St Louis, Robert (Committee member) / Zheng, Yi (Committee member) / Arizona State University (Publisher)
Created2017
Description
Generalized Linear Models (GLMs) are widely used for modeling responses with non-normal error distributions. When the values of the covariates in such models are controllable, finding an optimal (or at least efficient) design could greatly facilitate the work of collecting and analyzing data. In fact, many theoretical results are obtained on a case-by-case basis, while in other situations, researchers also rely heavily on computational tools for design selection.
Three topics are investigated in this dissertation with each one focusing on one type of GLMs. Topic I considers GLMs with factorial effects and one continuous covariate. Factors can have interactions among each other and there is no restriction on the possible values of the continuous covariate. The locally D-optimal design structures for such models are identified and results for obtaining smaller optimal designs using orthogonal arrays (OAs) are presented. Topic II considers GLMs with multiple covariates under the assumptions that all but one covariate are bounded within specified intervals and interaction effects among those bounded covariates may also exist. An explicit formula for D-optimal designs is derived and OA-based smaller D-optimal designs for models with one or two two-factor interactions are also constructed. Topic III considers multiple-covariate logistic models. All covariates are nonnegative and there is no interaction among them. Two types of D-optimal design structures are identified and their global D-optimality is proved using the celebrated equivalence theorem.
Three topics are investigated in this dissertation with each one focusing on one type of GLMs. Topic I considers GLMs with factorial effects and one continuous covariate. Factors can have interactions among each other and there is no restriction on the possible values of the continuous covariate. The locally D-optimal design structures for such models are identified and results for obtaining smaller optimal designs using orthogonal arrays (OAs) are presented. Topic II considers GLMs with multiple covariates under the assumptions that all but one covariate are bounded within specified intervals and interaction effects among those bounded covariates may also exist. An explicit formula for D-optimal designs is derived and OA-based smaller D-optimal designs for models with one or two two-factor interactions are also constructed. Topic III considers multiple-covariate logistic models. All covariates are nonnegative and there is no interaction among them. Two types of D-optimal design structures are identified and their global D-optimality is proved using the celebrated equivalence theorem.
ContributorsWang, Zhongsheng (Author) / Stufken, John (Thesis advisor) / Kamarianakis, Ioannis (Committee member) / Kao, Ming-Hung (Committee member) / Reiser, Mark R. (Committee member) / Zheng, Yi (Committee member) / Arizona State University (Publisher)
Created2018
Description
The Pearson and likelihood ratio statistics are well-known in goodness-of-fit testing and are commonly used for models applied to multinomial count data. When data are from a table formed by the cross-classification of a large number of variables, these goodness-of-fit statistics may have lower power and inaccurate Type I error rate due to sparseness. Pearson's statistic can be decomposed into orthogonal components associated with the marginal distributions of observed variables, and an omnibus fit statistic can be obtained as a sum of these components. When the statistic is a sum of components for lower-order marginals, it has good performance for Type I error rate and statistical power even when applied to a sparse table. In this dissertation, goodness-of-fit statistics using orthogonal components based on second- third- and fourth-order marginals were examined. If lack-of-fit is present in higher-order marginals, then a test that incorporates the higher-order marginals may have a higher power than a test that incorporates only first- and/or second-order marginals. To this end, two new statistics based on the orthogonal components of Pearson's chi-square that incorporate third- and fourth-order marginals were developed, and the Type I error, empirical power, and asymptotic power under different sparseness conditions were investigated. Individual orthogonal components as test statistics to identify lack-of-fit were also studied. The performance of individual orthogonal components to other popular lack-of-fit statistics were also compared. When the number of manifest variables becomes larger than 20, most of the statistics based on marginal distributions have limitations in terms of computer resources and CPU time. Under this problem, when the number manifest variables is larger than or equal to 20, the performance of a bootstrap based method to obtain p-values for Pearson-Fisher statistic, fit to confirmatory dichotomous variable factor analysis model, and the performance of Tollenaar and Mooijaart (2003) statistic were investigated.
ContributorsDassanayake, Mudiyanselage Maduranga Kasun (Author) / Reiser, Mark R. (Thesis advisor) / Kao, Ming-Hung (Committee member) / Wilson, Jeffrey (Committee member) / St. Louis, Robert (Committee member) / Kamarianakis, Ioannis (Committee member) / Arizona State University (Publisher)
Created2018
Description
In the last decade, the population of honey bees across the globe has declined sharply leaving scientists and bee keepers to wonder why? Amongst all nations, the United States has seen some of the greatest declines in the last 10 plus years. Without a definite explanation, Colony Collapse Disorder (CCD) was coined to explain the sudden and sharp decline of the honey bee colonies that beekeepers were experiencing. Colony collapses have been rising higher compared to expected averages over the years, and during the winter season losses are even more severe than what is normally acceptable. There are some possible explanations pointing towards meteorological variables, diseases, and even pesticide usage. Despite the cause of CCD being unknown, thousands of beekeepers have reported their losses, and even numbers of infected colonies and colonies under certain stressors in the most recent years. Using the data that was reported to The United States Department of Agriculture (USDA), as well as weather data collected by The National Centers for Environmental Information (NOAA) and the National Centers for Environmental Information (NCEI), regression analysis was used to investigate honey bee colonies to find relationships between stressors in honey bee colonies and meteorological variables, and colony collapses during the winter months. The regression analysis focused on the winter season, or quarter 4 of the year, which includes the months of October, November, and December. In the model, the response variables was the percentage of colonies lost in quarter 4. Through the model, it was concluded that certain weather thresholds and the percentage increase of colonies under certain stressors were related to colony loss.
ContributorsVasquez, Henry Antony (Author) / Zheng, Yi (Thesis director) / Saffell, Erinanne (Committee member) / School of Mathematical and Statistical Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Several studies on cheerleading as a sport can be found in the literature; however, there is no research done on the value added to the experience at a university, to an athletic department or at a particular sport. It has been the feeling that collegiate and professional cheerleaders are not given the appropriate recognition nor credit for the amount of work they do. This contribution is sometimes in question as it depends on the school and the sports teams. The benefits are believed to vary based on the university or professional teams. This research investigated how collegiate cheerleaders and dancers add value to the university sport experience. We interviewed key personnel at the university and conference level and polled spectators at sporting events such as basketball and football. We found that the university administration and athletic personnel see the ASU Spirit Squad as value added but spectators had a totally different perspective. The university acknowledges the added value of the Spirit Squad and its necessity. Spectators attend ASU sporting events to support the university and for the entertainment. They enjoy watching the ASU Spirit Squad perform but would continue to attend ASU sporting events even if cheerleaders and dancers were not there.
ContributorsThomas, Jessica Ann (Author) / Wilson, Jeffrey (Thesis director) / Garner, Deana (Committee member) / Department of Supply Chain Management (Contributor) / Department of Marketing (Contributor) / School of Community Resources and Development (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
Problems related to alcohol consumption cause not only extra economic expenses, but are an expense to the health of both drinkers and non-drinkers due to the harm directly and indirectly caused by alcohol consumption. Investigating predictors and reasons for alcohol-related problems is of importance, as alcohol-related problems could be prevented by quitting or limiting consumption of alcohol. We were interested in predicting alcohol-related problems using multiple linear regression and regression trees, and then comparing the regressions to the tree. Impaired control, anxiety sensitivity, mother permissiveness, father permissiveness, gender, and age were included as predictors. The data used was comprised of participants (n=835) sampled from students at Arizona State University. A multiple linear regression without interactions, multiple linear regression with two-way interactions and squares, and a regression tree were used and compared. The regression and the tree had similar results. Multiple interactions of variables predicted alcohol-related problems. Overall, the tree was easier to interpret than the regressions, however, the regressions provided specific predicted alcohol-related problems scores, whereas the tree formed large groups and had a predicted alcohol-related problems score for each group. Nevertheless, the tree still predicted alcohol-related problems nearly as well, if not better than the regressions.
ContributorsVoorhies, Kirsten Reed (Author) / McCulloch, Robert (Thesis director) / Zheng, Yi (Committee member) / Patock-Peckham, Julie (Committee member) / School of Mathematical and Statistical Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Quadratic growth curves of 2nd degree polynomial are widely used in longitudinal studies. For a 2nd degree polynomial, the vertex represents the location of the curve in the XY plane. For a quadratic growth curve, we propose an approximate confidence region as well as the confidence interval for x and y-coordinates of the vertex using two methods, the gradient method and the delta method. Under some models, an indirect test on the location of the curve can be based on the intercept and slope parameters, but in other models, a direct test on the vertex is required. We present a quadratic-form statistic for a test of the null hypothesis that there is no shift in the location of the vertex in a linear mixed model. The statistic has an asymptotic chi-squared distribution. For 2nd degree polynomials of two independent samples, we present an approximate confidence region for the difference of vertices of two quadratic growth curves using the modified gradient method and delta method. Another chi-square test statistic is derived for a direct test on the vertex and is compared to an F test statistic for the indirect test. Power functions are derived for both the indirect F test and the direct chi-square test. We calculate the theoretical power and present a simulation study to investigate the power of the tests. We also present a simulation study to assess the influence of sample size, measurement occasions and nature of the random effects. The test statistics will be applied to the Tell Efficacy longitudinal study, in which sound identification scores and language protocol scores for children are modeled as quadratic growth curves for two independent groups, TELL and control curriculum. The interpretation of shift in the location of the vertices is also presented.
ContributorsYu, Wanchunzi (Author) / Reiser, Mark R. (Thesis advisor) / Barber, Jarrett (Committee member) / Kao, Ming-Hung (Committee member) / St Louis, Robert D (Committee member) / Wilson, Jeffrey (Committee member) / Arizona State University (Publisher)
Created2015
Description
The Pearson and likelihood ratio statistics are commonly used to test goodness-of-fit for models applied to data from a multinomial distribution. When data are from a table formed by cross-classification of a large number of variables, the common statistics may have low power and inaccurate Type I error level due to sparseness in the cells of the table. The GFfit statistic can be used to examine model fit in subtables. It is proposed to assess model fit by using a new version of GFfit statistic based on orthogonal components of Pearson chi-square as a diagnostic to examine the fit on two-way subtables. However, due to variables with a large number of categories and small sample size, even the GFfit statistic may have low power and inaccurate Type I error level due to sparseness in the two-way subtable. In this dissertation, the theoretical power and empirical power of the GFfit statistic are studied. A method based on subsets of orthogonal components for the GFfit statistic on the subtables is developed to improve the performance of the GFfit statistic. Simulation results for power and type I error rate for several different cases along with comparisons to other diagnostics are presented.
ContributorsZhu, Junfei (Author) / Reiser, Mark R. (Thesis advisor) / Stufken, John (Committee member) / Zheng, Yi (Committee member) / St Louis, Robert (Committee member) / Kao, Ming-Hung (Committee member) / Arizona State University (Publisher)
Created2017