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- All Subjects: Middle-aged persons--Psychology.
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Description
Understanding how adherence affects outcomes is crucial when developing and assigning interventions. However, interventions are often evaluated by conducting randomized experiments and estimating intent-to-treat effects, which ignore actual treatment received. Dose-response effects can supplement intent-to-treat effects when participants are offered the full dose but many only receive a partial dose due to nonadherence. Using these data, we can estimate the magnitude of the treatment effect at different levels of adherence, which serve as a proxy for different levels of treatment. In this dissertation, I conducted Monte Carlo simulations to evaluate when linear dose-response effects can be accurately and precisely estimated in randomized experiments comparing a no-treatment control condition to a treatment condition with partial adherence. Specifically, I evaluated the performance of confounder adjustment and instrumental variable methods when their assumptions were met (Study 1) and when their assumptions were violated (Study 2). In Study 1, the confounder adjustment and instrumental variable methods provided unbiased estimates of the dose-response effect across sample sizes (200, 500, 2,000) and adherence distributions (uniform, right skewed, left skewed). The adherence distribution affected power for the instrumental variable method. In Study 2, the confounder adjustment method provided unbiased or minimally biased estimates of the dose-response effect under no or weak (but not moderate or strong) unobserved confounding. The instrumental variable method provided extremely biased estimates of the dose-response effect under violations of the exclusion restriction (no direct effect of treatment assignment on the outcome), though less severe violations of the exclusion restriction should be investigated.
ContributorsMazza, Gina L (Author) / Grimm, Kevin J. (Thesis advisor) / West, Stephen G. (Thesis advisor) / Mackinnon, David P (Committee member) / Tein, Jenn-Yun (Committee member) / Arizona State University (Publisher)
Created2018
Description
The comparison of between- versus within-person relations addresses a central issue in psychological research regarding whether group-level relations among variables generalize to individual group members. Between- and within-person effects may differ in magnitude as well as direction, and contextual multilevel models can accommodate this difference. Contextual multilevel models have been explicated mostly for cross-sectional data, but they can also be applied to longitudinal data where level-1 effects represent within-person relations and level-2 effects represent between-person relations. With longitudinal data, estimating the contextual effect allows direct evaluation of whether between-person and within-person effects differ. Furthermore, these models, unlike single-level models, permit individual differences by allowing within-person slopes to vary across individuals. This study examined the statistical performance of the contextual model with a random slope for longitudinal within-person fluctuation data.
A Monte Carlo simulation was used to generate data based on the contextual multilevel model, where sample size, effect size, and intraclass correlation (ICC) of the predictor variable were varied. The effects of simulation factors on parameter bias, parameter variability, and standard error accuracy were assessed. Parameter estimates were in general unbiased. Power to detect the slope variance and contextual effect was over 80% for most conditions, except some of the smaller sample size conditions. Type I error rates for the contextual effect were also high for some of the smaller sample size conditions. Conclusions and future directions are discussed.
A Monte Carlo simulation was used to generate data based on the contextual multilevel model, where sample size, effect size, and intraclass correlation (ICC) of the predictor variable were varied. The effects of simulation factors on parameter bias, parameter variability, and standard error accuracy were assessed. Parameter estimates were in general unbiased. Power to detect the slope variance and contextual effect was over 80% for most conditions, except some of the smaller sample size conditions. Type I error rates for the contextual effect were also high for some of the smaller sample size conditions. Conclusions and future directions are discussed.
ContributorsWurpts, Ingrid Carlson (Author) / Mackinnon, David P (Thesis advisor) / West, Stephen G. (Committee member) / Grimm, Kevin J. (Committee member) / Suk, Hye Won (Committee member) / Arizona State University (Publisher)
Created2016
Description
Time-to-event analysis or equivalently, survival analysis deals with two variables simultaneously: when (time information) an event occurs and whether an event occurrence is observed or not during the observation period (censoring information). In behavioral and social sciences, the event of interest usually does not lead to a terminal state such as death. Other outcomes after the event can be collected and thus, the survival variable can be considered as a predictor as well as an outcome in a study. One example of a case where the survival variable serves as a predictor as well as an outcome is a survival-mediator model. In a single survival-mediator model an independent variable, X predicts a survival variable, M which in turn, predicts a continuous outcome, Y. The survival-mediator model consists of two regression equations: X predicting M (M-regression), and M and X simultaneously predicting Y (Y-regression). To estimate the regression coefficients of the survival-mediator model, Cox regression is used for the M-regression. Ordinary least squares regression is used for the Y-regression using complete case analysis assuming censored data in M are missing completely at random so that the Y-regression is unbiased. In this dissertation research, different measures for the indirect effect were proposed and a simulation study was conducted to compare performance of different indirect effect test methods. Bias-corrected bootstrapping produced high Type I error rates as well as low parameter coverage rates in some conditions. In contrast, the Sobel test produced low Type I error rates as well as high parameter coverage rates in some conditions. The bootstrap of the natural indirect effect produced low Type I error and low statistical power when the censoring proportion was non-zero. Percentile bootstrapping, distribution of the product and the joint-significance test showed best performance. Statistical analysis of the survival-mediator model is discussed. Two indirect effect measures, the ab-product and the natural indirect effect are compared and discussed. Limitations and future directions of the simulation study are discussed. Last, interpretation of the survival-mediator model for a made-up empirical data set is provided to clarify the meaning of the quantities in the survival-mediator model.
ContributorsKim, Han Joe (Author) / Mackinnon, David P. (Thesis advisor) / Tein, Jenn-Yun (Thesis advisor) / West, Stephen G. (Committee member) / Grimm, Kevin J. (Committee member) / Arizona State University (Publisher)
Created2017
Description
Currently, there is a clear gap in the missing data literature for three-level models.
To date, the literature has only focused on the theoretical and algorithmic work
required to implement three-level imputation using the joint model (JM) method of
imputation, leaving relatively no work done on fully conditional specication (FCS)
method. Moreover, the literature lacks any methodological evaluation of three-level
imputation. Thus, this thesis serves two purposes: (1) to develop an algorithm in
order to implement FCS in the context of a three-level model and (2) to evaluate
both imputation methods. The simulation investigated a random intercept model
under both 20% and 40% missing data rates. The ndings of this thesis suggest
that the estimates for both JM and FCS were largely unbiased, gave good coverage,
and produced similar results. The sole exception for both methods was the slope for
the level-3 variable, which was modestly biased. The bias exhibited by the methods
could be due to the small number of clusters used. This nding suggests that future
research ought to investigate and establish clear recommendations for the number of
clusters required by these imputation methods. To conclude, this thesis serves as a
preliminary start in tackling a much larger issue and gap in the current missing data
literature.
To date, the literature has only focused on the theoretical and algorithmic work
required to implement three-level imputation using the joint model (JM) method of
imputation, leaving relatively no work done on fully conditional specication (FCS)
method. Moreover, the literature lacks any methodological evaluation of three-level
imputation. Thus, this thesis serves two purposes: (1) to develop an algorithm in
order to implement FCS in the context of a three-level model and (2) to evaluate
both imputation methods. The simulation investigated a random intercept model
under both 20% and 40% missing data rates. The ndings of this thesis suggest
that the estimates for both JM and FCS were largely unbiased, gave good coverage,
and produced similar results. The sole exception for both methods was the slope for
the level-3 variable, which was modestly biased. The bias exhibited by the methods
could be due to the small number of clusters used. This nding suggests that future
research ought to investigate and establish clear recommendations for the number of
clusters required by these imputation methods. To conclude, this thesis serves as a
preliminary start in tackling a much larger issue and gap in the current missing data
literature.
ContributorsKeller, Brian Tinnell (Author) / Enders, Craig K. (Thesis advisor) / Grimm, Kevin J. (Committee member) / Levy, Roy (Committee member) / Arizona State University (Publisher)
Created2015
Description
Interpersonal strain is linked with depressive symptoms in middle-aged adults. Self-compassion is an emerging resilience construct that may be advantageous in navigating relationship strain by helping individuals respond to emotions in a kind and nonjudgmental way. Although theory and empirical evidence suggests that self-compassion is protective against the impact of stress on mental health outcomes, many studies have not investigated how self-compassion operates in the context of relationship strain. In addition, few studies have examined psychological or physiological mechanisms by which self-compassion protects against mental health outcomes, depression in particular. Thus, this study examined 1) the extent to which trait self-compassion buffers the relation between family strain and depressive symptoms, and 2) whether these buffering effects are mediated by hope and inflammatory processes (IL-6) in a sample of 762 middle-aged, community-dwelling adults. Results from structural equation models indicated that family strain was unrelated to depressive symptoms and the relation was not moderated by self-compassion. Hope, but not IL-6, mediated the relation between family strain and depressive symptoms and the indirect effect was not conditional on levels of self-compassion. Taken together, the findings suggest that family strain may lead individuals to experience less hope and subsequent increases in depressive symptoms, and further, that a self-compassionate attitude does not affect this relation. Implications for future self-compassion interventions are discussed.
ContributorsMistretta, Erin (Author) / Davis, Mary C. (Thesis advisor) / Karoly, Paul (Committee member) / Infurna, Frank (Committee member) / Arizona State University (Publisher)
Created2019
Description
Lifespan psychological perspectives have long suggested the context in which individuals live having the potential to shape the course of development across the adult lifespan. Thus, it is imperative to examine the role of both the objective and subjective neighborhood context in mitigating the consequences of lifetime adversity on mental and physical health. To address the research questions, data was used from a sample of 362 individuals in midlife who were assessed on lifetime adversity, multiple outcomes of mental and physical health and aspects of the objective and subjective neighborhood. Results showed that reporting more lifetime adversity was associated with poorer mental and physical health. Aspects of the objective and subjective neighborhood, such as green spaces moderated these relationships. The discussion focuses on potential mechanisms underlying why objective and subjective indicators of the neighborhood are protective against lifetime adversity.
ContributorsStaben, Omar E (Author) / Infurna, Frank J. (Thesis advisor) / Luthar, Suniya S. (Committee member) / Grimm, Kevin J. (Committee member) / Arizona State University (Publisher)
Created2019