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- All Subjects: Statistics
- All Subjects: spatial statistics
- Creators: Fotheringham, A. Stewart
- Creators: Zhou, Shuang
- Member of: ASU Electronic Theses and Dissertations
grass) offers unique opportunities to mitigate climate change through avoided fossil fuel use and associated greenhouse gas reduction. Although conversion of existing agriculturally intensive lands (e.g., maize and soy) to perennial bioenergy cropping systems has been shown to reduce near-surface temperatures, unintended consequences on natural water resources via depletion of soil moisture may offset these benefits. In the effort of the cross-fertilization across the disciplines of physics-based modeling and spatio-temporal statistics, three topics are investigated in this dissertation aiming to provide a novel quantification and robust justifications of the hydroclimate impacts associated with bioenergy crop expansion. Topic 1 quantifies the hydroclimatic impacts associated with perennial bioenergy crop expansion over the contiguous United States using the Weather Research and Forecasting Model (WRF) dynamically coupled to a land surface model (LSM). A suite of continuous (2000–09) medium-range resolution (20-km grid spacing) ensemble-based simulations is conducted. Hovmöller and Taylor diagrams are utilized to evaluate simulated temperature and precipitation. In addition, Mann-Kendall modified trend tests and Sieve-bootstrap trend tests are performed to evaluate the statistical significance of trends in soil moisture differences. Finally, this research reveals potential hot spots of suitable deployment and regions to avoid. Topic 2 presents spatio-temporal Bayesian models which quantify the robustness of control simulation bias, as well as biofuel impacts, using three spatio-temporal correlation structures. A hierarchical model with spatially varying intercepts and slopes display satisfactory performance in capturing spatio-temporal associations. Simulated temperature impacts due to perennial bioenergy crop expansion are robust to physics parameterization schemes. Topic 3 further focuses on the accuracy and efficiency of spatial-temporal statistical modeling for large datasets. An ensemble of spatio-temporal eigenvector filtering algorithms (hereafter: STEF) is proposed to account for the spatio-temporal autocorrelation structure of the data while taking into account spatial confounding. Monte Carlo experiments are conducted. This method is then used to quantify the robustness of simulated hydroclimatic impacts associated with bioenergy crops to alternative physics parameterizations. Results are evaluated against those obtained from three alternative Bayesian spatio-temporal specifications.
The first topic is a Mixed Effects Transfer Learning (METL) model that can flexibly incorporate mixed effects and a general-form covariance matrix to better account for similarity and heterogeneity across subjects. I further develop computationally efficient procedures to handle unknown parameters and large covariance structures. Domain relations, such as domain similarity and domain covariance structure, are automatically quantified in the estimation steps. I demonstrate METL in an application of smartphone-based telemonitoring of PD.
The second topic focuses on an MRI-based transfer learning algorithm for non-invasive surgical guidance of glioblastoma patients. Limited biopsy samples per patient create a challenge to build a patient-specific model for glioblastoma. A transfer learning framework helps to leverage other patient’s knowledge for building a better predictive model. When modeling a target patient, not every patient’s information is helpful. Deciding the subset of other patients from which to transfer information to the modeling of the target patient is an important task to build an accurate predictive model. I define the subset of “transferrable” patients as those who have a positive rCBV-cell density correlation, because a positive correlation is confirmed by imaging theory and the its respective literature.
The last topic is a Privacy-Preserving Positive Transfer Learning (P3TL) model. Although negative transfer has been recognized as an important issue by the transfer learning research community, there is a lack of theoretical studies in evaluating the risk of negative transfer for a transfer learning method and identifying what causes the negative transfer. My work addresses this issue. Driven by the theoretical insights, I extend Bayesian Parameter Transfer (BPT) to a new method, i.e., P3TL. The unique features of P3TL include intelligent selection of patients to transfer in order to avoid negative transfer and maintain patient privacy. These features make P3TL an excellent model for telemonitoring of PD using an At-Home Testing Device.
The main objective of this work is to investigate and improve measurement policies on the basis of quality control in the transduction/expansion bio-manufacturing processes. More specifically, this study addresses the issue of measuring yield within the transduction/expansion phases of gene therapy. To do so, it was decided to model the process as a Markov Decision Process where the decisions being made are optimally chosen to create an overall optimal measurement policy; for a set of predefined parameters.
Embedded within the regression framework, local models can estimate conditioned relationships between observed spatial phenomena and hypothesized explanatory variables and help infer the intangible spatial processes that contribute to the observed spatial patterns. Rather than investigating averaged characteristics corresponding to processes over space as global models do, these models estimate a surface of spatially varying parameters with a value for each location. Additionally, some models such as variants within the Geographically Weighted Regression (GWR) framework, also estimate a parameter to represent the spatial scale across which the processes vary representing the inherent heterogeneity of the estimated surfaces. Since different processes tend to operate at unique spatial scales, some extensions to local models such as Multiscale GWR (MGWR) estimate unique scales of association for each predictor in a model and generate significantly more information on the nature of geographic processes than their predecessors. However, developments within the realm of local models are fairly nascent and hence an understanding around their correct application as well as recognizing their true potential in exploring fundamental spatial science issues is under-developed. The techniques within these frameworks are also currently limited thus restricting the kinds of data that can be analyzed using these models. Therefore the goal of this dissertation is to advance techniques within local multiscale modeling specifically by coining new diagnostics, exploring their novel application in understanding long-standing issues concerning spatial scale and by expanding the tool base to allow their use in wider empirical applications. This goal is realized through three distinct research objectives over four chapters, followed by a discussion on the future of the developments within local multiscale modeling. A correct understanding of the capability and promise of local multiscale models and expanding the fields where they can be employed will not only enhance geographical research by strengthening the intuition of the nature of geographic processes, but will also exemplify the importance and need for using such tools bringing quantitative spatial science to the fore.