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Is it possible to treat the mouth as a natural environment, and determine new methods to keep the microbiome in check? The need for biodiversity in health may suggest that every species carries out a specific function that is required to maintain equilibrium and homeostasis within the oral cavity. Furthermore,

Is it possible to treat the mouth as a natural environment, and determine new methods to keep the microbiome in check? The need for biodiversity in health may suggest that every species carries out a specific function that is required to maintain equilibrium and homeostasis within the oral cavity. Furthermore, the relationship between the microbiome and its host is mutually beneficial because the host is providing microbes with an environment in which they can flourish and, in turn, keep their host healthy. Reviewing examples of larger scale environmental shifts could provide a window by which scientists can make hypotheses. Certain medications and healthcare treatments have been proven to cause xerostomia. This disorder is characterized by a dry mouth, and known to be associated with a change in the composition, and reduction, of saliva. Two case studies performed by Bardow et al, and Leal et al, tested and studied the relationships of certain medications and confirmed their side effects on the salivary glands [2,3]. Their results confirmed a relationship between specific medicines, and the correlating complaints of xerostomia. In addition, Vissink et al conducted case studies that helped to further identify how radiotherapy causes hyposalivation of the salivary glands [4]. Specifically patients that have been diagnosed with oral cancer, and are treated by radiotherapy, have been diagnosed with xerostomia. As stated prior, studies have shown that patients having an ecologically balanced and diverse microbiome tend to have healthier mouths. The oral cavity is like any biome, consisting of commensalism within itself and mutualism with its host. Due to the decreased salivary output, caused by xerostomia, increased parasitic bacteria build up within the oral cavity thus causing dental disease. Every human body contains a personalized microbiome that is essential to maintaining health but capable of eliciting disease. The Human Oral Microbiomics Database (HOMD) is a set of reference 16S rRNA gene sequences. These are then used to define individual human oral taxa. By conducting metagenomic experiments at the molecular and cellular level, scientists can identify and label micro species that inhabit the mouth during parasitic outbreaks or a shifting of the microbiome. Because the HOMD is incomplete, so is our ability to cure, or prevent, oral disease. The purpose of the thesis is to research what is known about xerostomia and its effects on the complex microbiome of the oral cavity. It is important that researchers determine whether this particular perspective is worth considering. In addition, the goal is to create novel experiments for treatment and prevention of dental diseases.
ContributorsHalcomb, Michael Jordan (Author) / Chen, Qiang (Thesis director) / Steele, Kelly (Committee member) / Barrett, The Honors College (Contributor) / College of Letters and Sciences (Contributor)
Created2015-05
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In a cross memoir and essay format, I examine what connection barriers veterans face when communicating with civilians. I interviewed veterans after adapting an interview schedule and model release form. Additionally, I researched creative nonfiction, guided autobiography, and Posttraumatic Stress Disorder. I chose to focus mainly on soldiers returning from

In a cross memoir and essay format, I examine what connection barriers veterans face when communicating with civilians. I interviewed veterans after adapting an interview schedule and model release form. Additionally, I researched creative nonfiction, guided autobiography, and Posttraumatic Stress Disorder. I chose to focus mainly on soldiers returning from recent conflicts. Once I collected my interviews, I synthesized the stories I heard with personal memoir. The thesis focuses on three parts: coming home, communication barriers, and connection. Weaving in both my personal reflection and the voices of the soldiers I interviewed, I evaluate possible ways veterans and civilians fail to connect. I address the discrepancy between the apparent warm reception of soldiers and the feelings of disconnection soldiers express by noting the ways in which both the solider and the civilian struggle to communicate. Looking at reintegration struggles, I briefly note the transition difficulty post deployment soldiers face. From the responses I received, I reflect on how empty gestures, perceived ignorance, and an outsider effect contribute to communication barriers between soldiers and veterans. While I address how ignorance can be broken down into misunderstanding military jargon, detaching from war, hearing euphemisms, and having expectations, I also consider the ways in which situation and vagueness surrounding the war contribute to communication barriers surrounding perceived ignorance. From my reflection of communication barriers, I offer tools for soldiers and veterans making connections. I recommend that both soldiers and civilians stay informed about the military engagements as best they can, deconstruct expectations and generalizations, use empathy and active listening, and start being direct. Knowing the nuanced complexity of war and communication, I weave in my own reflections in contribution to the larger conversation.
ContributorsFletcher, Jessica Marie (Author) / Wells, Cornelia (Thesis director) / deLusé, Stephanie (Committee member) / Department of Psychology (Contributor) / Department of English (Contributor) / College of Letters and Sciences (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05