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Evaluating the viability of a DNA-based chip targeted for C. trachomatis, N. gonorrhoeae, and other pathogens of interest

Description
Sexually transmitted diseases like gonorrhea and chlamydia, standardly treated with antibiotics, produce over 1.2 million cases annually in the emergency department (Jenkins et al., 2013). To determine a need for antibiotics, hospital labs utilize bacterial cultures to isolate and identify possible pathogens. Unfortunately, this technique can take up to 72…

Sexually transmitted diseases like gonorrhea and chlamydia, standardly treated with antibiotics, produce over 1.2 million cases annually in the emergency department (Jenkins et al., 2013). To determine a need for antibiotics, hospital labs utilize bacterial cultures to isolate and identify possible pathogens. Unfortunately, this technique can take up to 72 hours, leading to several physicians presumptively treating patients based solely on history and physical presentation. With vague standards for diagnosis and a high percentage of asymptomatic carriers, several patients undergo two scenarios; over- or under-treatment. These two scenarios can lead to consequences like unnecessary exposure to antibiotics and development of secondary conditions (for example: pelvic inflammatory disease, infertility, etc.). This presents a need for a laboratory technique that can provide reliable results in an efficient matter. The viability of DNA-based chip targeted for C. trachomatis, N. gonorrhoeae, and other pathogens of interest were evaluated. The DNA-based chip presented several advantages as it can be easily integrated as a routine test given the process is already well-known, is customizable and able to target multiple pathogens within a single test and has the potential to return results within a few hours as opposed to days. As such, implementation of a DNA-based chip as a diagnostic tool is a timely and potentially impactful investigation.
ContributorsCharoenmins, Patherica (Author) / Penton, Christopher (Thesis director) / Moore, Marianne (Committee member) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
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The Art of Healing

Description
Art is an ancient, personal, and cultural phenomenon used to convey human creativity and emotion. Dating back as early as 40,000 years in Indonesian cave paintings, this medium has been used to record stories, histories, and shape cultural opinion throughout the history of mankind. While we have witnessed the rise…

Art is an ancient, personal, and cultural phenomenon used to convey human creativity and emotion. Dating back as early as 40,000 years in Indonesian cave paintings, this medium has been used to record stories, histories, and shape cultural opinion throughout the history of mankind. While we have witnessed the rise and fall of types of art in popular culture and traditions, the core of art remains the same, which is to express the imagery within the human mind into a tangible form. As such, this allows for the candid acknowledgement and projection of an individual’s state of being into a productive, expressive skill which reaps therapeutic benefits.
ContributorsMahmud, Aysha (Co-author) / Shahid, Marija (Co-author) / Button, Melissa (Thesis director) / Moore, Marianne (Committee member) / School of Art (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05