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The FDA-approved drug bexarotene has been predominantly utilized for the treatment of cutaneous T-cell lymphoma (CTLC), but has shown promise as an off label treatment for various other cancers as well as Alzheimer's disease (AD). However, harmful side effects such as hypothyroidism have catalyzed a search for alternative rexinoids which

The FDA-approved drug bexarotene has been predominantly utilized for the treatment of cutaneous T-cell lymphoma (CTLC), but has shown promise as an off label treatment for various other cancers as well as Alzheimer's disease (AD). However, harmful side effects such as hypothyroidism have catalyzed a search for alternative rexinoids which retain similar levels of RXR agonism while reducing the undesirable effects incurred by bexarotene. This honors thesis outlines the steps taken to design and synthesize novel analogues of the selective retinoid-X-receptor (RXR) agonist 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene). Corresponding NMR spectra indicates the successful construction of four novel compounds which are structurally similar to known, biologically-evaluated rexinoids that have induced fewer side effects while stimulating greater levels of RXR selectivity as compared to bexarotene. Future In vitro analyses of these four analogues coupled with the recognized efficacy of their parent compounds demonstrate the chemotherapeutic potential of structurally modified bexarotene analogues

ContributorsDavidson, Jesse Raymond (Author) / Wagner, Carl (Thesis director) / Ball, Rebecca (Committee member) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Lutein and zeaxanthin are two important carotenoid vitamins related to ocular health and human visual processing. These vitamins can be ingested through supplementation and in regular diet. They concentrate in the central retina where they form a filter of macular pigment and protect the eye from high energy blue and

Lutein and zeaxanthin are two important carotenoid vitamins related to ocular health and human visual processing. These vitamins can be ingested through supplementation and in regular diet. They concentrate in the central retina where they form a filter of macular pigment and protect the eye from high energy blue and yellow light. We examined participants who had a natural diet of high vs low lutein and zeaxanthin intake on tests of contrast sensitivity and glare disability. We also examined participant performance while wearing blue light blocking glasses in order to determine whether these glasses serve a similar protective function as macular pigment in benefiting participants on contrast sensitivity and glare disability tasks. Most of our data did not show statistically significant differences between the high and low lutein and zeaxanthin groups. An unexpected result that the blue blocker glasses hindered the ability of low lutein participants on their glare disability test was observed. We hypothesize that this is due to light scatter produced by the by glasses resulting in an impoverish retinal image reaching the primary visual cortex. Further research is required to examine this new finding.
ContributorsHormann, Breanna Susanne (Author) / Holloway, Steven (Thesis director) / Náñez Sr., José E (Committee member) / School of Mathematical and Natural Sciences (Contributor) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
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Throughout the year I had the opportunity to work on a business venture that utilized dendrites as a unique identifier. Dendrites themselves are completely unique, random, branching structures that occur everywhere in nature. This creative project was inspired by the shape of the dendrite and I created a series of

Throughout the year I had the opportunity to work on a business venture that utilized dendrites as a unique identifier. Dendrites themselves are completely unique, random, branching structures that occur everywhere in nature. This creative project was inspired by the shape of the dendrite and I created a series of 12 paintings reflecting on my own unique college journey.

ContributorsMann, Abigail (Author) / Trujillo, Rhett (Thesis director) / Reeves, James (Committee member) / Barrett, The Honors College (Contributor) / School of Humanities, Arts, and Cultural Studies (Contributor) / School of Mathematical and Natural Sciences (Contributor)
Created2022-05