As life expectancy increases worldwide, age related diseases are becoming greater health concerns. One of the most prevalent age-related diseases in the United States is dementia, with Alzheimer’s disease (AD) being the most common form, accounting for 60-80% of cases. Genetics plays a large role in a person’s risk of developing AD. Familial AD, which makes up less than 1% of all AD cases, is caused by autosomal dominant gene mutations and has almost 100% penetrance. Genetic risk factors are believed to make up about 49%-79% of the risk in sporadic cases. Many different genetic risk factors for both familial and sporadic AD have been identified, but there is still much work to be done in the field of AD, especially in non-Caucasian populations. This review summarizes the three major genes responsible for familial AD, namely APP, PSEN1 and PSEN2. Also discussed are seven identified genetic risk factors for sporadic AD, single nucleotide polymorphisms in the APOE, ABCA7, NEDD9, CASS4, PTK2B, CLU, and PICALM genes. An overview of the main function of the proteins associated with the genes is given, along with the supposed connection to AD pathology.

Suicide is one of the leading causes of death worldwide and statistical analysis of suicide by profession reveals that physicians and veterinarians experience abnormally high suicide rates. This paper seeks to provide a comprehensive literature review over what some general theories of suicide are, why these professions exhibit high suicide rates, what assistance is currently being provided, and where do these assistance efforts succeed or fail. Moreover, this paper addresses what advancements may be made within these fields to further combat suicide in physicians and veterinarians. To achieve this, general theories behind suicide, risk factors unique to or heavily prevalent in these professions, and current assistance efforts are read, organized, and summarized.<br/><br/>A summary of these risk factors includes stress and mental health disorders accumulated through school and work, personal and professional isolation, access to lethal substances, suicide contagion, exposure to euthanasia, and the role of perfectionism. There are several assistance efforts in place with the most successful ones being highly personalized, but many are still underutilized. Moreover, the stigma of suicide pervades these professions and is addressed by several researchers as something to combat or prevent. Going forward, it is hopeful that not only will more assistance efforts will be created and provided for physicians and veterinarians suffering from suicidal tendencies, but efforts to reduce the stigma of suicide be implemented and utilized as soon as possible.

As it currently stands, there are many barriers preventing racial minority students from being accepted into medical school at the same rates as their White peers. This has broad reaching effects that shape how medicine is practiced. In order to help mitigate this issue, different schools and medical groups have begun to develop programs designed to assist students in being accepted into medical school. In this literature review, I further examine these programs by selecting 12 articles to further examine the programs they mentioned. From this examination, trends in the types of programs and the target demographics emerged. The types of programs included academic enrichment, research and lab exposure, mentorship, admissions preparation, counseling, postbaccalaureate or master’s programs, pre-entrance, and recruitment programs. Target demographics varied in age which affected the format of the program. Analyzing different programs revealed the ways in which minority students are currently being assisted and that there is no current standardized measure of the effectiveness of these programs. It will be important to determine effectiveness in order to eliminate these disparities which will be crucial in reducing health disparities nationally.

In this study I hope to begin evaluating contemporary young adult literature that focuses on the bereavement of adolescents to see if the novels portray psychologically proven productive coping methods. I hope to initiate a conversation around how complicated bereavement is depicted within young adult literature that will establish a body of research that can be expanded into a further exploration into the young adult literature market. Within my study, I will conduct a psychological literature review on young adult complicated grief and coping mechanisms. Then I will create an instrument of analysis, a rubric/model to evaluate the fidelity of novels based on the research within the literature review. Finally, I will evaluate the depiction of productive adolescent grief coping mechanisms in the recently published novel All My Rage by Saaba Tahir based upon my literary model. Finally, I will write my own short story based upon my research and findings in analyzing the model, seeking to represent methods not seen in the literature or not discussed within research.

The North American deer mouse, Peromyscus maniculatus, is the most widespread mammal on the continent. It is of interest to the public health sector as a known host of several viruses which are transmissible to humans and can cause illness, including the acute respiratory disease Hantavirus Pulmonary Syndrome (HPS). This paper seeks to conduct a systematic review of existing literature on virus detection in wild P. maniculatus in order to develop an understanding of virus prevalence and distribution and identify potential areas of further research. Through the analysis of 22 studies published since 2010, it was found that detection effort has been concentrated on the American West with a focus on the spread of Sin Nombre virus, the causative agent of HPS. There are significant gaps in the existing literature both geographically and in regards to the types of viruses being sampled. Moving forward, a systematic approach to widespread sampling should be developed in order to better identify and minimize potential threats to human health.

This paper analyses key papers in audience cost literature and proposes a direction forward in audience cost literature by examining how an audience gets influenced and or how the audience's preferences are created. The paper posits that by looking at how audiences are influenced a leader's decision structure can be further clarified. The paper places an emphasis on how information and agenda-setting are crucial to developing a framework for the task of elucidating audience costs.