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- All Subjects: Biomedical Engineering
- Genre: Academic theses
Description
Concussion, a subset of mild traumatic brain injury (mTBI), has recently been brought to the forefront of the media due to a large lawsuit filed against the National Football League. Concussion resulting from injury varies in severity, duration, and type, based on many characteristics about the individual that research does not presently understand. Chronic fatigue, poor working memory, impaired self-awareness, and lack of attention to task are symptoms commonly present post-concussion. Currently, there is not a standard method of assessing concussion, nor is there a way to track an individual's recovery, resulting in misguided treatment for better prognosis. The aim of the following study was to determine patient specific higher-order cognitive processing deficits for clinical diagnosis and prognosis of concussion. Six individuals (N=6) were seen during the acute phase of concussion, two of whom were seen subsequently when their symptoms were deemed clinically resolved. Subjective information was collected from both the patient and from neurology testing. Each individual completed a task, in which they were presented with degraded speech, taxing their higher-order cognitive processing. Patient specific behavioral patterns are noted, creating a unique paradigm for mapping subjective and objective data for each patient's strategy to compensate for deficits and understand speech in a difficult listening situation. Keywords: concussion, cognitive processing
ContributorsBerg, Dena (Author) / Liss, Julie M (Committee member) / Azuma, Tamiko (Committee member) / Caviness, John (Committee member) / Arizona State University (Publisher)
Created2013
Description
The recent spotlight on concussion has illuminated deficits in the current standard of care with regard to addressing acute and persistent cognitive signs and symptoms of mild brain injury. This stems, in part, from the diffuse nature of the injury, which tends not to produce focal cognitive or behavioral deficits that are easily identified or tracked. Indeed it has been shown that patients with enduring symptoms have difficulty describing their problems; therefore, there is an urgent need for a sensitive measure of brain activity that corresponds with higher order cognitive processing. The development of a neurophysiological metric that maps to clinical resolution would inform decisions about diagnosis and prognosis, including the need for clinical intervention to address cognitive deficits. The literature suggests the need for assessment of concussion under cognitively demanding tasks. Here, a joint behavioral- high-density electroencephalography (EEG) paradigm was employed. This allows for the examination of cortical activity patterns during speech comprehension at various levels of degradation in a sentence verification task, imposing the need for higher-order cognitive processes. Eight participants with concussion listened to true-false sentences produced with either moderately to highly intelligible noise-vocoders. Behavioral data were simultaneously collected. The analysis of cortical activation patterns included 1) the examination of event-related potentials, including latency and source localization, and 2) measures of frequency spectra and associated power. Individual performance patterns were assessed during acute injury and a return visit several months following injury. Results demonstrate a combination of task-related electrophysiology measures correspond to changes in task performance during the course of recovery. Further, a discriminant function analysis suggests EEG measures are more sensitive than behavioral measures in distinguishing between individuals with concussion and healthy controls at both injury and recovery, suggesting the robustness of neurophysiological measures during a cognitively demanding task to both injury and persisting pathophysiology.
ContributorsUtianski, Rene (Author) / Liss, Julie M (Thesis advisor) / Berisha, Visar (Committee member) / Caviness, John N (Committee member) / Dorman, Michael (Committee member) / Arizona State University (Publisher)
Created2014
Description
Head movement is known to have the benefit of improving the accuracy of sound localization for humans and animals. Marmoset is a small bodied New World monkey species and it has become an emerging model for studying the auditory functions. This thesis aims to detect the horizontal and vertical rotation of head movement in marmoset monkeys.
Experiments were conducted in a sound-attenuated acoustic chamber. Head movement of marmoset monkey was studied under various auditory and visual stimulation conditions. With increasing complexity, these conditions are (1) idle, (2) sound-alone, (3) sound and visual signals, and (4) alert signal by opening and closing of the chamber door. All of these conditions were tested with either house light on or off. Infra-red camera with a frame rate of 90 Hz was used to capture of the head movement of monkeys. To assist the signal detection, two circular markers were attached to the top of monkey head. The data analysis used an image-based marker detection scheme. Images were processed using the Computation Vision Toolbox in Matlab. The markers and their positions were detected using blob detection techniques. Based on the frame-by-frame information of marker positions, the angular position, velocity and acceleration were extracted in horizontal and vertical planes. Adaptive Otsu Thresholding, Kalman filtering and bound setting for marker properties were used to overcome a number of challenges encountered during this analysis, such as finding image segmentation threshold, continuously tracking markers during large head movement, and false alarm detection.
The results show that the blob detection method together with Kalman filtering yielded better performances than other image based techniques like optical flow and SURF features .The median of the maximal head turn in the horizontal plane was in the range of 20 to 70 degrees and the median of the maximal velocity in horizontal plane was in the range of a few hundreds of degrees per second. In comparison, the natural alert signal - door opening and closing - evoked the faster head turns than other stimulus conditions. These results suggest that behaviorally relevant stimulus such as alert signals evoke faster head-turn responses in marmoset monkeys.
Experiments were conducted in a sound-attenuated acoustic chamber. Head movement of marmoset monkey was studied under various auditory and visual stimulation conditions. With increasing complexity, these conditions are (1) idle, (2) sound-alone, (3) sound and visual signals, and (4) alert signal by opening and closing of the chamber door. All of these conditions were tested with either house light on or off. Infra-red camera with a frame rate of 90 Hz was used to capture of the head movement of monkeys. To assist the signal detection, two circular markers were attached to the top of monkey head. The data analysis used an image-based marker detection scheme. Images were processed using the Computation Vision Toolbox in Matlab. The markers and their positions were detected using blob detection techniques. Based on the frame-by-frame information of marker positions, the angular position, velocity and acceleration were extracted in horizontal and vertical planes. Adaptive Otsu Thresholding, Kalman filtering and bound setting for marker properties were used to overcome a number of challenges encountered during this analysis, such as finding image segmentation threshold, continuously tracking markers during large head movement, and false alarm detection.
The results show that the blob detection method together with Kalman filtering yielded better performances than other image based techniques like optical flow and SURF features .The median of the maximal head turn in the horizontal plane was in the range of 20 to 70 degrees and the median of the maximal velocity in horizontal plane was in the range of a few hundreds of degrees per second. In comparison, the natural alert signal - door opening and closing - evoked the faster head turns than other stimulus conditions. These results suggest that behaviorally relevant stimulus such as alert signals evoke faster head-turn responses in marmoset monkeys.
ContributorsSimhadri, Sravanthi (Author) / Zhou, Yi (Thesis advisor) / Turaga, Pavan (Thesis advisor) / Berisha, Visar (Committee member) / Arizona State University (Publisher)
Created2014
Description
Through decades of clinical progress, cochlear implants have brought the world of speech and language to thousands of profoundly deaf patients. However, the technology has many possible areas for improvement, including providing information of non-linguistic cues, also called indexical properties of speech. The field of sensory substitution, providing information relating one sense to another, offers a potential avenue to further assist those with cochlear implants, in addition to the promise they hold for those without existing aids. A user study with a vibrotactile device is evaluated to exhibit the effectiveness of this approach in an auditory gender discrimination task. Additionally, preliminary computational work is included that demonstrates advantages and limitations encountered when expanding the complexity of future implementations.
ContributorsButts, Austin McRae (Author) / Helms Tillery, Stephen (Thesis advisor) / Berisha, Visar (Committee member) / Buneo, Christopher (Committee member) / McDaniel, Troy (Committee member) / Arizona State University (Publisher)
Created2015
Description
Motion estimation is a core task in computer vision and many applications utilize optical flow methods as fundamental tools to analyze motion in images and videos. Optical flow is the apparent motion of objects in image sequences that results from relative motion between the objects and the imaging perspective. Today, optical flow fields are utilized to solve problems in various areas such as object detection and tracking, interpolation, visual odometry, etc. In this dissertation, three problems from different areas of computer vision and the solutions that make use of modified optical flow methods are explained.
The contributions of this dissertation are approaches and frameworks that introduce i) a new optical flow-based interpolation method to achieve minimally divergent velocimetry data, ii) a framework that improves the accuracy of change detection algorithms in synthetic aperture radar (SAR) images, and iii) a set of new methods to integrate Proton Magnetic Resonance Spectroscopy (1HMRSI) data into threedimensional (3D) neuronavigation systems for tumor biopsies.
In the first application an optical flow-based approach for the interpolation of minimally divergent velocimetry data is proposed. The velocimetry data of incompressible fluids contain signals that describe the flow velocity. The approach uses the additional flow velocity information to guide the interpolation process towards reduced divergence in the interpolated data.
In the second application a framework that mainly consists of optical flow methods and other image processing and computer vision techniques to improve object extraction from synthetic aperture radar images is proposed. The proposed framework is used for distinguishing between actual motion and detected motion due to misregistration in SAR image sets and it can lead to more accurate and meaningful change detection and improve object extraction from a SAR datasets.
In the third application a set of new methods that aim to improve upon the current state-of-the-art in neuronavigation through the use of detailed three-dimensional (3D) 1H-MRSI data are proposed. The result is a progressive form of online MRSI-guided neuronavigation that is demonstrated through phantom validation and clinical application.
The contributions of this dissertation are approaches and frameworks that introduce i) a new optical flow-based interpolation method to achieve minimally divergent velocimetry data, ii) a framework that improves the accuracy of change detection algorithms in synthetic aperture radar (SAR) images, and iii) a set of new methods to integrate Proton Magnetic Resonance Spectroscopy (1HMRSI) data into threedimensional (3D) neuronavigation systems for tumor biopsies.
In the first application an optical flow-based approach for the interpolation of minimally divergent velocimetry data is proposed. The velocimetry data of incompressible fluids contain signals that describe the flow velocity. The approach uses the additional flow velocity information to guide the interpolation process towards reduced divergence in the interpolated data.
In the second application a framework that mainly consists of optical flow methods and other image processing and computer vision techniques to improve object extraction from synthetic aperture radar images is proposed. The proposed framework is used for distinguishing between actual motion and detected motion due to misregistration in SAR image sets and it can lead to more accurate and meaningful change detection and improve object extraction from a SAR datasets.
In the third application a set of new methods that aim to improve upon the current state-of-the-art in neuronavigation through the use of detailed three-dimensional (3D) 1H-MRSI data are proposed. The result is a progressive form of online MRSI-guided neuronavigation that is demonstrated through phantom validation and clinical application.
ContributorsKanberoglu, Berkay (Author) / Frakes, David (Thesis advisor) / Turaga, Pavan (Thesis advisor) / Spanias, Andreas (Committee member) / Berisha, Visar (Committee member) / Arizona State University (Publisher)
Created2018
Description
Machine learning (ML) has played an important role in several modern technological innovations and has become an important tool for researchers in various fields of interest. Besides engineering, ML techniques have started to spread across various departments of study, like health-care, medicine, diagnostics, social science, finance, economics etc. These techniques require data to train the algorithms and model a complex system and make predictions based on that model. Due to development of sophisticated sensors it has become easier to collect large volumes of data which is used to make necessary hypotheses using ML. The promising results obtained using ML have opened up new opportunities of research across various departments and this dissertation is a manifestation of it. Here, some unique studies have been presented, from which valuable inference have been drawn for a real-world complex system. Each study has its own unique sets of motivation and relevance to the real world. An ensemble of signal processing (SP) and ML techniques have been explored in each study. This dissertation provides the detailed systematic approach and discusses the results achieved in each study. Valuable inferences drawn from each study play a vital role in areas of science and technology, and it is worth further investigation. This dissertation also provides a set of useful SP and ML tools for researchers in various fields of interest.
ContributorsDutta, Arindam (Author) / Bliss, Daniel W (Thesis advisor) / Berisha, Visar (Committee member) / Richmond, Christ (Committee member) / Corman, Steven (Committee member) / Arizona State University (Publisher)
Created2018