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Description
There is a high demand for customized designs of various types of cement-based materials in order to address specific purposes in the construction field. These demands stem from the need to optimize the cementitious matrix properties and reinforcement choices, especially in high reliability, durability, and performance applications that include infrastructure,

There is a high demand for customized designs of various types of cement-based materials in order to address specific purposes in the construction field. These demands stem from the need to optimize the cementitious matrix properties and reinforcement choices, especially in high reliability, durability, and performance applications that include infrastructure, energy production, commercial buildings, and may ultimately be extended to low risk/high volume applications such as residential applications. The typical tools required to guide practicing engineers should be based on optimization algorithms that require highly efficient capacity and design alternatives and optimal computational tools. The general case of flexural design of members is an important aspect of design of structural members which can be extended to a variety of applications that include various cross-sections such as rectangular, W-sections, channels, angles, and T sections. The model utilized the simplified linear constitutive response of cement-based composite in compression and tension and extends into a two-segment elastic-plastic, strain softening, hardening, tension-stiffening, and a multi-segment system. The generalized parametric model proposed uses a dimensionless system in the stress-strain materials diagram to formulate piecewise equations for an equilibrium of internal stresses and obtains strain distributions for the closed-form solution of neutral axis location. This would allow for the computation of piecewise moment-curvature response. The number of linear residual stress implemented is flexible to a user to maintain a robust response. In the present approach bilinear, trilinear, and quad-linear models are addressed and a procedure for incorporating additional segments is presented. Moreover, a closed-form solution of moment-curvature can be solved and employed in calculating load-deflection response. The model is adaptable for various types of fiber-reinforced and textile reinforced concrete (FRC, TRC, UHPC, AAC, and Reinforced Concrete). The extensions to cover continuous fiber reinforcement such as textile reinforced concrete (TRC, FRCM) strengthening and repair are addressed. The theoretical model is extended to incorporate the hybrid design (HRC) with continuous rebar with FRC to increase the ductility and ultimate moment capacity. HRC extends the performance of the fiber system to incorporate residual capacity into a serviceability-based design that reduced the reliance on the design based on the limit state. The design chart for HRC and as well as conventional RC has been generated for practicing engineering applications. Results are compared to a large array of data from experimental results conducted at the ASU structural lab facilities and other published literature.
Contributorspleesudjai, chidchanok (Author) / Mobasher, Barzin (Thesis advisor) / Neithalath, Narayanan (Committee member) / Rajan, Subramaniam (Committee member) / Arizona State University (Publisher)
Created2021
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Description
In the structural engineering industry, the design of structures typically follows a prescriptive approach in which engineers conform to a series of code requirements that stipulate the design process. Prescriptive design is tested, reliable, and understood by practically every structural engineer in the industry; however, in recent history a new

In the structural engineering industry, the design of structures typically follows a prescriptive approach in which engineers conform to a series of code requirements that stipulate the design process. Prescriptive design is tested, reliable, and understood by practically every structural engineer in the industry; however, in recent history a new method of design has started to gain traction among certain groups of engineers. Performance-based design is a reversal of the prescriptive approach in that it allows engineers to set performance goals and work to prove that their proposed designs meet the criteria they have established. To many, it is an opportunity for growth in the structural design industry. Currently, performance-based design is most commonly utilized in regions where seismic activity plays an important role in the design process. Due to its flexible nature, performance-based design has proven extremely useful when applied to unique structures such as high-rises, stadiums, and other community-centric designs. With a focus placed on performance objectives and not on current code prescriptions, engineers utilizing performance-based design are more adept to implement new materials, design processes, and construction methods, and can more efficiently design their structures to exist on a specific area of land. Despite these many cited benefits, performance-based design is still considered an uncommon practice in the broad view of structural design. In order to ensure that structural engineers have the proper tools to practice performance-based design in instances where they see fit, a coordinated effort will be required of the engineers themselves, the firms of which they are employed, the professional societies to which they belong, and the educators who are preparing their next generation. Performance-based design holds with it the opportunity to elevate the role of the structural engineer to which they are informed members of the community, where the structures they create not only perform according to design prescriptions, but also perform according to the needs of the owners, engineers, and society.
ContributorsMaurer, Cole (Author) / Hjelmstad, Keith (Thesis advisor) / Chatziefstratiou, Efthalia (Committee member) / Dusenberry, Donald (Committee member) / Arizona State University (Publisher)
Created2021
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Description
The construction industry requires effective communication between project stakeholders in various locations. This communication can be facilitated through in person site visits or phone calls, but these methods can also lead to wasted travel time and misunderstandings from omitting critical site details, respectively. Theoretically, Augmented Reality (AR) can be as

The construction industry requires effective communication between project stakeholders in various locations. This communication can be facilitated through in person site visits or phone calls, but these methods can also lead to wasted travel time and misunderstandings from omitting critical site details, respectively. Theoretically, Augmented Reality (AR) can be as effective as in person site meetings. The vast majority of studies that have explored AR, for communication, have done so in controlled environments. This work investigates the efficacy of AR calls in uncontrolled settings (i.e., construction sites), by interviewing practitioner participants to identify common beneficial and detrimental behaviors and perceptions. Furthermore, the author examines the factors that might impact exchanges between people using AR as a tool of communication. The combination of these findings concludes that AR is effective in supporting remote communication between multiple locations. The contribution of this work is in documenting the challenges and opportunities of using AR in a live construction environment, where factors may be present that have not yet been studied by researchers exploring AR in a controlled setting. This contribution will guide subsequent academic research, as well as practical adoption of emerging AR tools in the industry.
ContributorsKassis, Rita (Author) / El Asmar, Mounir ME (Thesis advisor) / Ayer, Steven SA (Thesis advisor) / Parrish, kristen KP (Committee member) / Arizona State University (Publisher)
Created2021
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Description
Stroke occurs when the blood supply to part of the brain is interrupted or reduced, preventing brain tissue from getting oxygen and nutrients, thus causing brain cells to die. Stroke is the 5th leading cause of death in the United States and is one of the major causes of disability.

Stroke occurs when the blood supply to part of the brain is interrupted or reduced, preventing brain tissue from getting oxygen and nutrients, thus causing brain cells to die. Stroke is the 5th leading cause of death in the United States and is one of the major causes of disability. Conventional therapy is a form of stroke rehabilitation generally consisting of physical and occupational therapy. It focuses on customized exercises based on the patient’s feedback. Physical therapy includes exercises such as weight bearing (affected arm), vibration of affected muscle and gravity-eliminated movement of affected arm. Overall physical therapy aims at strengthening muscle groups and aides in the relearning process. Occupational aspect of conventional therapy includes activities of daily living (ADL) such as dressing, self-feeding, grooming and toileting. Overall occupational therapy focuses on improving the daily activities performed by individuals. In comparison to conventional therapy, robotic therapy is relatively newer therapy. It uses robotic devices to perform repetitive motions and delivers high dosage and high intensity training to stroke patients. Based on the research studies reviewed, it is known that neuroplasticity in stroke patients is linked to interventions which are high in dosage, intensity, repetition, difficulty, salience. Peer-reviewed literature suggests robotic therapy might be a viable option for recovery in stroke patients. However, the extent to which robotic therapy may provide greater benefits than conventional therapy remains unclear. This thesis addresses the key components of a study design for comparing the efficacy of robotic therapy relative to conventional therapy to improve upper limb sensorimotor function in stroke survivors. The study design is based on an extensive review of the literature of stroke clinical trials and robotic therapy studies, analyses of the capabilities of a robotic therapy device (M2, Fourier Intelligence), and pilot data collected on healthy controls to create a pipeline of tasks and analyses to extract biomarkers of sensorimotor functional changes. This work has laid the foundation for a pilot longitudinal study that will be conducted at the Barrow Neurological Institute, Phoenix, AZ, where conventional and robotic therapy will be compared in a small cohort of stroke survivors.
ContributorsThomas, Lovein (Author) / Santello, Marco (Thesis advisor) / Kleim, Jeffrey (Committee member) / Maruyama, Trent (Committee member) / Arizona State University (Publisher)
Created2021
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Description
Iodine and silver ions (Ag+), added as silver fluoride (AgF) or silver nitrate (AgNO3), are currently being used as a biocide to control the spread of bacteria in the water storage tanks of the International Space Station (ISS). Due to the complications of the iodine system, NASA is interested to

Iodine and silver ions (Ag+), added as silver fluoride (AgF) or silver nitrate (AgNO3), are currently being used as a biocide to control the spread of bacteria in the water storage tanks of the International Space Station (ISS). Due to the complications of the iodine system, NASA is interested to completely replace iodine with silver and apply it as an antibacterial surface coating on stainless steel (SS) surfaces for biofouling control in extended space missions. However, Ag+ is highly soluble and rapidly dissolves in water, as a result, the coated surface loses its antibacterial properties. The dissolution of NPs into Ag+ and subsequent solubilization reduces its effectivity or extended period application. This study focuses on the in-situ nucleation of silver nanoparticles (AgNP) on stainless steel followed by their partial passivation by the formation of a low solubility silver sulfide (Ag2S), silver bromide (AgBr), and silver iodide (AgI) shell with various concentrations for an increased long-term biofouling performance and a slower silver release over time. Antibacterial activity was evaluated using Pseudomonas aeruginosa. The highest bacterial inactivation (up to 75%) occurred with sulfidized AgNPs as opposed to bromidized (up to 50%) and iodized NPs (up to 60%). Surface analysis by scanning electron microscopy (SEM) showed considerably fewer particles on AgBr and AgI compared to Ag2S-coated samples. Silver iodide was not tested in additional experiments due to its drawbacks and its poor antibacterial performance compared to sulfidized samples. Compared to pristine AgNPs, Ag release from both sulfidized and bromidized NPs was significantly low (16% vs 6% or less) depending on the extent of sulfidation or bromidation. Experiments were also carried out to investigate the effect of passivation on biofilm formation. Biofilm growth was smaller on surfaces treated with 10-3 M Na2S and 10-3 M NaBr compared to the surface of pristine AgNPs. Overall, sulfidation appears to be the most effective option to control biofilm formation on stainless steel. However, future research is needed to verify the effectiveness of sulfidized AgNPs on other metals including Inconel 718 and Titanium 6Al-4V used in the spacecraft potable water systems.
ContributorsRanjbari, Kiarash (Author) / Perreault, Francois (Thesis advisor) / Abbaszadegan, Morteza (Committee member) / Islam, Mohammed R (Committee member) / Arizona State University (Publisher)
Created2021
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Description
Interictal spikes - transient bursts of neuronal depolarization observed between epileptic seizures - are typically regarded as a sign of epilepsy and have been used in the localization of seizure onsets. Interictal spikes are thought to arise primarily from large excitatory postsynaptic potentials (EPSPs), although not much is known about

Interictal spikes - transient bursts of neuronal depolarization observed between epileptic seizures - are typically regarded as a sign of epilepsy and have been used in the localization of seizure onsets. Interictal spikes are thought to arise primarily from large excitatory postsynaptic potentials (EPSPs), although not much is known about the precise role they play in epilepsy. Here the in vivo spatiotemporal dynamics of sequences of interictal spikes in a small (4mm x 4mm) patch of the cortex of a patient with intractable epilepsy is studied. In conjunction with this, the impact on action potential generation and firing of local voltage changes due to paroxysmal depolarizations similar to interictal spikes was also evaluated in vitro using resected neural tissue from an epileptic human neocortex. Sequences of interictal spikes were found to consistently propagate in a direction-specific manner across the neocortex. In addition to this, bursts of action potentials from the ex vivo samples underwent variable degrees of depolarization-induced inactivation. Intracellular recordings in neocortical slices of human brain tissue confirmed that bursts of inactivated action potentials occurred during spontaneous paroxysmal depolarization shifts. These ex vivo findings showed inactivated action potentials being generated by large depolarizations. The results suggest the existence of an aberrantly strong synchronization among neuronal populations in the epileptic cortex, triggered or enhanced by interictal spike depolarization and propagation. This supports a key element in the hypothesis that interictal spikes, and the associated alteration of action potential firing patterns, may alter the electrical environment of the brain and contribute to the progression of the underlying idiopathic seizure disorder.
ContributorsFoli, Crispin (Author) / Greger, Bradley B. G. (Thesis advisor) / Tsakalis, Konstantinos K.T. (Committee member) / Muthuswamy, Jitendran J.M. (Committee member) / Arizona State University (Publisher)
Created2021
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Description
Magnetic resonance imaging (MRI) is a noninvasive imaging modality, which is used for many different applications. The versatility of MRI is in acquiring high resolution anatomical and functional images with no use of ionizing radiation. The contrast in MR images can be engineered by two different mechanisms with imaging parameters

Magnetic resonance imaging (MRI) is a noninvasive imaging modality, which is used for many different applications. The versatility of MRI is in acquiring high resolution anatomical and functional images with no use of ionizing radiation. The contrast in MR images can be engineered by two different mechanisms with imaging parameters (TR, TE, α) and/or contrast agents. The contrast in the former is influenced by the intrinsic properties of the tissue (T1, T2, ρ), while the contrast agents change the relaxation rate of the protons to enhance contrast. Contrast agents have attracted a lot of attention because they can be modified with targeting groups to shed light on some physiological and biological questions, such as the presence of hypoxia in a tissue. Hypoxia, defined as lack of oxygen, has many known ramifications on the outcome of therapy in any condition. Hence its study is very important. The standard gold method to detect hypoxia, immunohistochemical (IHC) staining of pimonidazole, is invasive; however, there are many research groups focused on developing new and mainly noninvasive methods to investigate hypoxia in different tissues.Previously, a novel nitroimidazole-based T1 contrast agent, gadolinium tetraazacyclododecanetetraacetic acid monoamide conjugate of 2-nitroimidazole (GdDO3NI ), has been synthesized and characterized on subcutaneous prostate and lung tumor models. Here, its efficacy and performance on traumatic brain injuries and brain tumors are studied. The pharmacokinetic properties of the contrast agent the perfusion properties of brain tumors are investigated. These results can be used in personalized therapies for more effective results for patients. Gadolinium (Gd), which is a strongly paramagnetic heavy metal, is routinely and widely used as an MR contrast agent by chelation with a biocompatible ligand which is typically cleared through the kidneys. While widely used, there are serious concerns for patients with impaired kidney function, as well as recent studies showed Gd accumulation in the bone and brain. Iron as a physiological ion is also capable of generating contrast in MR images. Here synthesis and characterization of an iron-based hypoxia targeting contrast agent is proposed to eliminate Gd-related complications and provide a cheaper and more economical alternative contrast agent to detect hypoxia.
ContributorsMoghadas, Babak (Author) / Kodibagkar, Vikram D (Thesis advisor) / Beeman, Scott (Committee member) / Muthuswamy, Jitendran (Committee member) / Nikkhah, Mehdi (Committee member) / Turner, Gregory (Committee member) / Arizona State University (Publisher)
Created2021
Description
Layer-wise extrusion of soft-solid like cement pastes and mortars is commonly used in 3D printing of concrete. Rheological and mechanical characterization of the printable binder for on-demand flow and subsequent structuration is a critical challenge. This research is an effort to understand the mechanics of cementitious binders as soft solids

Layer-wise extrusion of soft-solid like cement pastes and mortars is commonly used in 3D printing of concrete. Rheological and mechanical characterization of the printable binder for on-demand flow and subsequent structuration is a critical challenge. This research is an effort to understand the mechanics of cementitious binders as soft solids in the fresh state, towards establishing material-process relationships to enhance print quality. This study introduces 3D printable binders developed based on rotational and capillary rheology test parameters, and establish the direct influence of packing coefficients, geometric ratio, slip velocities, and critical print velocities on the extrudate quality. The ratio of packing fraction to the square of average particle diameter (0.01-0.02), and equivalent microstructural index (5-20) were suitable for printing, and were directly related to the cohesion and extrusional yield stress of the material. In fact, steady state pressure for printing (30-40 kPa) is proportional to the extrusional yield stress, and increases with the geometric ratio (0-60) and print velocity (5-50 mm/s). Higher print velocities results in higher wall shear stresses and was exponentially related to the slip layer thickness (estimated between 1-5μ), while the addition of superplasticizers improve the slip layer thickness and the extrudate flow. However, the steady state pressure and printer capacity limits the maximum print velocity while the deadzone length limits the minimum velocity allowable (critical velocity regime) for printing. The evolution of buildability with time for the fresh state mortars was characterized with digital image correlation using compressive strain and strain rate in printed layers. The fresh state characteristics (interlayer and interfilamentous) and process parameters (layer height and fiber dimensions) influence the hardened mechanical properties. A lower layer height generally improves the mechanical properties and slight addition of fiber (up to 0.3% by volume) results in a 15-30% increase in the mechanical properties. 3D scanning and point-cloud analysis was also used to assess the geometric tolerance of a print based on mean error distances, print accuracy index, and layer-wise percent overlap. The research output will contribute to a synergistic material-process design and development of test methods for printability in the context of 3D printing of concrete.
ContributorsAmbadi Omanakuttan Nair, Sooraj Kumar (Author) / Neithalath, Narayanan (Thesis advisor) / Rajan, Subramaniam (Committee member) / Mobasher, Barzin (Committee member) / Hoover, Christian (Committee member) / Chawla, Nikhilesh (Committee member) / Arizona State University (Publisher)
Created2021
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Description
Systematic Reviews (SRs) aim to synthesize the totality of evidence for clinical practice and are important in making clinical practice guidelines and health policy decisions. However, conducting SRs manually is a laborious and time-consuming process. This challenge is growing due to the increase in the number of databases to search

Systematic Reviews (SRs) aim to synthesize the totality of evidence for clinical practice and are important in making clinical practice guidelines and health policy decisions. However, conducting SRs manually is a laborious and time-consuming process. This challenge is growing due to the increase in the number of databases to search and the papers being published. Hence, the automation of SRs is an essential task. The goal of this thesis work is to develop Natural Language Processing (NLP)-based classifiers to automate the title and abstract-based screening for clinical SRs based on inclusion/exclusion criteria. In clinical SRs, a high-sensitivity system is a key requirement. Most existing methods for SRs use binary classification systems trained on labeled data to predict inclusion/exclusion. While previous studies have shown that NLP-based classification methods can automate title and abstract-based screening for SRs, methods for achieving high-sensitivity have not been empirically studied. In addition, the training strategy for binary classification has several limitations: (1) it ignores the inclusion/exclusion criteria, (2) lacks generalization ability, (3) suffers from low resource data, and (4) fails to achieve reasonable precision at high-sensitivity levels. This thesis work presents contributions to several aspects of the clinical systematic review domain. First, it presents an empirical study of NLP-based supervised text classification and high-sensitivity methods on datasets developed from six different SRs in the clinical domain. Second, this thesis work provides a novel approach to view SR as a Question Answering (QA) problem in order to overcome the limitations of the binary classification training strategy; and propose a more general abstract screening model for different SRs. Finally, this work provides a new QA-based dataset for six different SRs which is made available to the community.
ContributorsParmar, Mihir Prafullsinh (Author) / Baral, Chitta (Thesis advisor) / Devarakonda, Murthy (Thesis advisor) / Riaz, Irbaz B (Committee member) / Arizona State University (Publisher)
Created2021
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Description
This thesis provides evidence that China has maximized building infrastructure byseeking new ways to utilize underground space. China is a shining example of how integrating underground space will improve quality of life, transportation, entertainment centers, and national safety. China is rethinking how they develop its cities by creating tunnels, commercial buildings, parking lots,

This thesis provides evidence that China has maximized building infrastructure byseeking new ways to utilize underground space. China is a shining example of how integrating underground space will improve quality of life, transportation, entertainment centers, and national safety. China is rethinking how they develop its cities by creating tunnels, commercial buildings, parking lots, subways, utility service tunnels, military defense bunkers, and storage facilities underground. Hundreds of kilometers of tunnels alleviate China’s growing traffic congestion problem, to help with vehicle congestion, other means of transportation are created like subway systems that sprawl underneath the city. Commercial buildings can be built underground to maximize the vertical growth of businesses in a city. A high number of personal vehicles means cities have to increase the availability of parking spaces, with underground parking garages, space can be maximized to hold hundreds of cars underground while maintaining commercial buildings above ground. The ease of having a central utility tunnel that houses all the utilities in one place is how China is forward-thinking of the maintenance of their future cities. As China grows, they must be prepared to protect their citizens and leaders so they store their most important military equipment underground so they can keep them secure. As a way of reusing old dried-up oil wells, natural gas is stored underground to mitigate risk and cut down on costs for storage facilities. China has made significant strides to ensure a bright future for its citizens, with the utilization of underground space, China maximizes productivity and quality of life for its people.
ContributorsWu, Binqing (Author) / Ariaratnam, Samuel SA (Thesis advisor) / Chong, Oswald OS (Committee member) / Czerniawski, Thomas TC (Committee member) / Arizona State University (Publisher)
Created2021