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Experiments were conducted in a sound-attenuated acoustic chamber. Head movement of marmoset monkey was studied under various auditory and visual stimulation conditions. With increasing complexity, these conditions are (1) idle, (2) sound-alone, (3) sound and visual signals, and (4) alert signal by opening and closing of the chamber door. All of these conditions were tested with either house light on or off. Infra-red camera with a frame rate of 90 Hz was used to capture of the head movement of monkeys. To assist the signal detection, two circular markers were attached to the top of monkey head. The data analysis used an image-based marker detection scheme. Images were processed using the Computation Vision Toolbox in Matlab. The markers and their positions were detected using blob detection techniques. Based on the frame-by-frame information of marker positions, the angular position, velocity and acceleration were extracted in horizontal and vertical planes. Adaptive Otsu Thresholding, Kalman filtering and bound setting for marker properties were used to overcome a number of challenges encountered during this analysis, such as finding image segmentation threshold, continuously tracking markers during large head movement, and false alarm detection.
The results show that the blob detection method together with Kalman filtering yielded better performances than other image based techniques like optical flow and SURF features .The median of the maximal head turn in the horizontal plane was in the range of 20 to 70 degrees and the median of the maximal velocity in horizontal plane was in the range of a few hundreds of degrees per second. In comparison, the natural alert signal - door opening and closing - evoked the faster head turns than other stimulus conditions. These results suggest that behaviorally relevant stimulus such as alert signals evoke faster head-turn responses in marmoset monkeys.
The contributions of this dissertation are approaches and frameworks that introduce i) a new optical flow-based interpolation method to achieve minimally divergent velocimetry data, ii) a framework that improves the accuracy of change detection algorithms in synthetic aperture radar (SAR) images, and iii) a set of new methods to integrate Proton Magnetic Resonance Spectroscopy (1HMRSI) data into threedimensional (3D) neuronavigation systems for tumor biopsies.
In the first application an optical flow-based approach for the interpolation of minimally divergent velocimetry data is proposed. The velocimetry data of incompressible fluids contain signals that describe the flow velocity. The approach uses the additional flow velocity information to guide the interpolation process towards reduced divergence in the interpolated data.
In the second application a framework that mainly consists of optical flow methods and other image processing and computer vision techniques to improve object extraction from synthetic aperture radar images is proposed. The proposed framework is used for distinguishing between actual motion and detected motion due to misregistration in SAR image sets and it can lead to more accurate and meaningful change detection and improve object extraction from a SAR datasets.
In the third application a set of new methods that aim to improve upon the current state-of-the-art in neuronavigation through the use of detailed three-dimensional (3D) 1H-MRSI data are proposed. The result is a progressive form of online MRSI-guided neuronavigation that is demonstrated through phantom validation and clinical application.
This paper serves to report the research performed towards detecting PD and the effects of medication through the use of machine learning and finger tapping data collected through mobile devices. The primary objective for this research is to prototype a PD classification model and a medication classification model that predict the following: the individual’s disease status and the medication intake time relative to performing the finger-tapping activity, respectively.
This paper serves to report the research performed towards detecting PD and the effects of medication through the use of machine learning and finger tapping data collected through mobile devices. The primary objective for this research is to prototype a PD classification model and a medication classification model that predict the following: the individual’s disease status and the medication intake time relative to performing the finger-tapping activity, respectively.