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Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost the immune system. Bex has been shown to be effective

Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost the immune system. Bex has been shown to be effective in the treatment of multiple types of cancer, including lung cancer. However, the disadvantages of using Bex include increased instances of hypothyroidism and excessive concentrations of blood triglycerides. If an analog of Bex can be developed which retains high affinity RXR binding similar to the 9-cis retinoic acid while exhibiting less interference for heterodimerization pathways, it would be of great clinical significance in improving the quality of life for patients with CTCL. This thesis will detail the biological profiling of additional novel (Generation Two) analogs, which are currently in submission for publication, as well as that of Generation Three analogs. The results from these studies reveal that specific alterations in the core structure of the Bex "parent" compound structure can have dramatic effects in modifying the biological activity of RXR agonists.
ContributorsYang, Joanna (Author) / Jurutka, Peter (Thesis director) / Wagner, Carl (Committee member) / Hibler, Elizabeth (Committee member) / Barrett, The Honors College (Contributor)
Created2012-05
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Description
This is an exploratory study that describes the activities of the Chive community as a popular religion. Using utilize Shan Suttons' framework from The Deadhead Community (2000) and Howard Beckers Jazz Places, I use categories of Community, Cultus, Creed, and Code as ways to explore describe the Chive community's activities

This is an exploratory study that describes the activities of the Chive community as a popular religion. Using utilize Shan Suttons' framework from The Deadhead Community (2000) and Howard Beckers Jazz Places, I use categories of Community, Cultus, Creed, and Code as ways to explore describe the Chive community's activities and how they are similar to the popular religion, the Deadheads. Chive people maintain a sense of community that operates online with social media sites like Facebook and Twitter where they began to connect with one another, offline in the form of Meet-ups, and charity drives, and in the fabric between these events of the shared consciousness that takes place among Chivers and Chivettes. Through participant observations, interviews with Chive chapter administrators, and survey responses, I set out to answer, or get closer to, what it is that leads someone to Chive On.
ContributorsHarrick, Travis Christopher (Author) / Renshaw, Scott (Thesis director) / Keahey, Jennifer (Committee member) / Barrett, The Honors College (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2015-05
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Description
Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor

Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor and in return control cell differentiation and proliferation. Bexarotene targets RXR homodimerization to drive transcription of tumor suppressing genes; however, adverse reactions occur simultaneously when bound to other nuclear receptors. In this study, we used novel bexarotene analogs throughout 5 iterations synthesized in the laboratory of Dr. Wagner to test for their potency and ability to bind RXR. The aim of our study is to quantitatively measure RXR homodimerization driven by bexarotene analogs using a yeast two-hybrid system. Our results suggests there to be several compounds with higher protein activity than bexarotene, particularly in generations 3.0 and 5.0. This higher affinity for RXR homodimers may help scientists identify a compound that will minimize adverse effects and toxicity of bexarotene and serve as a better cancer treatment alternative.
ContributorsSeto, David Hua (Author) / Marshall, Pamela (Thesis director) / Wagner, Carl (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2015-05
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Description
This research explores how to best communicate positive body images to women. This project was intended to improve a blog I created my freshmen year in college called You're Not A Potato where I used original illustrations to tell a narrative about body image issues. The thesis begins with an

This research explores how to best communicate positive body images to women. This project was intended to improve a blog I created my freshmen year in college called You're Not A Potato where I used original illustrations to tell a narrative about body image issues. The thesis begins with an historical overview of body image issues and finds that women have been dealing with high levels of body dissatisfaction since the Victorian era. The thesis then recaps the role of traditional media as well as contemporary social media and the role they play in imposing rigid beauty ideals on women's bodies. After an analysis of social media culture, it becomes evident women still communicate about their bodies in a negative manner, not only towards themselves, but towards others. To address this issue, I define the Body Positive movement and explore how public figures are using social media to implement Body Positivity. To conclude this project, I utilize my new-found knowledge in body positive communication by impacting my university campus community. I started a "You're Not a Potato" Campaign for Body Pride week with the help of the ASU Wellness Team and designed and facilitated several engaging programs that reflected the values of the Body Positive movement to our students. Through this research, I discovered how our appearance-based culture has stolen self-confidence from young women today, but by the end of this project, I explain how we can attempt to rebuild our culture by effectively communicating self-love and body acceptance in our online and physical communities.
ContributorsMouton, Brianna Anais (Author) / Gruber, Diane (Thesis director) / Taylor, Jameien (Committee member) / Manninen, Bertha (Committee member) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
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Description
This study derives from a developmental psychology viewpoint. The main research question is, "What are the effects of social media on children?" Aspects such as bullying, personality changes, and academic performances are considered. This topic is important because it has yet to be explored extensively. Given the ever changing nature

This study derives from a developmental psychology viewpoint. The main research question is, "What are the effects of social media on children?" Aspects such as bullying, personality changes, and academic performances are considered. This topic is important because it has yet to be explored extensively. Given the ever changing nature of social media, it is a challenge to keep up with research on how this technology is changing the direction of society. Studying children involved with social media allows a direct glimpse into what one aspect of the future of child social development holds. The main problem explored in this thesis is whether or not social media is currently affecting children negatively. Correlations will be examined to determine who is most likely to utilize social media, as well as who is most likely to be affected positively or negatively by networking sites. Motivations behind social media usage and time spent online will also be studied. This research is important in understanding today's youth, and once understood, parents and teachers can learn to guide children in using social media for beneficial reasons rather than potentially detrimental ones. I have conducted my research by means of a survey, one in which the entire fifth-grade class at Copper Creek Elementary School partook. Results showed that nearly all surveyed students used social media. Differences in social media usage between classmates based on gender and presence of older siblings were found. It was concluded that social media is affecting fifth-grade females more negatively than fifth-grade males. Also, it was found that children with older siblings may be at risk for using mature social media sites too soon. The long term effects of these findings were not explored, and further research on this subject is encouraged.
ContributorsWilkey, Brooke Nicole (Author) / Lewis, Stephen (Thesis director) / Gaffney, Cynthia (Committee member) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
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Description
Young voters are the future of the country, yet are disengaged and disinterested in politics, leading to low turnout rates. This paper focuses on the Millennial generation, which consists of adults ages 18 to 33, and at times, narrowly focuses on the subset of college students. Since individuals should learn

Young voters are the future of the country, yet are disengaged and disinterested in politics, leading to low turnout rates. This paper focuses on the Millennial generation, which consists of adults ages 18 to 33, and at times, narrowly focuses on the subset of college students. Since individuals should learn about the presidential candidates and the election before casting a vote, I analyze the similarities and differences between receiving election content through television news, a traditional source, compared to social media. Next, I examine the importance of political expression and political discussion, along with how millennials engaging in such activity on social media allows for a deeper level of engagement in elections than what was possible before the birth of social media. Thus, as opposed to focusing on the reasons milllennials shy away from politics, the purpose of the first three chapters is to highlight the potential benefits for using social media during presidential elections. Lastly, I analyze millennials' voting behaviors, particularly the generation's preference for liberal social values. Since we are currently in the 2016 U.S. presidential election season, the purpose of this chapter is to highlight current research regarding millennials' voting patterns, which should then be compared to the future 2016 general election studies. By analyzing consistent and divergent trends, researchers can further add to the discussion of millennials' political behavior. Although I dedicate a brief part to the 2016 presidential election in Chapters 2 through 4 to discuss how trends are similar or different from current research, the overall purpose of this paper is to inform readers about how millennials learn, engage, and participate in presidential elections.
ContributorsLarson, Dakota Alexis Ok-Ran (Author) / Ackroyd, William (Thesis director) / Cisler, Sherry (Committee member) / Department of Management (Contributor) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Description
In 2010, social media, being made available in Arabic, made a large impact in the Middle-East, and social movements throughout several countries exploded from those regions, using the power of social media to their advantage and creating new discussions which were not able to be spoken prior to the introduction

In 2010, social media, being made available in Arabic, made a large impact in the Middle-East, and social movements throughout several countries exploded from those regions, using the power of social media to their advantage and creating new discussions which were not able to be spoken prior to the introduction of social media in Arabic. Besides creating new social movements, social media has resulted in the transformation and evolution of socialization and how people communicate in their daily lives.
Social media changed the system of networks and connectivity, making communication more tenacious, adaptable, and efficient than ever. Social media is often criticized as a reason for why social movements have not met desired results; however, this is not the fault of social media, rather the fault of the disorganization of people. In this essay, these ideas will be explored, and the many criticisms and misconceptions of social media will be addressed and challenged, creating a more realistic image of social movements with the added power of the new technology called social media.
ContributorsMoen, Anders Jacob (Author) / Ackroyd, William (Thesis director) / Keahey, Jennifer (Committee member) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
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Description

This paper analyzes the r/fakedisordercringe subreddit to better understand the purpose of the server as it relates to socially gatekeeping disability, or determining who is legitimately disabled. A mixed-methods analysis is employed using communications, sociology, and psychology theoretical frameworks. Implications discuss disability visibility and other conditions affecting treatment of people

This paper analyzes the r/fakedisordercringe subreddit to better understand the purpose of the server as it relates to socially gatekeeping disability, or determining who is legitimately disabled. A mixed-methods analysis is employed using communications, sociology, and psychology theoretical frameworks. Implications discuss disability visibility and other conditions affecting treatment of people with disabilities.

ContributorsSpencer, Abigail (Author) / Cotton, Cassandra (Thesis director) / Symonds, Adam (Committee member) / Barrett, The Honors College (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2022-05