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- Creators: Harrington Bioengineering Program
- Creators: Department of Information Systems
- Member of: Barrett, The Honors College Thesis/Creative Project Collection
Polymer drug delivery system offers a key to a glaring issue in modern administration routes of drugs and biologics. Poly(lactic-co-glycolic acid) (PLGA) can be used to encapsulate drugs and biologics and deliver them into the patient, which allows high local concentration (compared to current treatment methods), protection of the cargo from the bodily environment, and reduction in systemic side effects. This experiment used a single emulsion technique to encapsulate L-tyrosine in PLGA microparticles and UV spectrophotometry to analyze the drug release over a period of one week. The release assay found that for the tested samples, the released amount is distinct initially, but is about the same after 4 days, and they generally follow the same normalized percent released pattern. The experiment could continue with testing more samples, test the same samples for a longer duration, and look into higher w/w concentrations such as 20% or 50%.
The goal of this research project is to create a Mathcad template file capable of statistically modelling the effects of mean and standard deviation on a microparticle batch characterized by the log normal distribution model. Such a file can be applied during manufacturing to explore tolerances and increase cost and time effectiveness. Theoretical data for the time to 60% drug release and the slope and intercept of the log-log plot were collected and subjected to statistical analysis in JMP. Since the scope of this project focuses on microparticle surface degradation drug release with no drug diffusion, the characteristic variables relating to the slope (n = diffusional release exponent) and the intercept (k = kinetic constant) do not directly apply to the distribution model within the scope of the research. However, these variables are useful for analysis when the Mathcad template is applied to other types of drug release models.
TradeUp is primarily developed to cater to K-12 institutions. This means that a school would purchase a future commercial version of TradeUp. Once this is done a local database would be created in the school’s network and hosted on a server. This would allow for students to access the application by downloading it from the school’s website and would create a local network for the program to exclusively function in. This would allow for students in a school to trade textbooks amongst each other.
TradeUp is currently not available for purchase or for official use. The application is fully functional, and a version of the program can be downloaded in its totality from GitHub through the following link:
https://github.com/mgutie36/TradeUp
It is important to note that for the application to function on your laptop you must be utilizing a Windows machine. Furthermore, you must also utilize the create SQL statements found in “Create.txt” file located in the Bin/Debug folder of the solution in order to create a local database on your machine using Microsoft SQL Server Management Studio. Once that is completed you must replace the connection string in the solution with the connection string that was just created on your machine.