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Description
The primary objective of this research project is to develop dual layered polymeric microparticles with a tunable delayed release profile. Poly(L-lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) phase separate in a double emulsion process due to differences in hydrophobicity, which allows for the synthesis of double-walled microparticles with a PLA

The primary objective of this research project is to develop dual layered polymeric microparticles with a tunable delayed release profile. Poly(L-lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) phase separate in a double emulsion process due to differences in hydrophobicity, which allows for the synthesis of double-walled microparticles with a PLA shell surrounding the PLGA core. The microparticles were loaded with bovine serum albumin (BSA) and different volumes of ethanol were added to the PLA shell phase to alter the porosity and release characteristics of the BSA. Different amounts of ethanol varied the total loading percentage of the BSA, the release profile, surface morphology, size distribution, and the localization of the protein within the particles. Scanning electron microscopy images detailed the surface morphology of the different particles. Loading the particles with fluorescently tagged insulin and imaging the particles through confocal microscopy supported the localization of the protein inside the particle. The study suggest that ethanol alters the release characteristics of the loaded BSA encapsulated in the microparticles supporting the use of a polar, protic solvent as a tool for tuning the delayed release profile of biological proteins.
ContributorsFauer, Chase Alexander (Author) / Stabenfeldt, Sarah (Thesis director) / Ankeny, Casey (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2015-05
Description

The goal of this research project is to create a Mathcad template file capable of statistically modelling the effects of mean and standard deviation on a microparticle batch characterized by the log normal distribution model. Such a file can be applied during manufacturing to explore tolerances and increase cost and

The goal of this research project is to create a Mathcad template file capable of statistically modelling the effects of mean and standard deviation on a microparticle batch characterized by the log normal distribution model. Such a file can be applied during manufacturing to explore tolerances and increase cost and time effectiveness. Theoretical data for the time to 60% drug release and the slope and intercept of the log-log plot were collected and subjected to statistical analysis in JMP. Since the scope of this project focuses on microparticle surface degradation drug release with no drug diffusion, the characteristic variables relating to the slope (n = diffusional release exponent) and the intercept (k = kinetic constant) do not directly apply to the distribution model within the scope of the research. However, these variables are useful for analysis when the Mathcad template is applied to other types of drug release models.

ContributorsHan, Priscilla (Author) / Vernon, Brent (Thesis director) / Nickle, Jacob (Committee member) / Harrington Bioengineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description
TradeUp is a Windows Forms Application written in C# that connects users that want to trade textbooks. The application allows users to list textbooks that they would like to trade for other textbooks. Users can then send and receive negotiation requests. If accepted a new negotiation is opened. This means

TradeUp is a Windows Forms Application written in C# that connects users that want to trade textbooks. The application allows users to list textbooks that they would like to trade for other textbooks. Users can then send and receive negotiation requests. If accepted a new negotiation is opened. This means that the two parties will have access to each other’s contact information so that they can complete the trade in person.

TradeUp is primarily developed to cater to K-12 institutions. This means that a school would purchase a future commercial version of TradeUp. Once this is done a local database would be created in the school’s network and hosted on a server. This would allow for students to access the application by downloading it from the school’s website and would create a local network for the program to exclusively function in. This would allow for students in a school to trade textbooks amongst each other.

TradeUp is currently not available for purchase or for official use. The application is fully functional, and a version of the program can be downloaded in its totality from GitHub through the following link:
https://github.com/mgutie36/TradeUp

It is important to note that for the application to function on your laptop you must be utilizing a Windows machine. Furthermore, you must also utilize the create SQL statements found in “Create.txt” file located in the Bin/Debug folder of the solution in order to create a local database on your machine using Microsoft SQL Server Management Studio. Once that is completed you must replace the connection string in the solution with the connection string that was just created on your machine.
ContributorsGutierrez Barnett, Marco Antonio (Author) / Christopher, Olsen (Thesis director) / Kathleen, Moser (Committee member) / Department of Information Systems (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05