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- All Subjects: Coding
- All Subjects: Microparticles
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- Member of: Barrett, The Honors College Thesis/Creative Project Collection
Description
The primary objective of this research project is to develop dual layered polymeric microparticles with a tunable delayed release profile. Poly(L-lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) phase separate in a double emulsion process due to differences in hydrophobicity, which allows for the synthesis of double-walled microparticles with a PLA shell surrounding the PLGA core. The microparticles were loaded with bovine serum albumin (BSA) and different volumes of ethanol were added to the PLA shell phase to alter the porosity and release characteristics of the BSA. Different amounts of ethanol varied the total loading percentage of the BSA, the release profile, surface morphology, size distribution, and the localization of the protein within the particles. Scanning electron microscopy images detailed the surface morphology of the different particles. Loading the particles with fluorescently tagged insulin and imaging the particles through confocal microscopy supported the localization of the protein inside the particle. The study suggest that ethanol alters the release characteristics of the loaded BSA encapsulated in the microparticles supporting the use of a polar, protic solvent as a tool for tuning the delayed release profile of biological proteins.
ContributorsFauer, Chase Alexander (Author) / Stabenfeldt, Sarah (Thesis director) / Ankeny, Casey (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2015-05
Description
This report is intended to serve as a comprehensive resource for parents, teachers and community members who are interested in learning more about the emergence, direction and scope of the computer science education movement. Many K-12 school districts begun to develop and facilitate their own computer science education programs, often in the form of extracurricular clubs and classes. However, third-party businesses play a significant role in supplementing classrooms with software and hardware products, professional development services, and instruction services. This report explores the complexity of the computer science education environment by exploring the movement of advocacy for increasing computer science in K-12 schools and analyzing the emergent competitive landscape of for-profit and non-profit businesses. Additionally, the report offers insight to the computer science education landscape in Arizona through the lens of the research study "Computer Science Education in Maricopa County Public School Districts for K-8 Students." This study presents the findings from in-depth interviews with educators about how school-based computer science programs are structured and how they are received by students, parents and teachers. The report also offers broad recommendations for school programs, analyzes the potential for a national model, and discusses next steps for states, businesses and individuals. Keywords: computer science education, K-12 schools, public education, coding, Code.org, Hour of Code
ContributorsCampbell, Amy Rose (Author) / Ostrom, Amy (Thesis director) / Giles, Bret (Committee member) / W. P. Carey School of Business (Contributor) / Department of Marketing (Contributor) / Walter Cronkite School of Journalism and Mass Communication (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
The goal of this research project is to create a Mathcad template file capable of statistically modelling the effects of mean and standard deviation on a microparticle batch characterized by the log normal distribution model. Such a file can be applied during manufacturing to explore tolerances and increase cost and time effectiveness. Theoretical data for the time to 60% drug release and the slope and intercept of the log-log plot were collected and subjected to statistical analysis in JMP. Since the scope of this project focuses on microparticle surface degradation drug release with no drug diffusion, the characteristic variables relating to the slope (n = diffusional release exponent) and the intercept (k = kinetic constant) do not directly apply to the distribution model within the scope of the research. However, these variables are useful for analysis when the Mathcad template is applied to other types of drug release models.
ContributorsHan, Priscilla (Author) / Vernon, Brent (Thesis director) / Nickle, Jacob (Committee member) / Harrington Bioengineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
At the University Technology Office – Polytechnic (UTOP), there is no way for managers to efficiently schedule their student workers’ shifts. It is not only difficult to acquire their availability, but also to adjust and schedule time off. The primary goal of this project was to create a software application, or Bot, that allows Slack, the main communication platform at UTOP, to communicate with Google Calendar, the primary scheduling tool for student workers. This results in managers and student workers being able to manage their work schedules more effectively, which catalyzes department productivity and staff availability.
ContributorsTakahashi, Torey Yasuko (Author) / Doheny, Damien (Thesis director) / Burggraff, Jacob (Committee member) / Information Technology (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2020-12