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- All Subjects: Coding
- All Subjects: Microparticles
- Member of: Barrett, The Honors College Thesis/Creative Project Collection
Description
The primary objective of this research project is to develop dual layered polymeric microparticles with a tunable delayed release profile. Poly(L-lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) phase separate in a double emulsion process due to differences in hydrophobicity, which allows for the synthesis of double-walled microparticles with a PLA shell surrounding the PLGA core. The microparticles were loaded with bovine serum albumin (BSA) and different volumes of ethanol were added to the PLA shell phase to alter the porosity and release characteristics of the BSA. Different amounts of ethanol varied the total loading percentage of the BSA, the release profile, surface morphology, size distribution, and the localization of the protein within the particles. Scanning electron microscopy images detailed the surface morphology of the different particles. Loading the particles with fluorescently tagged insulin and imaging the particles through confocal microscopy supported the localization of the protein inside the particle. The study suggest that ethanol alters the release characteristics of the loaded BSA encapsulated in the microparticles supporting the use of a polar, protic solvent as a tool for tuning the delayed release profile of biological proteins.
ContributorsFauer, Chase Alexander (Author) / Stabenfeldt, Sarah (Thesis director) / Ankeny, Casey (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2015-05
Description
The goal of this research project is to create a Mathcad template file capable of statistically modelling the effects of mean and standard deviation on a microparticle batch characterized by the log normal distribution model. Such a file can be applied during manufacturing to explore tolerances and increase cost and time effectiveness. Theoretical data for the time to 60% drug release and the slope and intercept of the log-log plot were collected and subjected to statistical analysis in JMP. Since the scope of this project focuses on microparticle surface degradation drug release with no drug diffusion, the characteristic variables relating to the slope (n = diffusional release exponent) and the intercept (k = kinetic constant) do not directly apply to the distribution model within the scope of the research. However, these variables are useful for analysis when the Mathcad template is applied to other types of drug release models.
ContributorsHan, Priscilla (Author) / Vernon, Brent (Thesis director) / Nickle, Jacob (Committee member) / Harrington Bioengineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
For my creative project, I built a musical robot and explored the possibilities for robots in music education. In addition, I wrote a guide to share what I learned and to provide helpful information to anyone who is planning on building their own musical robot. This is not a step-by-step set of instructions; however, it gives the reader a preview of many options they have for building a musical robot. This guide includes information about existing musical robots, outlines possible strategies for brainstorming ideas, and describes various capabilities of musical robots. While this project focused on the intersection of music and robotics, my approach also included design thinking, which helped provide a focus and shaped my creative process.
The robot building guide is targeted toward an audience with little or no knowledge of robotics. It begins by exploring existing musical robots and explaining how existing products can be used as a source for inspiration. Next, this guide outlines various methods of design thinking and encourages the reader to use design thinking throughout the brainstorming and building process. This guide also highlights options for designing 3D-printed parts, which can be added to a robot. After that, the guide explains options for robot movement, specifically chassis kit assembly and using a 1Sheeld board with Arduino. This guide also explores the possibilities for the interaction of lights and sound, including sound-reactive lights and remote-control lights. Practical information about materials and their organization is provided, as well. The guide concludes with exciting possibilities for robots in music education.
The robot building guide is targeted toward an audience with little or no knowledge of robotics. It begins by exploring existing musical robots and explaining how existing products can be used as a source for inspiration. Next, this guide outlines various methods of design thinking and encourages the reader to use design thinking throughout the brainstorming and building process. This guide also highlights options for designing 3D-printed parts, which can be added to a robot. After that, the guide explains options for robot movement, specifically chassis kit assembly and using a 1Sheeld board with Arduino. This guide also explores the possibilities for the interaction of lights and sound, including sound-reactive lights and remote-control lights. Practical information about materials and their organization is provided, as well. The guide concludes with exciting possibilities for robots in music education.
ContributorsDemassa, Katelyn Debra (Author) / Tobias, Dr. Evan (Thesis director) / Bacalzo, Dean (Committee member) / School of Music (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05