Filtering by
- All Subjects: Machine Learning
- All Subjects: Sensors
- Resource Type: Text
Colorimetric assays are an important tool in point-of-care testing that offers several advantages to traditional testing methods such as rapid response times and inexpensive costs. A factor that currently limits the portability and accessibility of these assays are methods that can objectively determine the results of these assays. Current solutions consist of creating a test reader that standardizes the conditions the strip is under before being measured in some way. However, this increases the cost and decreases the portability of these assays. The focus of this study is to create a machine learning algorithm that can objectively determine results of colorimetric assays under varying conditions. To ensure the flexibility of a model to several types of colorimetric assays, three models were trained on the same convolutional neural network with different datasets. The images these models are trained on consist of positive and negative images of ETG, fentanyl, and HPV Antibodies test strips taken under different lighting and background conditions. A fourth model is trained on an image set composed of all three strip types. The results from these models show it is able to predict positive and negative results to a high level of accuracy.
For each of these cases, I present a feasible image restoration pipeline to correct for their particular limitations. For the pinhole camera, I present an early pipeline to allow for practical pinhole photography by reducing noise levels caused by low-light imaging, enhancing exposure levels, and sharpening the blur caused by the pinhole. For lensless cameras, we explore a neural network architecture that performs joint image reconstruction and point spread function (PSF) estimation to robustly recover images captured with multiple PSFs from different cameras. Using adversarial learning, this approach achieves improved reconstruction results that do not require explicit knowledge of the PSF at test-time and shows an added improvement in the reconstruction model’s ability to generalize to variations in the camera’s PSF. This allows lensless cameras to be utilized in a wider range of applications that require multiple cameras without the need to explicitly train a separate model for each new camera. For UDCs, we utilize a multi-stage approach to correct for low light transmission, blur, and haze. This pipeline uses a PyNET deep neural network architecture to perform a majority of the restoration, while additionally using a traditional optimization approach which is then fused in a learned manner in the second stage to improve high-frequency features. I show results from this novel fusion approach that is on-par with the state of the art.