Matching Items (7)

Filtering by

Clear all filters

134184-Thumbnail Image.png

A Comprehensive Analysis of the Changing Ideological Frameworks Guiding Interpretations of the First, Second and Fourth Amendments, 1776-2017

Description

Historically, Supreme Court interpretations of the Constitution of the United States have been significantly important, impacting the lives of every American. This honors thesis seeks to understand the ways in which the Constitution has been interpreted through the lens of

Historically, Supreme Court interpretations of the Constitution of the United States have been significantly important, impacting the lives of every American. This honors thesis seeks to understand the ways in which the Constitution has been interpreted through the lens of political ideology. Using constitutional theory, I explain how the political ideologies of classical liberalism, conservatism, libertarianism, and progressive liberalism have played a role in the interpretations of the First, Second, and Fourth Amendments. I also examine how these ideological interpretations have changed from 1776 to 2017, dividing the history of the United States into four eras: the Founding Era, the Civil War Era, the New Deal Era, and the Modern Era. First, the First Amendment's clauses on religion are examined, where I focus on the separation between church and state as well as the concepts of "establishment" and "free exercise." The First Amendment transitions from classically liberal, to conservative, to progressively liberal and classically liberal, to progressively liberal and libertarian. Next, we look at the Second Amendment's notions of a "militia" and the "right to keep and bear arms." The Second Amendment's interpretations begin classically liberal, then change to classically liberal and progressively liberal, to progressively liberal, to conservative. Finally, the analysis on the Fourth Amendment's "unreasonable searches and seizures" as well as "warrants" lends evidence to ideological interpretations. The Fourth Amendment, like the other two, starts classically liberal for two eras, then becomes libertarian, and finally ends libertarian and conservative. The implications of each of these conclusions are then discussed, with emphasis on public opinion in society during the era in question, the ways in which the ideologies in each era seem to build upon one another, the ideologies of the justices who wrote the opinions, and the ideology of the court.

Contributors

Created

Date Created
2017-12

136167-Thumbnail Image.png

Analysis of Retinoid X Receptor (RXR) Homodimerization Driven by RXR Ligands Using Yeast Two-Hybrid

Description

Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors

Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor and in return control cell differentiation and proliferation. Bexarotene targets RXR homodimerization to drive transcription of tumor suppressing genes; however, adverse reactions occur simultaneously when bound to other nuclear receptors. In this study, we used novel bexarotene analogs throughout 5 iterations synthesized in the laboratory of Dr. Wagner to test for their potency and ability to bind RXR. The aim of our study is to quantitatively measure RXR homodimerization driven by bexarotene analogs using a yeast two-hybrid system. Our results suggests there to be several compounds with higher protein activity than bexarotene, particularly in generations 3.0 and 5.0. This higher affinity for RXR homodimers may help scientists identify a compound that will minimize adverse effects and toxicity of bexarotene and serve as a better cancer treatment alternative.

Contributors

Created

Date Created
2015-05

136012-Thumbnail Image.png

Characterization of Second and Third Generation, Novel RXR Selction Agonists for the Treatment of Cutaneous T-Cell Lymphoma

Description

Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost

Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost the immune system. Bex has been shown to be effective in the treatment of multiple types of cancer, including lung cancer. However, the disadvantages of using Bex include increased instances of hypothyroidism and excessive concentrations of blood triglycerides. If an analog of Bex can be developed which retains high affinity RXR binding similar to the 9-cis retinoic acid while exhibiting less interference for heterodimerization pathways, it would be of great clinical significance in improving the quality of life for patients with CTCL. This thesis will detail the biological profiling of additional novel (Generation Two) analogs, which are currently in submission for publication, as well as that of Generation Three analogs. The results from these studies reveal that specific alterations in the core structure of the Bex "parent" compound structure can have dramatic effects in modifying the biological activity of RXR agonists.

Contributors

Agent

Created

Date Created
2012-05

135289-Thumbnail Image.png

Click to Connect: The Internet's Influence on the Employment of Civic Republicanism through Online Political Engagement

Description

There exists a strong correlation between successful democratic governance and citizen participation. Pulling this sense of civic engagement to the furthest end of the spectrum, author and political theorist Benjamin Barber expresses the benefits of citizen independence and self-governance though

There exists a strong correlation between successful democratic governance and citizen participation. Pulling this sense of civic engagement to the furthest end of the spectrum, author and political theorist Benjamin Barber expresses the benefits of citizen independence and self-governance though political deliberation in a variety of texts, one of which being Strong Democracy. While the United States currently operates on a "democratic" base, the overall lack of political efficacy undermines democratic effectiveness. Benjamin Barber outlines a series of solutions and employment strategies in order to increase efficacy and bolster civic engagement and bring about a culture of self-legislation, but in his analysis seems to overlook the collaborative capacity of the Internet, more specifically social media outlets and blogs. This study will examine the use of the Internet in various political manners, to observe if the presence of platforms such as social networks and blogs are facilitating or hindering the push towards a more civic-republican political structure. While research has displayed that the numbers on political internet-usage are consistently increasing, it is evident that not all forms of online-engagement are beneficial towards Barber's Civic Republican ideals, and may serve to strengthen the current unsound system. Through this study, I argue that certain methods of political activity over the Internet may work to support the collaborative democratic culture, and increase a sense of Civic Republicanism through political creativity, deliberation and online-action. If we are to one day achieve the goal of recovering a true sense of cooperative democracy, these forms of participation may play a significant role in the struggle for change, and must be facilitated through both civic education and the cooperation of elites. If this Internet-mediated political deliberation continues to develop, I believe that it has the capacity to act as a significant catalyst towards Barber's Civic Republican ideals and an overall shift in the political culture.

Contributors

Agent

Created

Date Created
2016-05

147682-Thumbnail Image.png

The Forgotten: The DNC's Failure to Return to their Roots

Description

The contemporary Democratic Party has departed from their roots protecting working-class issues in favor of neoliberal ideology protecting the professional class; however, recent surges in progressive campaigns demonstrate the desire to move past this elitist ideology for New Deal-like policies,

The contemporary Democratic Party has departed from their roots protecting working-class issues in favor of neoliberal ideology protecting the professional class; however, recent surges in progressive campaigns demonstrate the desire to move past this elitist ideology for New Deal-like policies, namely, young people. By utilizing the works of Thomas Frank and Anand Giridharadas to analyze the faults of the DNC, I then make case for the path forward that is more inclusive of young people and older members Black, Indigenous, Latino, Asian, and LGBTQ+ communities with progressive policies to "bringing the party home."

Contributors

Agent

Created

Date Created
2021-05

134805-Thumbnail Image.png

Real Life Superheroes: An Ethnographic Exploration Behind Cosplay and Politics

Description

In this undergraduate thesis, I explore the relationship between politics and popular culture through an ethnography of Justice League Arizona, a cosplay ensemble devoted to costumed civic activism. While existing scholarship addresses cosplay ensembles and political theory, there is very

In this undergraduate thesis, I explore the relationship between politics and popular culture through an ethnography of Justice League Arizona, a cosplay ensemble devoted to costumed civic activism. While existing scholarship addresses cosplay ensembles and political theory, there is very little that examines how the act of cosplay can be a form of politics and what the impact of that interpretation has on both individuals and the community at large. Through both participant observation and interviews with members of the ensemble, I discovered that cosplay has the ability to intensify aspects of the self, the ability to expose new aspects of the self, and the ability to bring one closer to a particular character. I also found cosplay to be political through the sensibility and situated knowledge that proves to be in practice during cosplay, ultimately having the power to be used as a form of political resistance.

Contributors

Created

Date Created
2016-12

164760-Thumbnail Image.png

Media to the Polls: How Trafficking Knowledge Affects How Generation Z Votes in the United States

Description

Gen Z is very active on social media where there is a large amount of misinformation on human trafficking. This bears the question, does correct knowledge of human trafficking have a correlation with how Gen Z votes? This study looks

Gen Z is very active on social media where there is a large amount of misinformation on human trafficking. This bears the question, does correct knowledge of human trafficking have a correlation with how Gen Z votes? This study looks into the correlation between Generation Z’s (Gen Z) voting patterns and their knowledge of human trafficking. The underlying thought is how media and social media play a role in what information Gen Z is taking to the voting booths. The results will show if both Republicans and Democrats or just one are affected by inadequate knowledge of human trafficking and if therefore, they are voting a specific way. A result emerged by surveying 30 people across the United States with ages ranging from 18-24, on where trafficking happens and to whom it happens to, alongside asking the participants different political questions to determine their voting patterns. The survey questions were written and analyzed quantitatively to use the data numerically as the results.

Contributors

Agent

Created

Date Created
2022-05