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Historically, Supreme Court interpretations of the Constitution of the United States have been significantly important, impacting the lives of every American. This honors thesis seeks to understand the ways in which the Constitution has been interpreted through the lens of political ideology. Using constitutional theory, I explain how the political

Historically, Supreme Court interpretations of the Constitution of the United States have been significantly important, impacting the lives of every American. This honors thesis seeks to understand the ways in which the Constitution has been interpreted through the lens of political ideology. Using constitutional theory, I explain how the political ideologies of classical liberalism, conservatism, libertarianism, and progressive liberalism have played a role in the interpretations of the First, Second, and Fourth Amendments. I also examine how these ideological interpretations have changed from 1776 to 2017, dividing the history of the United States into four eras: the Founding Era, the Civil War Era, the New Deal Era, and the Modern Era. First, the First Amendment's clauses on religion are examined, where I focus on the separation between church and state as well as the concepts of "establishment" and "free exercise." The First Amendment transitions from classically liberal, to conservative, to progressively liberal and classically liberal, to progressively liberal and libertarian. Next, we look at the Second Amendment's notions of a "militia" and the "right to keep and bear arms." The Second Amendment's interpretations begin classically liberal, then change to classically liberal and progressively liberal, to progressively liberal, to conservative. Finally, the analysis on the Fourth Amendment's "unreasonable searches and seizures" as well as "warrants" lends evidence to ideological interpretations. The Fourth Amendment, like the other two, starts classically liberal for two eras, then becomes libertarian, and finally ends libertarian and conservative. The implications of each of these conclusions are then discussed, with emphasis on public opinion in society during the era in question, the ways in which the ideologies in each era seem to build upon one another, the ideologies of the justices who wrote the opinions, and the ideology of the court.
Created2017-12
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Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost the immune system. Bex has been shown to be effective

Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost the immune system. Bex has been shown to be effective in the treatment of multiple types of cancer, including lung cancer. However, the disadvantages of using Bex include increased instances of hypothyroidism and excessive concentrations of blood triglycerides. If an analog of Bex can be developed which retains high affinity RXR binding similar to the 9-cis retinoic acid while exhibiting less interference for heterodimerization pathways, it would be of great clinical significance in improving the quality of life for patients with CTCL. This thesis will detail the biological profiling of additional novel (Generation Two) analogs, which are currently in submission for publication, as well as that of Generation Three analogs. The results from these studies reveal that specific alterations in the core structure of the Bex "parent" compound structure can have dramatic effects in modifying the biological activity of RXR agonists.
ContributorsYang, Joanna (Author) / Jurutka, Peter (Thesis director) / Wagner, Carl (Committee member) / Hibler, Elizabeth (Committee member) / Barrett, The Honors College (Contributor)
Created2012-05
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Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor

Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor and in return control cell differentiation and proliferation. Bexarotene targets RXR homodimerization to drive transcription of tumor suppressing genes; however, adverse reactions occur simultaneously when bound to other nuclear receptors. In this study, we used novel bexarotene analogs throughout 5 iterations synthesized in the laboratory of Dr. Wagner to test for their potency and ability to bind RXR. The aim of our study is to quantitatively measure RXR homodimerization driven by bexarotene analogs using a yeast two-hybrid system. Our results suggests there to be several compounds with higher protein activity than bexarotene, particularly in generations 3.0 and 5.0. This higher affinity for RXR homodimers may help scientists identify a compound that will minimize adverse effects and toxicity of bexarotene and serve as a better cancer treatment alternative.
ContributorsSeto, David Hua (Author) / Marshall, Pamela (Thesis director) / Wagner, Carl (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2015-05
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Alexis de Tocqueville, French political theorist and scientist, theorized in the 19th century that “France cannot reform except through revolution” (Heisbourg, 2016). As France continues to face a strained economy with high unemployment and stalled growth, the OECD recommends that France should implement labor reform “to promote job growth” (OECD,

Alexis de Tocqueville, French political theorist and scientist, theorized in the 19th century that “France cannot reform except through revolution” (Heisbourg, 2016). As France continues to face a strained economy with high unemployment and stalled growth, the OECD recommends that France should implement labor reform “to promote job growth” (OECD, 2015). Labor reform refers to removing labor protections for French employees, resulting in an increase in firing and hiring flexibility for employers.

Recent governments in France have failed to bring about meaningful labor reform, faced with opposition in the streets or within their own political party. The election of Emanuel Macron, viewed as a political outsider who had never held elected office created his own political party, En Marche, seemed like the catalyst to lasting economic reform. However, if high unemployment and slow economic growth to comparable economies have been concerns for France since the beginning of the 21st century, why were past governments unsuccessful in implementing legislative actions to address labor reform?

This paper will argue that the election of Macron and the establishment of En Marche was caused by a shift in power that allowed Macron enough support to sway the political landscape of France and implement labor market reform. This largely has to do with the power struggle between France’s Outsiders, “those without secure employment, Insiders, “those with secure employment” and the Upscale group, “employers, the upper middle class, and the business and financial community” (Rudea, 2007). However, the degree and preservation of Macron’s reform plans are threatened by Insiders who have been stripped of employee protections.
ContributorsLoonam, Daniel Francis (Author) / Thomson, Henry (Thesis director) / Kirsch, Robert (Committee member) / Department of Information Systems (Contributor) / Department of Finance (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
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In this undergraduate thesis, I explore the relationship between politics and popular culture through an ethnography of Justice League Arizona, a cosplay ensemble devoted to costumed civic activism. While existing scholarship addresses cosplay ensembles and political theory, there is very little that examines how the act of cosplay can be

In this undergraduate thesis, I explore the relationship between politics and popular culture through an ethnography of Justice League Arizona, a cosplay ensemble devoted to costumed civic activism. While existing scholarship addresses cosplay ensembles and political theory, there is very little that examines how the act of cosplay can be a form of politics and what the impact of that interpretation has on both individuals and the community at large. Through both participant observation and interviews with members of the ensemble, I discovered that cosplay has the ability to intensify aspects of the self, the ability to expose new aspects of the self, and the ability to bring one closer to a particular character. I also found cosplay to be political through the sensibility and situated knowledge that proves to be in practice during cosplay, ultimately having the power to be used as a form of political resistance.
ContributorsBurrus, Ella Rene (Author) / Mack, Robert (Thesis director) / Behl, Natasha (Committee member) / School of Social and Behavioral Sciences (Contributor) / Herberger Institute for Design and the Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
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There exists a strong correlation between successful democratic governance and citizen participation. Pulling this sense of civic engagement to the furthest end of the spectrum, author and political theorist Benjamin Barber expresses the benefits of citizen independence and self-governance though political deliberation in a variety of texts, one of which

There exists a strong correlation between successful democratic governance and citizen participation. Pulling this sense of civic engagement to the furthest end of the spectrum, author and political theorist Benjamin Barber expresses the benefits of citizen independence and self-governance though political deliberation in a variety of texts, one of which being Strong Democracy. While the United States currently operates on a "democratic" base, the overall lack of political efficacy undermines democratic effectiveness. Benjamin Barber outlines a series of solutions and employment strategies in order to increase efficacy and bolster civic engagement and bring about a culture of self-legislation, but in his analysis seems to overlook the collaborative capacity of the Internet, more specifically social media outlets and blogs. This study will examine the use of the Internet in various political manners, to observe if the presence of platforms such as social networks and blogs are facilitating or hindering the push towards a more civic-republican political structure. While research has displayed that the numbers on political internet-usage are consistently increasing, it is evident that not all forms of online-engagement are beneficial towards Barber's Civic Republican ideals, and may serve to strengthen the current unsound system. Through this study, I argue that certain methods of political activity over the Internet may work to support the collaborative democratic culture, and increase a sense of Civic Republicanism through political creativity, deliberation and online-action. If we are to one day achieve the goal of recovering a true sense of cooperative democracy, these forms of participation may play a significant role in the struggle for change, and must be facilitated through both civic education and the cooperation of elites. If this Internet-mediated political deliberation continues to develop, I believe that it has the capacity to act as a significant catalyst towards Barber's Civic Republican ideals and an overall shift in the political culture.
ContributorsSalute, Nicholas John (Author) / Kirkpatrick, Jennet (Thesis director) / Halavais, Alex (Committee member) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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The contemporary Democratic Party has departed from their roots protecting working-class issues in favor of neoliberal ideology protecting the professional class; however, recent surges in progressive campaigns demonstrate the desire to move past this elitist ideology for New Deal-like policies, namely, young people. By utilizing the works of Thomas Frank

The contemporary Democratic Party has departed from their roots protecting working-class issues in favor of neoliberal ideology protecting the professional class; however, recent surges in progressive campaigns demonstrate the desire to move past this elitist ideology for New Deal-like policies, namely, young people. By utilizing the works of Thomas Frank and Anand Giridharadas to analyze the faults of the DNC, I then make case for the path forward that is more inclusive of young people and older members Black, Indigenous, Latino, Asian, and LGBTQ+ communities with progressive policies to "bringing the party home."

ContributorsThompson, Makayla Lynn (Author) / Gruber, Diane (Thesis director) / Ron, Amit (Committee member) / School of Social and Behavioral Sciences (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

The United States and the Soviet Union faced off in Europe, but what did the spread of their influence look like around the globe? This is answered through researching the economic and political nuances of the Cold War.

ContributorsVallely, Ethan (Author) / Niebuhr, Robert (Thesis director) / Collins, Gregory (Committee member) / Barrett, The Honors College (Contributor) / Department of Finance (Contributor)
Created2023-05
Description
This research paper examines the effects of politics on different aspects of citizenship within the United States. First, I will elaborate on the power of citizenship. Second, I will provide a broad understanding of birthright citizenship and the naturalization process. Third, I will explain how politics affects four key areas:

This research paper examines the effects of politics on different aspects of citizenship within the United States. First, I will elaborate on the power of citizenship. Second, I will provide a broad understanding of birthright citizenship and the naturalization process. Third, I will explain how politics affects four key areas: Birthright Citizenship, Naturalization, the 2020 Census, and Deferred Action for Childhood Arrivals (DACA). I will primarily be focusing on Hispanic and/or Latino communities in America. As explained in my paper, Hispanics and Latinos are some of the fastest growing communities within the United States. Additionally, in today’s political climate, the rhetoric towards immigrants from Latin American countries makes them a particularly marginalized group in the context of the politics of citizenship.

Citizenship Politics is a term I use to distinguish how politics over citizenship is different from other political conversations and describe how politics can influence and pose a threat to citizenship as a whole in America. In this paper, I will address how politics can influence birthright citizenship, the naturalization process, and other related government initiatives. For instance, I will discuss how politics can discourage Legal Permanents Residents from seeking citizenship. This paper will also show how Citizenship Politics permeates at the federal level, such as adding a citizenship question to the 2020 Census. Contrastingly, an analysis into a recent League of United Latin American Citizens (LULAC) settlement regarding voting rights in Arizona will also be provided. Furthermore, this paper will analyze how politics leads to the creation of reactive programs like Deferred Action for Childhood Arrivals (DACA), an initiative offering temporary protection with no pathway to citizenship. In the end, this research paper offers solutions and long-term implications.
ContributorsSeiwert, Matthew (Author) / Magaña, Lisa (Thesis director) / Sadowski-Smith, Claudia (Committee member) / Dean, W.P. Carey School of Business (Contributor) / School of Accountancy (Contributor) / Department of Finance (Contributor) / Historical, Philosophical & Religious Studies, Sch (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
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The goal of this research paper is to analyze how we define economic success and how that affects large corporations and consumers. This paper asks the questions: What do we define as a good economy? What metrics are currently utilized? And how do perceptions of a good economy influence politics?

The goal of this research paper is to analyze how we define economic success and how that affects large corporations and consumers. This paper asks the questions: What do we define as a good economy? What metrics are currently utilized? And how do perceptions of a good economy influence politics? Overall, the research seeks to identify common economic and financial fallacies held by the average citizen and offer alternative methods of how socio-economic information is presented to the consumers. Consumers play a major role in the market, and the information they receive has a considerable impact on their behaviors. Determining why the present economic analysis is used is the first step in finding ways to improve the system. Observing past political and economic trends and relating them to current issues is necessary for finding future solutions.
ContributorsTosca, Carlos (Author) / Brian, Jennifer (Thesis director) / Sadusky, Brian (Committee member) / Department of Information Systems (Contributor) / Department of Finance (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05