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Historically, Supreme Court interpretations of the Constitution of the United States have been significantly important, impacting the lives of every American. This honors thesis seeks to understand the ways in which the Constitution has been interpreted through the lens of political ideology. Using constitutional theory, I explain how the political

Historically, Supreme Court interpretations of the Constitution of the United States have been significantly important, impacting the lives of every American. This honors thesis seeks to understand the ways in which the Constitution has been interpreted through the lens of political ideology. Using constitutional theory, I explain how the political ideologies of classical liberalism, conservatism, libertarianism, and progressive liberalism have played a role in the interpretations of the First, Second, and Fourth Amendments. I also examine how these ideological interpretations have changed from 1776 to 2017, dividing the history of the United States into four eras: the Founding Era, the Civil War Era, the New Deal Era, and the Modern Era. First, the First Amendment's clauses on religion are examined, where I focus on the separation between church and state as well as the concepts of "establishment" and "free exercise." The First Amendment transitions from classically liberal, to conservative, to progressively liberal and classically liberal, to progressively liberal and libertarian. Next, we look at the Second Amendment's notions of a "militia" and the "right to keep and bear arms." The Second Amendment's interpretations begin classically liberal, then change to classically liberal and progressively liberal, to progressively liberal, to conservative. Finally, the analysis on the Fourth Amendment's "unreasonable searches and seizures" as well as "warrants" lends evidence to ideological interpretations. The Fourth Amendment, like the other two, starts classically liberal for two eras, then becomes libertarian, and finally ends libertarian and conservative. The implications of each of these conclusions are then discussed, with emphasis on public opinion in society during the era in question, the ways in which the ideologies in each era seem to build upon one another, the ideologies of the justices who wrote the opinions, and the ideology of the court.
Created2017-12
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Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost the immune system. Bex has been shown to be effective

Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost the immune system. Bex has been shown to be effective in the treatment of multiple types of cancer, including lung cancer. However, the disadvantages of using Bex include increased instances of hypothyroidism and excessive concentrations of blood triglycerides. If an analog of Bex can be developed which retains high affinity RXR binding similar to the 9-cis retinoic acid while exhibiting less interference for heterodimerization pathways, it would be of great clinical significance in improving the quality of life for patients with CTCL. This thesis will detail the biological profiling of additional novel (Generation Two) analogs, which are currently in submission for publication, as well as that of Generation Three analogs. The results from these studies reveal that specific alterations in the core structure of the Bex "parent" compound structure can have dramatic effects in modifying the biological activity of RXR agonists.
ContributorsYang, Joanna (Author) / Jurutka, Peter (Thesis director) / Wagner, Carl (Committee member) / Hibler, Elizabeth (Committee member) / Barrett, The Honors College (Contributor)
Created2012-05
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Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor

Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor and in return control cell differentiation and proliferation. Bexarotene targets RXR homodimerization to drive transcription of tumor suppressing genes; however, adverse reactions occur simultaneously when bound to other nuclear receptors. In this study, we used novel bexarotene analogs throughout 5 iterations synthesized in the laboratory of Dr. Wagner to test for their potency and ability to bind RXR. The aim of our study is to quantitatively measure RXR homodimerization driven by bexarotene analogs using a yeast two-hybrid system. Our results suggests there to be several compounds with higher protein activity than bexarotene, particularly in generations 3.0 and 5.0. This higher affinity for RXR homodimers may help scientists identify a compound that will minimize adverse effects and toxicity of bexarotene and serve as a better cancer treatment alternative.
ContributorsSeto, David Hua (Author) / Marshall, Pamela (Thesis director) / Wagner, Carl (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2015-05
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Recidivism rates in the United States are alarmingly high. The vast number of inmates who re- offend upon release and re-enter into correctional facilities upsets people and many individuals focus their blame on the private and public prisons. Currently, the research that is available on private and public prisons is

Recidivism rates in the United States are alarmingly high. The vast number of inmates who re- offend upon release and re-enter into correctional facilities upsets people and many individuals focus their blame on the private and public prisons. Currently, the research that is available on private and public prisons is unpersuasive because it creates a harsh polarization between the two prison systems. The benefits as well as the detriments of each sector are explained in great detail, but all of the current research is lacking one thing: insider experience. The majority of the available research is conducted by people behind a computer screen or behind the binding of a book. While a wide variety of different articles, short stories, and journals have been published and are readily available to eager readers and researchers, these arguments repeat themselves and fail to weigh the complex merits of each system against the other; specifically, each body of work is lacking knowledge from people who have experienced both private and public prisons from an internal perspective. To compensate for this lack of ethnographic research, the current study allows the reader to get an internal perspective of public and private prisons. This was done by interviewing two wardens who have served on the federal, state, and private levels as well as touring a private correctional facility in Arizona. These experiences paved the way for novel research to be conducted and was used as a tool to weave the complicated web of private and public prisons in the United States. Findings, interviews, and ideas for the future of prisons are discussed.
ContributorsTometich, Drake (Author) / Wright, Kevin (Thesis director) / Young, Jacob (Committee member) / School of Criminology and Criminal Justice (Contributor) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
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In this undergraduate thesis, I explore the relationship between politics and popular culture through an ethnography of Justice League Arizona, a cosplay ensemble devoted to costumed civic activism. While existing scholarship addresses cosplay ensembles and political theory, there is very little that examines how the act of cosplay can be

In this undergraduate thesis, I explore the relationship between politics and popular culture through an ethnography of Justice League Arizona, a cosplay ensemble devoted to costumed civic activism. While existing scholarship addresses cosplay ensembles and political theory, there is very little that examines how the act of cosplay can be a form of politics and what the impact of that interpretation has on both individuals and the community at large. Through both participant observation and interviews with members of the ensemble, I discovered that cosplay has the ability to intensify aspects of the self, the ability to expose new aspects of the self, and the ability to bring one closer to a particular character. I also found cosplay to be political through the sensibility and situated knowledge that proves to be in practice during cosplay, ultimately having the power to be used as a form of political resistance.
ContributorsBurrus, Ella Rene (Author) / Mack, Robert (Thesis director) / Behl, Natasha (Committee member) / School of Social and Behavioral Sciences (Contributor) / Herberger Institute for Design and the Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
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The objective of this study was to determine whether prosecutors would be more inclined to prosecute a juvenile sex offense case when the offender is gay versus straight. I also tested whether the effect of offender sexual orientation would be different for male versus female juvenile offenders. Based on previous

The objective of this study was to determine whether prosecutors would be more inclined to prosecute a juvenile sex offense case when the offender is gay versus straight. I also tested whether the effect of offender sexual orientation would be different for male versus female juvenile offenders. Based on previous research showing leniency toward lesbian juvenile sex offenders among laypeople, I hypothesized that prosecutors would be more likely to prosecute a case in which the offender was gay instead of heterosexual—but only if they were boys. In contrast, if the offenders were lesbians, I hypothesized that prosecutors would be less inclined to prosecute, compared to heterosexual girls. Based on survey data, I found that prosecutors’ decisions to prosecute were not affected by the offender’s gender or sexuality, but their impressions of the offender were. Prosecutors perceived males to be more likely to recidivate than females. Specifically, gay males were perceived as more likely to recidivate than heterosexual males; however the difference between lesbians and heterosexuals were nearly indistinguishable. Prosecutors also viewed gay males as having more negative attributes than heterosexual males. Contrarily, lesbian girls were perceived as having slightly less negative attributes than heterosexual girls. Still, females overall were perceived as having less negative attributes than males. These impressions on recidivism and negative attributes were important because they both positively correlated with the prosecutor’s decision to prosecute the case.
ContributorsFletcher, Sarah Renee (Author) / Salerno, Jessica (Thesis director) / Hall, Deborah (Committee member) / School of Social and Behavioral Sciences (Contributor) / School of Criminology and Criminal Justice (Contributor) / School of Politics and Global Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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There exists a strong correlation between successful democratic governance and citizen participation. Pulling this sense of civic engagement to the furthest end of the spectrum, author and political theorist Benjamin Barber expresses the benefits of citizen independence and self-governance though political deliberation in a variety of texts, one of which

There exists a strong correlation between successful democratic governance and citizen participation. Pulling this sense of civic engagement to the furthest end of the spectrum, author and political theorist Benjamin Barber expresses the benefits of citizen independence and self-governance though political deliberation in a variety of texts, one of which being Strong Democracy. While the United States currently operates on a "democratic" base, the overall lack of political efficacy undermines democratic effectiveness. Benjamin Barber outlines a series of solutions and employment strategies in order to increase efficacy and bolster civic engagement and bring about a culture of self-legislation, but in his analysis seems to overlook the collaborative capacity of the Internet, more specifically social media outlets and blogs. This study will examine the use of the Internet in various political manners, to observe if the presence of platforms such as social networks and blogs are facilitating or hindering the push towards a more civic-republican political structure. While research has displayed that the numbers on political internet-usage are consistently increasing, it is evident that not all forms of online-engagement are beneficial towards Barber's Civic Republican ideals, and may serve to strengthen the current unsound system. Through this study, I argue that certain methods of political activity over the Internet may work to support the collaborative democratic culture, and increase a sense of Civic Republicanism through political creativity, deliberation and online-action. If we are to one day achieve the goal of recovering a true sense of cooperative democracy, these forms of participation may play a significant role in the struggle for change, and must be facilitated through both civic education and the cooperation of elites. If this Internet-mediated political deliberation continues to develop, I believe that it has the capacity to act as a significant catalyst towards Barber's Civic Republican ideals and an overall shift in the political culture.
ContributorsSalute, Nicholas John (Author) / Kirkpatrick, Jennet (Thesis director) / Halavais, Alex (Committee member) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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With a prison population that has grown to 1.4 million, an imprisonment rate of 419 per 100,000 U.S. residents, and a recidivism rate of 52.2% for males and 36.4% for females, the United States is facing a crisis. Currently, no sufficient measures have been taken by the United States to

With a prison population that has grown to 1.4 million, an imprisonment rate of 419 per 100,000 U.S. residents, and a recidivism rate of 52.2% for males and 36.4% for females, the United States is facing a crisis. Currently, no sufficient measures have been taken by the United States to reduce recidivism. Attempts have been made, but they ultimately failed. Recently, however, there has been an increase in experimentation with the concept of teaching inmates basic computer skills to reduce recidivism. As labor becomes increasingly digitized, it becomes more difficult for inmates who spent a certain period away from technology to adapt and find employment. At the bare minimum, anybody entering the workforce must know how to use a computer and other technological appliances, even in the lowest-paid positions. By incorporating basic computer skills and coding educational programs within prisons, this issue can be addressed, since inmates would be better equipped to take on a more technologically advanced labor market.<br/>Additionally, thoroughly preparing inmates for employment is a necessity because it has been proven to reduce recidivism. Prisons typically have some work programs; however, these programs are typically outdated and prepare inmates for fields that may represent a difficult employment market moving forward. On the other hand, preparing inmates for tech-related fields of work is proving to be successful in the early stages of experimentation. A reason for this success is the growing demand. According to the U.S. Bureau of Labor Statistics, employment in computer and information technology occupations is projected to grow 11 percent between 2019 and 2029. This is noteworthy considering the national average for growth of all other jobs is only 4 percent. It also warrants the exploration of educating coders because software developers, in particular, have an expected growth rate of 22 percent between 2019 and 2029. <br/>Despite the security risks of giving inmates access to computers, the implementation of basic computer skills and coding in prisons should be explored further. Programs that give inmates access to a computing education already exist. The only issue with these programs is their scarcity. However, this is to no fault of their own, considering the complex nature and costs of running such a program. Accordingly, this leaves the opportunity for public universities to get involved. Public universities serve as perfect hosts because they are fully capable of leveraging the resources already available to them. Arizona State University, in particular, is a more than ideal candidate to spearhead such a program and serve as a model for other public universities to follow. Arizona State University (ASU) is already educating inmates in local Arizona prisons on subjects such as math and English through their PEP (Prison Education Programming) program.<br/>This thesis will focus on Arizona specifically and why this would benefit the state. It will also explain why Arizona State University is the perfect candidate to spearhead this kind of program. Additionally, it will also discuss why recidivism is detrimental and the reasons why formerly incarcerated individuals re-offend. Furthermore, it will also explore the current measures being taken in Arizona and their limitations. Finally, it will provide evidence for why programs like these tend to succeed and serve as a proposal to Arizona State University to create its own program using the provided framework in this thesis.

ContributorsAwawdeh, Bajis Tariq (Author) / Halavais, Alexander (Thesis director) / Funk, Kendall (Committee member) / School of Social and Behavioral Sciences (Contributor, Contributor) / School of Humanities, Arts, and Cultural Studies (Contributor) / Sandra Day O'Connor College of Law (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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The contemporary Democratic Party has departed from their roots protecting working-class issues in favor of neoliberal ideology protecting the professional class; however, recent surges in progressive campaigns demonstrate the desire to move past this elitist ideology for New Deal-like policies, namely, young people. By utilizing the works of Thomas Frank

The contemporary Democratic Party has departed from their roots protecting working-class issues in favor of neoliberal ideology protecting the professional class; however, recent surges in progressive campaigns demonstrate the desire to move past this elitist ideology for New Deal-like policies, namely, young people. By utilizing the works of Thomas Frank and Anand Giridharadas to analyze the faults of the DNC, I then make case for the path forward that is more inclusive of young people and older members Black, Indigenous, Latino, Asian, and LGBTQ+ communities with progressive policies to "bringing the party home."

ContributorsThompson, Makayla Lynn (Author) / Gruber, Diane (Thesis director) / Ron, Amit (Committee member) / School of Social and Behavioral Sciences (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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A recent analysis has predicted that close to a million Americans will have died from contracting COVID-19 (Sullivan, 2021, para. 1). Unsurprisingly, the most vulnerable people, like those who have been incarcerated, have been hit the hardest (Brennan Center for Justice, 2020, para. 1). The ongoing COVID-19 pandemic has created

A recent analysis has predicted that close to a million Americans will have died from contracting COVID-19 (Sullivan, 2021, para. 1). Unsurprisingly, the most vulnerable people, like those who have been incarcerated, have been hit the hardest (Brennan Center for Justice, 2020, para. 1). The ongoing COVID-19 pandemic has created additional stress affecting inmates both physically and mentally. Therefore, the maintenance of good mental health among inmates should be a concern. However, the nature of the correctional environment limits the therapeutic options available to health care professionals. Among the challenges mental health professionals face in ensuring quality care are a poor rapport between the care provider and client, having a client living in an environment where distressing factors are omnipresent, and a lack of resources (Gussak, 2015, p. 2). All of these issues are exacerbated when the client requiring mental health care is in the correctional system. Depression and anxiety are some of the most common disorders affecting the prison population. However, in the correctional system, therapies that have been found effective among a general population have been shown to not benefit 30% to 60% of clients (Abbing, Baars, Van Haastrecht, & Ponstein, 2019, p. 1). Effectively treating depression is of great concern because, as Gussak (2007) found, depression can lead to self-harming behaviors and suicide when left untreated (p. 2). Additionally, addressing and treating anxiety is of particular importance today as COVID-19 has been a significant source of distress; explicitly, one incarcerated journalist reported witnessing entire units of inmates experiencing high levels of anxiety and panic attacks (Popperl et al., 2020, para. 5). Thus, a critical review of the available literature can reveal the particular effectiveness of art therapy in treating depression and anxiety in prison populations. The impacts of implementing more effective therapies in the correctional system are a reduction in recidivism and successful reintegration into society. Consequently, this literature review will suggest a potential application of art therapy for improving the mental health of those incarcerated in the correctional system with the intent of engendering positive social impact.

ContributorsBayne Lopez, Alyssa (Author) / Knowles, Alissa (Thesis director) / Craft, Sherry (Committee member) / Barrett, The Honors College (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2021-12