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- All Subjects: deep learning
- Creators: Yang, Yezhou
- Creators: Wu, Teresa
Description
Computer Vision as a eld has gone through signicant changes in the last decade.
The eld has seen tremendous success in designing learning systems with hand-crafted
features and in using representation learning to extract better features. In this dissertation
some novel approaches to representation learning and task learning are studied.
Multiple-instance learning which is generalization of supervised learning, is one
example of task learning that is discussed. In particular, a novel non-parametric k-
NN-based multiple-instance learning is proposed, which is shown to outperform other
existing approaches. This solution is applied to a diabetic retinopathy pathology
detection problem eectively.
In cases of representation learning, generality of neural features are investigated
rst. This investigation leads to some critical understanding and results in feature
generality among datasets. The possibility of learning from a mentor network instead
of from labels is then investigated. Distillation of dark knowledge is used to eciently
mentor a small network from a pre-trained large mentor network. These studies help
in understanding representation learning with smaller and compressed networks.
The eld has seen tremendous success in designing learning systems with hand-crafted
features and in using representation learning to extract better features. In this dissertation
some novel approaches to representation learning and task learning are studied.
Multiple-instance learning which is generalization of supervised learning, is one
example of task learning that is discussed. In particular, a novel non-parametric k-
NN-based multiple-instance learning is proposed, which is shown to outperform other
existing approaches. This solution is applied to a diabetic retinopathy pathology
detection problem eectively.
In cases of representation learning, generality of neural features are investigated
rst. This investigation leads to some critical understanding and results in feature
generality among datasets. The possibility of learning from a mentor network instead
of from labels is then investigated. Distillation of dark knowledge is used to eciently
mentor a small network from a pre-trained large mentor network. These studies help
in understanding representation learning with smaller and compressed networks.
ContributorsVenkatesan, Ragav (Author) / Li, Baoxin (Thesis advisor) / Turaga, Pavan (Committee member) / Yang, Yezhou (Committee member) / Davulcu, Hasan (Committee member) / Arizona State University (Publisher)
Created2017
Description
The performance of most of the visual computing tasks depends on the quality of the features extracted from the raw data. Insightful feature representation increases the performance of many learning algorithms by exposing the underlying explanatory factors of the output for the unobserved input. A good representation should also handle anomalies in the data such as missing samples and noisy input caused by the undesired, external factors of variation. It should also reduce the data redundancy. Over the years, many feature extraction processes have been invented to produce good representations of raw images and videos.
The feature extraction processes can be categorized into three groups. The first group contains processes that are hand-crafted for a specific task. Hand-engineering features requires the knowledge of domain experts and manual labor. However, the feature extraction process is interpretable and explainable. Next group contains the latent-feature extraction processes. While the original feature lies in a high-dimensional space, the relevant factors for a task often lie on a lower dimensional manifold. The latent-feature extraction employs hidden variables to expose the underlying data properties that cannot be directly measured from the input. Latent features seek a specific structure such as sparsity or low-rank into the derived representation through sophisticated optimization techniques. The last category is that of deep features. These are obtained by passing raw input data with minimal pre-processing through a deep network. Its parameters are computed by iteratively minimizing a task-based loss.
In this dissertation, I present four pieces of work where I create and learn suitable data representations. The first task employs hand-crafted features to perform clinically-relevant retrieval of diabetic retinopathy images. The second task uses latent features to perform content-adaptive image enhancement. The third task ranks a pair of images based on their aestheticism. The goal of the last task is to capture localized image artifacts in small datasets with patch-level labels. For both these tasks, I propose novel deep architectures and show significant improvement over the previous state-of-art approaches. A suitable combination of feature representations augmented with an appropriate learning approach can increase performance for most visual computing tasks.
The feature extraction processes can be categorized into three groups. The first group contains processes that are hand-crafted for a specific task. Hand-engineering features requires the knowledge of domain experts and manual labor. However, the feature extraction process is interpretable and explainable. Next group contains the latent-feature extraction processes. While the original feature lies in a high-dimensional space, the relevant factors for a task often lie on a lower dimensional manifold. The latent-feature extraction employs hidden variables to expose the underlying data properties that cannot be directly measured from the input. Latent features seek a specific structure such as sparsity or low-rank into the derived representation through sophisticated optimization techniques. The last category is that of deep features. These are obtained by passing raw input data with minimal pre-processing through a deep network. Its parameters are computed by iteratively minimizing a task-based loss.
In this dissertation, I present four pieces of work where I create and learn suitable data representations. The first task employs hand-crafted features to perform clinically-relevant retrieval of diabetic retinopathy images. The second task uses latent features to perform content-adaptive image enhancement. The third task ranks a pair of images based on their aestheticism. The goal of the last task is to capture localized image artifacts in small datasets with patch-level labels. For both these tasks, I propose novel deep architectures and show significant improvement over the previous state-of-art approaches. A suitable combination of feature representations augmented with an appropriate learning approach can increase performance for most visual computing tasks.
ContributorsChandakkar, Parag Shridhar (Author) / Li, Baoxin (Thesis advisor) / Yang, Yezhou (Committee member) / Turaga, Pavan (Committee member) / Davulcu, Hasan (Committee member) / Arizona State University (Publisher)
Created2017
Description
In healthcare facilities, health information systems (HISs) are used to serve different purposes. The radiology department adopts multiple HISs in managing their operations and patient care. In general, the HISs that touch radiology fall into two categories: tracking HISs and archive HISs. Electronic Health Records (EHR) is a typical tracking HIS, which tracks the care each patient receives at multiple encounters and facilities. Archive HISs are typically specialized databases to store large-size data collected as part of the patient care. A typical example of an archive HIS is the Picture Archive and Communication System (PACS), which provides economical storage and convenient access to diagnostic images from multiple modalities. How to integrate such HISs and best utilize their data remains a challenging problem due to the disparity of HISs as well as high-dimensionality and heterogeneity of the data. My PhD dissertation research includes three inter-connected and integrated topics and focuses on designing integrated HISs and further developing statistical models and machine learning algorithms for process and patient care improvement.
Topic 1: Design of super-HIS and tracking of quality of care (QoC). My research developed an information technology that integrates multiple HISs in radiology, and proposed QoC metrics defined upon the data that measure various dimensions of care. The DDD assisted the clinical practices and enabled an effective intervention for reducing lengthy radiologist turnaround times for patients.
Topic 2: Monitoring and change detection of QoC data streams for process improvement. With the super-HIS in place, high-dimensional data streams of QoC metrics are generated. I developed a statistical model for monitoring high- dimensional data streams that integrated Singular Vector Decomposition (SVD) and process control. The algorithm was applied to QoC metrics data, and additionally extended to another application of monitoring traffic data in communication networks.
Topic 3: Deep transfer learning of archive HIS data for computer-aided diagnosis (CAD). The novelty of the CAD system is the development of a deep transfer learning algorithm that combines the ideas of transfer learning and multi- modality image integration under the deep learning framework. Our system achieved high accuracy in breast cancer diagnosis compared with conventional machine learning algorithms.
Topic 1: Design of super-HIS and tracking of quality of care (QoC). My research developed an information technology that integrates multiple HISs in radiology, and proposed QoC metrics defined upon the data that measure various dimensions of care. The DDD assisted the clinical practices and enabled an effective intervention for reducing lengthy radiologist turnaround times for patients.
Topic 2: Monitoring and change detection of QoC data streams for process improvement. With the super-HIS in place, high-dimensional data streams of QoC metrics are generated. I developed a statistical model for monitoring high- dimensional data streams that integrated Singular Vector Decomposition (SVD) and process control. The algorithm was applied to QoC metrics data, and additionally extended to another application of monitoring traffic data in communication networks.
Topic 3: Deep transfer learning of archive HIS data for computer-aided diagnosis (CAD). The novelty of the CAD system is the development of a deep transfer learning algorithm that combines the ideas of transfer learning and multi- modality image integration under the deep learning framework. Our system achieved high accuracy in breast cancer diagnosis compared with conventional machine learning algorithms.
ContributorsWang, Kun (Author) / Li, Jing (Thesis advisor) / Wu, Teresa (Committee member) / Pan, Rong (Committee member) / Zwart, Christine M. (Committee member) / Arizona State University (Publisher)
Created2018
Description
Rapid intraoperative diagnosis of brain tumors is of great importance for planning treatment and guiding the surgeon about the extent of resection. Currently, the standard for the preliminary intraoperative tissue analysis is frozen section biopsy that has major limitations such as tissue freezing and cutting artifacts, sampling errors, lack of immediate interaction between the pathologist and the surgeon, and time consuming.
Handheld, portable confocal laser endomicroscopy (CLE) is being explored in neurosurgery for its ability to image histopathological features of tissue at cellular resolution in real time during brain tumor surgery. Over the course of examination of the surgical tumor resection, hundreds to thousands of images may be collected. The high number of images requires significant time and storage load for subsequent reviewing, which motivated several research groups to employ deep convolutional neural networks (DCNNs) to improve its utility during surgery. DCNNs have proven to be useful in natural and medical image analysis tasks such as classification, object detection, and image segmentation.
This thesis proposes using DCNNs for analyzing CLE images of brain tumors. Particularly, it explores the practicality of DCNNs in three main tasks. First, off-the shelf DCNNs were used to classify images into diagnostic and non-diagnostic. Further experiments showed that both ensemble modeling and transfer learning improved the classifier’s accuracy in evaluating the diagnostic quality of new images at test stage. Second, a weakly-supervised learning pipeline was developed for localizing key features of diagnostic CLE images from gliomas. Third, image style transfer was used to improve the diagnostic quality of CLE images from glioma tumors by transforming the histology patterns in CLE images of fluorescein sodium-stained tissue into the ones in conventional hematoxylin and eosin-stained tissue slides.
These studies suggest that DCNNs are opted for analysis of CLE images. They may assist surgeons in sorting out the non-diagnostic images, highlighting the key regions and enhancing their appearance through pattern transformation in real time. With recent advances in deep learning such as generative adversarial networks and semi-supervised learning, new research directions need to be followed to discover more promises of DCNNs in CLE image analysis.
Handheld, portable confocal laser endomicroscopy (CLE) is being explored in neurosurgery for its ability to image histopathological features of tissue at cellular resolution in real time during brain tumor surgery. Over the course of examination of the surgical tumor resection, hundreds to thousands of images may be collected. The high number of images requires significant time and storage load for subsequent reviewing, which motivated several research groups to employ deep convolutional neural networks (DCNNs) to improve its utility during surgery. DCNNs have proven to be useful in natural and medical image analysis tasks such as classification, object detection, and image segmentation.
This thesis proposes using DCNNs for analyzing CLE images of brain tumors. Particularly, it explores the practicality of DCNNs in three main tasks. First, off-the shelf DCNNs were used to classify images into diagnostic and non-diagnostic. Further experiments showed that both ensemble modeling and transfer learning improved the classifier’s accuracy in evaluating the diagnostic quality of new images at test stage. Second, a weakly-supervised learning pipeline was developed for localizing key features of diagnostic CLE images from gliomas. Third, image style transfer was used to improve the diagnostic quality of CLE images from glioma tumors by transforming the histology patterns in CLE images of fluorescein sodium-stained tissue into the ones in conventional hematoxylin and eosin-stained tissue slides.
These studies suggest that DCNNs are opted for analysis of CLE images. They may assist surgeons in sorting out the non-diagnostic images, highlighting the key regions and enhancing their appearance through pattern transformation in real time. With recent advances in deep learning such as generative adversarial networks and semi-supervised learning, new research directions need to be followed to discover more promises of DCNNs in CLE image analysis.
ContributorsIzady Yazdanabadi, Mohammadhassan (Author) / Preul, Mark (Thesis advisor) / Yang, Yezhou (Thesis advisor) / Nakaji, Peter (Committee member) / Vernon, Brent (Committee member) / Arizona State University (Publisher)
Created2019
Description
The current Enterprise Requirements and Acquisition Model (ERAM), a discrete event simulation of the major tasks and decisions within the DoD acquisition system, identifies several what-if intervention strategies to improve program completion time. However, processes that contribute to the program acquisition completion time were not explicitly identified in the simulation study. This research seeks to determine the acquisition processes that contribute significantly to total simulated program time in the acquisition system for all programs reaching Milestone C. Specifically, this research examines the effect of increased scope management, technology maturity, and decreased variation and mean process times in post-Design Readiness Review contractor activities by performing additional simulation analyses. Potential policies are formulated from the results to further improve program acquisition completion time.
ContributorsWorger, Danielle Marie (Author) / Wu, Teresa (Thesis director) / Shunk, Dan (Committee member) / Wirthlin, J. Robert (Committee member) / Industrial, Systems (Contributor) / Barrett, The Honors College (Contributor)
Created2013-05
Description
To ensure system integrity, robots need to proactively avoid any unwanted physical perturbation that may cause damage to the underlying hardware. In this thesis work, we investigate a machine learning approach that allows robots to anticipate impending physical perturbations from perceptual cues. In contrast to other approaches that require knowledge about sources of perturbation to be encoded before deployment, our method is based on experiential learning. Robots learn to associate visual cues with subsequent physical perturbations and contacts. In turn, these extracted visual cues are then used to predict potential future perturbations acting on the robot. To this end, we introduce a novel deep network architecture which combines multiple sub- networks for dealing with robot dynamics and perceptual input from the environment. We present a self-supervised approach for training the system that does not require any labeling of training data. Extensive experiments in a human-robot interaction task show that a robot can learn to predict physical contact by a human interaction partner without any prior information or labeling. Furthermore, the network is able to successfully predict physical contact from either depth stream input or traditional video input or using both modalities as input.
ContributorsSur, Indranil (Author) / Amor, Heni B (Thesis advisor) / Fainekos, Georgios (Committee member) / Yang, Yezhou (Committee member) / Arizona State University (Publisher)
Created2017
Description
Compressive sensing theory allows to sense and reconstruct signals/images with lower sampling rate than Nyquist rate. Applications in resource constrained environment stand to benefit from this theory, opening up many possibilities for new applications at the same time. The traditional inference pipeline for computer vision sequence reconstructing the image from compressive measurements. However,the reconstruction process is a computationally expensive step that also provides poor results at high compression rate. There have been several successful attempts to perform inference tasks directly on compressive measurements such as activity recognition. In this thesis, I am interested to tackle a more challenging vision problem - Visual question answering (VQA) without reconstructing the compressive images. I investigate the feasibility of this problem with a series of experiments, and I evaluate proposed methods on a VQA dataset and discuss promising results and direction for future work.
ContributorsHuang, Li-Chin (Author) / Turaga, Pavan (Thesis advisor) / Yang, Yezhou (Committee member) / Li, Baoxin (Committee member) / Arizona State University (Publisher)
Created2017
Description
Light field imaging is limited in its computational processing demands of high
sampling for both spatial and angular dimensions. Single-shot light field cameras
sacrifice spatial resolution to sample angular viewpoints, typically by multiplexing
incoming rays onto a 2D sensor array. While this resolution can be recovered using
compressive sensing, these iterative solutions are slow in processing a light field. We
present a deep learning approach using a new, two branch network architecture,
consisting jointly of an autoencoder and a 4D CNN, to recover a high resolution
4D light field from a single coded 2D image. This network decreases reconstruction
time significantly while achieving average PSNR values of 26-32 dB on a variety of
light fields. In particular, reconstruction time is decreased from 35 minutes to 6.7
minutes as compared to the dictionary method for equivalent visual quality. These
reconstructions are performed at small sampling/compression ratios as low as 8%,
allowing for cheaper coded light field cameras. We test our network reconstructions
on synthetic light fields, simulated coded measurements of real light fields captured
from a Lytro Illum camera, and real coded images from a custom CMOS diffractive
light field camera. The combination of compressive light field capture with deep
learning allows the potential for real-time light field video acquisition systems in the
future.
sampling for both spatial and angular dimensions. Single-shot light field cameras
sacrifice spatial resolution to sample angular viewpoints, typically by multiplexing
incoming rays onto a 2D sensor array. While this resolution can be recovered using
compressive sensing, these iterative solutions are slow in processing a light field. We
present a deep learning approach using a new, two branch network architecture,
consisting jointly of an autoencoder and a 4D CNN, to recover a high resolution
4D light field from a single coded 2D image. This network decreases reconstruction
time significantly while achieving average PSNR values of 26-32 dB on a variety of
light fields. In particular, reconstruction time is decreased from 35 minutes to 6.7
minutes as compared to the dictionary method for equivalent visual quality. These
reconstructions are performed at small sampling/compression ratios as low as 8%,
allowing for cheaper coded light field cameras. We test our network reconstructions
on synthetic light fields, simulated coded measurements of real light fields captured
from a Lytro Illum camera, and real coded images from a custom CMOS diffractive
light field camera. The combination of compressive light field capture with deep
learning allows the potential for real-time light field video acquisition systems in the
future.
ContributorsGupta, Mayank (Author) / Turaga, Pavan (Thesis advisor) / Yang, Yezhou (Committee member) / Li, Baoxin (Committee member) / Arizona State University (Publisher)
Created2017
Description
In this thesis, the applications of deep learning in the analysis, detection and classification of medical imaging datasets were studied, with a focus on datasets having a limited sample size. A combined machine learning-deep learning model was designed to classify one small dataset, prostate cancer provided by Mayo Clinic, Arizona. Deep learning model was implemented to extract imaging features followed by machine learning classifier for prostate cancer diagnosis. The results were compared against models trained on texture-based features, namely gray level co-occurrence matrix (GLCM) and Gabor. Some of the challenges of performing diagnosis on medical imaging datasets with limited sample sizes, have been identified. Lastly, a set of future works have been proposed. Keywords: Deep learning, radiology, transfer learning, convolutional neural network.
ContributorsSarkar, Suryadipto (Author) / Wu, Teresa (Thesis advisor) / Papandreou-Suppappola, Antonia (Committee member) / Silva, Alvin (Committee member) / Arizona State University (Publisher)
Created2021
Description
Over the past few decades, medical imaging is becoming important in medicine for disease diagnosis, prognosis, treatment assessment and health monitoring. As medical imaging has progressed, imaging biomarkers are being rapidly developed for early diagnosis and staging of disease. Detecting and segmenting objects from images are often the first steps in quantitative measurement of these biomarkers. While large objects can often be automatically or semi-automatically delineated, segmenting small objects (blobs) is challenging. The small object of particular interest in this dissertation are glomeruli from kidney magnetic resonance (MR) images. This problem has its unique challenges. First of all, the size of glomeruli is extremely small and very similar with noises from images. Second, there are massive of glomeruli in kidney, e.g. over 1 million glomeruli in human kidney, and the intensity distribution is heterogenous. A third recognized issue is that a large portion of glomeruli are overlapping and touched in images. The goal of this dissertation is to develop computational algorithms to identify and discover glomeruli related imaging biomarkers. The first phase is to develop a U-net joint with Hessian based Difference of Gaussians (UH-DoG) blob detector. Joining effort from deep learning alleviates the over-detection issue from Hessian analysis. Next, as extension of UH-DoG, a small blob detector using Bi-Threshold Constrained Adaptive Scales (BTCAS) is proposed. Deep learning is treated as prior of Difference of Gaussian (DoG) to improve its efficiency. By adopting BTCAS, under-segmentation issue of deep learning is addressed. The second phase is to develop a denoising convexity-consistent Blob Generative Adversarial Network (BlobGAN). BlobGAN could achieve high denoising performance and selectively denoise the image without affecting the blobs. These detectors are validated on datasets of 2D fluorescent images, 3D synthetic images, 3D MR (18 mice, 3 humans) images and proved to be outperforming the competing detectors. In the last phase, a Fréchet Descriptors Distance based Coreset approach (FDD-Coreset) is proposed for accelerating BlobGAN’s training. Experiments have shown that BlobGAN trained on FDD-Coreset not only significantly reduces the training time, but also achieves higher denoising performance and maintains approximate performance of blob identification compared with training on entire dataset.
ContributorsXu, Yanzhe (Author) / Wu, Teresa (Thesis advisor) / Iquebal, Ashif (Committee member) / Yan, Hao (Committee member) / Beeman, Scott (Committee member) / Arizona State University (Publisher)
Created2022