Matching Items (29)
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- All Subjects: Creative Project
- Creators: Dean, W.P. Carey School of Business
- Status: Published
Description
Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost the immune system. Bex has been shown to be effective in the treatment of multiple types of cancer, including lung cancer. However, the disadvantages of using Bex include increased instances of hypothyroidism and excessive concentrations of blood triglycerides. If an analog of Bex can be developed which retains high affinity RXR binding similar to the 9-cis retinoic acid while exhibiting less interference for heterodimerization pathways, it would be of great clinical significance in improving the quality of life for patients with CTCL. This thesis will detail the biological profiling of additional novel (Generation Two) analogs, which are currently in submission for publication, as well as that of Generation Three analogs. The results from these studies reveal that specific alterations in the core structure of the Bex "parent" compound structure can have dramatic effects in modifying the biological activity of RXR agonists.
ContributorsYang, Joanna (Author) / Jurutka, Peter (Thesis director) / Wagner, Carl (Committee member) / Hibler, Elizabeth (Committee member) / Barrett, The Honors College (Contributor)
Created2012-05
Description
This thesis aims to explain how a child can deal with loss through a children's book that I have written and illustrated. The goal is to have a child, as young as the age of seven, be able to pick up the book and come away with an initial understanding of how grief affects people. There are references to other works of literature similarly dealing with the above topic. The different stages of grief are examined, as well as the ways in which grief can be handled. Facial expressions and body language are crucial to understanding others' pain and grief, so this thesis delves into how to translate different expressions and actions, and how artwork and illustrations can portray these same ideas. The story from the book is interwoven throughout the thesis, so as to show my reasoning for each section of the text. Finally, there is a full analysis of the text as well as the illustrations that explains why the text is fitting for each section of the story.
ContributorsFauste, Cristina Maria (Author) / Lewis, Stephen (Thesis director) / Gruber, Diane (Committee member) / Barrett, The Honors College (Contributor) / School of Social and Behavioral Sciences (Contributor) / School of Humanities, Arts, and Cultural Studies (Contributor)
Created2015-05
Description
Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor and in return control cell differentiation and proliferation. Bexarotene targets RXR homodimerization to drive transcription of tumor suppressing genes; however, adverse reactions occur simultaneously when bound to other nuclear receptors. In this study, we used novel bexarotene analogs throughout 5 iterations synthesized in the laboratory of Dr. Wagner to test for their potency and ability to bind RXR. The aim of our study is to quantitatively measure RXR homodimerization driven by bexarotene analogs using a yeast two-hybrid system. Our results suggests there to be several compounds with higher protein activity than bexarotene, particularly in generations 3.0 and 5.0. This higher affinity for RXR homodimers may help scientists identify a compound that will minimize adverse effects and toxicity of bexarotene and serve as a better cancer treatment alternative.
ContributorsSeto, David Hua (Author) / Marshall, Pamela (Thesis director) / Wagner, Carl (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2015-05
Description
Chicago, the third largest city in the United States, is frequently in the national media's spotlight for negative news such as violence or failed gun laws. The city is hardly ever talked about in a positive light. This study aims to inform and educate outsiders of what the city is like through the perspective lens of Chicago residents. To grasp a general understanding of Chicago, this creative project was completed through a narrative and interview-driven podcast series and split up into different topic categories. These categories were Chicago food, Chicago neighborhoods, Chicago's Southside, and Chicago sports. These topic areas are some of the things Chicago is most known for and give an adequate representation of what the city is like. Researching and putting this creative project into a podcast form proved how podcasts can be an alternative to in-depth and long-form journalism projects. The Chicago food episode called "Harold's v. Uncle Remus" explains the delicious food culture and showed two of the popular black restaurant chains that cater to the city. These two chicken spots are always a hot topic in heated debates of what place has the best chicken. The neighborhoods episode called "Won't You Be My Neighbor" highlights some of Chicago's interesting neighborhoods that tourists may not have on their attractions lists. This episode talks about the Pill Hill, Printers Row, and Little Italy neighborhoods, which all have unique histories. "Southside With You" explores the infamous region of Chicago, tells its history, and gives a theory as to why it continues to be the area it is known for in the media. Lastly, the sports episode "Sports: A History Lesson" is a full interview with a Chicago resident who has been a Chicago sports fan since the mid-60s and who has experienced the effects of racial divisions in sports. The episodes give only a peak of what the large city is like, but they demonstrate that Chicago is not this scary place, but a place with a complicatedly fascinating history.
ContributorsCarter, Jade (Author) / Thornton, Leslie-Jean (Thesis director) / Gatewood, Kira (Committee member) / School of Social and Behavioral Sciences (Contributor) / Walter Cronkite School of Journalism & Mass Comm (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
Description
The purpose of this creative project was to investigate the process a start-up or small business must complete to have a sell-able apparel product manufactured. The initial goal of the project was to experience the manufacturing process from start to finish and complete a full production run from a professional manufacturer. The conclusion found was that start-ups and small businesses will have to begin production within the United States.
ContributorsBour, Melissa (Author) / Sewell, Dennita (Thesis director) / Rogers, Dale (Committee member) / Ellis, Naomi (Committee member) / Dean, Herberger Institute for Design and the Arts (Contributor) / Department of Supply Chain Management (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
The story of Sor Juana Ines de la Cruz is one of a woman who defied the odds of her time. Sor Juana was a nun born in the 1600's in Mexico. From an early start, she had an endless passion for knowledge and always strove to learn as much as she could. She went on to become a nun at the Convent of Santa Paula and used her intellect to advocate for women's rights. Though met with opposition, she wrote many poems, letters, and even plays which included her strong push for women's equality. However, the name Sor Juana Ines de la Cruz is almost never mentioned in popular feminist discourse, despite Sor Juana being credited as one of the first feminist authors. This paper works to not only tell the story of Sor Juana Ines de la Cruz in detail, but also works to answer the question, "Why do people not know about Sor Juana". By diving into the origins of the Feminist movement in the United States, the dark underbelly of Feminism is uncovered. Primarily, the topic of how racism in feminism has plague the civil rights movement, what damage has been done to people of color because of feminism's history, and how does that pertain to modern day feminism and Sor Juana. By telling her story through both written and visual aids, the voice of Sor Juana Ines de la Cruz is no longer silenced but free to tell her tale and move a generation.
ContributorsParker, Natalie (Author) / Devine, Theresa (Thesis director) / Walker, Michael (Committee member) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
Description
As a writer and reader of young adult (YA) literature, I find it is impossible to ignore the rise of traditional masculinity within new, adolescent heroines. In the 21st century, readers have seen the rise of supposedly strong female characters—heroines who carry assault rifles and avoid their emotions. By relinquishing their emotions and their flaws, these heroines have sacrificed the qualities about themselves that initially made them appear so interesting. My desire to see more realistic heroines like myself developed into a creative fiction project that follows and acknowledges the voices of feminine heroines. I call these protagonists “female strong.” My project—a collection of linked short stories—is peopled with the types of heroines that are severely lacking in YA novels and in the film industry. In my own short stories, I have embraced the narratives about young women who are both strong and emotional. I wanted to create memorable female characters that the reader could root for simply because of their feminine strength, even if their flaws were naivety, or lack of confidence, or even if they failed to achieve their resolution in the end. Female-strong characters are vital because they present a view of women who aren’t purely fantasy; they are placed in the real and are feminine, too. In other words, they don’t have to be a gorgeous, knockout model who can kick butt; instead, they can derive strength from their intellect, or their intuition, or perhaps even from their emotion.
ContributorsGoldsmith, Ilyssa Sallie (Author) / Gruber, Diane (Thesis director) / Amparano, Julie (Committee member) / School of Humanities, Arts, and Cultural Studies (Contributor) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
DescriptionThrough artist book, printed photographs, paintings, writing, and web design, August Tang deconstructed their identity as a nonbinary person. Both educational and expressive, the creative project was a manifestation of a coming out journey, affirmation of gender identity, and experiences relating to gender with friends, family, and strangers.
ContributorsTang, August B (Author) / Button, Melissa (Thesis director) / Sanft, Alfred (Committee member) / School of Art (Contributor) / Dean, W.P. Carey School of Business (Contributor) / The Design School (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
SmartAid aims to target a small, yet relevant issue in a cost effective, easily replicable, and innovative manner. This paper outlines how to replicate the design and building process to create an intelligent first aid kit. SmartAid utilizes Alexa Voice Service technologies to provide a new and improved way to teach users about the different types of first aid kit items and how to treat minor injuries, step by step. Using Alexa and RaspberryPi, SmartAid was designed as an added attachment to first aid kits. Alexa Services were installed into a RaspberryPi to create a custom Amazon device, and from there, using the Alexa Interaction Model and the Lambda function services, SmartAid was developed. After the designing and coding of the application, a user guide was created to provide users with information on what items are included in the first aid kit, what types of injuries can be treated through first aid, and how to use SmartAid. The
application was tested for its usability and practicality by a small sample of students. Users provided suggestions on how to make the application more versatile and functional, and confirmed that the application made first aid easier and was something that they could see themselves using. While this application is not aimed to replace the current physical guide solution completely, the findings of this project show that SmartAid has potential to stand in as an improved, easy to use, and convenient alternative for first aid guidance.
application was tested for its usability and practicality by a small sample of students. Users provided suggestions on how to make the application more versatile and functional, and confirmed that the application made first aid easier and was something that they could see themselves using. While this application is not aimed to replace the current physical guide solution completely, the findings of this project show that SmartAid has potential to stand in as an improved, easy to use, and convenient alternative for first aid guidance.
ContributorsHasan, Bushra Anwara (Author) / Kobayashi, Yoshihiro (Thesis director) / Nakamura, Mutsumi (Committee member) / Computer Science and Engineering Program (Contributor) / Department of Psychology (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
A playwright behind the scenes of my personal struggle with PTSD, experience that caused it, and journey to healing from it. The playwright consists of deeper causes of PTSD and its effects, more than the average textbook can teach anyone. With the help of a couple people and Russ, a famous artist, I was able to grow and become stronger and show it all within my playwright. Enjoy the journey to healing of a person, a warrior who wanted to fight and made it through the night.
ContributorsCristobal, Nicky Desiree (Author) / Lewis, Stephen (Thesis director) / Zygutis, Linda (Committee member) / School of Humanities, Arts, and Cultural Studies (Contributor) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05