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Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost the immune system. Bex has been shown to be effective

Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost the immune system. Bex has been shown to be effective in the treatment of multiple types of cancer, including lung cancer. However, the disadvantages of using Bex include increased instances of hypothyroidism and excessive concentrations of blood triglycerides. If an analog of Bex can be developed which retains high affinity RXR binding similar to the 9-cis retinoic acid while exhibiting less interference for heterodimerization pathways, it would be of great clinical significance in improving the quality of life for patients with CTCL. This thesis will detail the biological profiling of additional novel (Generation Two) analogs, which are currently in submission for publication, as well as that of Generation Three analogs. The results from these studies reveal that specific alterations in the core structure of the Bex "parent" compound structure can have dramatic effects in modifying the biological activity of RXR agonists.
ContributorsYang, Joanna (Author) / Jurutka, Peter (Thesis director) / Wagner, Carl (Committee member) / Hibler, Elizabeth (Committee member) / Barrett, The Honors College (Contributor)
Created2012-05
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This thesis aims to explain how a child can deal with loss through a children's book that I have written and illustrated. The goal is to have a child, as young as the age of seven, be able to pick up the book and come away with an initial understanding

This thesis aims to explain how a child can deal with loss through a children's book that I have written and illustrated. The goal is to have a child, as young as the age of seven, be able to pick up the book and come away with an initial understanding of how grief affects people. There are references to other works of literature similarly dealing with the above topic. The different stages of grief are examined, as well as the ways in which grief can be handled. Facial expressions and body language are crucial to understanding others' pain and grief, so this thesis delves into how to translate different expressions and actions, and how artwork and illustrations can portray these same ideas. The story from the book is interwoven throughout the thesis, so as to show my reasoning for each section of the text. Finally, there is a full analysis of the text as well as the illustrations that explains why the text is fitting for each section of the story.
ContributorsFauste, Cristina Maria (Author) / Lewis, Stephen (Thesis director) / Gruber, Diane (Committee member) / Barrett, The Honors College (Contributor) / School of Social and Behavioral Sciences (Contributor) / School of Humanities, Arts, and Cultural Studies (Contributor)
Created2015-05
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Description
Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor

Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor and in return control cell differentiation and proliferation. Bexarotene targets RXR homodimerization to drive transcription of tumor suppressing genes; however, adverse reactions occur simultaneously when bound to other nuclear receptors. In this study, we used novel bexarotene analogs throughout 5 iterations synthesized in the laboratory of Dr. Wagner to test for their potency and ability to bind RXR. The aim of our study is to quantitatively measure RXR homodimerization driven by bexarotene analogs using a yeast two-hybrid system. Our results suggests there to be several compounds with higher protein activity than bexarotene, particularly in generations 3.0 and 5.0. This higher affinity for RXR homodimers may help scientists identify a compound that will minimize adverse effects and toxicity of bexarotene and serve as a better cancer treatment alternative.
ContributorsSeto, David Hua (Author) / Marshall, Pamela (Thesis director) / Wagner, Carl (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2015-05
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Description
Chicago, the third largest city in the United States, is frequently in the national media's spotlight for negative news such as violence or failed gun laws. The city is hardly ever talked about in a positive light. This study aims to inform and educate outsiders of what the city is

Chicago, the third largest city in the United States, is frequently in the national media's spotlight for negative news such as violence or failed gun laws. The city is hardly ever talked about in a positive light. This study aims to inform and educate outsiders of what the city is like through the perspective lens of Chicago residents. To grasp a general understanding of Chicago, this creative project was completed through a narrative and interview-driven podcast series and split up into different topic categories. These categories were Chicago food, Chicago neighborhoods, Chicago's Southside, and Chicago sports. These topic areas are some of the things Chicago is most known for and give an adequate representation of what the city is like. Researching and putting this creative project into a podcast form proved how podcasts can be an alternative to in-depth and long-form journalism projects. The Chicago food episode called "Harold's v. Uncle Remus" explains the delicious food culture and showed two of the popular black restaurant chains that cater to the city. These two chicken spots are always a hot topic in heated debates of what place has the best chicken. The neighborhoods episode called "Won't You Be My Neighbor" highlights some of Chicago's interesting neighborhoods that tourists may not have on their attractions lists. This episode talks about the Pill Hill, Printers Row, and Little Italy neighborhoods, which all have unique histories. "Southside With You" explores the infamous region of Chicago, tells its history, and gives a theory as to why it continues to be the area it is known for in the media. Lastly, the sports episode "Sports: A History Lesson" is a full interview with a Chicago resident who has been a Chicago sports fan since the mid-60s and who has experienced the effects of racial divisions in sports. The episodes give only a peak of what the large city is like, but they demonstrate that Chicago is not this scary place, but a place with a complicatedly fascinating history.
ContributorsCarter, Jade (Author) / Thornton, Leslie-Jean (Thesis director) / Gatewood, Kira (Committee member) / School of Social and Behavioral Sciences (Contributor) / Walter Cronkite School of Journalism & Mass Comm (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
Description
The story of Sor Juana Ines de la Cruz is one of a woman who defied the odds of her time. Sor Juana was a nun born in the 1600's in Mexico. From an early start, she had an endless passion for knowledge and always strove to learn as much

The story of Sor Juana Ines de la Cruz is one of a woman who defied the odds of her time. Sor Juana was a nun born in the 1600's in Mexico. From an early start, she had an endless passion for knowledge and always strove to learn as much as she could. She went on to become a nun at the Convent of Santa Paula and used her intellect to advocate for women's rights. Though met with opposition, she wrote many poems, letters, and even plays which included her strong push for women's equality. However, the name Sor Juana Ines de la Cruz is almost never mentioned in popular feminist discourse, despite Sor Juana being credited as one of the first feminist authors. This paper works to not only tell the story of Sor Juana Ines de la Cruz in detail, but also works to answer the question, "Why do people not know about Sor Juana". By diving into the origins of the Feminist movement in the United States, the dark underbelly of Feminism is uncovered. Primarily, the topic of how racism in feminism has plague the civil rights movement, what damage has been done to people of color because of feminism's history, and how does that pertain to modern day feminism and Sor Juana. By telling her story through both written and visual aids, the voice of Sor Juana Ines de la Cruz is no longer silenced but free to tell her tale and move a generation.
ContributorsParker, Natalie (Author) / Devine, Theresa (Thesis director) / Walker, Michael (Committee member) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
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As a writer and reader of young adult (YA) literature, I find it is impossible to ignore the rise of traditional masculinity within new, adolescent heroines. In the 21st century, readers have seen the rise of supposedly strong female characters—heroines who carry assault rifles and avoid their emotions. By relinquishing

As a writer and reader of young adult (YA) literature, I find it is impossible to ignore the rise of traditional masculinity within new, adolescent heroines. In the 21st century, readers have seen the rise of supposedly strong female characters—heroines who carry assault rifles and avoid their emotions. By relinquishing their emotions and their flaws, these heroines have sacrificed the qualities about themselves that initially made them appear so interesting. My desire to see more realistic heroines like myself developed into a creative fiction project that follows and acknowledges the voices of feminine heroines. I call these protagonists “female strong.” My project—a collection of linked short stories—is peopled with the types of heroines that are severely lacking in YA novels and in the film industry. In my own short stories, I have embraced the narratives about young women who are both strong and emotional. I wanted to create memorable female characters that the reader could root for simply because of their feminine strength, even if their flaws were naivety, or lack of confidence, or even if they failed to achieve their resolution in the end. Female-strong characters are vital because they present a view of women who aren’t purely fantasy; they are placed in the real and are feminine, too. In other words, they don’t have to be a gorgeous, knockout model who can kick butt; instead, they can derive strength from their intellect, or their intuition, or perhaps even from their emotion.
ContributorsGoldsmith, Ilyssa Sallie (Author) / Gruber, Diane (Thesis director) / Amparano, Julie (Committee member) / School of Humanities, Arts, and Cultural Studies (Contributor) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
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Description

A playwright behind the scenes of my personal struggle with PTSD, experience that caused it, and journey to healing from it. The playwright consists of deeper causes of PTSD and its effects, more than the average textbook can teach anyone. With the help of a couple people and Russ, a

A playwright behind the scenes of my personal struggle with PTSD, experience that caused it, and journey to healing from it. The playwright consists of deeper causes of PTSD and its effects, more than the average textbook can teach anyone. With the help of a couple people and Russ, a famous artist, I was able to grow and become stronger and show it all within my playwright. Enjoy the journey to healing of a person, a warrior who wanted to fight and made it through the night.

ContributorsCristobal, Nicky Desiree (Author) / Lewis, Stephen (Thesis director) / Zygutis, Linda (Committee member) / School of Humanities, Arts, and Cultural Studies (Contributor) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

This is a composition of information derived from the research conducted to produce each episode of Nefarious. As part of my final thesis project for my undergraduate degrees in criminal justice and forensic psychology, I created a podcast on the topic of true crime with an academic approach titled Nefarious.

This is a composition of information derived from the research conducted to produce each episode of Nefarious. As part of my final thesis project for my undergraduate degrees in criminal justice and forensic psychology, I created a podcast on the topic of true crime with an academic approach titled Nefarious. Each episode of Nefarious examines a particular case in relation to some academic theme learned throughout my educational career at Arizona State University. Episode one examines the life and crimes of Richard Ramirez and different criminological theories that could be used to explain his behavior. Episode two looks at the case of Brock Turner and Chanel Miller and focuses on the larger problem of rape culture in America and sexual assault on college campuses. In episode three the case of the Central Park Five is detailed in relation to false confessions and wrongful convictions within the legal system. Episode four is centered around Kyle Rittenhouse and the use of self-defense as a legal defense in the justice system as well as the political atmosphere surrounding this case. The fifth episode explores three cases of police brutality against racial minorities and the history of police in America. The final episode of Nefarious covers the life and crimes of Jeffrey Dahmer and analyzes such actions from a forensic psychology approach.

ContributorsBuche, Bailee (Author) / McClelland, Blake (Thesis director) / DeCarolis, Claudine (Committee member) / Barrett, The Honors College (Contributor) / School of Criminology and Criminal Justice (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2023-05
Description

In the United States, the majority of the population suffers from some form of trauma. There are many ways that an individual can cope and accept their trauma, but two practices stand out as an inexpensive, flexible option for many. Bibliotherapy is the use of reading literature as a way

In the United States, the majority of the population suffers from some form of trauma. There are many ways that an individual can cope and accept their trauma, but two practices stand out as an inexpensive, flexible option for many. Bibliotherapy is the use of reading literature as a way to learn more about and understand one’s trauma through the perspective of others. Expressive writing is the practice of writing and reflecting about one’s own traumatic experiences, as well as the emotions that are tethered to it. In this paper, I explore the fields of bibliotherapy and expressive writing as forms of therapy by reviewing the history, use, goals, and effects of each in the context of mental and emotional well-being. Intertwined with the scholarship is my own self-guided bibliotherapy of reading memoirs and poetry collections related to my trauma and self-guided expressive writing in which I wrote a short collection of personal essays and poetry, finding that both fields, separately and used together, are effective avenues for trauma healing.

ContributorsGonzales, Veronica (Author) / Kirsch, Sharon (Thesis director) / Amparano Garcia, Julie (Committee member) / Barrett, The Honors College (Contributor) / School of Humanities, Arts, and Cultural Studies (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2022-12