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In the medical industry, there have been promising advances in the increase of new types of healthcare to the public. As of 2015, there was a 98% Premarket Approval rate, a 38% increase since 2010. In addition, there were 41 new novel drugs approved for clinical usage in 2014 where

In the medical industry, there have been promising advances in the increase of new types of healthcare to the public. As of 2015, there was a 98% Premarket Approval rate, a 38% increase since 2010. In addition, there were 41 new novel drugs approved for clinical usage in 2014 where the average in the previous years from 2005-2013 was 25. However, the research process towards creating and delivering new healthcare to the public remains remarkably inefficient. It takes on average 15 years, over $900 million by one estimate, for a less than 12% success rate of discovering a novel drug for clinical usage. Medical devices do not fare much better. Between 2005-2009, there were over 700 recalls per year. In addition, it takes at minimum 3.25 years for a 510(k) exempt premarket approval. Plus, a time lag exists where it takes 17 years for only 14% of medical discoveries to be implemented clinically. Coupled with these inefficiencies, government funding for medical research has been decreasing since 2002 (2.5% of Gross Domestic Product) and is predicted to be 1.5% of Gross Domestic Product by 2019. Translational research, the conversion of bench-side discoveries to clinical usage for a simplistic definition, has been on the rise since the 1990s. This may be driving the increased premarket approvals and new novel drug approvals. At the very least, it is worth considering as translational research is directly related towards healthcare practices. In this paper, I propose to improve the outcomes of translational research in order to better deliver advancing healthcare to the public. I suggest Best Value Performance Information Procurement System (BV PIPS) should be adapted in the selection process of translational research projects to fund. BV PIPS has been shown to increase the efficiency and success rate of delivering projects and services. There has been over 17 years of research with $6.3 billion of projects and services delivered showing that BV PIPS has a 98% customer satisfaction, 90% minimized management effort, and utilizes 50% less manpower and effort. Using University of Michigan \u2014 Coulter Foundation Program's funding process as a baseline and standard in the current selection of translational research projects to fund, I offer changes to this process based on BV PIPS that may ameliorate it. As concepts implemented in this process are congruent with literature on successful translational research, it may suggest that this new model for selecting translational research projects to fund will reduce costs, increase efficiency, and increase success. This may then lead to more Premarket Approvals, more new novel drug approvals, quicker delivery time to the market, and lower recalls.
ContributorsDel Rosario, Joseph Paul (Author) / Kashiwagi, Dean (Thesis director) / Kashiwagi, Jacob (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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The effects of temperatures found commonly along the supply chain were explored when interacting with dendritic identifiers of various common materials. Regression analyses showed that there was no statistical significance in relating SIFT correspondence values to the surface temperature of the dendrites. Physical inspection helped evaluate the integrity of specific

The effects of temperatures found commonly along the supply chain were explored when interacting with dendritic identifiers of various common materials. Regression analyses showed that there was no statistical significance in relating SIFT correspondence values to the surface temperature of the dendrites. Physical inspection helped evaluate the integrity of specific material and substrate combinations along with possibilities for improvement in key point designation within SIFT and ORB image recognition software.

ContributorsMolzen, Noah (Author) / Hedges, Craig (Thesis director) / Reeves, James (Committee member) / Trujillo, Rhett (Committee member) / Barrett, The Honors College (Contributor) / Mechanical and Aerospace Engineering Program (Contributor)
Created2022-05
Description
The production and incineration of single-use micropipette tips and disposable gloves, which are heavily used within laboratory facilities, generate large amounts of greenhouse gasses (GHGs) and accelerate climate change. Plastic waste that is not incinerated often is lost in the environment. The long degradation times associated with this waste exacerbates

The production and incineration of single-use micropipette tips and disposable gloves, which are heavily used within laboratory facilities, generate large amounts of greenhouse gasses (GHGs) and accelerate climate change. Plastic waste that is not incinerated often is lost in the environment. The long degradation times associated with this waste exacerbates a variety of environmental problems such as substance runoff and ocean pollution. The objective of this study was to evaluate the efficacy of possible solutions for minimizing micropipette tip and disposable glove waste within laboratory spaces. It was hypothesized that simultaneously implementing the use of micropipette tip washers (MTWs) and energy-from-glove-waste programs (EGWs) would significantly reduce (p < 0.05) the average combined annual single-use plastic micropipette tip and nitrile glove waste (in kg) per square meter of laboratory space in the United States. ASU’s Biodesign Institute (BDI) was used as a case study to inform on the thousands of different laboratory facilities that exist all across the United States. Four separate research laboratories within the largest public university of the U.S. were sampled to assess the volume of plastic waste from single-use micropipette tips and gloves. Resultant data were used to represent the totality of single-use waste from the case study location and then extrapolated to all laboratory space in the United States. With the implementation of EGWs, annual BDI glove waste is reduced by 100% (0.47 ± 0.26 kg/m2; 35.5 ± 19.3 metric tons total) and annual BDI glove-related carbon emissions are reduced by ~5.01% (0.165 ± 0.09 kg/m2; 1.24 ± 0.68 metric tons total). With the implementation of MTWs, annual BDI micropipette tip waste is reduced by 92% (0.117 ± 0.03 kg/m2; 0.88 ± 0.25 metric tons total) and annual BDI tip-related carbon emissions are reduced by ~83.6% (4.04 ± 1.25 kg/m2; 30.5 ± 9.43 metric tons total). There was no significant difference (p = 0.06) observed between the mass of single-use waste (kg) in the sampled laboratory spaces before (x̄ = 47.1; σ = 43.3) and after (x̄ =0.070; σ = 0.033) the implementation of the solutions. When examining both solutions (MTWs & EGWs) implemented in conjunction with one another, the annual BDI financial savings (in regard to both purchasing and disposal costs) after the first year were determined to be ~$7.92 ± $9.31/m2 (7,500 m2 of total wet laboratory space) or ~$60,000 ± $70,000 total. These savings represent ~15.77% of annual BDI spending on micropipette tips and nitrile gloves. The large error margins in these financial estimates create high uncertainty for whether or not BDI would see net savings from implementing both solutions simultaneously. However, when examining the implementation of only MTWs, the annual BDI financial savings (in regard to both purchasing and disposal costs) after the first year were determined to be ~$12.01 ± $6.79 kg/m2 or ~$91,000 ± $51,200 total. These savings represent ~23.92% of annual BDI spending on micropipette tips and nitrile gloves. The lower error margins for this estimate create a much higher likelihood of net savings for BDI. Extrapolating to all laboratory space in the United States, the total annual amount of plastic waste avoided with the implementation of the MTWs was identified as 8,130 ± 2,290 tons or 0.023% of all solid plastic waste produced in the United States in 2018. The total amount of nitrile waste avoided with the implementation of the EGWs was identified as 32,800 ± 17,900 tons or 0.36% of all rubber solid waste produced in the United States in 2018. The total amount of carbon emissions avoided with the implementation of the MTWs was identified as 281,000 ± 87,000 tons CO2eq or 5.4*10-4 % of all CO2eq GHG emissions produced in the United States in 2020. Both the micropipette tip washer and the glove waste avoidance program solutions can be easily integrated into existing laboratories without compromising the integrity of the activities taking place. Implemented on larger scales, these solutions hold the potential for significant single-use waste reduction.
ContributorsZdrale, Gabriel (Author) / Mahant, Akhil (Co-author) / Halden, Rolf (Thesis director) / Biyani, Nivedita (Committee member) / Driver, Erin (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2022-05
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Description

The production and incineration of single-use micropipette tips and disposable gloves, which are heavily used within laboratory facilities, generate large amounts of greenhouse gasses (GHGs) and accelerate climate change. Plastic waste that is not incinerated often is lost in the environment. The long degradation times associated with this waste exacerbates

The production and incineration of single-use micropipette tips and disposable gloves, which are heavily used within laboratory facilities, generate large amounts of greenhouse gasses (GHGs) and accelerate climate change. Plastic waste that is not incinerated often is lost in the environment. The long degradation times associated with this waste exacerbates a variety of environmental problems such as substance runoff and ocean pollution. The objective of this study was to evaluate the efficacy of possible solutions for minimizing micropipette tip and disposable glove waste within laboratory spaces. It was hypothesized that simultaneously implementing the use of micropipette tip washers (MTWs) and energy-from-glove-waste programs (EGWs) would significantly reduce (p < 0.05) the average combined annual single-use plastic micropipette tip and nitrile glove waste (in kg) per square meter of laboratory space in the United States. ASU’s Biodesign Institute (BDI) was used as a case study to inform on the thousands of different laboratory facilities that exist all across the United States. Four separate research laboratories within the largest public university of the U.S. were sampled to assess the volume of plastic waste from single-use micropipette tips and gloves. Resultant data were used to represent the totality of single-use waste from the case study location and then extrapolated to all laboratory space in the United States. With the implementation of EGWs, annual BDI glove waste is reduced by 100% (0.47 ± 0.26 kg/m2; 35.5 ± 19.3 metric tons total) and annual BDI glove-related carbon emissions are reduced by ~5.01% (0.165 ± 0.09 kg/m2; 1.24 ± 0.68 metric tons total). With the implementation of MTWs, annual BDI micropipette tip waste is reduced by 92% (0.117 ± 0.03 kg/m2; 0.88 ± 0.25 metric tons total) and annual BDI tip-related carbon emissions are reduced by ~83.6% (4.04 ± 1.25 kg/m2; 30.5 ± 9.43 metric tons total). There was no significant difference (p = 0.06) observed between the mass of single-use waste (kg) in the sampled laboratory spaces before (x̄ = 47.1; σ = 43.3) and after (x̄ =0.070; σ = 0.033) the implementation of the solutions. When examining both solutions (MTWs & EGWs) implemented in conjunction with one another, the annual BDI financial savings (in regard to both purchasing and disposal costs) after the first year were determined to be ~$7.92 ± $9.31/m2 (7,500 m2 of total wet laboratory space) or ~$60,000 ± $70,000 total. These savings represent ~15.77% of annual BDI spending on micropipette tips and nitrile gloves. The large error margins in these financial estimates create high uncertainty for whether or not BDI would see net savings from implementing both solutions simultaneously. However, when examining the implementation of only MTWs, the annual BDI financial savings (in regard to both purchasing and disposal costs) after the first year were determined to be ~$12.01 ± $6.79 kg/m2 or ~$91,000 ± $51,200 total. These savings represent ~23.92% of annual BDI spending on micropipette tips and nitrile gloves. The lower error margins for this estimate create a much higher likelihood of net savings for BDI. Extrapolating to all laboratory space in the United States, the total annual amount of plastic waste avoided with the implementation of the MTWs was identified as 8,130 ± 2,290 tons or 0.023% of all solid plastic waste produced in the United States in 2018. The total amount of nitrile waste avoided with the implementation of the EGWs was identified as 32,800 ± 17,900 tons or 0.36% of all rubber solid waste produced in the United States in 2018. The total amount of carbon emissions avoided with the implementation of the MTWs was identified as 281,000 ± 87,000 tons CO2eq or 5.4*10-4 % of all CO2eq GHG emissions produced in the United States in 2020. Both the micropipette tip washer and the glove waste avoidance program solutions can be easily integrated into existing laboratories without compromising the integrity of the activities taking place. Implemented on larger scales, these solutions hold the potential for significant single-use waste reduction.

ContributorsZdrale, Gabriel (Author) / Mahant, Akhil (Co-author) / Halden, Rolf (Thesis director) / Biyani, Nivedita (Committee member) / Driver, Erin (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2022-05
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Description

The production and incineration of single-use micropipette tips and disposable gloves, which are heavily used within laboratory facilities, generate large amounts of greenhouse gasses (GHGs) and accelerate climate change. Plastic waste that is not incinerated often is lost in the environment. The long degradation times associated with this waste exacerbates

The production and incineration of single-use micropipette tips and disposable gloves, which are heavily used within laboratory facilities, generate large amounts of greenhouse gasses (GHGs) and accelerate climate change. Plastic waste that is not incinerated often is lost in the environment. The long degradation times associated with this waste exacerbates a variety of environmental problems such as substance runoff and ocean pollution. The objective of this study was to evaluate the efficacy of possible solutions for minimizing micropipette tip and disposable glove waste within laboratory spaces. It was hypothesized that simultaneously implementing the use of micropipette tip washers (MTWs) and energy-from-glove-waste programs (EGWs) would significantly reduce (p < 0.05) the average combined annual single-use plastic micropipette tip and nitrile glove waste (in kg) per square meter of laboratory space in the United States. ASU’s Biodesign Institute (BDI) was used as a case study to inform on the thousands of different laboratory facilities that exist all across the United States. Four separate research laboratories within the largest public university of the U.S. were sampled to assess the volume of plastic waste from single-use micropipette tips and gloves. Resultant data were used to represent the totality of single-use waste from the case study location and then extrapolated to all laboratory space in the United States. With the implementation of EGWs, annual BDI glove waste is reduced by 100% (0.47 ± 0.26 kg/m2; 35.5 ± 19.3 metric tons total) and annual BDI glove-related carbon emissions are reduced by ~5.01% (0.165 ± 0.09 kg/m2; 1.24 ± 0.68 metric tons total). With the implementation of MTWs, annual BDI micropipette tip waste is reduced by 92% (0.117 ± 0.03 kg/m2; 0.88 ± 0.25 metric tons total) and annual BDI tip-related carbon emissions are reduced by ~83.6% (4.04 ± 1.25 kg/m2; 30.5 ± 9.43 metric tons total). There was no significant difference (p = 0.06) observed between the mass of single-use waste (kg) in the sampled laboratory spaces before (x̄ = 47.1; σ = 43.3) and after (x̄ =0.070; σ = 0.033) the implementation of the solutions. When examining both solutions (MTWs & EGWs) implemented in conjunction with one another, the annual BDI financial savings (in regard to both purchasing and disposal costs) after the first year were determined to be ~$7.92 ± $9.31/m2 (7,500 m2 of total wet laboratory space) or ~$60,000 ± $70,000 total. These savings represent ~15.77% of annual BDI spending on micropipette tips and nitrile gloves. The large error margins in these financial estimates create high uncertainty for whether or not BDI would see net savings from implementing both solutions simultaneously. However, when examining the implementation of only MTWs, the annual BDI financial savings (in regard to both purchasing and disposal costs) after the first year were determined to be ~$12.01 ± $6.79 kg/m2 or ~$91,000 ± $51,200 total. These savings represent ~23.92% of annual BDI spending on micropipette tips and nitrile gloves. The lower error margins for this estimate create a much higher likelihood of net savings for BDI. Extrapolating to all laboratory space in the United States, the total annual amount of plastic waste avoided with the implementation of the MTWs was identified as 8,130 ± 2,290 tons or 0.023% of all solid plastic waste produced in the United States in 2018. The total amount of nitrile waste avoided with the implementation of the EGWs was identified as 32,800 ± 17,900 tons or 0.36% of all rubber solid waste produced in the United States in 2018. The total amount of carbon emissions avoided with the implementation of the MTWs was identified as 281,000 ± 87,000 tons CO2eq or 5.4*10-4 % of all CO2eq GHG emissions produced in the United States in 2020. Both the micropipette tip washer and the glove waste avoidance program solutions can be easily integrated into existing laboratories without compromising the integrity of the activities taking place. Implemented on larger scales, these solutions hold the potential for significant single-use waste reduction.

ContributorsZdrale, Gabriel (Author) / Mahant, Akhil (Co-author) / Halden, Rolf (Thesis director) / Biyani, Nivedita (Committee member) / Driver, Erin (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2022-05
Description
The Difference Engine at Arizona State University developed the Women’s Power and Influence Index (WPI) in order to combat the systemic inequality faced by women in the workplace. It aims to analyze data, such as Equal Employment Opportunity data, from various Fortune 500 companies to provide a measure of workplace

The Difference Engine at Arizona State University developed the Women’s Power and Influence Index (WPI) in order to combat the systemic inequality faced by women in the workplace. It aims to analyze data, such as Equal Employment Opportunity data, from various Fortune 500 companies to provide a measure of workplace inequality as well as encourage these institutions to adopt more equitable policies. By rating companies based on what truly matters to women, ASU’s Difference Engine hopes to help both women in existing career paths as well as women seeking a new career or position in companies. However, in order for the WPI to become a relevant scoring metric of gender equality within the workplace, we must raise awareness about the issue of gender equality and of the index itself. By raising awareness about gender inequality as well as inspiring companies to further equality within their workplaces, the WPI will serve to have an integral role in increasing gender equality in the workplace. Our approach for raising awareness utilizes two different strategies: (1) establishing a new version of the WPI website that is both informative and aesthetically pleasing and (2) generating social media content on TikTok that appeal to a variety of audiences and introduce them to the WPI and our mission.
ContributorsHoward, Brooke (Author) / Tieu, Lienna (Co-author) / Thomas, Elisa (Co-author) / Zaffar, Ehsan (Thesis director) / Gel, Esma (Committee member) / Barrett, The Honors College (Contributor) / Mechanical and Aerospace Engineering Program (Contributor) / Department of Psychology (Contributor)
Created2022-05
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Description

The Difference Engine at Arizona State University developed the Women’s Power and Influence Index (WPI) in order to combat the systemic inequality faced by women in the workplace. It aims to analyze data, such as Equal Employment Opportunity data, from various Fortune 500 companies to provide a measure of workplace

The Difference Engine at Arizona State University developed the Women’s Power and Influence Index (WPI) in order to combat the systemic inequality faced by women in the workplace. It aims to analyze data, such as Equal Employment Opportunity data, from various Fortune 500 companies to provide a measure of workplace inequality as well as encourage these institutions to adopt more equitable policies. By rating companies based on what truly matters to women, ASU’s Difference Engine hopes to help both women in existing career paths as well as women seeking a new career or position in companies. However, in order for the WPI to become a relevant scoring metric of gender equality within the workplace, we must raise awareness about the issue of gender equality and of the index itself. By raising awareness about gender inequality as well as inspiring companies to further equality within their workplaces, the WPI will serve to have an integral role in increasing gender equality in the workplace. Our approach for raising awareness utilizes two different strategies: (1) establishing a new version of the WPI website that is both informative and aesthetically pleasing and (2) generating social media content on TikTok that appeal to a variety of audiences and introduce them to the WPI and our mission.

ContributorsHoward, Brooke (Author) / Tieu, Lienna (Co-author) / Thomas, Elisa (Co-author) / Zaffar, Ehsan (Thesis director) / Gel, Esma (Committee member) / Barrett, The Honors College (Contributor) / Mechanical and Aerospace Engineering Program (Contributor)
Created2022-05
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Description

The Difference Engine at Arizona State University developed the Women’s Power and Influence Index (WPI) in order to combat the systemic inequality faced by women in the workplace. It aims to analyze data, such as Equal Employment Opportunity data, from various Fortune 500 companies to provide a measure of workplace

The Difference Engine at Arizona State University developed the Women’s Power and Influence Index (WPI) in order to combat the systemic inequality faced by women in the workplace. It aims to analyze data, such as Equal Employment Opportunity data, from various Fortune 500 companies to provide a measure of workplace inequality as well as encourage these institutions to adopt more equitable policies. By rating companies based on what truly matters to women, ASU’s Difference Engine hopes to help both women in existing career paths as well as women seeking a new career or position in companies. However, in order for the WPI to become a relevant scoring metric of gender equality within the workplace, we must raise awareness about the issue of gender equality and of the index itself. By raising awareness about gender inequality as well as inspiring companies to further equality within their workplaces, the WPI will serve to have an integral role in increasing gender equality in the workplace. Our approach for raising awareness utilizes two different strategies: (1) establishing a new version of the WPI website that is both informative and aesthetically pleasing and (2) generating social media content on TikTok that appeal to a variety of audiences and introduce them to the WPI and our mission.

ContributorsHoward, Brooke (Author) / Tieu, Lienna (Co-author) / Thomas, Elisa (Co-author) / Zaffar, Ehsan (Thesis director) / Gel, Esma (Committee member) / Barrett, The Honors College (Contributor) / Mechanical and Aerospace Engineering Program (Contributor)
Created2022-05
165885-Thumbnail Image.jpg
Description

The Difference Engine at Arizona State University developed the Women’s Power and Influence Index (WPI) in order to combat the systemic inequality faced by women in the workplace. It aims to analyze data, such as Equal Employment Opportunity data, from various Fortune 500 companies to provide a measure of workplace

The Difference Engine at Arizona State University developed the Women’s Power and Influence Index (WPI) in order to combat the systemic inequality faced by women in the workplace. It aims to analyze data, such as Equal Employment Opportunity data, from various Fortune 500 companies to provide a measure of workplace inequality as well as encourage these institutions to adopt more equitable policies. By rating companies based on what truly matters to women, ASU’s Difference Engine hopes to help both women in existing career paths as well as women seeking a new career or position in companies. However, in order for the WPI to become a relevant scoring metric of gender equality within the workplace, we must raise awareness about the issue of gender equality and of the index itself. By raising awareness about gender inequality as well as inspiring companies to further equality within their workplaces, the WPI will serve to have an integral role in increasing gender equality in the workplace. Our approach for raising awareness utilizes two different strategies: (1) establishing a new version of the WPI website that is both informative and aesthetically pleasing and (2) generating social media content on TikTok that appeal to a variety of audiences and introduce them to the WPI and our mission.

ContributorsHoward, Brooke (Author) / Tieu, Lienna (Co-author) / Thomas, Elisa (Co-author) / Zaffar, Ehsan (Thesis director) / Gel, Esma (Committee member) / Barrett, The Honors College (Contributor) / Mechanical and Aerospace Engineering Program (Contributor)
Created2022-05
165886-Thumbnail Image.jpg
Description

The Difference Engine at Arizona State University developed the Women’s Power and Influence Index (WPI) in order to combat the systemic inequality faced by women in the workplace. It aims to analyze data, such as Equal Employment Opportunity data, from various Fortune 500 companies to provide a measure of workplace

The Difference Engine at Arizona State University developed the Women’s Power and Influence Index (WPI) in order to combat the systemic inequality faced by women in the workplace. It aims to analyze data, such as Equal Employment Opportunity data, from various Fortune 500 companies to provide a measure of workplace inequality as well as encourage these institutions to adopt more equitable policies. By rating companies based on what truly matters to women, ASU’s Difference Engine hopes to help both women in existing career paths as well as women seeking a new career or position in companies. However, in order for the WPI to become a relevant scoring metric of gender equality within the workplace, we must raise awareness about the issue of gender equality and of the index itself. By raising awareness about gender inequality as well as inspiring companies to further equality within their workplaces, the WPI will serve to have an integral role in increasing gender equality in the workplace. Our approach for raising awareness utilizes two different strategies: (1) establishing a new version of the WPI website that is both informative and aesthetically pleasing and (2) generating social media content on TikTok that appeal to a variety of audiences and introduce them to the WPI and our mission.

ContributorsHoward, Brooke (Author) / Tieu, Lienna (Co-author) / Thomas, Elisa (Co-author) / Zaffar, Ehsan (Thesis director) / Gel, Esma (Committee member) / Barrett, The Honors College (Contributor) / Mechanical and Aerospace Engineering Program (Contributor)
Created2022-05