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- All Subjects: Research
- Creators: Arizona State University Retirees Association
Differences between basic and applied research were explored through a wet-lab case study. Vaccinia virus (VACV) infections are a prime model of the competition between a virus and its host. VACV contains a gene that is highly evasive of the host immune system, gene E3L. The protein encoded by E3L is E3, which contains two highly conserved regions, a C-terminus, and a N-terminus. While the C-terminus is well-understood, the mechanism by which the N-terminus grants IFN resistance was previously unknown. This project demonstrated that the N-terminus prevents the initiation of programmed necrosis through host-encoded cellular proteins RIP3 and DAI. These findings provide insight into the function of the N-terminus of E3, as well as the unique functions of induced programmed necrosis.
This project was an example of “basic” research. However, it highlights the interconnectivity of basic and applied research and the danger in isolating both projects and perspectives. It points to the difficult decisions that must be made in science, and the need for a better research classification system that considers what makes science “good” outside of antiquated social class ideologies that have shaped science since ancient Greece. While there are no easy answers to determine what makes research “good,” thinking critically about the types of research projects that will be pursued, and the effects that research has on both science and society, will raise awareness, initiate new conversations, and encourage more dialogue about science in the 21st century.
Brent Brown, a faculty member of the School of Public Programs, served for many years as ASU's chief lobbyist. The interview covered a number of topics including: working to get ASU to be viewed as a player at the Legislature and Board of Regents, planning for West Campus, Downtown Campus, and Polytechnic Campus, the arrival of the NFL and becoming a Research 1 University.
Doug Anderson came to ASU in the summer of 1979 and joined the newly formed College of Public Programs. He left ASU as the Director of the Walter Cronkite School of Journalism and Mass Communication. Important ASU stories include:
1) the birth of the COLLEGE OF PUBLIC PROGRAMS,
2) the Tempe Campus SIZE and working ENVIRONMENT in 1979.
3) the naming of the WALTER CRONKITE School of Journalism and Mass Communications, and
4) the importance of the 1987 accreditation as a turning point for the School of Journalism and Mass Communications
Kristin Valentine came to ASU in 1976 and joined the Communication faculty in the Fine Arts College. She retired as professor of Human Communication in the Hugh Downs School of Human Communication twenty-eight years later. Kristin describes what oral interpretation of literature is and the interview includes numerous examples of oral interp and how it enhanced the transfer of new ideas to an audience / community. The interview covers the creation of the School of Public Programs and the changing role of women at ASU. The interview ends with a discussion of the importance of community.
Paige Mulhollan came to ASU in 1978 as ASU’s first Provost. He left in 1985 to become President of Wright State University in Ohio. Paige discusses the impact of Frank Kush’s firing on President John Schwada and the birthing of ASU West. At several points Paige discusses the need for ASU to take advantage of Phoenix rather than just being located in Phoenix. Aspects of the University budget are discussed. There are a set of ASU reflections and reflections on an academic career.
Charlie Arntzen joined ASU in August 2000 as the Florence Ely Nelson Presidential Endowed Chair and retired in 2016 from the School of Life Sciences and Biodesign Institute. Charlie was the founding Director of the Biodesign Institute.
Important ASU stories include:
1) the creation of the Biodesign Institute,
2) the design and operation of the Biodesign labs,
3) the development of ZMapp to fight Ebola,
4) The New American University - a discussion of the importance of collaboration, and
5) several comments about Presidents Coor and Crow and Provost Glick