Telemedicine is a multipurpose tool that allows medical professionals to use technology as a means to evaluate, diagnose, and treat patients remotely. This paper focuses on the challenges that developing telemedicine programs face, specifically discussing target population, user experience, and physician adoption. Various users of telemedicine share their experiences overcoming such challenges with the greater goal of this paper being to facilitate the growth of telemedicine programs.

The purpose of this project was to construct and write code for an Internet-of-Things (IoT) based smart pet feeder to promote owner involvement in the health of their pets through the Internet to combat the high rate of obesity in pets in the United States. To achieve this, a pet feeder was developed to track the weight of the pet as well as how much food the pet eats while allowing the owner to see video of their pet eating, all through the owner's smartphone. In this thesis, current pet feeder strengths and weaknesses were researched, pet owners were surveyed, prototype features were decided upon, physical prototype components were purchased, a physical model of the pet feeder was developed in SolidWorks, a prototype was manufactured, and existing IoT libraries were utilized to develop code.

Concussions and traumatic brain injuries are mechanical events which can derive from no specific activity or event. However, these injuries occur often during athletic and sporting events but many athletes experiencing these symptoms go undiagnosed and continue playing without proper medical attention. The current gold standard for diagnosing athletes with concussions is to have medical professionals on the sidelines of events to perform qualitative standardized assessments which may not be performed frequently enough and are not specialized for each athlete. The purpose of this report is to discuss a study sanctioned by Arizona State University's Project HoneyBee and additional affiliations to validate a third-party mouth guard device product to recognize and detect force impacts blown to an athlete's head during athletic activity. Current technology in health monitoring medical devices can allow users to apply this device as an additional safety mechanism for early concussion awareness and diagnosis. This report includes the materials and methods used for experimentation, the discussion of its results, and the complications which occurred and areas for improvement during the preliminary efforts of this project. Participants in the study were five non-varsity ASU Wrestling athletes who volunteered to wear a third-party mouth guard device during sparring contact at practice. Following a needed calibration period for the devices, results were recorded both through visual observation and with the mouth guard devices using an accelerometer and gyroscope. This study provided a sound understanding for the operation and functionality of the mouth guard devices. The mouth guard devices have the capability to provide fundamental avenues of research for future investigations.

The thesis, titled Identifying Emerging Technologies and Techniques to Assess Indoor Environmental Quality and its Impact on Occupant Health, consists of an in-depth literature review outlining the various impacts of building factors on inhabitant health. Approximately 120 studies analyzing how environmental factors influence occupant health were reviewed and 25 were used to build this literature review. The thesis provides insight into the definitions of well-being, health, and the built environment and analyzes the relationship between the three. This complex relationship has been at the forefront of academic research in recent years, especially given the impact of the COVID-19 pandemic. Essentially, an individual’s health and well-being is encompassed by their physical, mental, and social state of being. Due to the increasing amount of time spent in indoor environments the built environment influences these measures of health and well-being through various environmental factors (Indoor Air Quality, humidity, temperature, lighting, acoustics, ergonomics) defining the overall Indoor Environmental Quality. This thesis reviewed the mentioned intervention and experimental studies conducted to determine how fluctuations in environmental factors influence reported health results of occupants in the short and long term. Questionnaires, interviews, medical tests, physical measurements, and sensors were used to track occupant health measures. Sensors are also used to record environmental factor levels and are now beginning to be incorporated into the building production process to promote occupant health in healthy and smart buildings. The goal is ultimately to develop these smart and healthy buildings using study results and advancing technologies and techniques as outlined in the thesis.

Identifying disease biomarkers may aid in the early detection of breast cancer and improve patient outcomes. Recent evidence suggests that tumors are immunogenic and therefore patients may launch an autoantibody response to tumor associated antigens. Single-chain variable fragments of autoantibodies derived from regional lymph node B cells of breast cancer patients were used to discover these tumor associated biomarkers on protein microarrays. Six candidate biomarkers were discovered from 22 heavy chain-only variable region antibody fragments screened. Validation tests are necessary to confirm the tumorgenicity of these antigens. However, the use of single-chain variable autoantibody fragments presents a novel platform for diagnostics and cancer therapeutics.

In 2004, the South Korean geneticist Woo-Suk Hwang published what was widely regarded as the most important research result in biotechnology of the year. In the prestigious American journal Science, he claimed that he had succeeded in cloning a human blastocyst, an embryo in its early stages (Hwang et al. 2004). A year later, in a second Science article, he made the earth-shattering announcement that he had derived eleven embryonic stem cell lines using his cloning technique (Hwang et al. 2005). The international scientific community was stunned. American scientists publicly fretted that President George W. Bush‘s 2001 executive order limiting federal funding for stem-cell research in the United States had put American bioscience behind the Koreans‘ (Paarlberg 2005). These breakthroughs offered potential solutions to immune system rejection of transplanted organs and possible cures for diseases such as rheumatoid arthritis, Parkinson‘s, Down‘s syndrome, and paralysis (Svenaeus 2007). However, within a year, Hwang was exposed as a fraud who had faked his results and pressured his female colleagues to donate eggs without informed consent. Despite protests against his methods from Korean religious and nongovernmental organizations, Hwang had used his prestige to ignore his ethical obligations. The Korean government, too, was slow to investigate Hwang and to subject his work to appropriate regulation.

Menstruation has been characterized as powerful, magical, and mysterious. Historically, it was believed menstrual blood could cure leprosy, warts, birthmarks, gout, goiter, hemorrhoids, epilepsy, worms, and headaches. Menstrual blood was used as a love charm and as a means to ward off river demons or evil spirits, and could be used to honor a god (DeLaney, Lupton, & Toth, 1988, pp.8-9). Contemporary studies reveal that women around the world continue to celebrate their power to create. The World Health Organization studied attitudes of women of all socioeconomic classes in 10 countries (Egypt, India, Indonesia, Jamaica, Pakistan, Philippines, United Kingdom, United States, Yugoslavia, Mexico, Korea) and found that most women saw menstruation as a positive event (DeLaney et al., 1988, p. 14). In a similar study, Mexican-American women perceived menstruation positively, as a process that "cleans" the body (DeLaney et al., 1988, p. 14).

Childhood obesity is a growing public health concern in the United States. For several years, many interventions have been established to reduce the prevalence of childhood obesity. However, these interventions have not adequately utilized existing models of behavior change, and as a result, have been unsuccessful in increasing levels of physical activity and healthy dietary intake. One such model of change, the Transtheoretical Model, views behavior change as occurring through a series of stages with progression through the stages being facilitated by cognitive and behavioral processes. Within these processes the constructs of consciousness-raising, helping relationships, and self-efficacy have been shown to be most influential in changing behaviors. Thus, the objective of this paper is to evaluate the effectiveness of such constructs and establish a multi-faceted approach to combat this epidemic.

Affecting over 34 million people worldwide, (0.5% of the world population) HIV/AIDS is a pandemic that is not receding its control anytime soon (Sidibe 2011). Thirty years since the chaotic emergence of fear and misunderstanding, our knowledge of the virus and its subsequent syndrome has grown exponentially, but how much of this information is really getting to the people that need it? In the corners of the Earth, where scientific knowledge rarely reaches, what can we do to stop the deadly spread of this virus? And what of the countries with a large amount of knowledge, but still a ravaging problem present in their countries? When this information is disseminated- sometimes a matter of ‘if’ in certain countries, it is primarily through unreliable sources, most of the countries examined through the media, which has a tendency to skew and misinterpret information-specially scientific. This is the information that enters the lives of people in several different countries, for example, the United States, France, China, Brazil, Uganda, and South Africa: Misunderstandings of how to protect themselves from the virus, and its effects on the body. These misunderstandings have led to millions of lives lost as myths such as showering to cure AIDS and that AIDS only infect the ‘sinners’ continue to surface throughout the globe. The Public Health threat is due to knowledge deficits, and incorrect perceived ‘knowledge’ and ‘awareness of the problem’. Here, in a six-country analysis of common misconceptions and the subsequent policies and prevalence rate, it has begun to be clear that the hardest hit areas are those with the most stigma, the most misguided policies, the most uninformed leadership, and because of this, the most mislead citizens. The biological misunderstandings of HIV/AIDS are at the root of the public health threat continuing to keep its hold in the modern world, 30 years after its documented outbreak.

This study was conducted as part of an underlying initiative to elucidate the mechanism of action of natural antibacterial clay minerals for application as therapeutic agents for difficult-to-treat infections such as methicillin-resistant Staphylococcus aureus (MRSA)-derived skin lesions and Buruli ulcer. The goal of this investigation was to determine whether exposure to the leachate of an antibacterial clay mineral, designated as CB, produced DNA double-strand breaks (DSBs) in Escherichia coli. A neutral comet assay for bacterial cells was adapted to assess DSB levels upon exposure to soluble antimicrobial compounds. Challenges involved with the adaptation process included comet visualization and data collection. To appropriately account for antimicrobial-mediated strand fragmentation, suitable control reactions comprised of exposures to water, ethanol, kanamycin, and bleomycin were developed and optimized for the assay. Bacterial exposure to CB resulted in significantly longer comet lengths compared to negative control exposures, suggesting that CB killing activity involves the induction of DNA DSBs. The results of this investigation further characterize the antimicrobial mechanisms associated with a particular clay mineral mixture. The adapted comet assay protocol described herein functions as an effective tool to assess double-strand fragmentation resulting from exposure to soluble antimicrobial compounds and to visually compare results from experimental and control reactions.